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The map label for this gene is yngE [H]

Identifier: 66766600

GI number: 66766600

Start: 310342

End: 311952

Strand: Reverse

Name: yngE [H]

Synonym: XC_0255

Alternate gene names: 66766600

Gene position: 311952-310342 (Counterclockwise)

Preceding gene: 66766601

Following gene: 66766599

Centisome position: 6.06

GC content: 65.61

Gene sequence:

>1611_bases
ATGAGCGTGATCAACAGCCAGCTGCAGGTGGGCGGCGAGAGCTTCCAGCACAACGCGGCAGCGATGCGCGCGGTGGTCGA
GGACTTGCGTGCCACGCTGGCGCGCACCGCGCTGGGTGGCAGCGAGGCGGCCCGTGCCAAGCACACCGCGCGCGGTAAAT
TGCTGGTGCGTGCGCGCATCGATGCACTGCTGGACCCGGGCGGTGCGCTGCTGGAAATTGCGCCGCTGGCTGCGCATGGC
ATGTACGACGATCAGGTGCCCTGCGCCGGCGTGGTGGCCGGGATCGGCCGCGTGTCCGGGGTGGAATGCGTGATCGTGGC
CAACGATGCCACCGTCAAGGGCGGCACCTATTACCCGATGACGGTGAAGAAGCATCTGCGCGCGCAAGAAATCGCGCAGC
AGAACCGGCTGCCGTGCATCTATCTGGTCGACTCCGGCGGTGCGTTCCTGCCGCTGCAGGACGAGGTCTTCCCGGACCGC
GATCACTTCGGCCGCATCTTCTACAACCAGGCCAATCTATCTGCGCAAGGCATCCCGCAGATCGCCTGCGTGATGGGCTC
GTGCACCGCGGGCGGCGCGTACGTGCCGGCGATGAGCGATGAAACGGTGATCGTGCGCGAGCAGGGCACCATCTTCCTCG
GCGGCCCGCCCCTGGTCAAAGCCGCCACCGGTGAAGAAGTCAGCGCTGAAGAATTGGGCGGTGCGGATGTGCACACGCGC
ATTTCCGGGGTGGCCGATCATTTCGCCGACAACGATCTACAGGCGCTGGCACGGGTGCGCGCGATCATTGCGCAACTCAA
CTGGCGCAAGCCTGCGCTCTCCATGGCGGTGCAGGCACCGCTGCCGCCGCGGCATGCCGCCGACGAATTGTATGGCGTGA
TTCCGGCTGATACGCGCAGGCCCTACGACGTGCGCGAAGTGATCGCGCGTATCGTGGACGACTCGCGCCTGGACGAATTC
AAGCCGCGCTACGGCAGCACCCTGGTGACCGGGTTTGCGCACCTGCATGGATACCCGGTTGGCATCATCGCCAACAACGG
CATCCTGTTTTCCGAGTCCGCGCTCAAGGGTGCGCATTTCATCGAACTATGCACGCAGCGCGGCATTCCGCTGGTGTTCC
TGCAGAACATCACCGGCTTCATGGTGGGCCGTAAATACGAGCACGGCGGCATCGCCAAGGACGGCGCCAAGCTGGTGATG
GCCGTGGCCTGCGCCAAGGTGCCCAAGTTCACCGTGGTGATTGGCGGCTCGTTCGGCGCCGGCAATTACGGCATGTGCGG
CCGCGCGTATTCGCCCAACTTTTTATGGATGTGGCCGAATGCGCGGATCGGCGTGATGGGCGGCGAACAGGCTGCCAGCG
TGTTGGCAACCGTGCGGCGCGATGGCATCGAAGCCAAGGGCGGCGCGTGGTCGGGCGACGACGAAGAAGCCTTCAAATCG
CCAATCCGTGCGCAGTTCGAACAGCAAGGCCACCCGTATTACGCCAGCGCGCGCCTGTGGGACGACGGCATCATCGACCC
GGCCGATACCCGCCGCGTGCTGGGCCTGGGGTTGTCGGCCGCCTTGAATGCGCCGATCGACGCCACGCGCTTCGGCGTGT
TCCGGATGTGA

Upstream 100 bases:

>100_bases
CGCGATGCCAAGCTGTACGAGATTGGCGCCGGCACGTCTGAAATCCGGCGCATGCTGATCGGCCGCGAGTTGTTCGAACG
CACTGCCTGACGGAGCCATC

Downstream 100 bases:

>100_bases
TGCAGATGCGGCGTGCCGGCTCGCCGAAACGACACGATGCGCGTGGATACACGCAGGAGTGTTTTCGGCTGCGGGGCCGC
AGCGCGCCACGTGCGTACGC

Product: acyl-CoA carboxyltransferase beta chain

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MSVINSQLQVGGESFQHNAAAMRAVVEDLRATLARTALGGSEAARAKHTARGKLLVRARIDALLDPGGALLEIAPLAAHG
MYDDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPMTVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDR
DHFGRIFYNQANLSAQGIPQIACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEELGGADVHTR
ISGVADHFADNDLQALARVRAIIAQLNWRKPALSMAVQAPLPPRHAADELYGVIPADTRRPYDVREVIARIVDDSRLDEF
KPRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHFIELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVM
AVACAKVPKFTVVIGGSFGAGNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGAWSGDDEEAFKS
PIRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIDATRFGVFRM

Sequences:

>Translated_536_residues
MSVINSQLQVGGESFQHNAAAMRAVVEDLRATLARTALGGSEAARAKHTARGKLLVRARIDALLDPGGALLEIAPLAAHG
MYDDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPMTVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDR
DHFGRIFYNQANLSAQGIPQIACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEELGGADVHTR
ISGVADHFADNDLQALARVRAIIAQLNWRKPALSMAVQAPLPPRHAADELYGVIPADTRRPYDVREVIARIVDDSRLDEF
KPRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHFIELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVM
AVACAKVPKFTVVIGGSFGAGNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGAWSGDDEEAFKS
PIRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIDATRFGVFRM
>Mature_535_residues
SVINSQLQVGGESFQHNAAAMRAVVEDLRATLARTALGGSEAARAKHTARGKLLVRARIDALLDPGGALLEIAPLAAHGM
YDDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPMTVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDRD
HFGRIFYNQANLSAQGIPQIACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEELGGADVHTRI
SGVADHFADNDLQALARVRAIIAQLNWRKPALSMAVQAPLPPRHAADELYGVIPADTRRPYDVREVIARIVDDSRLDEFK
PRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHFIELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVMA
VACAKVPKFTVVIGGSFGAGNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGAWSGDDEEAFKSP
IRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIDATRFGVFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=534, Percent_Identity=65.5430711610487, Blast_Score=714, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=533, Percent_Identity=32.8330206378987, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI295821216, Length=553, Percent_Identity=31.8264014466546, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI310133460, Length=143, Percent_Identity=56.6433566433566, Blast_Score=152, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17552936, Length=534, Percent_Identity=60.6741573033708, Blast_Score=681, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=499, Percent_Identity=34.4689378757515, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI25147359, Length=499, Percent_Identity=34.4689378757515, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=61.524500907441, Blast_Score=697, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 57219; Mature: 57088

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVINSQLQVGGESFQHNAAAMRAVVEDLRATLARTALGGSEAARAKHTARGKLLVRARI
CCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEEEH
DALLDPGGALLEIAPLAAHGMYDDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPM
HHHHCCCCCEEEEEHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEECCCEECCH
TVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDRDHFGRIFYNQANLSAQGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCC
IACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEELGGADVHTR
EEHEECCCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCCCCHHHCCCCCHHHH
ISGVADHFADNDLQALARVRAIIAQLNWRKPALSMAVQAPLPPRHAADELYGVIPADTRR
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCCCCHHHHEEECCCCCCC
PYDVREVIARIVDDSRLDEFKPRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHF
CCHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCCEEEECHHHCCHHH
IELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVMAVACAKVPKFTVVIGGSFGA
HHHHHHCCCCEEEECCCHHHHHCCEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
GNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGAWSGDDEEAFKS
CCCCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
PIRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIDATRFGVFRM
HHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHCCHHHHCCCCCCHHCCCEECC
>Mature Secondary Structure 
SVINSQLQVGGESFQHNAAAMRAVVEDLRATLARTALGGSEAARAKHTARGKLLVRARI
CCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEEEEH
DALLDPGGALLEIAPLAAHGMYDDQVPCAGVVAGIGRVSGVECVIVANDATVKGGTYYPM
HHHHCCCCCEEEEEHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEECCCEECCH
TVKKHLRAQEIAQQNRLPCIYLVDSGGAFLPLQDEVFPDRDHFGRIFYNQANLSAQGIPQ
HHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCC
IACVMGSCTAGGAYVPAMSDETVIVREQGTIFLGGPPLVKAATGEEVSAEELGGADVHTR
EEHEECCCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCCCCHHHCCCCCHHHH
ISGVADHFADNDLQALARVRAIIAQLNWRKPALSMAVQAPLPPRHAADELYGVIPADTRR
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCCCCCHHHHEEECCCCCCC
PYDVREVIARIVDDSRLDEFKPRYGSTLVTGFAHLHGYPVGIIANNGILFSESALKGAHF
CCHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCCEEEECHHHCCHHH
IELCTQRGIPLVFLQNITGFMVGRKYEHGGIAKDGAKLVMAVACAKVPKFTVVIGGSFGA
HHHHHHCCCCEEEECCCHHHHHCCEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCC
GNYGMCGRAYSPNFLWMWPNARIGVMGGEQAASVLATVRRDGIEAKGGAWSGDDEEAFKS
CCCCCCCCCCCCCEEEECCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
PIRAQFEQQGHPYYASARLWDDGIIDPADTRRVLGLGLSAALNAPIDATRFGVFRM
HHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHCCHHHHCCCCCCHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]