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The map label for this gene is fdhA [H]

Identifier: 66047942

GI number: 66047942

Start: 5591208

End: 5592407

Strand: Direct

Name: fdhA [H]

Synonym: Psyr_4718

Alternate gene names: 66047942

Gene position: 5591208-5592407 (Clockwise)

Preceding gene: 66047941

Following gene: 66047946

Centisome position: 91.75

GC content: 62.5

Gene sequence:

>1200_bases
ATGTCTGGTAATCGCGGTGTAGTGTATCTCGGCGCTGGCAAGGTCGAAGTGCAATCAATTCCTTTCCCGAAAATGGAAGA
TCCACGCGGCAAGCGCATCGAACACGGCGTGATCCTGCGCGTGGTCTCCACCAACATCTGCGGCTCGGACCAGCACATGG
TACGCGGCCGCACCACGGCGCAAACCGGGCTGGTACTCGGTCATGAAATCACTGGCGAGGTGCTGGAAGCCGGTCGTGAC
GTGGAACATCTGAAAGTCGGTGACCTGGTTTCTGTGCCATTCAACGTGGCGTGCGGTCGCTGCCGCAGTTGCAAGGAACA
GAACACCGGCGTCTGCCTGACGGTCAACCCTGCGCGCCCCGGTGGTGCCTATGGTTATGTCGACATGGGCGATTGGGTCG
GCGGCCAGGCTGAATACGTGCTGGTGCCTTACGCCGACTTCAACCTGCTCAAACTTCCGGACCGCGATGCGGCGATGGAA
AAAATTCGCGACCTGACCTGCCTGTCCGACATCCTGCCCACCGGCTACCACGGCGCAGTGACTGCCGGGGTGGGGCCGGG
CAGCACAGTCTACGTTGCAGGCGCTGGCCCGGTCGGCCTGGCTGCGGCGGCGTCAGCACGCTTGCTGGGCGCTGCCGTGG
TGATCGTCGGCGACGTGAACCCGACGCGTCTGGTTCACGCCAAGGCCCAGGGCTTCGAAATTGCCGACCTGTCCCAGGAC
ACTCCCTTGCACGAGCAGATCGCTGCCCTGCTCGGCGAACCCGAAGTGGATTGCGCCATCGACGCCGTAGGCTTCGAAGC
ACGCGGTCACGGTCATGCTGGCGCTCAGGCCGAAGCACCCGCCACCGTGCTCAACTCGTTGATGGGCGTAGTGCGCGTCG
CCGGCAAGATCGGCATCCCCGGCCTGTACGTCACCGAAGACCCGGGAGCCGTTGACGCCGCCGCCAAAATGGGCAGCCTG
AGCATTCGCTTCGGCCTGGGCTGGGCCAAATCCCACAGCTTCCACACCGGCCAGACCCCGGTCATGAAATACAACCGCCA
ACTGATGCAGGCGATCATGTGGGACCGCATCAAGATCGCCGACATAGTGGGTGTCGAGGTGATCAGTCTGGATGATGCTC
CGCGGGGTTATGGCGAGTTTGATTCGGGCGTGCCGAAGAAGTTTGTGATTGATCCGCATGGGTTGTTTGGTGCTGCGTAA

Upstream 100 bases:

>100_bases
TGCAAGCTGCAAGCGATCCGTATTTCTCGCCGCTTGAAGCTTGCAACTGTTCTTCTCTGCTCTAAATCTGCTTCATCACA
ATAAAAGCGAGGTGACATGT

Downstream 100 bases:

>100_bases
GCATCAACAGTAAAGTCGGTTTCTTGGCTACTTACCTTGGCAGATTCGAAGCGGGTTGCTTAACCCCTCGAATCTGCTCC
ATTATCAACTCCAACTCCTT

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: FALDH; FDH [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSGNRGVVYLGAGKVEVQSIPFPKMEDPRGKRIEHGVILRVVSTNICGSDQHMVRGRTTAQTGLVLGHEITGEVLEAGRD
VEHLKVGDLVSVPFNVACGRCRSCKEQNTGVCLTVNPARPGGAYGYVDMGDWVGGQAEYVLVPYADFNLLKLPDRDAAME
KIRDLTCLSDILPTGYHGAVTAGVGPGSTVYVAGAGPVGLAAAASARLLGAAVVIVGDVNPTRLVHAKAQGFEIADLSQD
TPLHEQIAALLGEPEVDCAIDAVGFEARGHGHAGAQAEAPATVLNSLMGVVRVAGKIGIPGLYVTEDPGAVDAAAKMGSL
SIRFGLGWAKSHSFHTGQTPVMKYNRQLMQAIMWDRIKIADIVGVEVISLDDAPRGYGEFDSGVPKKFVIDPHGLFGAA

Sequences:

>Translated_399_residues
MSGNRGVVYLGAGKVEVQSIPFPKMEDPRGKRIEHGVILRVVSTNICGSDQHMVRGRTTAQTGLVLGHEITGEVLEAGRD
VEHLKVGDLVSVPFNVACGRCRSCKEQNTGVCLTVNPARPGGAYGYVDMGDWVGGQAEYVLVPYADFNLLKLPDRDAAME
KIRDLTCLSDILPTGYHGAVTAGVGPGSTVYVAGAGPVGLAAAASARLLGAAVVIVGDVNPTRLVHAKAQGFEIADLSQD
TPLHEQIAALLGEPEVDCAIDAVGFEARGHGHAGAQAEAPATVLNSLMGVVRVAGKIGIPGLYVTEDPGAVDAAAKMGSL
SIRFGLGWAKSHSFHTGQTPVMKYNRQLMQAIMWDRIKIADIVGVEVISLDDAPRGYGEFDSGVPKKFVIDPHGLFGAA
>Mature_398_residues
SGNRGVVYLGAGKVEVQSIPFPKMEDPRGKRIEHGVILRVVSTNICGSDQHMVRGRTTAQTGLVLGHEITGEVLEAGRDV
EHLKVGDLVSVPFNVACGRCRSCKEQNTGVCLTVNPARPGGAYGYVDMGDWVGGQAEYVLVPYADFNLLKLPDRDAAMEK
IRDLTCLSDILPTGYHGAVTAGVGPGSTVYVAGAGPVGLAAAASARLLGAAVVIVGDVNPTRLVHAKAQGFEIADLSQDT
PLHEQIAALLGEPEVDCAIDAVGFEARGHGHAGAQAEAPATVLNSLMGVVRVAGKIGIPGLYVTEDPGAVDAAAKMGSLS
IRFGLGWAKSHSFHTGQTPVMKYNRQLMQAIMWDRIKIADIVGVEVISLDDAPRGYGEFDSGVPKKFVIDPHGLFGAA

Specific function: Catalyzes the oxidation of long-chain alcohols but is inactive against ethanol [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=227, Percent_Identity=31.2775330396476, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI34577061, Length=227, Percent_Identity=30.8370044052863, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4501929, Length=235, Percent_Identity=30.6382978723404, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI156627571, Length=280, Percent_Identity=29.6428571428571, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI262073058, Length=299, Percent_Identity=27.4247491638796, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI71565154, Length=226, Percent_Identity=30.5309734513274, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI71743840, Length=268, Percent_Identity=27.2388059701493, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1786825, Length=401, Percent_Identity=34.6633416458853, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1790045, Length=221, Percent_Identity=32.579185520362, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI87082125, Length=240, Percent_Identity=32.5, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788073, Length=238, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790718, Length=204, Percent_Identity=27.9411764705882, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI226510992, Length=275, Percent_Identity=30.5454545454545, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787863, Length=216, Percent_Identity=34.7222222222222, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081918, Length=209, Percent_Identity=33.4928229665072, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=270, Percent_Identity=29.6296296296296, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=236, Percent_Identity=29.2372881355932, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=260, Percent_Identity=32.3076923076923, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71997431, Length=280, Percent_Identity=30.7142857142857, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319955, Length=273, Percent_Identity=33.6996336996337, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=273, Percent_Identity=33.6996336996337, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6319258, Length=299, Percent_Identity=25.752508361204, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=238, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737897, Length=277, Percent_Identity=30.3249097472924, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137530, Length=273, Percent_Identity=30.7692307692308, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17737895, Length=211, