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The map label for this gene is acdA [H]

Identifier: 66766601

GI number: 66766601

Start: 311963

End: 313126

Strand: Reverse

Name: acdA [H]

Synonym: XC_0256

Alternate gene names: 66766601

Gene position: 313126-311963 (Counterclockwise)

Preceding gene: 66766605

Following gene: 66766600

Centisome position: 6.08

GC content: 65.64

Gene sequence:

>1164_bases
ATGCATGTGCCGTCCTTGAATTTCGAGCTTGGCGAAGACATCGATCTGCTGCGCGAAAGCGTGGCCGCCTTCGCCAGCCA
CCATATCGCCCCGCTTGCCGCGGCGGCCGATCACGACAACGTCTTCCCCGCGCAGTTGTGGCGGCTGTTCGGTGAGCAGG
GCCTGCTGGGCCTGACCGTGGAAGAAGCATACGGCGGCAGCGGCATGGGCTACCTGGCGCACGTGGTGGCGATGGAAGAA
ATTTCGCGTGCCGGCGGTGCGATCGGGCTGTCCTACGGCGCGCACTCCAACCTGTGCCTCAACCAGCTGCGCAAGAACGC
CACCCACGAACAGAAGCAGCGCTACCTGCCCAAGCTGTGCACCGGTGAGCACGTCGGCGCACTGGCGATGAGCGAGGCCG
GTTCGGGCTCGGACGTGGTGTCGATGAAGCTGCGCGCCGAGGCACGCGGCGACCGCTTTGTACTCAACGGCAGCAAGATG
TGGATCACCAATGGCCCCGATGCCGACGTGCTGGTGGTGTACGCCAAGACCGACCCCAGCGCCGGTGCGCGCGGCATCAC
TGCCTTCATCGTCGAAAAGGGCATGCCCGGGTTTTCCACCGCGCAGAAGCTCGACAAGCTCGGCATGCGCGGCTCCAACA
CCTGCGAACTGGTGTTCACCGATTGCGAAGTGCCGGCCGAAAACGTGCTGGGCACGCTCAACGGCGGCGTGCGCGTGTTG
ATGTCCGGGCTGGATTTCGAACGCGTGGTGCTGGCGGGTGGACCACTCGGCTTGATGGCCGCGGCCATGGACGTGGTGCT
GCCGTACGTGCACGAGCGCAAGCAGTTTGGCGAGCCGATCGGCACCTTCCAGCTGATGCAGGCCAAGCTGGCCGACATGT
ACGTGGGGCTCAACGCGTGCCGTGCGTACGTCTATGCCGTGGCACGCGCCTGCGATGCCGGCCGCACCACGCGCCAGGAT
GCGGCTGGCGCGATTCTGTATGCCGCCGAGAAGGCCACCTGGCTCACCGGCCAAGCGATCCAGGTGCTGGGCGGCAACGG
CTACATCAACGAGTACCCCACCGGGCGGTTGTGGCGCGATGCCAAGCTGTACGAGATTGGCGCCGGCACGTCTGAAATCC
GGCGCATGCTGATCGGCCGCGAGTTGTTCGAACGCACTGCCTGA

Upstream 100 bases:

>100_bases
TTTAGTTCACTTCTTCGATCAGGACCGCTACGCTGGTCACCACGCCGCGCGGCCCTGCCCGCTCCCACCGGCACGTCCCG
ATCCTTAGCGGAGCCGTTTC

Downstream 100 bases:

>100_bases
CGGAGCCATCATGAGCGTGATCAACAGCCAGCTGCAGGTGGGCGGCGAGAGCTTCCAGCACAACGCGGCAGCGATGCGCG
CGGTGGTCGAGGACTTGCGT

Product: acyl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MHVPSLNFELGEDIDLLRESVAAFASHHIAPLAAAADHDNVFPAQLWRLFGEQGLLGLTVEEAYGGSGMGYLAHVVAMEE
ISRAGGAIGLSYGAHSNLCLNQLRKNATHEQKQRYLPKLCTGEHVGALAMSEAGSGSDVVSMKLRAEARGDRFVLNGSKM
WITNGPDADVLVVYAKTDPSAGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGVRVL
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNACRAYVYAVARACDAGRTTRQD
AAGAILYAAEKATWLTGQAIQVLGGNGYINEYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFERTA

Sequences:

>Translated_387_residues
MHVPSLNFELGEDIDLLRESVAAFASHHIAPLAAAADHDNVFPAQLWRLFGEQGLLGLTVEEAYGGSGMGYLAHVVAMEE
ISRAGGAIGLSYGAHSNLCLNQLRKNATHEQKQRYLPKLCTGEHVGALAMSEAGSGSDVVSMKLRAEARGDRFVLNGSKM
WITNGPDADVLVVYAKTDPSAGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGVRVL
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNACRAYVYAVARACDAGRTTRQD
AAGAILYAAEKATWLTGQAIQVLGGNGYINEYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFERTA
>Mature_387_residues
MHVPSLNFELGEDIDLLRESVAAFASHHIAPLAAAADHDNVFPAQLWRLFGEQGLLGLTVEEAYGGSGMGYLAHVVAMEE
ISRAGGAIGLSYGAHSNLCLNQLRKNATHEQKQRYLPKLCTGEHVGALAMSEAGSGSDVVSMKLRAEARGDRFVLNGSKM
WITNGPDADVLVVYAKTDPSAGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGVRVL
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNACRAYVYAVARACDAGRTTRQD
AAGAILYAAEKATWLTGQAIQVLGGNGYINEYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFERTA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=64, Blast_Score=500, Evalue=1e-142,
Organism=Homo sapiens, GI226958414, Length=370, Percent_Identity=63.5135135135135, Blast_Score=483, Evalue=1e-137,
Organism=Homo sapiens, GI4557233, Length=383, Percent_Identity=39.4255874673629, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=36.7847411444142, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=35.3246753246753, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=35.3246753246753, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI4501857, Length=370, Percent_Identity=32.7027027027027, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI21361497, Length=355, Percent_Identity=36.9014084507042, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI7656849, Length=385, Percent_Identity=32.4675324675325, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI4557235, Length=388, Percent_Identity=35.3092783505155, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI76496475, Length=388, Percent_Identity=35.3092783505155, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI4503943, Length=392, Percent_Identity=31.3775510204082, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=32.3204419889503, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI48976061, Length=286, Percent_Identity=24.8251748251748, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI211971008, Length=286, Percent_Identity=24.8251748251748, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38505218, Length=276, Percent_Identity=21.3768115942029, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=29.3963254593176, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=29.0575916230367, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI87082384, Length=259, Percent_Identity=30.5019305019305, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081702, Length=272, Percent_Identity=25, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=62.5994694960212, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17508101, Length=379, Percent_Identity=34.8284960422164, Blast_Score=240, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=34.1269841269841, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=35.6020942408377, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17570075, Length=385, Percent_Identity=34.8051948051948, Blast_Score=231, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI17534899, Length=389, Percent_Identity=33.6760925449871, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI71990804, Length=280, Percent_Identity=39.2857142857143, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=31.2169312169312, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI71985184, Length=355, Percent_Identity=33.5211267605634, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=35.7664233576642, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=35.4978354978355, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=368, Percent_Identity=30.9782608695652, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=28.7206266318538, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17551932, Length=372, Percent_Identity=28.494623655914, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=285, Percent_Identity=33.6842105263158, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=30.9623430962343, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI86563383, Length=279, Percent_Identity=27.2401433691756, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=279, Percent_Identity=27.2401433691756, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=64.3799472295514, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=39.4179894179894, Blast_Score=285, Evalue=5e-77,
Organism=Drosophila melanogaster, GI24646207, Length=369, Percent_Identity=38.4823848238482, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24666513, Length=377, Percent_Identity=35.8090185676393, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=36.2204724409449, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI281363737, Length=353, Percent_Identity=33.4277620396601, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI19920834, Length=386, Percent_Identity=28.7564766839378, Blast_Score=152, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 41504; Mature: 41504

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVPSLNFELGEDIDLLRESVAAFASHHIAPLAAAADHDNVFPAQLWRLFGEQGLLGLTV
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHCCCCCEEEEE
EEAYGGSGMGYLAHVVAMEEISRAGGAIGLSYGAHSNLCLNQLRKNATHEQKQRYLPKLC
ECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCHHHHHHHCHHHC
TGEHVGALAMSEAGSGSDVVSMKLRAEARGDRFVLNGSKMWITNGPDADVLVVYAKTDPS
CCCCCCCEEECCCCCCCCEEEEEEEECCCCCEEEEECCEEEEECCCCCCEEEEEEECCCC
AGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGVRVL
CCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHH
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNAC
HCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
RAYVYAVARACDAGRTTRQDAAGAILYAAEKATWLTGQAIQVLGGNGYINEYPTGRLWRD
HHHHHHHHHHHCCCCCCHHHHCCEEEEEECCCEEECCCEEEEECCCCCCCCCCCCCEECC
AKLYEIGAGTSEIRRMLIGRELFERTA
CEEEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHVPSLNFELGEDIDLLRESVAAFASHHIAPLAAAADHDNVFPAQLWRLFGEQGLLGLTV
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHCCCCCEEEEE
EEAYGGSGMGYLAHVVAMEEISRAGGAIGLSYGAHSNLCLNQLRKNATHEQKQRYLPKLC
ECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCHHHHHHHCHHHC
TGEHVGALAMSEAGSGSDVVSMKLRAEARGDRFVLNGSKMWITNGPDADVLVVYAKTDPS
CCCCCCCEEECCCCCCCCEEEEEEEECCCCCEEEEECCEEEEECCCCCCEEEEEEECCCC
AGARGITAFIVEKGMPGFSTAQKLDKLGMRGSNTCELVFTDCEVPAENVLGTLNGGVRVL
CCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHH
MSGLDFERVVLAGGPLGLMAAAMDVVLPYVHERKQFGEPIGTFQLMQAKLADMYVGLNAC
HCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
RAYVYAVARACDAGRTTRQDAAGAILYAAEKATWLTGQAIQVLGGNGYINEYPTGRLWRD
HHHHHHHHHHHCCCCCCHHHHCCEEEEEECCCEEECCCEEEEECCCCCCCCCCCCCEECC
AKLYEIGAGTSEIRRMLIGRELFERTA
CEEEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]