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The map label for this gene is dctA [C]

Identifier: 66767846

GI number: 66767846

Start: 1829491

End: 1830831

Strand: Direct

Name: dctA [C]

Synonym: XC_1520

Alternate gene names: 66767846

Gene position: 1829491-1830831 (Clockwise)

Preceding gene: 66767839

Following gene: 66767847

Centisome position: 35.53

GC content: 65.1

Gene sequence:

>1341_bases
ATGACATTGGTCTCGGCCTGGTTGCGCATTCCGTTCTGGCAACGCGTGGTGGCCGGCTTCGTGCTGGGCGCGATCGCGGG
CGCAGCCATGGGCCCGGCCGCCGAGGTGTGGTTTGGGCCGCTGGGCGATCTGTACGTCACCCTGATCAAGATGATCGCGG
TGCCGCTGGTGTTCTTTGCGGTGATCAACGCGATCTCGTCCTTGCACGGGCAAAAATCCGTTGCGGCCTTGGGCGGGCGC
ACCTTCCTGTGGTTCGTCATCACCGCCGCACTGGCAGTGGGCGTGGGCCTGGCGGTGGGCACGATCATGCAGCCCGGCGC
CGGCCATTTCAGCCTGAGTGTGGACTCGGCGTGGAAGCCGCGCGATGTGCCCAGCCCGATCAAGGTGCTGCTGGATGTGG
TGCCTTCCAACCCGTTCTACGCGCTGACAGGCATCGGCACCAAGACCAATGCCGCCGGTGAAACCGTGCTGGCCGCCGGG
CGTGGCTCGATCCTGCCGGTGATCTTCTTTGCCGCGCTGCTCGGCTTTGCGATGGTCAAGCTGGGTGACCGCGTGGCCGA
GGCACGCAAGCTCACCGGGCAGATGAGCGACATCATGATTCAGGTCACCCGCTTCGTGCTGGAGATGACCCCGCTGGGCA
CCTTCGGCCTGATTGCCGGTTTGGTGGGCAGCTACGGCTTTGCGAAGCTGCTGCCGTTCGGCAATTTCGTGCTGGCGCTG
TATGTGGCCTGCGCGCTTCACATCGTGGTGGTCTACAGCAGCCTGTTGCTGCTGCACGGGCTGAACCCGTGGAAGTTCTT
CCGCGGTGCGGCGCCTGGCATGCAAGTGGCGTTCGTGAGCTCGTCAAGCTTCGCCGCGATGCCAGTGGCGATGCGCTCGA
TCACCCACAACCTCGGCGTGAACAAGGACTACGCCGCCTTCGCCGTGCCGCTGGGCGCGAGCATCAAGATGGACGGCTGT
GGCGCGATCTTCCCGGCGTTGTGCGCCGTGTTCATCGCGCAATACACCGGCGTGCCGTTGACCGCCAACCAGTATTTCGT
GGTGCTGATCGCCTCGGTGCTGGGCAGCTTCGGTACCGCTGGCGTGCCGGGCACCGCGGTGGTGATGGCCACGGTGGTGC
TTAGCGCCGCCAACCTGCCGCTGGAAGTGATCGGCTATCTGTACGCCATCGACCGGATCCTCGACATGATGCGCACCATG
ACCAACGTCACCGGGCAGATGCTGGTGCCGGTGCTGGTGGCCAAGGAGACCGGTCTGCTGGACAAGACGATCTACGAGTC
TGCGTCCACCAATGTGGGGCTTGAGGATCCGCCCACCGATCGCGCCGCGCCGCTGCGCTGA

Upstream 100 bases:

>100_bases
CATCCGTCGCACTGATGACACGCCGCTGTTCCAGTCGTGGCCTCGCGGGCAGGGCGGCCCTGCGATAAGGTGCATGCACT
CCCCCCGGATGATTTCACGC

Downstream 100 bases:

>100_bases
GCCGGTGATGGAAGACGGGTTTCCCACCGTGCGCGGGCAATTGCAGGCGCTTGCGCCGTTGCATGTCATCGACGGTGTGC
TGGTGCAGGACGGCCTGCCC

Product: glutamate symport protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTLVSAWLRIPFWQRVVAGFVLGAIAGAAMGPAAEVWFGPLGDLYVTLIKMIAVPLVFFAVINAISSLHGQKSVAALGGR
TFLWFVITAALAVGVGLAVGTIMQPGAGHFSLSVDSAWKPRDVPSPIKVLLDVVPSNPFYALTGIGTKTNAAGETVLAAG
RGSILPVIFFAALLGFAMVKLGDRVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFAKLLPFGNFVLAL
YVACALHIVVVYSSLLLLHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVAMRSITHNLGVNKDYAAFAVPLGASIKMDGC
GAIFPALCAVFIAQYTGVPLTANQYFVVLIASVLGSFGTAGVPGTAVVMATVVLSAANLPLEVIGYLYAIDRILDMMRTM
TNVTGQMLVPVLVAKETGLLDKTIYESASTNVGLEDPPTDRAAPLR

Sequences:

>Translated_446_residues
MTLVSAWLRIPFWQRVVAGFVLGAIAGAAMGPAAEVWFGPLGDLYVTLIKMIAVPLVFFAVINAISSLHGQKSVAALGGR
TFLWFVITAALAVGVGLAVGTIMQPGAGHFSLSVDSAWKPRDVPSPIKVLLDVVPSNPFYALTGIGTKTNAAGETVLAAG
RGSILPVIFFAALLGFAMVKLGDRVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFAKLLPFGNFVLAL
YVACALHIVVVYSSLLLLHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVAMRSITHNLGVNKDYAAFAVPLGASIKMDGC
GAIFPALCAVFIAQYTGVPLTANQYFVVLIASVLGSFGTAGVPGTAVVMATVVLSAANLPLEVIGYLYAIDRILDMMRTM
TNVTGQMLVPVLVAKETGLLDKTIYESASTNVGLEDPPTDRAAPLR
>Mature_445_residues
TLVSAWLRIPFWQRVVAGFVLGAIAGAAMGPAAEVWFGPLGDLYVTLIKMIAVPLVFFAVINAISSLHGQKSVAALGGRT
FLWFVITAALAVGVGLAVGTIMQPGAGHFSLSVDSAWKPRDVPSPIKVLLDVVPSNPFYALTGIGTKTNAAGETVLAAGR
GSILPVIFFAALLGFAMVKLGDRVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFAKLLPFGNFVLALY
VACALHIVVVYSSLLLLHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVAMRSITHNLGVNKDYAAFAVPLGASIKMDGCG
AIFPALCAVFIAQYTGVPLTANQYFVVLIASVLGSFGTAGVPGTAVVMATVVLSAANLPLEVIGYLYAIDRILDMMRTMT
NVTGQMLVPVLVAKETGLLDKTIYESASTNVGLEDPPTDRAAPLR

Specific function: Responsible For The Aerobic Transport Of The Dicarboxylates Fumarate And Malate And To A Lesser Extent Succinate, From The Periplasm Across The Inner Membrane. [C]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=442, Percent_Identity=26.4705882352941, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI21314632, Length=393, Percent_Identity=27.2264631043257, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI5032093, Length=457, Percent_Identity=29.3216630196937, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI194239697, Length=446, Percent_Identity=25.3363228699552, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI66773030, Length=281, Percent_Identity=30.6049822064057, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI169790839, Length=449, Percent_Identity=25.3897550111359, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI223468564, Length=292, Percent_Identity=29.1095890410959, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI223468566, Length=292, Percent_Identity=29.1095890410959, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4827012, Length=428, Percent_Identity=25.7009345794392, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI301601644, Length=124, Percent_Identity=40.3225806451613, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI262359914, Length=389, Percent_Identity=23.3933161953728, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1789947, Length=404, Percent_Identity=29.2079207920792, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1790514, Length=420, Percent_Identity=29.2857142857143, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788024, Length=413, Percent_Identity=31.7191283292978, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI1789473, Length=390, Percent_Identity=24.3589743589744, Blast_Score=85, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17537407, Length=424, Percent_Identity=28.7735849056604, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71983099, Length=435, Percent_Identity=27.5862068965517, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71983106, Length=435, Percent_Identity=27.5862068965517, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI193206505, Length=422, Percent_Identity=27.9620853080569, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71996953, Length=410, Percent_Identity=24.390243902439, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193206654, Length=398, Percent_Identity=24.8743718592965, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17541374, Length=400, Percent_Identity=23, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24583025, Length=396, Percent_Identity=25.5050505050505, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17137668, Length=396, Percent_Identity=25.5050505050505, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24583023, Length=396, Percent_Identity=25.5050505050505, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281360483, Length=477, Percent_Identity=24.9475890985325, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137666, Length=477, Percent_Identity=24.9475890985325, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281360481, Length=477, Percent_Identity=24.9475890985325, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46763; Mature: 46632

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVSAWLRIPFWQRVVAGFVLGAIAGAAMGPAAEVWFGPLGDLYVTLIKMIAVPLVFFA
CCHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VINAISSLHGQKSVAALGGRTFLWFVITAALAVGVGLAVGTIMQPGAGHFSLSVDSAWKP
HHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
RDVPSPIKVLLDVVPSNPFYALTGIGTKTNAAGETVLAAGRGSILPVIFFAALLGFAMVK
CCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
LGDRVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFAKLLPFGNFVLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCHHHHHHH
YVACALHIVVVYSSLLLLHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVAMRSITHNLGV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
NKDYAAFAVPLGASIKMDGCGAIFPALCAVFIAQYTGVPLTANQYFVVLIASVLGSFGTA
CCCCHHEEECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
GVPGTAVVMATVVLSAANLPLEVIGYLYAIDRILDMMRTMTNVTGQMLVPVLVAKETGLL
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCH
DKTIYESASTNVGLEDPPTDRAAPLR
HHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TLVSAWLRIPFWQRVVAGFVLGAIAGAAMGPAAEVWFGPLGDLYVTLIKMIAVPLVFFA
CHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
VINAISSLHGQKSVAALGGRTFLWFVITAALAVGVGLAVGTIMQPGAGHFSLSVDSAWKP
HHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCC
RDVPSPIKVLLDVVPSNPFYALTGIGTKTNAAGETVLAAGRGSILPVIFFAALLGFAMVK
CCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
LGDRVAEARKLTGQMSDIMIQVTRFVLEMTPLGTFGLIAGLVGSYGFAKLLPFGNFVLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCHHHHHHH
YVACALHIVVVYSSLLLLHGLNPWKFFRGAAPGMQVAFVSSSSFAAMPVAMRSITHNLGV
HHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCC
NKDYAAFAVPLGASIKMDGCGAIFPALCAVFIAQYTGVPLTANQYFVVLIASVLGSFGTA
CCCCHHEEECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
GVPGTAVVMATVVLSAANLPLEVIGYLYAIDRILDMMRTMTNVTGQMLVPVLVAKETGLL
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCH
DKTIYESASTNVGLEDPPTDRAAPLR
HHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]