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The map label for this gene is ptpA [H]

Identifier: 66768039

GI number: 66768039

Start: 2068896

End: 2071238

Strand: Direct

Name: ptpA [H]

Synonym: XC_1715

Alternate gene names: 66768039

Gene position: 2068896-2071238 (Clockwise)

Preceding gene: 66768038

Following gene: 66768040

Centisome position: 40.18

GC content: 66.75

Gene sequence:

>2343_bases
ATGCTCCTGCAGTTGCAACGTCCCGCGCGCCTGTCGCAATTTCGTCTCCTTATCGCGTGCTGTCTAAGCATTGCCATGCT
GCCAACGCTGGCGCACGCGGCGGCGCAGCCTGCCGAGCCCACACCGGCGCAGTACACCGCGGCGATCGGGTTGACCGACC
GCTACGACGCCCTGGTCGACCGCCAGCCCAGCGCGCCGGTATGGGTGGATGCGCAGCGCTTTTTGTACCGGCGCGGGAGC
ATGCGCCAGGGCCAGGCGCCGGCGATCGCGTACCGGCTGGTGGACGCCGCCAGCGGGCGCAACACGCCGGCCTTCGACCA
CGCACGTCTTGCCGCCGCGCTGACCCAGGCCGGCGCACACAACGTGGATGCGGCAGCGTTGCATTTGCAGGATCCAGCGC
TGGAACAGCAGACGCTGCGCTTTCAGCTGGCAGATCTTGGCTGGCAGTGCGAGTTGGTACGTTACCGCTGCACGCACCTG
CCCGAGCGCGATGTGCGGCCCGAGTCGATGGACATGAGTTTCCCGCTCAAGCAGGGCGAGCGCTATGCCAAGCACTCGCC
GGACGGGCGCTGGCGGGTGTGGGTGGAGCAGGGCAATCTGCTGATCGCCCCGGTGGGCGGCGGCACGCCAACGGCCATCA
GTGACGATGGCAGTGCGAGCGACTTCTACGCCATCGACACGGTGGTGTGGTCGCCCGACTCGCAACATGTGGCCGCCTAT
CGGGTCAAGGCGCCGCCGCCGCACATCGTGTATTACATCGAATCGGCGCCGGCCGATCGCGTGCAACCCAAGCTGCATCA
GCAGGTCTATCCCAAGCCCGGCGACCCATTGCCGGTGATGCAGCCAGTGCTGTTCGACGTGGCCACGCGCACCGCGCGCC
CGGTGGACATGACCCTGCTGCCCAACGCCTTCACCCTTAGCGAGCTGCAATGGTGGAAGGACAGCCGCGGCGTGACCTTC
GAATACAACGCCCGTGGGCATCAGCTGTACCGCGTGATCGAAGTGGATGCAGGCACCGCCGTTGCGCGCACCGTGATCGA
GGAAACCTCGCCCACCTTTATCGAGTACTCGCCACTCAGTGGCGACAACGAAGACGGCGGCAAGTACGCGCGCCACGATC
TTGCCGATGGCGCGCAACTGCTGTGGGCCTCCGAGCGCGATGGCTGGGAACACCTGTATCTCTACGATGGCCGCACTGGT
CGCGTGATGCGCCAGGTCACCCGTGGCGAGTGGGTGGTGCGCAGGCTCGATCATGTCGACGAGGCGGCCGGGCAGGTGTA
CTTCAGCGCCTCCGGCATGCAACCCGGTGAAGACCCGTACTACCGCCATGCCTATCGCATCGGCCTGGACGGCACCGGCC
TGACCGCGCTGACCCCGCTGGCCGCCGATCATGATGTGCGTTATTCGCCGGACGGGCGCTGGTTTCTGGACCTGTCTTCG
CGCGTGGACCTGGGGCCGGTACTGGAGCTGCGGCGCAGTGCGGATGGCAGCCTGGTACACACGGTGGAGCGCACAGATCT
AAGCCACCTGCTGGCGGCCGGTTGGCAGCCGCCGTTGCCGTTCCATACCCCCGGGCGCGATGGCAAGACCGAGATCTGGG
GCGTCATTTTCCGCCCCCAGCAGCTCGATGCCCAGCAGCCGTATCGCGTCGTCGAATACATCTACGCCGGGCCGCAGGGC
TCGTTCGTGCCGAAGCGCTTCACCACGCGCACGCCGCCGCTGACGGGGCTCGGCTTTGCGGTGGCGCAGATCGACGGCAT
GGGCACCAACAACCGCTCGCGCGCTTTTCACGACGTGGCCTGGCGCAATCTTAAAGACGCCGGCTTGCCGGACCGCATCG
CCTGGCACAAGGCGGCCGCCGCACGTTACCCCTGGTACGACATTCGCGGCGGGGTGGGCGTGTACGGCACCTCGGCCGGC
GGGCAGAACGCGCTGGGCGCGTTGCTGTTCCATCCCGAGTTCTACGTGGCCGGCGTGGCGAACTCAGGCTGCCACGACAA
TCGCATGGACAAGATCTGGTGGAACGAGCAATGGATGGGCTGGCCGGTGGGGCCGTGGTACGCCGAATCCTCGAACGTGG
AAAACGCCGCGCGCCTGCAGGGCCATTTGCTGCTGGTCACCGGCGACATGGACAAGAATGTCGATCCTGCCAGCACCTTC
CAGGTGGCCGATCGCCTGATCAAGGCGGGCAAGGATTTCGACCTGCTGGTGGTGCCCGGCGGCGATCACGGCGCAGGCGG
TGACTACGGCAAGCGCCGCCTGTTGGATTTTTTCCAGCGCTGGTTGCACCGCACTCCGACGCCGGAGTGGAATCAGGTCT
CTGCCGCAGTGCCCGCGCCATGA

