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The map label for this gene is rihA [H]

Identifier: 66767278

GI number: 66767278

Start: 1135595

End: 1136533

Strand: Reverse

Name: rihA [H]

Synonym: XC_0946

Alternate gene names: 66767278

Gene position: 1136533-1135595 (Counterclockwise)

Preceding gene: 66767279

Following gene: 66767277

Centisome position: 22.07

GC content: 68.48

Gene sequence:

>939_bases
ATGACAAAAAAGATACCGCTGCTGATCGACACCGACCCGGGCGTGGATGACGCGCTGGCGCTGCTGATGGCGTTCAACGA
TACCCGCCATGACGTGGTCGGCCTGACCATCGCCGCAGGCAATGTCGGTCTGGAGCACACCGTGCGCAATGCGCTCAAAG
TGTGCGAGGTGGCCGGTCGCGCCGATGTGCCGGTGTATGCGGGCTGCCCGCAACCGCTGCTGCACCCGTCGGTGGACGCG
GCGCATGTGCATGGCATCGACGGCTTCGGCGATGTCGGCCTGCCGCCTGCCGCGCGGGCTGCGGACGCCGAGCATGCCGC
GCTGGCCATCCTGCGGCTGTCGCACGTGCATGCAGGCGAGTTGTTGCTGGTGGCACTTGGCCCGCTGACCAACCTCGCCC
TGGCTCTGACCCTGGACCCGACCCTGCCACAGCGTGTGGCGCGGCTGGTGGTGATGGGCGGGGCGCTGACCGGGCACGGC
AACATTACCGCCGCGGCTGAATTCAATATCGGCTTCGACCCGGAGGCGGCGCATATCGTGTTCCGCGGGTTTCCCCAGTT
CGATGTGGCCGATTGGGAGGCGACCGTCGCGCACGGCCTGCTGCACCGTGATGTGGAGCAGTGGCTGGCGGCCGATTCGC
CGCGTGCGCGCTTCTACGAAGAAATCTCGCGCAAGACCCGGCTGTGGTCGGAGGACAGTCGTGGCGAGTACTGGTATGCC
GCAGACGCGTTGGCGATGGCCTTCGCCCTGCAGCCGGACGGCGCGCAGCGCCTGGAGCAGCGGCCGGTGCACATCGAACT
GTCGGGCACGCACACCCGCGGCATGACCCTGGTGGACTGGAACCGGCAGGGCGGGGCGGCCGACAACGCCACCCTGTTGC
TGGACTACGACCGCCAGCGCTTCTACGGCCTGGTCGGGCAGGCGCTTGCGGCCGGCTAG

Upstream 100 bases:

>100_bases
GGATTTGTCAGAGCGGGGCTGCTGCCTCATCTGATTCGCTTGCCTCGCCGATCCTTGCGAAGATGCGACAACGAATCCCG
AATGACCAATTCCGAATCCC

Downstream 100 bases:

>100_bases
GGCCGGCTTGCACCGGGTGCCGGGCGGTGGCTATAATGCCCGGCTTACCCAGGCAGCCCGGCGCCAAGTCCATGAAAGAT
AACGTTCATCCCAGCTACAA

Product: inosine-uridine preferring nucleoside hydrolase

Products: uracil; ribose; cytosine [C]

Alternate protein names: Cytidine/uridine-specific hydrolase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTKKIPLLIDTDPGVDDALALLMAFNDTRHDVVGLTIAAGNVGLEHTVRNALKVCEVAGRADVPVYAGCPQPLLHPSVDA
AHVHGIDGFGDVGLPPAARAADAEHAALAILRLSHVHAGELLLVALGPLTNLALALTLDPTLPQRVARLVVMGGALTGHG
NITAAAEFNIGFDPEAAHIVFRGFPQFDVADWEATVAHGLLHRDVEQWLAADSPRARFYEEISRKTRLWSEDSRGEYWYA
ADALAMAFALQPDGAQRLEQRPVHIELSGTHTRGMTLVDWNRQGGAADNATLLLDYDRQRFYGLVGQALAAG

Sequences:

>Translated_312_residues
MTKKIPLLIDTDPGVDDALALLMAFNDTRHDVVGLTIAAGNVGLEHTVRNALKVCEVAGRADVPVYAGCPQPLLHPSVDA
AHVHGIDGFGDVGLPPAARAADAEHAALAILRLSHVHAGELLLVALGPLTNLALALTLDPTLPQRVARLVVMGGALTGHG
NITAAAEFNIGFDPEAAHIVFRGFPQFDVADWEATVAHGLLHRDVEQWLAADSPRARFYEEISRKTRLWSEDSRGEYWYA
ADALAMAFALQPDGAQRLEQRPVHIELSGTHTRGMTLVDWNRQGGAADNATLLLDYDRQRFYGLVGQALAAG
>Mature_311_residues
TKKIPLLIDTDPGVDDALALLMAFNDTRHDVVGLTIAAGNVGLEHTVRNALKVCEVAGRADVPVYAGCPQPLLHPSVDAA
HVHGIDGFGDVGLPPAARAADAEHAALAILRLSHVHAGELLLVALGPLTNLALALTLDPTLPQRVARLVVMGGALTGHGN
ITAAAEFNIGFDPEAAHIVFRGFPQFDVADWEATVAHGLLHRDVEQWLAADSPRARFYEEISRKTRLWSEDSRGEYWYAA
DALAMAFALQPDGAQRLEQRPVHIELSGTHTRGMTLVDWNRQGGAADNATLLLDYDRQRFYGLVGQALAAG

Specific function: Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively [H]

COG id: COG1957

COG function: function code F; Inosine-uridine nucleoside N-ribohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IUNH family. RihA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786871, Length=307, Percent_Identity=35.5048859934853, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788486, Length=308, Percent_Identity=31.4935064935065, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786213, Length=308, Percent_Identity=35.3896103896104, Blast_Score=118, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17565698, Length=294, Percent_Identity=31.6326530612245, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32565474, Length=290, Percent_Identity=30.6896551724138, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320608, Length=210, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24641839, Length=300, Percent_Identity=33.6666666666667, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24583915, Length=335, Percent_Identity=29.8507462686567, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24641837, Length=324, Percent_Identity=29.320987654321, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015910
- InterPro:   IPR023186
- InterPro:   IPR001910
- InterPro:   IPR022975 [H]

Pfam domain/function: PF01156 IU_nuc_hydro [H]

EC number: NA

Molecular weight: Translated: 33481; Mature: 33350

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKIPLLIDTDPGVDDALALLMAFNDTRHDVVGLTIAAGNVGLEHTVRNALKVCEVAGR
CCCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCC
ADVPVYAGCPQPLLHPSVDAAHVHGIDGFGDVGLPPAARAADAEHAALAILRLSHVHAGE
CCCCEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
LLLVALGPLTNLALALTLDPTLPQRVARLVVMGGALTGHGNITAAAEFNIGFDPEAAHIV
EEEEEECCHHCEEEEEEECCCHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCCCCEEEE
FRGFPQFDVADWEATVAHGLLHRDVEQWLAADSPRARFYEEISRKTRLWSEDSRGEYWYA
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEH
ADALAMAFALQPDGAQRLEQRPVHIELSGTHTRGMTLVDWNRQGGAADNATLLLDYDRQR
HHHHHHHEEECCCHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEECCHHH
FYGLVGQALAAG
HHHHHHHHHHCC
>Mature Secondary Structure 
TKKIPLLIDTDPGVDDALALLMAFNDTRHDVVGLTIAAGNVGLEHTVRNALKVCEVAGR
CCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCC
ADVPVYAGCPQPLLHPSVDAAHVHGIDGFGDVGLPPAARAADAEHAALAILRLSHVHAGE
CCCCEECCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
LLLVALGPLTNLALALTLDPTLPQRVARLVVMGGALTGHGNITAAAEFNIGFDPEAAHIV
EEEEEECCHHCEEEEEEECCCHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCCCCEEEE
FRGFPQFDVADWEATVAHGLLHRDVEQWLAADSPRARFYEEISRKTRLWSEDSRGEYWYA
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEH
ADALAMAFALQPDGAQRLEQRPVHIELSGTHTRGMTLVDWNRQGGAADNATLLLDYDRQR
HHHHHHHEEECCCHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEECCHHH
FYGLVGQALAAG
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine; H2O; cytidine [C]

Specific reaction: uridine + H2O = uracil + ribose cytidine + H2O = cytosine + ribose [C]

General reaction: Pyrimidine-specific nucleoside hydrolase [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA