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The map label for this gene is cysJ [H]

Identifier: 66767661

GI number: 66767661

Start: 1620152

End: 1621756

Strand: Reverse

Name: cysJ [H]

Synonym: XC_1334

Alternate gene names: 66767661

Gene position: 1621756-1620152 (Counterclockwise)

Preceding gene: 66767662

Following gene: 66767658

Centisome position: 31.5

GC content: 68.35

Gene sequence:

>1605_bases
ATGAGCCTCGCCTCCCCACGCGTGTGGCTTGGCAACGGCGTCATCCTGCTGGCCTTGGCGGTACTGGCCGCCTGGTTGGG
CAGCCTGCATGCGGGCCCGTGGTGGAGCGCCCCCGCCCCACACCGTTGGCAATGGGCGGGCCTCAGCCTGGCGGCTTACG
CCATCGTCTGTTTCGGCCTGTGGCTGCGCGGGCGTCCACGCGTTGCGGCTGCGCGCGGCGATGACAGCAACCTGCTGATC
GCCTGGGCGAGCCAGACCGGGTTCGCGCGTGAATTGGCCGAACGCAGCGCCACTGCCCTGCAGCAGGCCGGCGTCGGTGC
GCATGCATTGCCGCTGGACGCGTTGGATGCCAATCAACTATCGCGCGTGCCGCGCCTGCTCTGCATCGTCAGCACCACCG
GCGAAGGCGATGCACCCGATCACGTACAAGCAGCCGAGCGCACCTGGCTCGCCGGCAGCGATACCGATCTGGCCGCGCTG
CGTTACGCGGTCGTGGCGCTGGGCGACCGCCGTTACGCGCAGTTCTGCGCATTTGGGCGGCGCCTGGATGCACGCTTGCA
GGCGCAAGGTGCAACCCCCTTGTTCGCACGCATCGAGGTCGACAACGCCGAGCCGCAGTCCCTGCAGCAGTGGCAGCAAA
GGCTGGCTGAACTGGCACCGGCACTGGCGACGCAAGCGGATTGGAGTGTGCCCAGTTATGCCGACTGGCAGCTGCAGCAG
CGCGTGCATATCAATCCGGGCAGCGCGGGCGCCGCGGTGTATCGCTTGCGCCTGATCCCGTGCGGCGGTCATTTGCCGCA
GTGGAGCGCGGGCGACATTGCCGAAATCCGCCCGCAGCATTCGCCACAAGTGGTGGAGACCTGGCTGCAGCGGCATCTGC
TGGACGGCACCCAACAGGTGCAGGGGCGTTCGTTGCACGCCTGGCTCAGCGGCGCGACCCTGCCTGACGACAGCCCCGAC
ATCACTTCGCTGGATGCATGGGTACACACGCTGGCAGCGCTGCCACACCGCGACTACTCGCTGGCCTCGCTCCCCGACGA
AGGCCATGCCGAACTGCTGATCCGTCAACACCTGCATGCCGATGGCACGCCCGGCCTGGGAAGCGGCTGGCTTTGCCGGG
CGGCTCCAATCGGCGCGCGCATCGCGCTACGCGTGCGGACCAATCCCGGCTTCCACCCGCCCGCCGCCGCGCAACCGATG
CTGCTGATCGGCAATGGCACCGGGATCGCCGGCTTGCGTGCACACCTGCGCGCGCGCATCGCCGCCGGTGCGCGCCGCAA
CTGGCTGTTGTTCGGCGAACGCAACGCAGCCTACGACACGCTCTATGGCGATGAACTCGAACACTGGCAGCGCGACGGCT
GGATCGAACGACTGGACCGCGTCTATTCCCGCGACAGTAGCCAGCCGCATCGCTACGTTCAACACGCCTTGGCCGCCGCG
GCGGCGGACGTGCGCGCATGGGTGGCGCAAGGCGCCTGCGTGTACGTCTGCGGCAGCCTGCGCGGCATGGCCCCGGAGGT
CGATGCCACCCTCGACAGCATTCTGGGAACCGACCTCAAACACGCACTACTCAGCAGCGGGCGGTATCGTCGCGACGTGT
ACTGA

Upstream 100 bases:

>100_bases
ATGCGACGAACGCAGGGCTTGCGGTGCGCTTTTTGCAGCGCCGCGGCGCGGATTTGCAGGAATCCATGAGCCCGGCGTTT
GAAACGCATCTGGCTGCCGC

Downstream 100 bases:

>100_bases
TGGTCGTTATTGCAAGCGAAACTCCACTGCTGTGAACGGATATGTTGCGCTTCACTTGTTAGCCGCAGTGCAGCGGCTTG
CATGGATCTGCACATGCAAC

Product: sulfite reductase

Products: NA

Alternate protein names: SiR-FP [H]

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MSLASPRVWLGNGVILLALAVLAAWLGSLHAGPWWSAPAPHRWQWAGLSLAAYAIVCFGLWLRGRPRVAAARGDDSNLLI
AWASQTGFARELAERSATALQQAGVGAHALPLDALDANQLSRVPRLLCIVSTTGEGDAPDHVQAAERTWLAGSDTDLAAL
RYAVVALGDRRYAQFCAFGRRLDARLQAQGATPLFARIEVDNAEPQSLQQWQQRLAELAPALATQADWSVPSYADWQLQQ
RVHINPGSAGAAVYRLRLIPCGGHLPQWSAGDIAEIRPQHSPQVVETWLQRHLLDGTQQVQGRSLHAWLSGATLPDDSPD
ITSLDAWVHTLAALPHRDYSLASLPDEGHAELLIRQHLHADGTPGLGSGWLCRAAPIGARIALRVRTNPGFHPPAAAQPM
LLIGNGTGIAGLRAHLRARIAAGARRNWLLFGERNAAYDTLYGDELEHWQRDGWIERLDRVYSRDSSQPHRYVQHALAAA
AADVRAWVAQGACVYVCGSLRGMAPEVDATLDSILGTDLKHALLSSGRYRRDVY

Sequences:

>Translated_534_residues
MSLASPRVWLGNGVILLALAVLAAWLGSLHAGPWWSAPAPHRWQWAGLSLAAYAIVCFGLWLRGRPRVAAARGDDSNLLI
AWASQTGFARELAERSATALQQAGVGAHALPLDALDANQLSRVPRLLCIVSTTGEGDAPDHVQAAERTWLAGSDTDLAAL
RYAVVALGDRRYAQFCAFGRRLDARLQAQGATPLFARIEVDNAEPQSLQQWQQRLAELAPALATQADWSVPSYADWQLQQ
RVHINPGSAGAAVYRLRLIPCGGHLPQWSAGDIAEIRPQHSPQVVETWLQRHLLDGTQQVQGRSLHAWLSGATLPDDSPD
ITSLDAWVHTLAALPHRDYSLASLPDEGHAELLIRQHLHADGTPGLGSGWLCRAAPIGARIALRVRTNPGFHPPAAAQPM
LLIGNGTGIAGLRAHLRARIAAGARRNWLLFGERNAAYDTLYGDELEHWQRDGWIERLDRVYSRDSSQPHRYVQHALAAA
AADVRAWVAQGACVYVCGSLRGMAPEVDATLDSILGTDLKHALLSSGRYRRDVY
>Mature_533_residues
SLASPRVWLGNGVILLALAVLAAWLGSLHAGPWWSAPAPHRWQWAGLSLAAYAIVCFGLWLRGRPRVAAARGDDSNLLIA
WASQTGFARELAERSATALQQAGVGAHALPLDALDANQLSRVPRLLCIVSTTGEGDAPDHVQAAERTWLAGSDTDLAALR
YAVVALGDRRYAQFCAFGRRLDARLQAQGATPLFARIEVDNAEPQSLQQWQQRLAELAPALATQADWSVPSYADWQLQQR
VHINPGSAGAAVYRLRLIPCGGHLPQWSAGDIAEIRPQHSPQVVETWLQRHLLDGTQQVQGRSLHAWLSGATLPDDSPDI
TSLDAWVHTLAALPHRDYSLASLPDEGHAELLIRQHLHADGTPGLGSGWLCRAAPIGARIALRVRTNPGFHPPAAAQPML
LIGNGTGIAGLRAHLRARIAAGARRNWLLFGERNAAYDTLYGDELEHWQRDGWIERLDRVYSRDSSQPHRYVQHALAAAA
ADVRAWVAQGACVYVCGSLRGMAPEVDATLDSILGTDLKHALLSSGRYRRDVY

Specific function: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow f

COG id: COG0369

COG function: function code P; Sulfite reductase, alpha subunit (flavoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 flavodoxin-like domain [H]

Homologues:

Organism=Homo sapiens, GI127139033, Length=237, Percent_Identity=28.6919831223629, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI10835173, Length=225, Percent_Identity=30.2222222222222, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI40254422, Length=225, Percent_Identity=30.2222222222222, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI24041029, Length=231, Percent_Identity=30.7359307359307, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789123, Length=540, Percent_Identity=26.1111111111111, Blast_Score=138, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17566446, Length=200, Percent_Identity=30.5, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17554134, Length=193, Percent_Identity=29.0155440414508, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321832, Length=177, Percent_Identity=31.0734463276836, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010199
- InterPro:   IPR003097
- InterPro:   IPR017927
- InterPro:   IPR001094
- InterPro:   IPR008254
- InterPro:   IPR001709
- InterPro:   IPR023173
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00667 FAD_binding_1; PF00258 Flavodoxin_1; PF00175 NAD_binding_1 [H]

EC number: =1.8.1.2 [H]

Molecular weight: Translated: 58077; Mature: 57946

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS50902 FLAVODOXIN_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLASPRVWLGNGVILLALAVLAAWLGSLHAGPWWSAPAPHRWQWAGLSLAAYAIVCFGL
CCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHH
WLRGRPRVAAARGDDSNLLIAWASQTGFARELAERSATALQQAGVGAHALPLDALDANQL
HHCCCCCEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
SRVPRLLCIVSTTGEGDAPDHVQAAERTWLAGSDTDLAALRYAVVALGDRRYAQFCAFGR
HHCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
RLDARLQAQGATPLFARIEVDNAEPQSLQQWQQRLAELAPALATQADWSVPSYADWQLQQ
HHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
RVHINPGSAGAAVYRLRLIPCGGHLPQWSAGDIAEIRPQHSPQVVETWLQRHLLDGTQQV
EEEECCCCCCCEEEEEEEEECCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCHHHH
QGRSLHAWLSGATLPDDSPDITSLDAWVHTLAALPHRDYSLASLPDEGHAELLIRQHLHA
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCC
DGTPGLGSGWLCRAAPIGARIALRVRTNPGFHPPAAAQPMLLIGNGTGIAGLRAHLRARI
CCCCCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
AAGARRNWLLFGERNAAYDTLYGDELEHWQRDGWIERLDRVYSRDSSQPHRYVQHALAAA
HCCCCCCEEEEECCCCCHHHHCCHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AADVRAWVAQGACVYVCGSLRGMAPEVDATLDSILGTDLKHALLSSGRYRRDVY
HHHHHHHHHCCCCEEEECHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SLASPRVWLGNGVILLALAVLAAWLGSLHAGPWWSAPAPHRWQWAGLSLAAYAIVCFGL
CCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHH
WLRGRPRVAAARGDDSNLLIAWASQTGFARELAERSATALQQAGVGAHALPLDALDANQL
HHCCCCCEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
SRVPRLLCIVSTTGEGDAPDHVQAAERTWLAGSDTDLAALRYAVVALGDRRYAQFCAFGR
HHCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHH
RLDARLQAQGATPLFARIEVDNAEPQSLQQWQQRLAELAPALATQADWSVPSYADWQLQQ
HHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
RVHINPGSAGAAVYRLRLIPCGGHLPQWSAGDIAEIRPQHSPQVVETWLQRHLLDGTQQV
EEEECCCCCCCEEEEEEEEECCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCHHHH
QGRSLHAWLSGATLPDDSPDITSLDAWVHTLAALPHRDYSLASLPDEGHAELLIRQHLHA
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCC
DGTPGLGSGWLCRAAPIGARIALRVRTNPGFHPPAAAQPMLLIGNGTGIAGLRAHLRARI
CCCCCCCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
AAGARRNWLLFGERNAAYDTLYGDELEHWQRDGWIERLDRVYSRDSSQPHRYVQHALAAA
HCCCCCCEEEEECCCCCHHHHCCHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AADVRAWVAQGACVYVCGSLRGMAPEVDATLDSILGTDLKHALLSSGRYRRDVY
HHHHHHHHHCCCCEEEECHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]