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The map label for this gene is thrS

Identifier: 66767974

GI number: 66767974

Start: 1985330

End: 1987240

Strand: Direct

Name: thrS

Synonym: XC_1650

Alternate gene names: 66767974

Gene position: 1985330-1987240 (Clockwise)

Preceding gene: 66767972

Following gene: 66767975

Centisome position: 38.56

GC content: 63.27

Gene sequence:

>1911_bases
TTGCCCATGATCACCATTACGCTTCCCGACGGCAGCCGCCGCGAATTCGATGCTCCCGTGTCCGTCATGCAGGTCGCCCA
GTCGATCGGCGCCGGCCTGGCCAAGGCCACCATCGCCGGCCAGGTGGACGGCCAGCTGGTCGACGCCAGCGACCTCATCG
AACATGACGCCAGCCTGCGCATCATCACCGCCAAGGACGCCGAAGGCGTGGAGATCATCCGCCACTCCTGCGCCCACCTG
GTCGGCCATGCGGTCAAGCAGCTGTACCCGGACGTCAAGATGGTGATCGGCCCGGTGATTGCCGAAGGCTTCTATTACGA
CATCTACAGCGAGCGCCCGTTCACGCCGGAAGACATGGCGGCGATCGAGCAACGCATGCAGCAACTGATCGCGCAGGACT
ACGACGTGATCAAGAAGGTCACCCCGCGCGCCGAGGTGATTGAGGTGTTCGCCCAGCGCGGTGAGGAGTACAAGCTGCGC
CTGATTGAGGACATGTCCGACGACATCACCGCGATGGGCCTGTACTACCACCAGGAATACGTGGACATGTGCCGCGGCCC
GCACGTGCCCAACACGCGCTTCCTCAAGGCCTTCAAGCTGACGCGCATCTCCGGCGCCTACTGGCGTGGCGATGCCAAGA
ACGAGCAGCTGCAGCGCATCTACGGCACCGCCTGGGCCGACAAGAAGCAGCTCGACGCCTACATCCTGCGCATGGAAGAA
GCCGACAAGCGCGACCACCGCAAGATCGGCAAGGCACAGGACCTGTTCCACCTGCAGGAAGAGGCCCCGGGCCTGGTGTT
CTGGCACCCCAAGGGCTGGTCGCTATGGCAGGTGGTCGAGCAATACATGCGCAAGGTCTACCGCGACAGCGGCTATGGCG
AGGTGCGTTGCCCGCAGATCCTGGACGTGTCGCTGTGGCAGAAATCCGGCCACTGGGACAACTACCAGGACGCGATGTTC
TTCACCGAATCGGAGAAGCGCACCTACGCAGTCAAGCCGATGAACTGCCCCGGCCACGTGCAGGTGTTCAATCAGGGCCT
GCACAGTTACCGCGACCTGCCGATCCGCTACGGTGAGTTCGGCGCCTGCCACCGTAACGAGCCCTCCGGCGCGCTGCACG
GCATCCTGCGCGTGCGTGGCTTCACCCAGGACGACGGGCACGTGTTCTGCCTGGAATCGCAGATCGAAGCCGAAGTCACC
GCCTTCCATCAGCAGGCGCTGGCGGTCTATACCGCCTTCGGTTTCGACGACATCCAAATCAAGATCGCGCTGCGCCCGGA
AAAGCGCCTCGGCGACGATGCGACCTGGGACAAGGCCGAGGCCGCGCTGCGCAGCGCGCTGGGCGTATGCGGCGTGGAAT
GGCAGGAGCTGCCGGGCGAGGGCGCCTTCTATGGCCCGAAGATCGAGTACCACCTCAAGGATGCGATCGGCCGCACCTGG
CAACTGGGTACGATGCAGGTCGACTTCATGATGCCTGGCCGCCTCGGCGCCGAGTACGTGGACGAGCACAGCCAGAAGAA
GCATCCGGTCATGCTGCATCGGGCCATCGTCGGTTCGATGGAGCGTTTCATCGGCATTTTGATCGAGCACCACGCCGGCG
CATTCCCGGCCTGGCTGGCTCCGGTCCAGGTCGTTGTCGCCAACATCACCGACGCTCAGGCTGAATATGTGGACTCGGTT
CGGAAAACCCTTGCAAATCAAGGCTTCCGTGTCAGCGCCGATTTGCGTAACGAGAAGATCGGTTATAAGATTCGCGAGCA
TACGCTGCAACGCGTGCCGTATTTGCTCGTGGTTGGTGACCGCGAGAAGGAAAATGGCGCGGTCGCCGTGCGGACGCGTT
CGGGAGAGGACCTCGGAACCATGACGGTTTCGGCCTTCATCGAACGCCTGCAGGCAGAGCAGGCAGCGTGA

Upstream 100 bases:

>100_bases
TTGCGCCTGACTTCTTCGCCTGACCCTTTCGAGCCTGTCCCCGCGTGGACGGATCTCTCACTGCAGCAGCCACCGGCTGC
GGCCAGACCAGACCCTATCG

Downstream 100 bases:

>100_bases
GCCAACCCCGGCCGGTCTGGATGATCCGGATGCGCCGGTTCGATTCCCCTGGGAGATTGCAATATCAGTACCCCTGACAA
CAAACAGAACCGCAAGAACC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MPMITITLPDGSRREFDAPVSVMQVAQSIGAGLAKATIAGQVDGQLVDASDLIEHDASLRIITAKDAEGVEIIRHSCAHL
VGHAVKQLYPDVKMVIGPVIAEGFYYDIYSERPFTPEDMAAIEQRMQQLIAQDYDVIKKVTPRAEVIEVFAQRGEEYKLR
LIEDMSDDITAMGLYYHQEYVDMCRGPHVPNTRFLKAFKLTRISGAYWRGDAKNEQLQRIYGTAWADKKQLDAYILRMEE
ADKRDHRKIGKAQDLFHLQEEAPGLVFWHPKGWSLWQVVEQYMRKVYRDSGYGEVRCPQILDVSLWQKSGHWDNYQDAMF
FTESEKRTYAVKPMNCPGHVQVFNQGLHSYRDLPIRYGEFGACHRNEPSGALHGILRVRGFTQDDGHVFCLESQIEAEVT
AFHQQALAVYTAFGFDDIQIKIALRPEKRLGDDATWDKAEAALRSALGVCGVEWQELPGEGAFYGPKIEYHLKDAIGRTW
QLGTMQVDFMMPGRLGAEYVDEHSQKKHPVMLHRAIVGSMERFIGILIEHHAGAFPAWLAPVQVVVANITDAQAEYVDSV
RKTLANQGFRVSADLRNEKIGYKIREHTLQRVPYLLVVGDREKENGAVAVRTRSGEDLGTMTVSAFIERLQAEQAA

Sequences:

>Translated_636_residues
MPMITITLPDGSRREFDAPVSVMQVAQSIGAGLAKATIAGQVDGQLVDASDLIEHDASLRIITAKDAEGVEIIRHSCAHL
VGHAVKQLYPDVKMVIGPVIAEGFYYDIYSERPFTPEDMAAIEQRMQQLIAQDYDVIKKVTPRAEVIEVFAQRGEEYKLR
LIEDMSDDITAMGLYYHQEYVDMCRGPHVPNTRFLKAFKLTRISGAYWRGDAKNEQLQRIYGTAWADKKQLDAYILRMEE
ADKRDHRKIGKAQDLFHLQEEAPGLVFWHPKGWSLWQVVEQYMRKVYRDSGYGEVRCPQILDVSLWQKSGHWDNYQDAMF
FTESEKRTYAVKPMNCPGHVQVFNQGLHSYRDLPIRYGEFGACHRNEPSGALHGILRVRGFTQDDGHVFCLESQIEAEVT
AFHQQALAVYTAFGFDDIQIKIALRPEKRLGDDATWDKAEAALRSALGVCGVEWQELPGEGAFYGPKIEYHLKDAIGRTW
QLGTMQVDFMMPGRLGAEYVDEHSQKKHPVMLHRAIVGSMERFIGILIEHHAGAFPAWLAPVQVVVANITDAQAEYVDSV
RKTLANQGFRVSADLRNEKIGYKIREHTLQRVPYLLVVGDREKENGAVAVRTRSGEDLGTMTVSAFIERLQAEQAA
>Mature_635_residues
PMITITLPDGSRREFDAPVSVMQVAQSIGAGLAKATIAGQVDGQLVDASDLIEHDASLRIITAKDAEGVEIIRHSCAHLV
GHAVKQLYPDVKMVIGPVIAEGFYYDIYSERPFTPEDMAAIEQRMQQLIAQDYDVIKKVTPRAEVIEVFAQRGEEYKLRL
IEDMSDDITAMGLYYHQEYVDMCRGPHVPNTRFLKAFKLTRISGAYWRGDAKNEQLQRIYGTAWADKKQLDAYILRMEEA
DKRDHRKIGKAQDLFHLQEEAPGLVFWHPKGWSLWQVVEQYMRKVYRDSGYGEVRCPQILDVSLWQKSGHWDNYQDAMFF
TESEKRTYAVKPMNCPGHVQVFNQGLHSYRDLPIRYGEFGACHRNEPSGALHGILRVRGFTQDDGHVFCLESQIEAEVTA
FHQQALAVYTAFGFDDIQIKIALRPEKRLGDDATWDKAEAALRSALGVCGVEWQELPGEGAFYGPKIEYHLKDAIGRTWQ
LGTMQVDFMMPGRLGAEYVDEHSQKKHPVMLHRAIVGSMERFIGILIEHHAGAFPAWLAPVQVVVANITDAQAEYVDSVR
KTLANQGFRVSADLRNEKIGYKIREHTLQRVPYLLVVGDREKENGAVAVRTRSGEDLGTMTVSAFIERLQAEQAA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=632, Percent_Identity=39.2405063291139, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI38570111, Length=633, Percent_Identity=37.914691943128, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI20070344, Length=648, Percent_Identity=35.1851851851852, Blast_Score=390, Evalue=1e-108,
Organism=Escherichia coli, GI1788013, Length=631, Percent_Identity=61.4896988906498, Blast_Score=835, Evalue=0.0,
Organism=Escherichia coli, GI1786392, Length=157, Percent_Identity=24.8407643312102, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71984192, Length=636, Percent_Identity=38.2075471698113, Blast_Score=473, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI71984184, Length=636, Percent_Identity=38.2075471698113, Blast_Score=472, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322112, Length=629, Percent_Identity=37.5198728139905, Blast_Score=445, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322654, Length=413, Percent_Identity=35.8353510895884, Blast_Score=289, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24583842, Length=634, Percent_Identity=39.7476340694006, Blast_Score=487, Evalue=1e-137,
Organism=Drosophila melanogaster, GI28574141, Length=634, Percent_Identity=39.7476340694006, Blast_Score=487, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24583839, Length=634, Percent_Identity=39.7476340694006, Blast_Score=487, Evalue=1e-137,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_XANC8 (Q4UW57)

Other databases:

- EMBL:   CP000050
- RefSeq:   YP_242736.1
- HSSP:   P0A8M3
- ProteinModelPortal:   Q4UW57
- SMR:   Q4UW57
- STRING:   Q4UW57
- GeneID:   3380199
- GenomeReviews:   CP000050_GR
- KEGG:   xcb:XC_1650
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- PhylomeDB:   Q4UW57
- ProtClustDB:   PRK00413
- BioCyc:   XCAM314565:XC_1650-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 72003; Mature: 71872

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMITITLPDGSRREFDAPVSVMQVAQSIGAGLAKATIAGQVDGQLVDASDLIEHDASLR
CCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHEECCCCCCEECHHHHHHCCCCEE
IITAKDAEGVEIIRHSCAHLVGHAVKQLYPDVKMVIGPVIAEGFYYDIYSERPFTPEDMA
EEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCCCCHHHHH
AIEQRMQQLIAQDYDVIKKVTPRAEVIEVFAQRGEEYKLRLIEDMSDDITAMGLYYHQEY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEHHHHCCCCCHHHHHHHHHHHH
VDMCRGPHVPNTRFLKAFKLTRISGAYWRGDAKNEQLQRIYGTAWADKKQLDAYILRMEE
HHHHCCCCCCCHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
ADKRDHRKIGKAQDLFHLQEEAPGLVFWHPKGWSLWQVVEQYMRKVYRDSGYGEVRCPQI
HCCHHHHHCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEECCHH
LDVSLWQKSGHWDNYQDAMFFTESEKRTYAVKPMNCPGHVQVFNQGLHSYRDLPIRYGEF
HHHHHHHCCCCCCCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GACHRNEPSGALHGILRVRGFTQDDGHVFCLESQIEAEVTAFHQQALAVYTAFGFDDIQI
CCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHEECCCEEEE
KIALRPEKRLGDDATWDKAEAALRSALGVCGVEWQELPGEGAFYGPKIEYHLKDAIGRTW
EEEECCHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCEECCEEEEEEHHHCCCEE
QLGTMQVDFMMPGRLGAEYVDEHSQKKHPVMLHRAIVGSMERFIGILIEHHAGAFPAWLA
EECEEEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
PVQVVVANITDAQAEYVDSVRKTLANQGFRVSADLRNEKIGYKIREHTLQRVPYLLVVGD
HHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCEEEEECC
REKENGAVAVRTRSGEDLGTMTVSAFIERLQAEQAA
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PMITITLPDGSRREFDAPVSVMQVAQSIGAGLAKATIAGQVDGQLVDASDLIEHDASLR
CEEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHEECCCCCCEECHHHHHHCCCCEE
IITAKDAEGVEIIRHSCAHLVGHAVKQLYPDVKMVIGPVIAEGFYYDIYSERPFTPEDMA
EEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCCCCHHHHH
AIEQRMQQLIAQDYDVIKKVTPRAEVIEVFAQRGEEYKLRLIEDMSDDITAMGLYYHQEY
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEHHHHCCCCCHHHHHHHHHHHH
VDMCRGPHVPNTRFLKAFKLTRISGAYWRGDAKNEQLQRIYGTAWADKKQLDAYILRMEE
HHHHCCCCCCCHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
ADKRDHRKIGKAQDLFHLQEEAPGLVFWHPKGWSLWQVVEQYMRKVYRDSGYGEVRCPQI
HCCHHHHHCCCHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEECCHH
LDVSLWQKSGHWDNYQDAMFFTESEKRTYAVKPMNCPGHVQVFNQGLHSYRDLPIRYGEF
HHHHHHHCCCCCCCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCC
GACHRNEPSGALHGILRVRGFTQDDGHVFCLESQIEAEVTAFHQQALAVYTAFGFDDIQI
CCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHEECCCEEEE
KIALRPEKRLGDDATWDKAEAALRSALGVCGVEWQELPGEGAFYGPKIEYHLKDAIGRTW
EEEECCHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCEECCEEEEEEHHHCCCEE
QLGTMQVDFMMPGRLGAEYVDEHSQKKHPVMLHRAIVGSMERFIGILIEHHAGAFPAWLA
EECEEEEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
PVQVVVANITDAQAEYVDSVRKTLANQGFRVSADLRNEKIGYKIREHTLQRVPYLLVVGD
HHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCEEEEECC
REKENGAVAVRTRSGEDLGTMTVSAFIERLQAEQAA
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA