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The map label for this gene is yveA [H]

Identifier: 66768030

GI number: 66768030

Start: 2048994

End: 2050580

Strand: Direct

Name: yveA [H]

Synonym: XC_1706

Alternate gene names: 66768030

Gene position: 2048994-2050580 (Clockwise)

Preceding gene: 66768029

Following gene: 66768031

Centisome position: 39.8

GC content: 65.72

Gene sequence:

>1587_bases
ATGACCACACACGGTGCGAGCGCACAGGGCAAGTTCCACAAGCGGCTCAGCCTGACCGACCTGACCTTCATCGGGCTGGG
CTCGATCTTCGGCTCGGGCTGGCTGTTTTCCGCCAGCCACGTGTCCTCGATCGCCGGGCCGGCCGGCATCGTATCGTGGA
TTCTCGGCGGCATCGCGGTGTTGTTGCTGGGGCTGGTGTATTGCGAACTCGGCGCCGCGTTGCCACGCGCCGGCGGCGTG
GTGCGCTACCCCGAGTACTCGCACGGGCCCTTGCTCGGGTCGTTGACCGGCTTCATTACATTGATTGCGTTTTCCAGCCT
GATCGCAATCGAAGTGGAAGCGGCGCGCCAGTATGCGGCGGCCTGGTTCCCGGCGCTCAGCCAGGCCGGCAGCACGCATC
CCAGCCTGCTGGGCTGGCTGGTGCAACTGGCGTTGTTGCTGCTGTTCTTTGCGCTCAATTACTTCAGCGTCAAGACCTTT
GCGCTGGCCAACAACATCGTCAGCGTCTTCAAGTTTCTGGTGCCGATCCTGGTGATCGTGCTGCTGATGAAGCACTTCAA
TGCCGACAACCTGAGCGTGCATGGCTTTGCACCGTCGGGCATGGCCGGGGTGGAAGCGGCGATCTCCGCCGGCGGCATCA
TCTTTGCGTACCTGGGGCTCACCCCGATCGTCTCGGTCGCCAGCGAGGTGCGCAACCCGCAACGCAATATTCCGATTGCC
TTGATCCTGTCGGTGGCGCTGTCCACGGTGATCTACGTGCTGTTGCAATTGGCATTTCTGGGCAGCATTCCGGCCGCGCA
ACTGGCGCAGGGCTGGAGCGGCATCGACAAGGCGTTTTCGCTGCCGTACCACGACATCGCGCTGGCACTGGGGATGGCGT
GGCTGGCCGCGCTGGTGATCTGCGATGCGATGGTGTCGCCCAGCGGCACCGGCAATATCTACATGAATGCCACGCCGCGC
GTGGTGTACGGCTGGGCGCGCAGCGGCGGGTTTCTGCCGGTGTTGACGCGGGTGGATCCGGCCTCGGGCATCCCGCGGCC
GGCGTTGTGGCTGAGCCTGGGGTTGTCGATCTTCTGGACCTTGCCGTTCCCGTCCTGGGAAACCTTGATTGGCGTGGTGT
CGGCCGCGTTGGTGCTGAGCTATGCGGTGGCGCCGGTCACGGTGGCCGCGCTGCGCCGCAGTGCGCCCGGCCTGGCGCGG
CCGTTCCGCGTGCGCGGATTTGCGGTGCTGGGGCCGCTGTCGTTCGTGGTGGCCGCGCTGATCGTGTACTGGTCCACCTG
GCCCACGCTGTCCTGGCTGCTGGGCCTTCAGGTGCTCGCGTTCGCGGCGTACGTGCTGTATCGCCTGCCATCGCGCGCGT
GCAGGGCCCGGCTGTTGCGCCAGGTCCGTGCGTCGCTGTGGCTGATCGTGTTTTTCGTGCTGGTGATGGCAGTGTCGTGG
GCGGGCACCTTCGGTGGCCATGGCTGGATCGCGCATCCGTTCGACACGCTGAGCGTGGCGGTGATCGCCTTCGGCATCTA
TCACTGGGGCGCGCGTAGCGGCCTGCGCAGCGACGAACTGGCGCTGGAGGAGGACGATGGTGAGTGA

Upstream 100 bases:

>100_bases
TCCGATGCCGATGCCAAGGTGTCGGCCAGCGACTGAGCTGCTTTGCCTCATGCCGGCGCACGCCGCGCGGTTTCACTGCT
TTCCTCTCTGGGGGTGACGT

Downstream 100 bases:

>100_bases
GCACTGCAAACGCACCTACGTGCGGCAGTGGTTGCGCGGCGTGGTTGCCTACGCGGTACTGCTCACCGCTGCGGCGCAAG
CCGCGCCAAGCGTTGCCGAC

Product: amino acid permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: L-aspartate transporter [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MTTHGASAQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAVLLLGLVYCELGAALPRAGGV
VRYPEYSHGPLLGSLTGFITLIAFSSLIAIEVEAARQYAAAWFPALSQAGSTHPSLLGWLVQLALLLLFFALNYFSVKTF
ALANNIVSVFKFLVPILVIVLLMKHFNADNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRNPQRNIPIA
LILSVALSTVIYVLLQLAFLGSIPAAQLAQGWSGIDKAFSLPYHDIALALGMAWLAALVICDAMVSPSGTGNIYMNATPR
VVYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWTLPFPSWETLIGVVSAALVLSYAVAPVTVAALRRSAPGLAR
PFRVRGFAVLGPLSFVVAALIVYWSTWPTLSWLLGLQVLAFAAYVLYRLPSRACRARLLRQVRASLWLIVFFVLVMAVSW
AGTFGGHGWIAHPFDTLSVAVIAFGIYHWGARSGLRSDELALEEDDGE

Sequences:

>Translated_528_residues
MTTHGASAQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAVLLLGLVYCELGAALPRAGGV
VRYPEYSHGPLLGSLTGFITLIAFSSLIAIEVEAARQYAAAWFPALSQAGSTHPSLLGWLVQLALLLLFFALNYFSVKTF
ALANNIVSVFKFLVPILVIVLLMKHFNADNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRNPQRNIPIA
LILSVALSTVIYVLLQLAFLGSIPAAQLAQGWSGIDKAFSLPYHDIALALGMAWLAALVICDAMVSPSGTGNIYMNATPR
VVYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWTLPFPSWETLIGVVSAALVLSYAVAPVTVAALRRSAPGLAR
PFRVRGFAVLGPLSFVVAALIVYWSTWPTLSWLLGLQVLAFAAYVLYRLPSRACRARLLRQVRASLWLIVFFVLVMAVSW
AGTFGGHGWIAHPFDTLSVAVIAFGIYHWGARSGLRSDELALEEDDGE
>Mature_527_residues
TTHGASAQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAVLLLGLVYCELGAALPRAGGVV
RYPEYSHGPLLGSLTGFITLIAFSSLIAIEVEAARQYAAAWFPALSQAGSTHPSLLGWLVQLALLLLFFALNYFSVKTFA
LANNIVSVFKFLVPILVIVLLMKHFNADNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRNPQRNIPIAL
ILSVALSTVIYVLLQLAFLGSIPAAQLAQGWSGIDKAFSLPYHDIALALGMAWLAALVICDAMVSPSGTGNIYMNATPRV
VYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWTLPFPSWETLIGVVSAALVLSYAVAPVTVAALRRSAPGLARP
FRVRGFAVLGPLSFVVAALIVYWSTWPTLSWLLGLQVLAFAAYVLYRLPSRACRARLLRQVRASLWLIVFFVLVMAVSWA
GTFGGHGWIAHPFDTLSVAVIAFGIYHWGARSGLRSDELALEEDDGE

Specific function: Uptake of L-aspartate with the concomitant import of a proton. Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2.A.3.11) family [H]

Homologues:

Organism=Homo sapiens, GI187423910, Length=440, Percent_Identity=24.5454545454545, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI7657591, Length=440, Percent_Identity=24.5454545454545, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI258614005, Length=441, Percent_Identity=24.2630385487528, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI258614003, Length=441, Percent_Identity=24.2630385487528, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI110347453, Length=354, Percent_Identity=25.7062146892655, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI258645169, Length=441, Percent_Identity=24.2630385487528, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4507047, Length=425, Percent_Identity=23.7647058823529, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI181337167, Length=399, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI114326544, Length=430, Percent_Identity=23.7209302325581, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI114326550, Length=430, Percent_Identity=23.7209302325581, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI33286428, Length=410, Percent_Identity=24.6341463414634, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI71979932, Length=432, Percent_Identity=24.537037037037, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI186910308, Length=259, Percent_Identity=26.6409266409266, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI186910306, Length=259, Percent_Identity=26.6409266409266, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI186910304, Length=259, Percent_Identity=26.6409266409266, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790653, Length=376, Percent_Identity=22.6063829787234, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786602, Length=351, Percent_Identity=24.5014245014245, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082250, Length=360, Percent_Identity=25.8333333333333, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786789, Length=423, Percent_Identity=25.2955082742317, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI2367353, Length=345, Percent_Identity=27.2463768115942, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87081708, Length=356, Percent_Identity=22.1910112359551, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786302, Length=405, Percent_Identity=22.2222222222222, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788480, Length=348, Percent_Identity=25, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=413, Percent_Identity=24.455205811138, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17532491, Length=408, Percent_Identity=25.9803921568627, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17531343, Length=414, Percent_Identity=25.8454106280193, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17533459, Length=281, Percent_Identity=27.7580071174377, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17568033, Length=357, Percent_Identity=25.2100840336134, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24667468, Length=398, Percent_Identity=26.3819095477387, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24668806, Length=433, Percent_Identity=22.4018475750577, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356285, Length=433, Percent_Identity=22.4018475750577, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24668802, Length=433, Percent_Identity=22.4018475750577, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221512776, Length=420, Percent_Identity=23.3333333333333, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666159, Length=420, Percent_Identity=23.3333333333333, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24651635, Length=414, Percent_Identity=23.1884057971014, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24651633, Length=414, Percent_Identity=23.1884057971014, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357367, Length=418, Percent_Identity=24.8803827751196, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641993, Length=412, Percent_Identity=24.0291262135922, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641995, Length=412, Percent_Identity=24.0291262135922, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221331183, Length=365, Percent_Identity=24.3835616438356, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17647653, Length=365, Percent_Identity=24.3835616438356, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24664379, Length=365, Percent_Identity=24.3835616438356, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45550968, Length=439, Percent_Identity=23.9179954441913, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI19921172, Length=439, Percent_Identity=23.9179954441913, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 56246; Mature: 56115

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHGASAQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAV
CCCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCEEEHHHHHHHCCHHHHHHHHHHHHHH
LLLGLVYCELGAALPRAGGVVRYPEYSHGPLLGSLTGFITLIAFSSLIAIEVEAARQYAA
HHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWFPALSQAGSTHPSLLGWLVQLALLLLFFALNYFSVKTFALANNIVSVFKFLVPILVIV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMKHFNADNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRNPQRNIPIA
HHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LILSVALSTVIYVLLQLAFLGSIPAAQLAQGWSGIDKAFSLPYHDIALALGMAWLAALVI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
CDAMVSPSGTGNIYMNATPRVVYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWT
HHHHCCCCCCCCEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHCCHHEEE
LPFPSWETLIGVVSAALVLSYAVAPVTVAALRRSAPGLARPFRVRGFAVLGPLSFVVAAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHH
IVYWSTWPTLSWLLGLQVLAFAAYVLYRLPSRACRARLLRQVRASLWLIVFFVLVMAVSW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGTFGGHGWIAHPFDTLSVAVIAFGIYHWGARSGLRSDELALEEDDGE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTHGASAQGKFHKRLSLTDLTFIGLGSIFGSGWLFSASHVSSIAGPAGIVSWILGGIAV
CCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCEEEHHHHHHHCCHHHHHHHHHHHHHH
LLLGLVYCELGAALPRAGGVVRYPEYSHGPLLGSLTGFITLIAFSSLIAIEVEAARQYAA
HHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWFPALSQAGSTHPSLLGWLVQLALLLLFFALNYFSVKTFALANNIVSVFKFLVPILVIV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMKHFNADNLSVHGFAPSGMAGVEAAISAGGIIFAYLGLTPIVSVASEVRNPQRNIPIA
HHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHH
LILSVALSTVIYVLLQLAFLGSIPAAQLAQGWSGIDKAFSLPYHDIALALGMAWLAALVI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
CDAMVSPSGTGNIYMNATPRVVYGWARSGGFLPVLTRVDPASGIPRPALWLSLGLSIFWT
HHHHCCCCCCCCEEEECCCCEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHCCHHEEE
LPFPSWETLIGVVSAALVLSYAVAPVTVAALRRSAPGLARPFRVRGFAVLGPLSFVVAAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHH
IVYWSTWPTLSWLLGLQVLAFAAYVLYRLPSRACRARLLRQVRASLWLIVFFVLVMAVSW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGTFGGHGWIAHPFDTLSVAVIAFGIYHWGARSGLRSDELALEEDDGE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 12730183 [H]