Click here to switch to the map view.

The map label for this gene is gluQ

Identifier: 66768143

GI number: 66768143

Start: 2214844

End: 2215737

Strand: Reverse

Name: gluQ

Synonym: XC_1822

Alternate gene names: 66768143

Gene position: 2215737-2214844 (Counterclockwise)

Preceding gene: 66768145

Following gene: 66768142

Centisome position: 43.03

GC content: 70.69

Gene sequence:

>894_bases
ATGTCCTCACTCCCTTACCGCGGCCGCTTCGCGCCCTCGCCCACCGGCCCCCTGCACTTCGGCTCGCTCCTGGCTGCGTT
GGGCAGCTGGCTGCTCGCGCGCCATGCCGGTGGCGAATGGCATGTGCGAATCGAAGACATCGACCCGCCGCGTGCCGAGC
CAGGCGCCTCAGAGCGTCAATTGCATACGCTGGCTGCGTTCGGGCTGCACTCTGACGGGCCGGTGCTGTATCAGTCCGAC
CGCGATGCGTATTACGAGGCAGCACTGTCGCGGCTGCTGCGCAGCGGTGCGGCGTTCGAATGCAGTTGCAGCCGCGCAGA
GCTGGCCGCGATGGGTGGCATCCACCACGTCTGCGTGGCGCCACTGGGCATCCGCCGCGCCGTGCGCCTGCGGGTGCCGC
CGAACACCCAGGCAAGCTTTCAGGACGCGCTGCAGGGGCGCATCACCCAGGATGTGTACTCCGAAGTAGGCGACGTCGTC
CTGCGCCGGGCCGACGGCTACTGGGCCTACCAGCTGGCGGTGGTGGTCGACGATGCGGCGCAGGGCATCACCGATGTGGT
GCGCGGGGCGGACCTGCTCGACTCCACCCCGCGCCAATTGGTGCTGCAGCAGGCCCTGGGCGTGGCACCGCCGCGCTATC
TGCATCTGCCGCTGATCCTGGGCGCCGACGGGCGCAAGCTTTCCAAGTCGCATGCGGCGCAACCAGTGGATGACAGCGAC
CCGCTGCCAGCGCTGCGCGCGGCCTGGCGGGCGCTGGGCCAGGCACCGGCGGCCCTGCCCGCGCGCGCATCGGTGGCCGG
TGTGCTGCAGCATGCCGTGCAGCATTTTTCGCCGCAGCGGCTGCCGCGCGTTGCCAGCCTGGACGCTGCCACGCGCATCG
ACGCCCCGGCTTGA

Upstream 100 bases:

>100_bases
AGAGGCAGTGGCTCCGCACGCAAAGAGGGTGAACTGCTGCGGATCTGCGGACGTGGCGGGTTGAAATCAAGCAAGCACCT
GACCGACGATTCAGCTGCCC

Downstream 100 bases:

>100_bases
CTAGAATTGCGACCCAGCACCGGCTTTCGCCCTGACGCCTCCGCAGCGTCGCGGGCGCCGCCAGCCCTATCTGCTCATTG
GAGTTGCGCATGACATCTCG

Product: aminoacyl-tRNA synthetase: glutamyl-like protein

Products: NA

Alternate protein names: Glu-Q-RSs

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSSLPYRGRFAPSPTGPLHFGSLLAALGSWLLARHAGGEWHVRIEDIDPPRAEPGASERQLHTLAAFGLHSDGPVLYQSD
RDAYYEAALSRLLRSGAAFECSCSRAELAAMGGIHHVCVAPLGIRRAVRLRVPPNTQASFQDALQGRITQDVYSEVGDVV
LRRADGYWAYQLAVVVDDAAQGITDVVRGADLLDSTPRQLVLQQALGVAPPRYLHLPLILGADGRKLSKSHAAQPVDDSD
PLPALRAAWRALGQAPAALPARASVAGVLQHAVQHFSPQRLPRVASLDAATRIDAPA

Sequences:

>Translated_297_residues
MSSLPYRGRFAPSPTGPLHFGSLLAALGSWLLARHAGGEWHVRIEDIDPPRAEPGASERQLHTLAAFGLHSDGPVLYQSD
RDAYYEAALSRLLRSGAAFECSCSRAELAAMGGIHHVCVAPLGIRRAVRLRVPPNTQASFQDALQGRITQDVYSEVGDVV
LRRADGYWAYQLAVVVDDAAQGITDVVRGADLLDSTPRQLVLQQALGVAPPRYLHLPLILGADGRKLSKSHAAQPVDDSD
PLPALRAAWRALGQAPAALPARASVAGVLQHAVQHFSPQRLPRVASLDAATRIDAPA
>Mature_296_residues
SSLPYRGRFAPSPTGPLHFGSLLAALGSWLLARHAGGEWHVRIEDIDPPRAEPGASERQLHTLAAFGLHSDGPVLYQSDR
DAYYEAALSRLLRSGAAFECSCSRAELAAMGGIHHVCVAPLGIRRAVRLRVPPNTQASFQDALQGRITQDVYSEVGDVVL
RRADGYWAYQLAVVVDDAAQGITDVVRGADLLDSTPRQLVLQQALGVAPPRYLHLPLILGADGRKLSKSHAAQPVDDSDP
LPALRAAWRALGQAPAALPARASVAGVLQHAVQHFSPQRLPRVASLDAATRIDAPA

Specific function: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble positi

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily

Homologues:

Organism=Homo sapiens, GI134288884, Length=251, Percent_Identity=38.6454183266932, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI226510925, Length=294, Percent_Identity=47.2789115646259, Blast_Score=228, Evalue=3e-61,
Organism=Escherichia coli, GI1788743, Length=308, Percent_Identity=33.1168831168831, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71993394, Length=299, Percent_Identity=32.7759197324415, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324540, Length=326, Percent_Identity=32.8220858895706, Blast_Score=150, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24665321, Length=252, Percent_Identity=36.1111111111111, Blast_Score=148, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLUQ_XANC8 (Q4UVN8)

Other databases:

- EMBL:   CP000050
- RefSeq:   YP_242905.1
- ProteinModelPortal:   Q4UVN8
- SMR:   Q4UVN8
- STRING:   Q4UVN8
- GeneID:   3380369
- GenomeReviews:   CP000050_GR
- KEGG:   xcb:XC_1822
- eggNOG:   COG0008
- HOGENOM:   HBG628189
- OMA:   IIKRSDG
- PhylomeDB:   Q4UVN8
- ProtClustDB:   PRK05710
- BioCyc:   XCAM314565:XC_1822-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_01428
- InterPro:   IPR022380
- InterPro:   IPR000924
- InterPro:   IPR020058
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10119
- PRINTS:   PR00987
- TIGRFAMs:   TIGR03838

Pfam domain/function: PF00749 tRNA-synt_1c

EC number: NA

Molecular weight: Translated: 31771; Mature: 31640

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 45-45 BINDING 170-170 BINDING 188-188 BINDING 229-229

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLPYRGRFAPSPTGPLHFGSLLAALGSWLLARHAGGEWHVRIEDIDPPRAEPGASERQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHH
LHTLAAFGLHSDGPVLYQSDRDAYYEAALSRLLRSGAAFECSCSRAELAAMGGIHHVCVA
HHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHCCHHHHHHC
PLGIRRAVRLRVPPNTQASFQDALQGRITQDVYSEVGDVVLRRADGYWAYQLAVVVDDAA
CHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECHHH
QGITDVVRGADLLDSTPRQLVLQQALGVAPPRYLHLPLILGADGRKLSKSHAAQPVDDSD
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHCCCCCCCCC
PLPALRAAWRALGQAPAALPARASVAGVLQHAVQHFSPQRLPRVASLDAATRIDAPA
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCHHHHCCHHHHCCCCC
>Mature Secondary Structure 
SSLPYRGRFAPSPTGPLHFGSLLAALGSWLLARHAGGEWHVRIEDIDPPRAEPGASERQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHH
LHTLAAFGLHSDGPVLYQSDRDAYYEAALSRLLRSGAAFECSCSRAELAAMGGIHHVCVA
HHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHCCHHHHHHC
PLGIRRAVRLRVPPNTQASFQDALQGRITQDVYSEVGDVVLRRADGYWAYQLAVVVDDAA
CHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECHHH
QGITDVVRGADLLDSTPRQLVLQQALGVAPPRYLHLPLILGADGRKLSKSHAAQPVDDSD
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHCCCCCCCCC
PLPALRAAWRALGQAPAALPARASVAGVLQHAVQHFSPQRLPRVASLDAATRIDAPA
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA