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The map label for this gene is emrA [H]

Identifier: 66768094

GI number: 66768094

Start: 2156699

End: 2157898

Strand: Direct

Name: emrA [H]

Synonym: XC_1773

Alternate gene names: 66768094

Gene position: 2156699-2157898 (Clockwise)

Preceding gene: 66768093

Following gene: 66768095

Centisome position: 41.89

GC content: 69.17

Gene sequence:

>1200_bases
TTGAGCAACCACGATCAGCAGTCCACCGATGGCCAGTCCACAGCAGCGGACGGGCAGGGCAATGCGTCCCGCGACGACGA
CGCCAAGAAGCCCTCGCCGCTGAAGAATCCCAAGGTGAAGTGGACGCTGATCATCGTCGGCGTGCTGGTGGTGGTGCTGC
TGGTGATCTGGCTGGCCTACTACCTGATCAAGGGCCGCTACATGCAGGACACCAACAACGCCTACCTGCAGGCGGACTCG
GTGGCGGTGGCTCCGCGCGTCAGCGGCTATGTCACTCAGGTGATGGTGGGCGACAACCAGATTGTCGACGCCGGCCAGCC
CCTGCTGCAGATCGACGACCGCACCTACCAGGCCACGCTGCAACAGGCCGAAGCCGCAATCGCCGCGCGCGAAGCCGACA
TCGCCGCCGCCACCGCCAATGTGGCCGCGCAGGAATCGTCGCTGGTGCAGGCGCGCACCCAGGTGGCCTCGGCCGCGGCA
AGCCTGCGCTTTGCCCAGGCCGAGGTGAAGCGCTTCGCGCCGCTGGCCGCCTCCGGCGCCGACACCCACGAACACCAGGA
AAGCCTGCAGCACGATCTGGAGCGCGCCCGCGCCCAGTACGAGGCCGCACAGGCGCAGGCCAAGGGGGCGCAGAGCCAGA
TCCAGGCCAGCAGCGCCCAGCTGGAGCAGGCCAAGGCCGGGGTGAAGCAGGCCACCGCCGATGCCGACCAGGCGCGCGTG
GCGGTGGAAGACACCCGCCTGACCAGCCGTATCCACGGCCGGGTGGGCGACAAGACCGTGCAGGTGGGGCAGTTCCTGGC
CGCCGGCACCCGCACCATGACCATCGTGCCGCAGCAGTCGCTGTACCTGGTGGCCAACTTCAAGGAAACCCAGGTCGGCC
TGATGCGCCCCGGCCAGCCAGCCGAGATCGAGGTCGACGCGCTGTCGGGCGTGAAGCTGCACGGCAAGGTGGAAAGCCTG
TCGCCCGGCACCGGCTCGCAGTTCGCGCTGTTGCCGCCGGAGAACGCCACCGGCAACTTCACCAAGGTGGTGCAGCGCGT
GCCGGTGCGCATCCGCGTGCTGGCCGGTGAGGAAGCGCGCAAGGTGCTGGTGCCTGGCATGTCGGTGGAGGTCACCGTGG
ATACCCGCTCGGCCAAGGACGCCAAGCAGCGCGCCGAGGAGGAATCGGACCGCGTGCAGGCGCAGGAGCGCGCGCGATGA

Upstream 100 bases:

>100_bases
CTGGGCGGTTCAAATAATTGTATGGTTGCGCCGCCTCGCCGGGCCCGTTGATGCGGGCATGCCAGCGCGCGCGCCCAGCC
CACGACACAGGACGCCCCCT

Downstream 100 bases:

>100_bases
ATGCCGCGGCGGCCACCGGCGAGCGTGCCGGCGGCAGCGCCGGACGCGAGAAAGCCGAACCGGGCGCGTGGCTGGCGGTA
CTGGCCGGCACCATCGGCTC

Product: transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSNHDQQSTDGQSTAADGQGNASRDDDAKKPSPLKNPKVKWTLIIVGVLVVVLLVIWLAYYLIKGRYMQDTNNAYLQADS
VAVAPRVSGYVTQVMVGDNQIVDAGQPLLQIDDRTYQATLQQAEAAIAAREADIAAATANVAAQESSLVQARTQVASAAA
SLRFAQAEVKRFAPLAASGADTHEHQESLQHDLERARAQYEAAQAQAKGAQSQIQASSAQLEQAKAGVKQATADADQARV
AVEDTRLTSRIHGRVGDKTVQVGQFLAAGTRTMTIVPQQSLYLVANFKETQVGLMRPGQPAEIEVDALSGVKLHGKVESL
SPGTGSQFALLPPENATGNFTKVVQRVPVRIRVLAGEEARKVLVPGMSVEVTVDTRSAKDAKQRAEEESDRVQAQERAR

Sequences:

>Translated_399_residues
MSNHDQQSTDGQSTAADGQGNASRDDDAKKPSPLKNPKVKWTLIIVGVLVVVLLVIWLAYYLIKGRYMQDTNNAYLQADS
VAVAPRVSGYVTQVMVGDNQIVDAGQPLLQIDDRTYQATLQQAEAAIAAREADIAAATANVAAQESSLVQARTQVASAAA
SLRFAQAEVKRFAPLAASGADTHEHQESLQHDLERARAQYEAAQAQAKGAQSQIQASSAQLEQAKAGVKQATADADQARV
AVEDTRLTSRIHGRVGDKTVQVGQFLAAGTRTMTIVPQQSLYLVANFKETQVGLMRPGQPAEIEVDALSGVKLHGKVESL
SPGTGSQFALLPPENATGNFTKVVQRVPVRIRVLAGEEARKVLVPGMSVEVTVDTRSAKDAKQRAEEESDRVQAQERAR
>Mature_398_residues
SNHDQQSTDGQSTAADGQGNASRDDDAKKPSPLKNPKVKWTLIIVGVLVVVLLVIWLAYYLIKGRYMQDTNNAYLQADSV
AVAPRVSGYVTQVMVGDNQIVDAGQPLLQIDDRTYQATLQQAEAAIAAREADIAAATANVAAQESSLVQARTQVASAAAS
LRFAQAEVKRFAPLAASGADTHEHQESLQHDLERARAQYEAAQAQAKGAQSQIQASSAQLEQAKAGVKQATADADQARVA
VEDTRLTSRIHGRVGDKTVQVGQFLAAGTRTMTIVPQQSLYLVANFKETQVGLMRPGQPAEIEVDALSGVKLHGKVESLS
PGTGSQFALLPPENATGNFTKVVQRVPVRIRVLAGEEARKVLVPGMSVEVTVDTRSAKDAKQRAEEESDRVQAQERAR

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=332, Percent_Identity=34.0361445783133, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788711, Length=338, Percent_Identity=31.3609467455621, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1790519, Length=291, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789637, Length=348, Percent_Identity=26.4367816091954, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081951, Length=318, Percent_Identity=24.8427672955975, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1790024, Length=301, Percent_Identity=26.2458471760797, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790012, Length=298, Percent_Identity=26.510067114094, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789900, Length=276, Percent_Identity=25.3623188405797, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42752; Mature: 42621

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNHDQQSTDGQSTAADGQGNASRDDDAKKPSPLKNPKVKWTLIIVGVLVVVLLVIWLAY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
YLIKGRYMQDTNNAYLQADSVAVAPRVSGYVTQVMVGDNQIVDAGQPLLQIDDRTYQATL
HHHCCCEEECCCCCEEEECCEEECCCCCCEEEEEEECCCEEECCCCCEEEECCHHHHHHH
QQAEAAIAAREADIAAATANVAAQESSLVQARTQVASAAASLRFAQAEVKRFAPLAASGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DTHEHQESLQHDLERARAQYEAAQAQAKGAQSQIQASSAQLEQAKAGVKQATADADQARV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEE
AVEDTRLTSRIHGRVGDKTVQVGQFLAAGTRTMTIVPQQSLYLVANFKETQVGLMRPGQP
EEHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCEEECCCCCCC
AEIEVDALSGVKLHGKVESLSPGTGSQFALLPPENATGNFTKVVQRVPVRIRVLAGEEAR
CEEEEECCCCEEEECEECCCCCCCCCEEEEECCCCCCCHHHHHHHHCCEEEEEEECCCCC
KVLVPGMSVEVTVDTRSAKDAKQRAEEESDRVQAQERAR
EEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNHDQQSTDGQSTAADGQGNASRDDDAKKPSPLKNPKVKWTLIIVGVLVVVLLVIWLAY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
YLIKGRYMQDTNNAYLQADSVAVAPRVSGYVTQVMVGDNQIVDAGQPLLQIDDRTYQATL
HHHCCCEEECCCCCEEEECCEEECCCCCCEEEEEEECCCEEECCCCCEEEECCHHHHHHH
QQAEAAIAAREADIAAATANVAAQESSLVQARTQVASAAASLRFAQAEVKRFAPLAASGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DTHEHQESLQHDLERARAQYEAAQAQAKGAQSQIQASSAQLEQAKAGVKQATADADQARV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEE
AVEDTRLTSRIHGRVGDKTVQVGQFLAAGTRTMTIVPQQSLYLVANFKETQVGLMRPGQP
EEHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCEEECCCCCCC
AEIEVDALSGVKLHGKVESLSPGTGSQFALLPPENATGNFTKVVQRVPVRIRVLAGEEAR
CEEEEECCCCEEEECEECCCCCCCCCEEEEECCCCCCCHHHHHHHHCCEEEEEEECCCCC
KVLVPGMSVEVTVDTRSAKDAKQRAEEESDRVQAQERAR
EEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]