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The map label for this gene is dapA [H]

Identifier: 66768025

GI number: 66768025

Start: 2041005

End: 2041913

Strand: Direct

Name: dapA [H]

Synonym: XC_1701

Alternate gene names: 66768025

Gene position: 2041005-2041913 (Clockwise)

Preceding gene: 66768024

Following gene: 77761163

Centisome position: 39.64

GC content: 65.79

Gene sequence:

>909_bases
ATGAGCATTGCTGCGTTCTGGCACGGCGTGTTGCCGGCCATCACTACCCCGTTCACCGCCAACGGCGACATCGACCACGA
CTTCCTGGCCAAGCATGCCAATCAGCTGGTGGACGCCGGCTGCACCGCGATCGTGCCGCTGGGTTCGTTGGGCGAAGCCG
CCACCTTGAGCGTGGACGACAAGCTCGCCATCCTCAAGACGTTGGTAACGGCCTTGCAGGGCCGCGTGCCGGTGGTGCCG
GGCATCGCCAGCCTGGCCACGGGCGAGGCGGTGGCATTGGCAAAGGCGGCAAAGGAACTGGGCTGCGGCGGGCTGATGGT
GTTGCCGCCGTACGTGTATTCCACCGACTGGCGCGAGATGGGCGCGCATGTGCGTGCGGTGATCGCGGCCACCGATCTGC
CGGTGATCCTCTACAACAACCCGGTGGCCTACAAGACCGATTTCGGCCCGGCACAGATCGCCGAGCTGGCGGCCGAATTC
CCCAATCTGCAGGCAGTAAAGGAATCTTCCGGCGATGTGCGCCGCTTCGCCGCGCTGCAGGAATTGCTGGGCGATCGTCT
GGCGCTGCTGGTCGGCATGGACGACGCCATCGTCGAAGGCCTGAGCATGGGCGCCAAGGGGTGGATCGCCGGGCTGGTCA
ATGCATATCCGAAGGAGTCGGTACGCCTGTTCGAACTGGCACGCGACGGCGGTTACCCCGCCGCCAAGGAACTGTACGAC
TGGTTCCTGCCGCTGCTGCGCCTGGATACCGTGCCCAAGTTCGTGCAGCTGATCAAACTGGTGCAGGAAAAGGTGGGCCT
GGGCAGCGAGCGTGTCCGTGCGCCACGCCTGGTGGTGGACGGTGCCGAGCGCGAGGCAGCGCTGAAGGTGATCGACCACG
CCATCGCCACCGCGCCCAGCCTGCACTGA

Upstream 100 bases:

>100_bases
CCGCACTTTCCACCGACGCCGGCCGCCGGCCGCCGTTGTTCCCGGTCCGCCTCGCGGCGCTGGCCGACTCCTTCACTTCC
GACTCGCAAGGGAATCATCC

Downstream 100 bases:

>100_bases
GCACGCGCCACCGCCGTCGCGCGGCCTTGTTTAGCGCAGCCGCGGTGCGTGCTGCGTTGTATGGGCCGGTGCCGGTAGTG
GTCCACGATTCAAACGGGTG

Product: dihydrodipicolinate synthetase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSIAAFWHGVLPAITTPFTANGDIDHDFLAKHANQLVDAGCTAIVPLGSLGEAATLSVDDKLAILKTLVTALQGRVPVVP
GIASLATGEAVALAKAAKELGCGGLMVLPPYVYSTDWREMGAHVRAVIAATDLPVILYNNPVAYKTDFGPAQIAELAAEF
PNLQAVKESSGDVRRFAALQELLGDRLALLVGMDDAIVEGLSMGAKGWIAGLVNAYPKESVRLFELARDGGYPAAKELYD
WFLPLLRLDTVPKFVQLIKLVQEKVGLGSERVRAPRLVVDGAEREAALKVIDHAIATAPSLH

Sequences:

>Translated_302_residues
MSIAAFWHGVLPAITTPFTANGDIDHDFLAKHANQLVDAGCTAIVPLGSLGEAATLSVDDKLAILKTLVTALQGRVPVVP
GIASLATGEAVALAKAAKELGCGGLMVLPPYVYSTDWREMGAHVRAVIAATDLPVILYNNPVAYKTDFGPAQIAELAAEF
PNLQAVKESSGDVRRFAALQELLGDRLALLVGMDDAIVEGLSMGAKGWIAGLVNAYPKESVRLFELARDGGYPAAKELYD
WFLPLLRLDTVPKFVQLIKLVQEKVGLGSERVRAPRLVVDGAEREAALKVIDHAIATAPSLH
>Mature_301_residues
SIAAFWHGVLPAITTPFTANGDIDHDFLAKHANQLVDAGCTAIVPLGSLGEAATLSVDDKLAILKTLVTALQGRVPVVPG
IASLATGEAVALAKAAKELGCGGLMVLPPYVYSTDWREMGAHVRAVIAATDLPVILYNNPVAYKTDFGPAQIAELAAEFP
NLQAVKESSGDVRRFAALQELLGDRLALLVGMDDAIVEGLSMGAKGWIAGLVNAYPKESVRLFELARDGGYPAAKELYDW
FLPLLRLDTVPKFVQLIKLVQEKVGLGSERVRAPRLVVDGAEREAALKVIDHAIATAPSLH

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI13540533, Length=309, Percent_Identity=24.2718446601942, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI31543060, Length=281, Percent_Identity=23.4875444839858, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=28.1786941580756, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082415, Length=298, Percent_Identity=29.1946308724832, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786463, Length=265, Percent_Identity=28.6792452830189, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789620, Length=213, Percent_Identity=27.6995305164319, Blast_Score=87, Evalue=1e-18,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32064; Mature: 31932

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAAFWHGVLPAITTPFTANGDIDHDFLAKHANQLVDAGCTAIVPLGSLGEAATLSVDD
CCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCH
KLAILKTLVTALQGRVPVVPGIASLATGEAVALAKAAKELGCGGLMVLPPYVYSTDWREM
HHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHH
GAHVRAVIAATDLPVILYNNPVAYKTDFGPAQIAELAAEFPNLQAVKESSGDVRRFAALQ
HHHHHHHHHHCCCCEEEECCCEEEECCCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHH
ELLGDRLALLVGMDDAIVEGLSMGAKGWIAGLVNAYPKESVRLFELARDGGYPAAKELYD
HHHHHHHEEHCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHH
WFLPLLRLDTVPKFVQLIKLVQEKVGLGSERVRAPRLVVDGAEREAALKVIDHAIATAPS
HHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCC
LH
CC
>Mature Secondary Structure 
SIAAFWHGVLPAITTPFTANGDIDHDFLAKHANQLVDAGCTAIVPLGSLGEAATLSVDD
CHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCH
KLAILKTLVTALQGRVPVVPGIASLATGEAVALAKAAKELGCGGLMVLPPYVYSTDWREM
HHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHH
GAHVRAVIAATDLPVILYNNPVAYKTDFGPAQIAELAAEFPNLQAVKESSGDVRRFAALQ
HHHHHHHHHHCCCCEEEECCCEEEECCCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHH
ELLGDRLALLVGMDDAIVEGLSMGAKGWIAGLVNAYPKESVRLFELARDGGYPAAKELYD
HHHHHHHEEHCCCCHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHH
WFLPLLRLDTVPKFVQLIKLVQEKVGLGSERVRAPRLVVDGAEREAALKVIDHAIATAPS
HHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCC
LH
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA