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The map label for this gene is kefBC [H]

Identifier: 66768252

GI number: 66768252

Start: 2330692

End: 2332542

Strand: Direct

Name: kefBC [H]

Synonym: XC_1931

Alternate gene names: 66768252

Gene position: 2330692-2332542 (Clockwise)

Preceding gene: 66768251

Following gene: 66768254

Centisome position: 45.27

GC content: 64.78

Gene sequence:

>1851_bases
ATGAGCCAGCCTGCCGAATCCAGTGAACTGATCAACGTGGTGACCCTGCTGGGCGCTGCGGTGGTCGCCATTCCGCTGTT
CCGACGGCTGGGCCTTGGCTCGGTGCTCGGCTATCTGGCCGCCGGCTTGGCGATTGGGCCGTTCGGGTTTGGCCTGTTCG
ATGACCCGCAAGCGATCCTGCATGTGGCCGAACTGGGCGTGGTGATGTTTCTGTTCGTGATCGGGCTGGAGATGCGGCCC
TCGCATCTGTGGAGCTTGCGCTCTGAAATTTTTGGCCTAGGCACGGTGCAGATCTGCGTGTGCGCGCTGGTCTTGACCGG
CATCGGCATCCTGCTCGGCTTTGCGCCGCCGGTGGCCTTCGTGGCCGCGTCCGGTTTCGTGCTGACCTCCACTGCAGTGG
TGATGCAGTTGCTTGCCGAGCGCGGCGACGTGGCGCTGCCATCGGGGCAGAAGATCGTGGCGATCCTGCTGTTCGAGGAC
CTGCTGATCGTGCCGCTGTTGGCGATCGTTGCCTGGATGGGCGCCAGTGGCGACCCGCAAGCCGCTTCGCAGCGTTGGCA
GGGCATTGGCATTGGCCTGGCCTGCATCGTTGGACTGCTGGTGGCCGGCCGGTGGTTGCTCAATCCTTTGTTCCGCATCC
TGGCCGCCAGCAAGGCGCGCGAGGTGATGACCGCTGCCGCGCTGCTGGTGGTGCTGGGCGCCGCGCTCTTGATGCAGGTT
GGCGGGTTGTCGATGGCGATGGGCGCGTTCCTGGCCGGGGTGCTGTTGTCTGAATCCACCTTCCGCCATCAGATCGAAGC
CGACATCGAACCGTTCCGCGGCATCCTGCTGGGTCTGTTCTTCCTGGGTGTCGGCATGAGCCTGGATCTGCGCGTGGTCG
CGGCGGACTGGCGCTTGATCCTGGTCGGCGTGCTGGCGTTGATGGTGGGCAAGGCGGTGTGCATCTATGCGGTGGCGCGC
CTGATGCGCAGCGATCACCGGCAGGCGCTGGATCGTGGCGTGCTGATGGCGCAGGGCGGCGAGTTTGCGTTTGTGTTGTT
CGCGGCGGCGTCCGCATCCGGTGTCATCGACGCGCAGGTCAATGCCAGCCTTACCGCGATCGTGGTGTTGTCGATGGCAC
TGACGCCGTTGTTCGTGCTGTTGCAGCGGCGCCTGACGCCGGCAGCGGCGGTGTCGCTGGATGGCGTGGAGGAAGCCAGC
GGCCAGACCGGCAGCGTATTGATCATCGGGTTCGGGCGCTTCGGTCAGGTGGCCAGCCAGTCGCTGCTGGCGCGCGATGT
GGACGTGACCATCATCGATAACGACATCGAGATGATTCAGAGCGCGGAGGAATTCGGGTTCAAGATCTACTACGGCGATG
GCACCCGGTTGGATGTGTTGCATGCCTCCGGTGCACATACCGCGCGTGCGATTGCGGTGTGCGTTGACAACCGCGAGGCG
GCCAATCGCATCGTCGAATTGGCAACGCGCGAGTTCCCGCACGCGAAATTGCTGGTGCGTTCCTTTGATCGCGAACACGC
TTTGGAGTTGATTGCTGCTGGCGTGGACTACCAGATCCGCGAAACCTTCGAGTCGGCGGTCGCGTTCGGCGAAGTGGCCC
TGGTCGAACTGGGCGTGGACGAGGATGAGGCCCGCACGATTGCGCGCGAGATCCGGCGCCGCGATGCCGAGCGCCTGGAG
CTGGAAATTGCCGCGGGCAATGTGCGCGCCGGGGCAGGGCTGATGTACGGCAACATCATGCCGACCGTGCCCAAGCCCAC
GCCCTTTACCCCGCCCAAGCGCGAGAGCCGCACGCTCAATCGCGATGCGCTGCCGCAGGAGTTGCGCGAAGAAACGGCTG
AGCGGGACTAA

Upstream 100 bases:

>100_bases
AGAGTGGTGCCATGCTTGAGATCGCTGCCATCCATATCGCGCGTCACATACGCAAGCACGTGCAGGCCAGCGGCCGCCAC
GTGCCGCTAAAATCCTTGTC

Downstream 100 bases:

>100_bases
ACACAGCGGTCAAATCACCGCGTAACTGGCAGGCGGGCGCGGCCGGTGCTCGGGATCTGCATTTGCCCGAGGCACTTAGG
TTTCTTCGCACCCGCCTTGA

Product: transport protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MSQPAESSELINVVTLLGAAVVAIPLFRRLGLGSVLGYLAAGLAIGPFGFGLFDDPQAILHVAELGVVMFLFVIGLEMRP
SHLWSLRSEIFGLGTVQICVCALVLTGIGILLGFAPPVAFVAASGFVLTSTAVVMQLLAERGDVALPSGQKIVAILLFED
LLIVPLLAIVAWMGASGDPQAASQRWQGIGIGLACIVGLLVAGRWLLNPLFRILAASKAREVMTAAALLVVLGAALLMQV
GGLSMAMGAFLAGVLLSESTFRHQIEADIEPFRGILLGLFFLGVGMSLDLRVVAADWRLILVGVLALMVGKAVCIYAVAR
LMRSDHRQALDRGVLMAQGGEFAFVLFAAASASGVIDAQVNASLTAIVVLSMALTPLFVLLQRRLTPAAAVSLDGVEEAS
GQTGSVLIIGFGRFGQVASQSLLARDVDVTIIDNDIEMIQSAEEFGFKIYYGDGTRLDVLHASGAHTARAIAVCVDNREA
ANRIVELATREFPHAKLLVRSFDREHALELIAAGVDYQIRETFESAVAFGEVALVELGVDEDEARTIAREIRRRDAERLE
LEIAAGNVRAGAGLMYGNIMPTVPKPTPFTPPKRESRTLNRDALPQELREETAERD

Sequences:

>Translated_616_residues
MSQPAESSELINVVTLLGAAVVAIPLFRRLGLGSVLGYLAAGLAIGPFGFGLFDDPQAILHVAELGVVMFLFVIGLEMRP
SHLWSLRSEIFGLGTVQICVCALVLTGIGILLGFAPPVAFVAASGFVLTSTAVVMQLLAERGDVALPSGQKIVAILLFED
LLIVPLLAIVAWMGASGDPQAASQRWQGIGIGLACIVGLLVAGRWLLNPLFRILAASKAREVMTAAALLVVLGAALLMQV
GGLSMAMGAFLAGVLLSESTFRHQIEADIEPFRGILLGLFFLGVGMSLDLRVVAADWRLILVGVLALMVGKAVCIYAVAR
LMRSDHRQALDRGVLMAQGGEFAFVLFAAASASGVIDAQVNASLTAIVVLSMALTPLFVLLQRRLTPAAAVSLDGVEEAS
GQTGSVLIIGFGRFGQVASQSLLARDVDVTIIDNDIEMIQSAEEFGFKIYYGDGTRLDVLHASGAHTARAIAVCVDNREA
ANRIVELATREFPHAKLLVRSFDREHALELIAAGVDYQIRETFESAVAFGEVALVELGVDEDEARTIAREIRRRDAERLE
LEIAAGNVRAGAGLMYGNIMPTVPKPTPFTPPKRESRTLNRDALPQELREETAERD
>Mature_615_residues
SQPAESSELINVVTLLGAAVVAIPLFRRLGLGSVLGYLAAGLAIGPFGFGLFDDPQAILHVAELGVVMFLFVIGLEMRPS
HLWSLRSEIFGLGTVQICVCALVLTGIGILLGFAPPVAFVAASGFVLTSTAVVMQLLAERGDVALPSGQKIVAILLFEDL
LIVPLLAIVAWMGASGDPQAASQRWQGIGIGLACIVGLLVAGRWLLNPLFRILAASKAREVMTAAALLVVLGAALLMQVG
GLSMAMGAFLAGVLLSESTFRHQIEADIEPFRGILLGLFFLGVGMSLDLRVVAADWRLILVGVLALMVGKAVCIYAVARL
MRSDHRQALDRGVLMAQGGEFAFVLFAAASASGVIDAQVNASLTAIVVLSMALTPLFVLLQRRLTPAAAVSLDGVEEASG
QTGSVLIIGFGRFGQVASQSLLARDVDVTIIDNDIEMIQSAEEFGFKIYYGDGTRLDVLHASGAHTARAIAVCVDNREAA
NRIVELATREFPHAKLLVRSFDREHALELIAAGVDYQIRETFESAVAFGEVALVELGVDEDEARTIAREIRRRDAERLEL
EIAAGNVRAGAGLMYGNIMPTVPKPTPFTPPKRESRTLNRDALPQELREETAERD

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=358, Percent_Identity=25.4189944134078, Blast_Score=80, Evalue=8e-15,
Organism=Escherichia coli, GI1789749, Length=561, Percent_Identity=42.9590017825312, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1786232, Length=559, Percent_Identity=39.7137745974955, Blast_Score=394, Evalue=1e-110,
Organism=Escherichia coli, GI1786685, Length=515, Percent_Identity=28.1553398058252, Blast_Score=146, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 65594; Mature: 65463

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPAESSELINVVTLLGAAVVAIPLFRRLGLGSVLGYLAAGLAIGPFGFGLFDDPQAIL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
HVAELGVVMFLFVIGLEMRPSHLWSLRSEIFGLGTVQICVCALVLTGIGILLGFAPPVAF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHH
VAASGFVLTSTAVVMQLLAERGDVALPSGQKIVAILLFEDLLIVPLLAIVAWMGASGDPQ
HHCCCHHHHHHHHHHHHHHCCCCEECCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCH
AASQRWQGIGIGLACIVGLLVAGRWLLNPLFRILAASKAREVMTAAALLVVLGAALLMQV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGLSMAMGAFLAGVLLSESTFRHQIEADIEPFRGILLGLFFLGVGMSLDLRVVAADWRLI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHH
LVGVLALMVGKAVCIYAVARLMRSDHRQALDRGVLMAQGGEFAFVLFAAASASGVIDAQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCCCCEEEEC
NASLTAIVVLSMALTPLFVLLQRRLTPAAAVSLDGVEEASGQTGSVLIIGFGRFGQVASQ
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHCCCCCCCEEEEECCCHHHHHHH
SLLARDVDVTIIDNDIEMIQSAEEFGFKIYYGDGTRLDVLHASGAHTARAIAVCVDNREA
HHHHCCCEEEEECCHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCHHEEEEEEECCHHH
ANRIVELATREFPHAKLLVRSFDREHALELIAAGVDYQIRETFESAVAFGEVALVELGVD
HHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECCC
EDEARTIAREIRRRDAERLELEIAAGNVRAGAGLMYGNIMPTVPKPTPFTPPKRESRTLN
HHHHHHHHHHHHHCCHHHEEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCC
RDALPQELREETAERD
CCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SQPAESSELINVVTLLGAAVVAIPLFRRLGLGSVLGYLAAGLAIGPFGFGLFDDPQAIL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
HVAELGVVMFLFVIGLEMRPSHLWSLRSEIFGLGTVQICVCALVLTGIGILLGFAPPVAF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHH
VAASGFVLTSTAVVMQLLAERGDVALPSGQKIVAILLFEDLLIVPLLAIVAWMGASGDPQ
HHCCCHHHHHHHHHHHHHHCCCCEECCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCH
AASQRWQGIGIGLACIVGLLVAGRWLLNPLFRILAASKAREVMTAAALLVVLGAALLMQV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGLSMAMGAFLAGVLLSESTFRHQIEADIEPFRGILLGLFFLGVGMSLDLRVVAADWRLI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHH
LVGVLALMVGKAVCIYAVARLMRSDHRQALDRGVLMAQGGEFAFVLFAAASASGVIDAQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCCCCEEEEC
NASLTAIVVLSMALTPLFVLLQRRLTPAAAVSLDGVEEASGQTGSVLIIGFGRFGQVASQ
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHCCCCCCCEEEEECCCHHHHHHH
SLLARDVDVTIIDNDIEMIQSAEEFGFKIYYGDGTRLDVLHASGAHTARAIAVCVDNREA
HHHHCCCEEEEECCHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCHHEEEEEEECCHHH
ANRIVELATREFPHAKLLVRSFDREHALELIAAGVDYQIRETFESAVAFGEVALVELGVD
HHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECCC
EDEARTIAREIRRRDAERLELEIAAGNVRAGAGLMYGNIMPTVPKPTPFTPPKRESRTLN
HHHHHHHHHHHHHCCHHHEEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCC
RDALPQELREETAERD
CCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]