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The map label for this gene is 66768021

Identifier: 66768021

GI number: 66768021

Start: 2037293

End: 2038231

Strand: Direct

Name: 66768021

Synonym: XC_1697

Alternate gene names: NA

Gene position: 2037293-2038231 (Clockwise)

Preceding gene: 66768016

Following gene: 77761162

Centisome position: 39.57

GC content: 70.82

Gene sequence:

>939_bases
ATGCACACCATCGACGTCATCGACTCCCATACCGCAGGCGAACCGACCCGCGTGGTCCTGGCCGGCTTCCCCGACCTGGG
CGATGGCGACCTGGCGCAGTGCCGCGAGCGCTTCCGCAGCGACTTCGACCACTGGCGCAGTGCCATTGCCTGCGAGCCGC
GCGGCTCGGACACCATGGTCGGTGCCTTGTTGCTGCCGCCACGCGACCCGAGCGCCTGCACCGGGGTGATCTTCTTCAAC
AACGTCGGCTACCTGGGCATGTGTGGGCACGGCACCATCGGCGTGGTGCGCACGCTGGCCGAACTGGGCCGCATCGCGCC
GGGGCAGCACCGCATCGAGACGCCGGTGGGCACGGTAGGCGTGGCGCTGGCCGACGACGGCACGGTGTCGATCGACAACG
TCGAAAGCTACCGCCACGCCGCCGGCGTGGAAGTGGACGTACCCGGGCATGGCCGCGTGCGCGGCGACGTGGCCTGGGGC
GGCAATTGGTTCTTCATCACCGAGCAGGCGCCGTGCGCGTTGGGCCTGGCCCAGCAGCGCGAACTCACCGCCTACACCGA
GGCGATCCGCCTGGCCCTGGAAGCGGCCGGCATCACCGGCGAGGCGGGCGGGGAGATCGACCATATCGAGATCAGCGGCG
TGGCCCCGGACGGCAGCGGCGCGGCACGCAACTTCGTGCTGTGCCCCGGCTTGGCCTACGACCGCTCGCCGTGCGGCACC
GGCACCAGTGCGAAGCTGGCCTGCCTGGCCGCCGACGGCAAGCTGGCCGAAGGCGAGCGCTGGCTGCAGCAAGGCATCCT
CGGCAGTGCGTTCGAAGGCAGCTACCGGCACAGCGGGCGTGGCATTGCGCCGCGCATCAGCGGGCACGCGTTCATCACCG
CGCGGTCGCAACTGCTGATCGATCCGGCCGACCCATTCGCCTGGGGCATCGTGGCCTGA

Upstream 100 bases:

>100_bases
CGCGCGGCTGTGAATCAGGTCGGCGATTGTGCGGATTTCCGCATTTGCGCCTCGCATTGCGCGCTAGTCGCCCGCGCGCC
GTGGATGGGAGCATGGCGGC

Downstream 100 bases:

>100_bases
TGCAGCCGCCACCGCGCGCGCAGGGCGGTACCGGTGCAGCGCCTGCTGCGGCGACTGCCGTGCCCGAAGCCGCACCGCCA
TCACATAGCGACACGCACGC

Product: hypothetical protein

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; HyPRE [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MHTIDVIDSHTAGEPTRVVLAGFPDLGDGDLAQCRERFRSDFDHWRSAIACEPRGSDTMVGALLLPPRDPSACTGVIFFN
NVGYLGMCGHGTIGVVRTLAELGRIAPGQHRIETPVGTVGVALADDGTVSIDNVESYRHAAGVEVDVPGHGRVRGDVAWG
GNWFFITEQAPCALGLAQQRELTAYTEAIRLALEAAGITGEAGGEIDHIEISGVAPDGSGAARNFVLCPGLAYDRSPCGT
GTSAKLACLAADGKLAEGERWLQQGILGSAFEGSYRHSGRGIAPRISGHAFITARSQLLIDPADPFAWGIVA

Sequences:

>Translated_312_residues
MHTIDVIDSHTAGEPTRVVLAGFPDLGDGDLAQCRERFRSDFDHWRSAIACEPRGSDTMVGALLLPPRDPSACTGVIFFN
NVGYLGMCGHGTIGVVRTLAELGRIAPGQHRIETPVGTVGVALADDGTVSIDNVESYRHAAGVEVDVPGHGRVRGDVAWG
GNWFFITEQAPCALGLAQQRELTAYTEAIRLALEAAGITGEAGGEIDHIEISGVAPDGSGAARNFVLCPGLAYDRSPCGT
GTSAKLACLAADGKLAEGERWLQQGILGSAFEGSYRHSGRGIAPRISGHAFITARSQLLIDPADPFAWGIVA
>Mature_312_residues
MHTIDVIDSHTAGEPTRVVLAGFPDLGDGDLAQCRERFRSDFDHWRSAIACEPRGSDTMVGALLLPPRDPSACTGVIFFN
NVGYLGMCGHGTIGVVRTLAELGRIAPGQHRIETPVGTVGVALADDGTVSIDNVESYRHAAGVEVDVPGHGRVRGDVAWG
GNWFFITEQAPCALGLAQQRELTAYTEAIRLALEAAGITGEAGGEIDHIEISGVAPDGSGAARNFVLCPGLAYDRSPCGT
GTSAKLACLAADGKLAEGERWLQQGILGSAFEGSYRHSGRGIAPRISGHAFITARSQLLIDPADPFAWGIVA

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases [H]

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=337, Percent_Identity=30.8605341246291, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 32711; Mature: 32711

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTIDVIDSHTAGEPTRVVLAGFPDLGDGDLAQCRERFRSDFDHWRSAIACEPRGSDTMV
CCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCEEE
GALLLPPRDPSACTGVIFFNNVGYLGMCGHGTIGVVRTLAELGRIAPGQHRIETPVGTVG
EEEEECCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEECCCCCEEE
VALADDGTVSIDNVESYRHAAGVEVDVPGHGRVRGDVAWGGNWFFITEQAPCALGLAQQR
EEEECCCEEEECCHHHHHHHCCCEEECCCCCEEEEEEEECCEEEEEECCCCCCCCCHHHH
ELTAYTEAIRLALEAAGITGEAGGEIDHIEISGVAPDGSGAARNFVLCPGLAYDRSPCGT
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCCC
GTSAKLACLAADGKLAEGERWLQQGILGSAFEGSYRHSGRGIAPRISGHAFITARSQLLI
CCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCEEEEECCEEEE
DPADPFAWGIVA
ECCCCCCCCCCC
>Mature Secondary Structure
MHTIDVIDSHTAGEPTRVVLAGFPDLGDGDLAQCRERFRSDFDHWRSAIACEPRGSDTMV
CCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCEEE
GALLLPPRDPSACTGVIFFNNVGYLGMCGHGTIGVVRTLAELGRIAPGQHRIETPVGTVG
EEEEECCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCCCEECCCCCEEE
VALADDGTVSIDNVESYRHAAGVEVDVPGHGRVRGDVAWGGNWFFITEQAPCALGLAQQR
EEEECCCEEEECCHHHHHHHCCCEEECCCCCEEEEEEEECCEEEEEECCCCCCCCCHHHH
ELTAYTEAIRLALEAAGITGEAGGEIDHIEISGVAPDGSGAARNFVLCPGLAYDRSPCGT
HHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCCC
GTSAKLACLAADGKLAEGERWLQQGILGSAFEGSYRHSGRGIAPRISGHAFITARSQLLI
CCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCEEEEECCEEEE
DPADPFAWGIVA
ECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA