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The map label for this gene is phhA [H]

Identifier: 66766510

GI number: 66766510

Start: 206017

End: 206907

Strand: Reverse

Name: phhA [H]

Synonym: XC_0165

Alternate gene names: 66766510

Gene position: 206907-206017 (Counterclockwise)

Preceding gene: 66766513

Following gene: 66766509

Centisome position: 4.02

GC content: 65.88

Gene sequence:

>891_bases
ATGAACACAGCGCCGCGCCGCGTCGAGAACCAGCTCACCGACAAGGGCTATGTGCCGGTCTACACCACCGCGGTGGTGGA
GCAGCCGTGGGATGGTTACAGCGCCGACGACCATGCCACCTGGGGCACGCTGTACCGGCGGCAGCGCGCGCTGCTGGTCG
GGCGGGCCTGCGATGAGTTCCTGCAGGCGCAGGACGCAATGGGCATGGACGACACCCAGATTCCGCGCTTCGACGCGCTC
AACGCGGTGCTGCAGGCGACCACCGGCTGGACGCTGGTCGGTGTGGAAGGGCTGCTGCCGGAGCTGGATTTCTTCGATCA
TCTGGCCAACCGGCGCTTCCCGGTGACCTGGTGGATCCGCCGCCCGGACCAGATCGACTACATCGCCGAACCGGACCTGT
TCCATGATCTGTTCGGGCACGTGCCGCTGCTGATGAATCCGCTGTTTGCCGACTTCATGCAGGCCTATGGGCGCGGTGGC
GTCAAGGCGCACGGAATTGGCCCGGACGCGTTGCAAAATCTCACCCGGCTGTACTGGTACACGGTGGAATTCGGCCTGAT
TGCCACGCCGCAGGGGTTGCGCATCTACGGTGCGGGCATCGTCTCGTCCAAGGGCGAATCGCTGCATTCGCTGGAATCGG
CGGCGCCGAACCGGGTGGGCTTCGATCTGCAGCGGGTGATGCGCACGCGCTACCGCATCGACAGTTTCCAAAAGACCTAC
TTCGTCATCGACAGCTTTACGCAGCTGATGGACGCCACCGCCCCGGATTTCACCCCGATCTATGCCGCGCTGGCGCAACA
GCCGCAGGTGCCGGCCGGCGAGGTGCTGGCAACCGACCACGTCCTGCAGCGCGGCAGCGGCGAAGGCTGGAGCCGCGACG
GCGACGTGTGA

Upstream 100 bases:

>100_bases
ACGAATCTTGCGTCTAACGGCCGCCGGTGCGCAACATTCGCAATCCCGTTGCGTGGCCATTTGGCTAAGGTGAAGCCATC
CGTTTCGGGAACCACACCGC

Downstream 100 bases:

>100_bases
GGGGTTGGCTGGCGCCGGTGTGTTCGGCCTGGCGTGGCGTGTTGGCGTCGGCGCCGCTTCGTCGACGATGACATGACGAT
GGCGCGCTAGCGCCTGCACT

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MNTAPRRVENQLTDKGYVPVYTTAVVEQPWDGYSADDHATWGTLYRRQRALLVGRACDEFLQAQDAMGMDDTQIPRFDAL
NAVLQATTGWTLVGVEGLLPELDFFDHLANRRFPVTWWIRRPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGG
VKAHGIGPDALQNLTRLYWYTVEFGLIATPQGLRIYGAGIVSSKGESLHSLESAAPNRVGFDLQRVMRTRYRIDSFQKTY
FVIDSFTQLMDATAPDFTPIYAALAQQPQVPAGEVLATDHVLQRGSGEGWSRDGDV

Sequences:

>Translated_296_residues
MNTAPRRVENQLTDKGYVPVYTTAVVEQPWDGYSADDHATWGTLYRRQRALLVGRACDEFLQAQDAMGMDDTQIPRFDAL
NAVLQATTGWTLVGVEGLLPELDFFDHLANRRFPVTWWIRRPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGG
VKAHGIGPDALQNLTRLYWYTVEFGLIATPQGLRIYGAGIVSSKGESLHSLESAAPNRVGFDLQRVMRTRYRIDSFQKTY
FVIDSFTQLMDATAPDFTPIYAALAQQPQVPAGEVLATDHVLQRGSGEGWSRDGDV
>Mature_296_residues
MNTAPRRVENQLTDKGYVPVYTTAVVEQPWDGYSADDHATWGTLYRRQRALLVGRACDEFLQAQDAMGMDDTQIPRFDAL
NAVLQATTGWTLVGVEGLLPELDFFDHLANRRFPVTWWIRRPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGG
VKAHGIGPDALQNLTRLYWYTVEFGLIATPQGLRIYGAGIVSSKGESLHSLESAAPNRVGFDLQRVMRTRYRIDSFQKTY
FVIDSFTQLMDATAPDFTPIYAALAQQPQVPAGEVLATDHVLQRGSGEGWSRDGDV

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=244, Percent_Identity=35.655737704918, Blast_Score=138, Evalue=5e-33,
Organism=Homo sapiens, GI88900505, Length=244, Percent_Identity=35.655737704918, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI88900501, Length=244, Percent_Identity=35.655737704918, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI4557819, Length=224, Percent_Identity=34.8214285714286, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI31795563, Length=224, Percent_Identity=34.8214285714286, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4759248, Length=222, Percent_Identity=34.6846846846847, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17531391, Length=246, Percent_Identity=35.3658536585366, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71980736, Length=220, Percent_Identity=34.0909090909091, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI115533973, Length=237, Percent_Identity=32.0675105485232, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI115532103, Length=237, Percent_Identity=32.0675105485232, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI71980731, Length=153, Percent_Identity=32.0261437908497, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24660393, Length=229, Percent_Identity=35.3711790393013, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI62472054, Length=229, Percent_Identity=35.3711790393013, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI17136776, Length=227, Percent_Identity=32.5991189427313, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17136774, Length=227, Percent_Identity=32.5991189427313, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24654994, Length=226, Percent_Identity=32.7433628318584, Blast_Score=118, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 33233; Mature: 33233

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTAPRRVENQLTDKGYVPVYTTAVVEQPWDGYSADDHATWGTLYRRQRALLVGRACDEF
CCCCHHHHHHHHCCCCCCEEEEHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LQAQDAMGMDDTQIPRFDALNAVLQATTGWTLVGVEGLLPELDFFDHLANRRFPVTWWIR
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEHHHHCCHHHHHHHHHCCCCCEEEEEE
RPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGGVKAHGIGPDALQNLTRLYWY
CCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHH
TVEFGLIATPQGLRIYGAGIVSSKGESLHSLESAAPNRVGFDLQRVMRTRYRIDSFQKTY
EEEECEEECCCCCEEEECCEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
FVIDSFTQLMDATAPDFTPIYAALAQQPQVPAGEVLATDHVLQRGSGEGWSRDGDV
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNTAPRRVENQLTDKGYVPVYTTAVVEQPWDGYSADDHATWGTLYRRQRALLVGRACDEF
CCCCHHHHHHHHCCCCCCEEEEHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LQAQDAMGMDDTQIPRFDALNAVLQATTGWTLVGVEGLLPELDFFDHLANRRFPVTWWIR
HHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEHHHHCCHHHHHHHHHCCCCCEEEEEE
RPDQIDYIAEPDLFHDLFGHVPLLMNPLFADFMQAYGRGGVKAHGIGPDALQNLTRLYWY
CCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHH
TVEFGLIATPQGLRIYGAGIVSSKGESLHSLESAAPNRVGFDLQRVMRTRYRIDSFQKTY
EEEECEEECCCCCEEEECCEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
FVIDSFTQLMDATAPDFTPIYAALAQQPQVPAGEVLATDHVLQRGSGEGWSRDGDV
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]