Upstream 100 bases:

>100_bases
ACAGCCGCCACTGCGATGCGCCGTGATTGCGCTGACGACAACGCAACCGCTGCCTACATTTCTCTCCACCCATCACCGGC
TTTCTCACCTGGATCGACCC

Downstream 100 bases:

>100_bases
CAACGGATTGGCAGGCCGGCGTTGCGCAACGTGGCGATCCAGCCGAACGCCGCCGAAAAACTGCGCTTGTGAGTCGGCGT
CTCCCGCAGCTCATCGGTAA

Product: peptidase

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 780; Mature: 780

Protein sequence:

>780_residues
MLLQLQRPARLSQFRLLIACCLSIAMLPTLAHAAAQPAEPTPAQYTAAIGLTDRYDALVDRQPSAPVWVDAQRFLYRRGS
MRQGQAPAIAYRLVDAASGRNTPAFDHARLAAALTQAGAHNVDAAALHLQDPALEQQTLRFQLADLGWQCELVRYRCTHL
PERDVRPESMDMSFPLKQGERYAKHSPDGRWRVWVEQGNLLIAPVGGGTPTAISDDGSASDFYAIDTVVWSPDSQHVAAY
RVKAPPPHIVYYIESAPADRVQPKLHQQVYPKPGDPLPVMQPVLFDVATRTARPVDMTLLPNAFTLSELQWWKDSRGVTF
EYNARGHQLYRVIEVDAGTAVARTVIEETSPTFIEYSPLSGDNEDGGKYARHDLADGAQLLWASERDGWEHLYLYDGRTG
RVMRQVTRGEWVVRRLDHVDEAAGQVYFSASGMQPGEDPYYRHAYRIGLDGTGLTALTPLAADHDVRYSPDGRWFLDLSS
RVDLGPVLELRRSADGSLVHTVERTDLSHLLAAGWQPPLPFHTPGRDGKTEIWGVIFRPQQLDAQQPYRVVEYIYAGPQG
SFVPKRFTTRTPPLTGLGFAVAQIDGMGTNNRSRAFHDVAWRNLKDAGLPDRIAWHKAAAARYPWYDIRGGVGVYGTSAG
GQNALGALLFHPEFYVAGVANSGCHDNRMDKIWWNEQWMGWPVGPWYAESSNVENAARLQGHLLLVTGDMDKNVDPASTF
QVADRLIKAGKDFDLLVVPGGDHGAGGDYGKRRLLDFFQRWLHRTPTPEWNQVSAAVPAP

Sequences:

>Translated_780_residues
MLLQLQRPARLSQFRLLIACCLSIAMLPTLAHAAAQPAEPTPAQYTAAIGLTDRYDALVDRQPSAPVWVDAQRFLYRRGS
MRQGQAPAIAYRLVDAASGRNTPAFDHARLAAALTQAGAHNVDAAALHLQDPALEQQTLRFQLADLGWQCELVRYRCTHL
PERDVRPESMDMSFPLKQGERYAKHSPDGRWRVWVEQGNLLIAPVGGGTPTAISDDGSASDFYAIDTVVWSPDSQHVAAY
RVKAPPPHIVYYIESAPADRVQPKLHQQVYPKPGDPLPVMQPVLFDVATRTARPVDMTLLPNAFTLSELQWWKDSRGVTF
EYNARGHQLYRVIEVDAGTAVARTVIEETSPTFIEYSPLSGDNEDGGKYARHDLADGAQLLWASERDGWEHLYLYDGRTG
RVMRQVTRGEWVVRRLDHVDEAAGQVYFSASGMQPGEDPYYRHAYRIGLDGTGLTALTPLAADHDVRYSPDGRWFLDLSS
RVDLGPVLELRRSADGSLVHTVERTDLSHLLAAGWQPPLPFHTPGRDGKTEIWGVIFRPQQLDAQQPYRVVEYIYAGPQG
SFVPKRFTTRTPPLTGLGFAVAQIDGMGTNNRSRAFHDVAWRNLKDAGLPDRIAWHKAAAARYPWYDIRGGVGVYGTSAG
GQNALGALLFHPEFYVAGVANSGCHDNRMDKIWWNEQWMGWPVGPWYAESSNVENAARLQGHLLLVTGDMDKNVDPASTF
QVADRLIKAGKDFDLLVVPGGDHGAGGDYGKRRLLDFFQRWLHRTPTPEWNQVSAAVPAP
>Mature_780_residues
MLLQLQRPARLSQFRLLIACCLSIAMLPTLAHAAAQPAEPTPAQYTAAIGLTDRYDALVDRQPSAPVWVDAQRFLYRRGS
MRQGQAPAIAYRLVDAASGRNTPAFDHARLAAALTQAGAHNVDAAALHLQDPALEQQTLRFQLADLGWQCELVRYRCTHL
PERDVRPESMDMSFPLKQGERYAKHSPDGRWRVWVEQGNLLIAPVGGGTPTAISDDGSASDFYAIDTVVWSPDSQHVAAY
RVKAPPPHIVYYIESAPADRVQPKLHQQVYPKPGDPLPVMQPVLFDVATRTARPVDMTLLPNAFTLSELQWWKDSRGVTF
EYNARGHQLYRVIEVDAGTAVARTVIEETSPTFIEYSPLSGDNEDGGKYARHDLADGAQLLWASERDGWEHLYLYDGRTG
RVMRQVTRGEWVVRRLDHVDEAAGQVYFSASGMQPGEDPYYRHAYRIGLDGTGLTALTPLAADHDVRYSPDGRWFLDLSS
RVDLGPVLELRRSADGSLVHTVERTDLSHLLAAGWQPPLPFHTPGRDGKTEIWGVIFRPQQLDAQQPYRVVEYIYAGPQG
SFVPKRFTTRTPPLTGLGFAVAQIDGMGTNNRSRAFHDVAWRNLKDAGLPDRIAWHKAAAARYPWYDIRGGVGVYGTSAG
GQNALGALLFHPEFYVAGVANSGCHDNRMDKIWWNEQWMGWPVGPWYAESSNVENAARLQGHLLLVTGDMDKNVDPASTF
QVADRLIKAGKDFDLLVVPGGDHGAGGDYGKRRLLDFFQRWLHRTPTPEWNQVSAAVPAP

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI194394146, Length=381, Percent_Identity=25.4593175853018, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI18450280, Length=381, Percent_Identity=26.246719160105, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI37577089, Length=381, Percent_Identity=26.246719160105, Blast_Score=94, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17508017, Length=260, Percent_Identity=28.4615384615385, Blast_Score=93, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17508019, Length=260, Percent_Identity=28.4615384615385, Blast_Score=93, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 86725; Mature: 86725

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLQLQRPARLSQFRLLIACCLSIAMLPTLAHAAAQPAEPTPAQYTAAIGLTDRYDALVD
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHC
RQPSAPVWVDAQRFLYRRGSMRQGQAPAIAYRLVDAASGRNTPAFDHARLAAALTQAGAH
CCCCCCEEECHHHHHHHCCCCCCCCCCEEEEEEEHHCCCCCCCCHHHHHHHHHHHHCCCC
NVDAAALHLQDPALEQQTLRFQLADLGWQCELVRYRCTHLPERDVRPESMDMSFPLKQGE
CCCEEEEEECCCCCHHHHHEEEEECCCCEEEEEHHHHHCCCCCCCCCCCCCCCCCHHHCC
RYAKHSPDGRWRVWVEQGNLLIAPVGGGTPTAISDDGSASDFYAIDTVVWSPDSQHVAAY
HHHCCCCCCCEEEEEECCCEEEEECCCCCCCEECCCCCCCCEEEEEEEEECCCCCCEEEE
RVKAPPPHIVYYIESAPADRVQPKLHQQVYPKPGDPLPVMQPVLFDVATRTARPVDMTLL
EECCCCCEEEEEEECCCCHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEC
PNAFTLSELQWWKDSRGVTFEYNARGHQLYRVIEVDAGTAVARTVIEETSPTFIEYSPLS
CCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCHHHHHHHHHCCCCCEEEECCCC
GDNEDGGKYARHDLADGAQLLWASERDGWEHLYLYDGRTGRVMRQVTRGEWVVRRLDHVD
CCCCCCCHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
EAAGQVYFSASGMQPGEDPYYRHAYRIGLDGTGLTALTPLAADHDVRYSPDGRWFLDLSS
HHHCEEEEEECCCCCCCCCCEEEEEEECCCCCCCHHCCCCCCCCCCEECCCCCEEEEECC
RVDLGPVLELRRSADGSLVHTVERTDLSHLLAAGWQPPLPFHTPGRDGKTEIWGVIFRPQ
CCCCCHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCH
QLDAQQPYRVVEYIYAGPQGSFVPKRFTTRTPPLTGLGFAVAQIDGMGTNNRSRAFHDVA
HCCCCCCHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHH
WRNLKDAGLPDRIAWHKAAAARYPWYDIRGGVGVYGTSAGGQNALGALLFHPEFYVAGVA
HHCCCCCCCCCHHHHHHHHHCCCCCEECCCCCEEEECCCCCCCCCEEEEECCCEEEEECC
NSGCHDNRMDKIWWNEQWMGWPVGPWYAESSNVENAARLQGHLLLVTGDMDKNVDPASTF
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEEECCCCCCCCCHHHH
QVADRLIKAGKDFDLLVVPGGDHGAGGDYGKRRLLDFFQRWLHRTPTPEWNQVSAAVPAP
HHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLLQLQRPARLSQFRLLIACCLSIAMLPTLAHAAAQPAEPTPAQYTAAIGLTDRYDALVD
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHC
RQPSAPVWVDAQRFLYRRGSMRQGQAPAIAYRLVDAASGRNTPAFDHARLAAALTQAGAH
CCCCCCEEECHHHHHHHCCCCCCCCCCEEEEEEEHHCCCCCCCCHHHHHHHHHHHHCCCC
NVDAAALHLQDPALEQQTLRFQLADLGWQCELVRYRCTHLPERDVRPESMDMSFPLKQGE
CCCEEEEEECCCCCHHHHHEEEEECCCCEEEEEHHHHHCCCCCCCCCCCCCCCCCHHHCC
RYAKHSPDGRWRVWVEQGNLLIAPVGGGTPTAISDDGSASDFYAIDTVVWSPDSQHVAAY
HHHCCCCCCCEEEEEECCCEEEEECCCCCCCEECCCCCCCCEEEEEEEEECCCCCCEEEE
RVKAPPPHIVYYIESAPADRVQPKLHQQVYPKPGDPLPVMQPVLFDVATRTARPVDMTLL
EECCCCCEEEEEEECCCCHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEC
PNAFTLSELQWWKDSRGVTFEYNARGHQLYRVIEVDAGTAVARTVIEETSPTFIEYSPLS
CCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCHHHHHHHHHCCCCCEEEECCCC
GDNEDGGKYARHDLADGAQLLWASERDGWEHLYLYDGRTGRVMRQVTRGEWVVRRLDHVD
CCCCCCCHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
EAAGQVYFSASGMQPGEDPYYRHAYRIGLDGTGLTALTPLAADHDVRYSPDGRWFLDLSS
HHHCEEEEEECCCCCCCCCCEEEEEEECCCCCCCHHCCCCCCCCCCEECCCCCEEEEECC
RVDLGPVLELRRSADGSLVHTVERTDLSHLLAAGWQPPLPFHTPGRDGKTEIWGVIFRPQ
CCCCCHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCH
QLDAQQPYRVVEYIYAGPQGSFVPKRFTTRTPPLTGLGFAVAQIDGMGTNNRSRAFHDVA
HCCCCCCHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHH
WRNLKDAGLPDRIAWHKAAAARYPWYDIRGGVGVYGTSAGGQNALGALLFHPEFYVAGVA
HHCCCCCCCCCHHHHHHHHHCCCCCEECCCCCEEEECCCCCCCCCEEEEECCCEEEEECC
NSGCHDNRMDKIWWNEQWMGWPVGPWYAESSNVENAARLQGHLLLVTGDMDKNVDPASTF
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEEECCCCCCCCCHHHH
QVADRLIKAGKDFDLLVVPGGDHGAGGDYGKRRLLDFFQRWLHRTPTPEWNQVSAAVPAP
HHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA