Click here to switch to the map view.

The map label for this gene is trpI [H]

Identifier: 66767898

GI number: 66767898

Start: 1892918

End: 1893814

Strand: Reverse

Name: trpI [H]

Synonym: XC_1574

Alternate gene names: 66767898

Gene position: 1893814-1892918 (Counterclockwise)

Preceding gene: 66767909

Following gene: 66767888

Centisome position: 36.78

GC content: 73.36

Gene sequence:

>897_bases
ATGCCCACCTCCCTGCCCCCGCTTGCTGCCTTGCGCGCCTTTGAGGCCGCGGCGCGCCTGCAAAGTGTCAGCCGCGCCGC
CGACGCCCTGCACGTGACCCACGGTGCCATCAGCCGGCATGTGCGTTCTCTGGAACAGCTATTGGGCACCGCCCTGTTTA
CCCGCCAGGGCCGCGGGCTGGTGCTGACCGCCGCCGGCACGCGCCTGCGCGATGCCACCAGCGAGGGCTTTGCGCTGATC
GCCGACACCTGGGCGGACCTGGCCAGCCCGCGCAACGAGGCGCCGTTGGTGCTGGGCTGCTCCGGCAGCCTGCTGGCGCG
CTGGGTGATTCCGCGGCTGGGCCGGCTGCAGCGCGATCTGCCCGATCTGCGCGTGCATCTGTCGGCAAACGAGCAACCGC
CCGGGCCGGACCTGGACGGCCTGGACGCCGCGCTGCTGCTCGACACCCCGCCCTGGCCGGGCGACTGGCAGGTGCACGAG
CTGGGCGTGGAGTGGATCGGGCCGGTGCTCAGCCCGCAAAGCCCGCTGGCGACCCAGCTGGCCGGGCAGCCGCCGCACGC
ACTGCTGGCGCACCCGCTGCTGCATACCCGTTCACGCCCGCAAGCCTGGCCGGACTGGGCGCAGGCGCATGGCATCCCGG
CCGACAGCTTGCGCTTCGGCACTGAGTTCGAGCATCTGATGTATCTGCTGGAAGCCGCTGCGGCCGGACTGGGCGTGGCG
ATCGCGCCGCAATCGCTGGTCGCCGCCGACCTGGCGGCCGGGCGGCTGGTGGCGCCGTGGGGCTTTACCCCGACCCGGGG
CCGCTGGGGCCTGTGCGCGGCGCGGCGCAATCCCGATCCGCGGATCGCACAGCTTGCCGGCTGGTTGCGCGGCGAGCTTG
CGGCGGATCAGCCCTGA

Upstream 100 bases:

>100_bases
CTCCGCAACACTGCGGAAATACGGGAAAGACGCACTCTAACGCAGGCGACGTAGCGGATAAATCGATAAGATCGCCGCAA
CCTGTGACCTGTACTCACAT

Downstream 100 bases:

>100_bases
TCAGAGGCGAGGCGCTACATCGAGCAGCGGCGTCTTCGCGCTACCACGCATGAAAAAAGCCCCGGAAACCGGAGCCTTGA
AGAGTTCTCAGCTGCCCGAA

Product: transcriptional regulator

Products: NA

Alternate protein names: TrpBA operon transcriptional activator [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MPTSLPPLAALRAFEAAARLQSVSRAADALHVTHGAISRHVRSLEQLLGTALFTRQGRGLVLTAAGTRLRDATSEGFALI
ADTWADLASPRNEAPLVLGCSGSLLARWVIPRLGRLQRDLPDLRVHLSANEQPPGPDLDGLDAALLLDTPPWPGDWQVHE
LGVEWIGPVLSPQSPLATQLAGQPPHALLAHPLLHTRSRPQAWPDWAQAHGIPADSLRFGTEFEHLMYLLEAAAAGLGVA
IAPQSLVAADLAAGRLVAPWGFTPTRGRWGLCAARRNPDPRIAQLAGWLRGELAADQP

Sequences:

>Translated_298_residues
MPTSLPPLAALRAFEAAARLQSVSRAADALHVTHGAISRHVRSLEQLLGTALFTRQGRGLVLTAAGTRLRDATSEGFALI
ADTWADLASPRNEAPLVLGCSGSLLARWVIPRLGRLQRDLPDLRVHLSANEQPPGPDLDGLDAALLLDTPPWPGDWQVHE
LGVEWIGPVLSPQSPLATQLAGQPPHALLAHPLLHTRSRPQAWPDWAQAHGIPADSLRFGTEFEHLMYLLEAAAAGLGVA
IAPQSLVAADLAAGRLVAPWGFTPTRGRWGLCAARRNPDPRIAQLAGWLRGELAADQP
>Mature_297_residues
PTSLPPLAALRAFEAAARLQSVSRAADALHVTHGAISRHVRSLEQLLGTALFTRQGRGLVLTAAGTRLRDATSEGFALIA
DTWADLASPRNEAPLVLGCSGSLLARWVIPRLGRLQRDLPDLRVHLSANEQPPGPDLDGLDAALLLDTPPWPGDWQVHEL
GVEWIGPVLSPQSPLATQLAGQPPHALLAHPLLHTRSRPQAWPDWAQAHGIPADSLRFGTEFEHLMYLLEAAAAGLGVAI
APQSLVAADLAAGRLVAPWGFTPTRGRWGLCAARRNPDPRIAQLAGWLRGELAADQP

Specific function: Activates the expression of the trpBA genes encoding the two tryptophan synthase subunits. In the absence of the inducer (indoleglycerol phosphate), trpI binds upstream of the trpAB operon, overlapping its own promoter region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789173, Length=304, Percent_Identity=31.9078947368421, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1786448, Length=253, Percent_Identity=32.4110671936759, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1788706, Length=298, Percent_Identity=28.1879194630872, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31861; Mature: 31730

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTSLPPLAALRAFEAAARLQSVSRAADALHVTHGAISRHVRSLEQLLGTALFTRQGRGL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VLTAAGTRLRDATSEGFALIADTWADLASPRNEAPLVLGCSGSLLARWVIPRLGRLQRDL
EEEECCCHHHHCCCCCCEEEHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCC
PDLRVHLSANEQPPGPDLDGLDAALLLDTPPWPGDWQVHELGVEWIGPVLSPQSPLATQL
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHCHHHHCCCCCCCCCHHHHH
AGQPPHALLAHPLLHTRSRPQAWPDWAQAHGIPADSLRFGTEFEHLMYLLEAAAAGLGVA
CCCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHCCCEE
IAPQSLVAADLAAGRLVAPWGFTPTRGRWGLCAARRNPDPRIAQLAGWLRGELAADQP
ECCHHHHHHHHHCCCEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PTSLPPLAALRAFEAAARLQSVSRAADALHVTHGAISRHVRSLEQLLGTALFTRQGRGL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VLTAAGTRLRDATSEGFALIADTWADLASPRNEAPLVLGCSGSLLARWVIPRLGRLQRDL
EEEECCCHHHHCCCCCCEEEHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCC
PDLRVHLSANEQPPGPDLDGLDAALLLDTPPWPGDWQVHELGVEWIGPVLSPQSPLATQL
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHCHHHHCCCCCCCCCHHHHH
AGQPPHALLAHPLLHTRSRPQAWPDWAQAHGIPADSLRFGTEFEHLMYLLEAAAAGLGVA
CCCCCHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHCCCEE
IAPQSLVAADLAAGRLVAPWGFTPTRGRWGLCAARRNPDPRIAQLAGWLRGELAADQP
ECCHHHHHHHHHCCCEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8423001 [H]