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The map label for this gene is ptpA [H]

Identifier: 66768031

GI number: 66768031

Start: 2050570

End: 2052906

Strand: Direct

Name: ptpA [H]

Synonym: XC_1707

Alternate gene names: 66768031

Gene position: 2050570-2052906 (Clockwise)

Preceding gene: 66768030

Following gene: 66768032

Centisome position: 39.83

GC content: 66.75

Gene sequence:

>2337_bases
ATGGTGAGTGAGCACTGCAAACGCACCTACGTGCGGCAGTGGTTGCGCGGCGTGGTTGCCTACGCGGTACTGCTCACCGC
TGCGGCGCAAGCCGCGCCAAGCGTTGCCGACTACCAGCGGTCGCTGGGCCTGCGTGCGCAGTGGATGACACTGACGGAGA
ACGTGAGCTGGCCGGCGCAATGGCACGACGCTGAGACGTTCTACTACCGCAAGACCGTGCCGGGCGGCTTCGCGTTCATG
CGCGAAGACCTGGCCACGCTGCAGAAAACGCCCGCCTTCGATCACGCGCAGCTGGCGCGTGCGGTGTCTGCTGACGGCGG
CAACAGCGTCACCGCGACGACACTGCCGTTCGAGCGTTTTGCGTATGCCCAGGAGGACGGGCGTGCCGATGGCGCGATGG
AATTCGAGATCGGCGATACCAGCTGGCGCTGCACACTGACCAACTACCAATGCGCGCCGGTGGCTGCCACTGCGCAGCCG
CGCCCACGCGGGTTTGGTGTGGTGCGCGATCCGGCTGTGCCGGCCGACGCCACGCCGCGGCGCTCGCCCGATGGTGCGTG
GGAGGTGGTGGCCAACGGCTGGAATCTGCAGCTGCGGCGCGTTGCCGACGGCCAGAGTACGCGGTTGAGCAGCGACGGCC
GCGCCGAGGATTTCTATGATCTTGAAAGCGTCGCCTGGTCGCCGGATTCGCAGCACCTCGCGGTGTACCGCGTACGCCCC
GGGTATGCGCGGCGGGTGACCCGCGTGGAAGCGGCGCCGCCTGGTGGCGGGCAGCCGGTGGTGCACACGCAGCTGTACCC
AAAGCCGGGCGATGCGGTGGACGTGGAGCGGCCGGTGCTGTTTGCACTGGATGGCAGCCGGCGTGAGGTGGACACGGCGT
TGTTCGGCAACCCGTATGCGCTGTCGCCGTTGCAGTGGCGCAGCGATAGCCGCAGCGTGAGTTTCGAGTACGTGCAACGC
GGGTTTCAACGCATGCGCGTGATTGCGGTGGACGCGCAGACCGGCCGCGCGCACGTGGCCGTGGGCGAGGACGCGCGCAC
GTTTGTGTATGCCGACCGCAGCTTTCGCCACGATGTCGAAGGGCGCGGCGATGAGATCCTGTGGATCTCCGAACGCGACG
GCTGGCGCCATCTGTATCTGTTCGACGGCCGCAGCGGCAAGGTCAAACGCCAGCTCACCCGCGGTGCATGGATCGTGCGC
GATGTGCTGCGCGTGGACGATGCACAACGCCGCATCTGGTTCACCGCCAGTGGCATGGATGCTGGCAAGGACCCGTACTA
CCGCCAGCTCTACAGCGTGGATTTCGATGGCCGTCAGCTCACCCGGCTGACCCACAGCGATGCCGACCACGACGTGGCGA
TTGCCCCCGATGGGCAGCATTACGTCGATACCTATTCGCGCCCGGATCTGCCCCCGGTGATGGAGCTGCATGCCATCGAT
GGCCGCCTGCTGCAGCAGGTGGAGCAGGGCAGCATCGATAAACTACAGGCCGCCGGCTGGCGTGCGCCGGAGACCTTCGT
GGCCAAGGGCCGCGATGGCCGCACCGACATTTGGGGCATGGTGGTGCGCCCGCGCGATTACGACCCGCGCAAGCGCTACC
CGGTGATCGAGAACATCTACGCCGGGCCGCACGACGCCTTCGTGCCGAAGACGTTCTGGCCGTTCGGCTACCACTCCGGT
GGCGACAAGCAGATCGGCATGCAGGCGCAGGCGGACCTGGGCTTCATCGTGGTGATGATCGACGGCATGGGCACCGCCAA
CCGCTCCAAGGCCTTCCACGATGTGGCGTGGAAGAACCTGGGCGATTCCGGCTTTGCCGACCGCATTGCCTGGCACCGTG
CGCTGGCCGCAAAGGACCCCTCGTACGACATCAGCCGGGTCGGCATCTATGGTGCCTCTGCGGGCGGGCAGAGCACCCTG
GGCGCTCTCGAACGCCACCCGGAGTTCTACAAGGTAGGCGTGGCGTTTGCGGGCTGCTACGACAACCGCATGGACAAGAT
CAGCTGGAACGAGCAGTGGATGGGCTGGCCGGTGGATGCCAGTTATGCCGCCGCATCGGGCGTGGTCAATGCAGCAGCGC
TGCAGGGCGATGTGTTGCTGATCGTCGGCGAGCAGGACAGCAACGTGGATCCTGCGTCCACCGCGCAGGTGGTGGATGCG
CTGATCCAGGCCGGCAAGGATTTCGACCTGCTCAACGTGCCGGGTGGTGAGCATTCGGTAGGCCGCTCCAGCGGGCCGAT
CGACTACGTGCAGCGCCGCCAGTACGACTTTTTCGTTCGCCATCTGCGCGGCGACGCCACGCCGCGCTGGAATGCCACTG
CCCAGGAGGCCCGCTGA

Upstream 100 bases:

>100_bases
CCGTTCGACACGCTGAGCGTGGCGGTGATCGCCTTCGGCATCTATCACTGGGGCGCGCGTAGCGGCCTGCGCAGCGACGA
ACTGGCGCTGGAGGAGGACG

Downstream 100 bases:

>100_bases
TGCGCCTGTTTCTTTCCCGTGGCGCCGTGCGTCGCTGTGTTGCGCAAGTGCTGCTCTGCATGCTGGCATTGCTGGGCGGC
CCCGCTGTTGCCAATGCTGA

Product: peptidase

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 778; Mature: 778

Protein sequence:

>778_residues
MVSEHCKRTYVRQWLRGVVAYAVLLTAAAQAAPSVADYQRSLGLRAQWMTLTENVSWPAQWHDAETFYYRKTVPGGFAFM
REDLATLQKTPAFDHAQLARAVSADGGNSVTATTLPFERFAYAQEDGRADGAMEFEIGDTSWRCTLTNYQCAPVAATAQP
RPRGFGVVRDPAVPADATPRRSPDGAWEVVANGWNLQLRRVADGQSTRLSSDGRAEDFYDLESVAWSPDSQHLAVYRVRP
GYARRVTRVEAAPPGGGQPVVHTQLYPKPGDAVDVERPVLFALDGSRREVDTALFGNPYALSPLQWRSDSRSVSFEYVQR
GFQRMRVIAVDAQTGRAHVAVGEDARTFVYADRSFRHDVEGRGDEILWISERDGWRHLYLFDGRSGKVKRQLTRGAWIVR
DVLRVDDAQRRIWFTASGMDAGKDPYYRQLYSVDFDGRQLTRLTHSDADHDVAIAPDGQHYVDTYSRPDLPPVMELHAID
GRLLQQVEQGSIDKLQAAGWRAPETFVAKGRDGRTDIWGMVVRPRDYDPRKRYPVIENIYAGPHDAFVPKTFWPFGYHSG
GDKQIGMQAQADLGFIVVMIDGMGTANRSKAFHDVAWKNLGDSGFADRIAWHRALAAKDPSYDISRVGIYGASAGGQSTL
GALERHPEFYKVGVAFAGCYDNRMDKISWNEQWMGWPVDASYAAASGVVNAAALQGDVLLIVGEQDSNVDPASTAQVVDA
LIQAGKDFDLLNVPGGEHSVGRSSGPIDYVQRRQYDFFVRHLRGDATPRWNATAQEAR

Sequences:

>Translated_778_residues
MVSEHCKRTYVRQWLRGVVAYAVLLTAAAQAAPSVADYQRSLGLRAQWMTLTENVSWPAQWHDAETFYYRKTVPGGFAFM
REDLATLQKTPAFDHAQLARAVSADGGNSVTATTLPFERFAYAQEDGRADGAMEFEIGDTSWRCTLTNYQCAPVAATAQP
RPRGFGVVRDPAVPADATPRRSPDGAWEVVANGWNLQLRRVADGQSTRLSSDGRAEDFYDLESVAWSPDSQHLAVYRVRP
GYARRVTRVEAAPPGGGQPVVHTQLYPKPGDAVDVERPVLFALDGSRREVDTALFGNPYALSPLQWRSDSRSVSFEYVQR
GFQRMRVIAVDAQTGRAHVAVGEDARTFVYADRSFRHDVEGRGDEILWISERDGWRHLYLFDGRSGKVKRQLTRGAWIVR
DVLRVDDAQRRIWFTASGMDAGKDPYYRQLYSVDFDGRQLTRLTHSDADHDVAIAPDGQHYVDTYSRPDLPPVMELHAID
GRLLQQVEQGSIDKLQAAGWRAPETFVAKGRDGRTDIWGMVVRPRDYDPRKRYPVIENIYAGPHDAFVPKTFWPFGYHSG
GDKQIGMQAQADLGFIVVMIDGMGTANRSKAFHDVAWKNLGDSGFADRIAWHRALAAKDPSYDISRVGIYGASAGGQSTL
GALERHPEFYKVGVAFAGCYDNRMDKISWNEQWMGWPVDASYAAASGVVNAAALQGDVLLIVGEQDSNVDPASTAQVVDA
LIQAGKDFDLLNVPGGEHSVGRSSGPIDYVQRRQYDFFVRHLRGDATPRWNATAQEAR
>Mature_778_residues
MVSEHCKRTYVRQWLRGVVAYAVLLTAAAQAAPSVADYQRSLGLRAQWMTLTENVSWPAQWHDAETFYYRKTVPGGFAFM
REDLATLQKTPAFDHAQLARAVSADGGNSVTATTLPFERFAYAQEDGRADGAMEFEIGDTSWRCTLTNYQCAPVAATAQP
RPRGFGVVRDPAVPADATPRRSPDGAWEVVANGWNLQLRRVADGQSTRLSSDGRAEDFYDLESVAWSPDSQHLAVYRVRP
GYARRVTRVEAAPPGGGQPVVHTQLYPKPGDAVDVERPVLFALDGSRREVDTALFGNPYALSPLQWRSDSRSVSFEYVQR
GFQRMRVIAVDAQTGRAHVAVGEDARTFVYADRSFRHDVEGRGDEILWISERDGWRHLYLFDGRSGKVKRQLTRGAWIVR
DVLRVDDAQRRIWFTASGMDAGKDPYYRQLYSVDFDGRQLTRLTHSDADHDVAIAPDGQHYVDTYSRPDLPPVMELHAID
GRLLQQVEQGSIDKLQAAGWRAPETFVAKGRDGRTDIWGMVVRPRDYDPRKRYPVIENIYAGPHDAFVPKTFWPFGYHSG
GDKQIGMQAQADLGFIVVMIDGMGTANRSKAFHDVAWKNLGDSGFADRIAWHRALAAKDPSYDISRVGIYGASAGGQSTL
GALERHPEFYKVGVAFAGCYDNRMDKISWNEQWMGWPVDASYAAASGVVNAAALQGDVLLIVGEQDSNVDPASTAQVVDA
LIQAGKDFDLLNVPGGEHSVGRSSGPIDYVQRRQYDFFVRHLRGDATPRWNATAQEAR

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI18450280, Length=416, Percent_Identity=26.9230769230769, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI37577089, Length=416, Percent_Identity=26.9230769230769, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI194394146, Length=367, Percent_Identity=26.4305177111717, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI16933540, Length=510, Percent_Identity=22.9411764705882, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI37577091, Length=416, Percent_Identity=24.5192307692308, Blast_Score=88, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17508019, Length=278, Percent_Identity=28.0575539568345, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17508017, Length=278, Percent_Identity=28.0575539568345, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321817, Length=403, Percent_Identity=24.8138957816377, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324793, Length=396, Percent_Identity=22.2222222222222, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45551969, Length=576, Percent_Identity=23.4375, Blast_Score=107, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45550825, Length=574, Percent_Identity=23.3449477351916, Blast_Score=106, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45553511, Length=574, Percent_Identity=23.3449477351916, Blast_Score=106, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 86576; Mature: 86576

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSEHCKRTYVRQWLRGVVAYAVLLTAAAQAAPSVADYQRSLGLRAQWMTLTENVSWPAQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEEECCCCCCCC
WHDAETFYYRKTVPGGFAFMREDLATLQKTPAFDHAQLARAVSADGGNSVTATTLPFERF
CCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEECCHHHH
AYAQEDGRADGAMEFEIGDTSWRCTLTNYQCAPVAATAQPRPRGFGVVRDPAVPADATPR
HHHHCCCCCCCEEEEEECCCEEEEEECCCEECCEEECCCCCCCCCCEEECCCCCCCCCCC
RSPDGAWEVVANGWNLQLRRVADGQSTRLSSDGRAEDFYDLESVAWSPDSQHLAVYRVRP
CCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEECC
GYARRVTRVEAAPPGGGQPVVHTQLYPKPGDAVDVERPVLFALDGSRREVDTALFGNPYA
CHHHHEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCEECHHHCCCCEE
LSPLQWRSDSRSVSFEYVQRGFQRMRVIAVDAQTGRAHVAVGEDARTFVYADRSFRHDVE
CCCCEECCCCCCEEHHHHHHHHHEEEEEEEECCCCCEEEEECCCCEEEEEECCCCCCCCC
GRGDEILWISERDGWRHLYLFDGRSGKVKRQLTRGAWIVRDVLRVDDAQRRIWFTASGMD
CCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
AGKDPYYRQLYSVDFDGRQLTRLTHSDADHDVAIAPDGQHYVDTYSRPDLPPVMELHAID
CCCCHHHHHHEEECCCCCCEEEEECCCCCCCEEECCCCCHHHCCCCCCCCCCHHEEECCC
GRLLQQVEQGSIDKLQAAGWRAPETFVAKGRDGRTDIWGMVVRPRDYDPRKRYPVIENIY
HHHHHHHHCCCHHHHHHCCCCCCHHHEECCCCCCCCEEEEEEECCCCCCCCCCCHHHHHC
AGPHDAFVPKTFWPFGYHSGGDKQIGMQAQADLGFIVVMIDGMGTANRSKAFHDVAWKNL
CCCCCCCCCCCCCCCCCCCCCCCEECCEECCCCCEEEEEEECCCCCCCCHHHHHHHHHCC
GDSGFADRIAWHRALAAKDPSYDISRVGIYGASAGGQSTLGALERHPEFYKVGVAFAGCY
CCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEEEEEHH
DNRMDKISWNEQWMGWPVDASYAAASGVVNAAALQGDVLLIVGEQDSNVDPASTAQVVDA
CCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHEEECCCEEEEECCCCCCCCCHHHHHHHHH
LIQAGKDFDLLNVPGGEHSVGRSSGPIDYVQRRQYDFFVRHLRGDATPRWNATAQEAR
HHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCC
>Mature Secondary Structure
MVSEHCKRTYVRQWLRGVVAYAVLLTAAAQAAPSVADYQRSLGLRAQWMTLTENVSWPAQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEEECCCCCCCC
WHDAETFYYRKTVPGGFAFMREDLATLQKTPAFDHAQLARAVSADGGNSVTATTLPFERF
CCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEEEECCHHHH
AYAQEDGRADGAMEFEIGDTSWRCTLTNYQCAPVAATAQPRPRGFGVVRDPAVPADATPR
HHHHCCCCCCCEEEEEECCCEEEEEECCCEECCEEECCCCCCCCCCEEECCCCCCCCCCC
RSPDGAWEVVANGWNLQLRRVADGQSTRLSSDGRAEDFYDLESVAWSPDSQHLAVYRVRP
CCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEECC
GYARRVTRVEAAPPGGGQPVVHTQLYPKPGDAVDVERPVLFALDGSRREVDTALFGNPYA
CHHHHEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCEECHHHCCCCEE
LSPLQWRSDSRSVSFEYVQRGFQRMRVIAVDAQTGRAHVAVGEDARTFVYADRSFRHDVE
CCCCEECCCCCCEEHHHHHHHHHEEEEEEEECCCCCEEEEECCCCEEEEEECCCCCCCCC
GRGDEILWISERDGWRHLYLFDGRSGKVKRQLTRGAWIVRDVLRVDDAQRRIWFTASGMD
CCCCEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCC
AGKDPYYRQLYSVDFDGRQLTRLTHSDADHDVAIAPDGQHYVDTYSRPDLPPVMELHAID
CCCCHHHHHHEEECCCCCCEEEEECCCCCCCEEECCCCCHHHCCCCCCCCCCHHEEECCC
GRLLQQVEQGSIDKLQAAGWRAPETFVAKGRDGRTDIWGMVVRPRDYDPRKRYPVIENIY
HHHHHHHHCCCHHHHHHCCCCCCHHHEECCCCCCCCEEEEEEECCCCCCCCCCCHHHHHC
AGPHDAFVPKTFWPFGYHSGGDKQIGMQAQADLGFIVVMIDGMGTANRSKAFHDVAWKNL
CCCCCCCCCCCCCCCCCCCCCCCEECCEECCCCCEEEEEEECCCCCCCCHHHHHHHHHCC
GDSGFADRIAWHRALAAKDPSYDISRVGIYGASAGGQSTLGALERHPEFYKVGVAFAGCY
CCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCCEEEEEEEEEEHH
DNRMDKISWNEQWMGWPVDASYAAASGVVNAAALQGDVLLIVGEQDSNVDPASTAQVVDA
CCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHEEECCCEEEEECCCCCCCCCHHHHHHHHH
LIQAGKDFDLLNVPGGEHSVGRSSGPIDYVQRRQYDFFVRHLRGDATPRWNATAQEAR
HHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA