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The map label for this gene is ycgM [C]

Identifier: 66767342

GI number: 66767342

Start: 1222682

End: 1223395

Strand: Reverse

Name: ycgM [C]

Synonym: XC_1010

Alternate gene names: 66767342

Gene position: 1223395-1222682 (Counterclockwise)

Preceding gene: 66767343

Following gene: 66767341

Centisome position: 23.76

GC content: 64.71

Gene sequence:

>714_bases
ATGACCCACGATGTGATTCCCGCTGCCGATGTCCCGCGCATTCCGGTGGTGGGTGGCGGCAGTTTTCCGGTGCACCGCAT
CTACTGCGTCGGCCGCAACTTTGCAGATCACGCCCGAGAAATGGGTGCCACCGCGCCGGCGTCCAAGGCCGAACGTGGCC
AGCCCACGTTCTTCATGAAACCGGCCGACGCCATCGTGGTGGGTCATGGCGACCACATCCCCTACCCGCCCGGCACCAAG
GAGCTGCACCACGAGGTGGAGCTGGTGGTGGCCTTGGGCAGCGATGCACCCGCCGGTGAACTGCCTGTGGACCAGGCCGA
GGCCCTGATCTATGGCTACGGCGTGGGCCTGGACCTGACCCGTCGTGATCTGCAGGCCGCGGCCAAGGCCAAAGGCCTGC
CCTGGGACATCGCCAAGGGCTTCGATCATTCCGCACCGATCAGCGAGCTGGTGCATGCCGGCGAAGTGGGTGCACTGGAT
GCATTGAACCTGTCGCTGGAAGTCAACGGCGAAGTGCGCCAGCAATCGTTGCTGGACCAGATGATCTGGAACGTGCCGGA
GATCCTGCATGAGCTGTCCAAGCTCTATGCATTGCGCGCGGGCGATCTGATCTTCATGGGCACGCCGGCCGGCGTCGGCC
CGTTGTTGCCGGGCGATCACTTCAGTGCGCGCCTGGAAAACGTGGCCGAACGCCACGGCATCATCGCGGACTGA

Upstream 100 bases:

>100_bases
CGCACTGAGCCGCACGCTGCAGCGCGCCTGAGGCGAGCGTTGTTTTCGCCTGCACCGCCAAGCAGCTAGACTCACGCGTC
CTGTCTTTGAGGATGCGTGC

Downstream 100 bases:

>100_bases
CATCGGCCGGGCTACGATCGCTGCAGCGGCAGTGGGTCCGCGTCCCCCATCTGGAGTGCACTATGGGAATGGTCAGCGAA
TTCAAGCAATTCGCGATGCG

Product: fumarylacetoacetate hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MTHDVIPAADVPRIPVVGGGSFPVHRIYCVGRNFADHAREMGATAPASKAERGQPTFFMKPADAIVVGHGDHIPYPPGTK
ELHHEVELVVALGSDAPAGELPVDQAEALIYGYGVGLDLTRRDLQAAAKAKGLPWDIAKGFDHSAPISELVHAGEVGALD
ALNLSLEVNGEVRQQSLLDQMIWNVPEILHELSKLYALRAGDLIFMGTPAGVGPLLPGDHFSARLENVAERHGIIAD

Sequences:

>Translated_237_residues
MTHDVIPAADVPRIPVVGGGSFPVHRIYCVGRNFADHAREMGATAPASKAERGQPTFFMKPADAIVVGHGDHIPYPPGTK
ELHHEVELVVALGSDAPAGELPVDQAEALIYGYGVGLDLTRRDLQAAAKAKGLPWDIAKGFDHSAPISELVHAGEVGALD
ALNLSLEVNGEVRQQSLLDQMIWNVPEILHELSKLYALRAGDLIFMGTPAGVGPLLPGDHFSARLENVAERHGIIAD
>Mature_236_residues
THDVIPAADVPRIPVVGGGSFPVHRIYCVGRNFADHAREMGATAPASKAERGQPTFFMKPADAIVVGHGDHIPYPPGTKE
LHHEVELVVALGSDAPAGELPVDQAEALIYGYGVGLDLTRRDLQAAAKAKGLPWDIAKGFDHSAPISELVHAGEVGALDA
LNLSLEVNGEVRQQSLLDQMIWNVPEILHELSKLYALRAGDLIFMGTPAGVGPLLPGDHFSARLENVAERHGIIAD

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI13654274, Length=212, Percent_Identity=40.5660377358491, Blast_Score=147, Evalue=8e-36,
Organism=Homo sapiens, GI215422413, Length=199, Percent_Identity=42.2110552763819, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI66348062, Length=199, Percent_Identity=42.2110552763819, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI156231349, Length=189, Percent_Identity=32.2751322751323, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI40786394, Length=189, Percent_Identity=32.2751322751323, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1787428, Length=206, Percent_Identity=39.3203883495146, Blast_Score=144, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17557057, Length=196, Percent_Identity=36.734693877551, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324161, Length=230, Percent_Identity=33.0434782608696, Blast_Score=122, Evalue=5e-29,
Organism=Drosophila melanogaster, GI28571789, Length=177, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28572127, Length=189, Percent_Identity=31.7460317460317, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24663695, Length=236, Percent_Identity=26.6949152542373, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 25241; Mature: 25110

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHDVIPAADVPRIPVVGGGSFPVHRIYCVGRNFADHAREMGATAPASKAERGQPTFFMK
CCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCEEEEC
PADAIVVGHGDHIPYPPGTKELHHEVELVVALGSDAPAGELPVDQAEALIYGYGVGLDLT
CCCEEEEECCCCCCCCCCHHHHHHEEEEEEEECCCCCCCCCCHHHHCEEEEEECCCCCHH
RRDLQAAAKAKGLPWDIAKGFDHSAPISELVHAGEVGALDALNLSLEVNGEVRQQSLLDQ
HHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHCCCCCCEEEEEEEEEECCHHHHHHHHHH
MIWNVPEILHELSKLYALRAGDLIFMGTPAGVGPLLPGDHFSARLENVAERHGIIAD
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
THDVIPAADVPRIPVVGGGSFPVHRIYCVGRNFADHAREMGATAPASKAERGQPTFFMK
CCCCCCCCCCCCCEEEECCCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCEEEEC
PADAIVVGHGDHIPYPPGTKELHHEVELVVALGSDAPAGELPVDQAEALIYGYGVGLDLT
CCCEEEEECCCCCCCCCCHHHHHHEEEEEEEECCCCCCCCCCHHHHCEEEEEECCCCCHH
RRDLQAAAKAKGLPWDIAKGFDHSAPISELVHAGEVGALDALNLSLEVNGEVRQQSLLDQ
HHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHCCCCCCEEEEEEEEEECCHHHHHHHHHH
MIWNVPEILHELSKLYALRAGDLIFMGTPAGVGPLLPGDHFSARLENVAERHGIIAD
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]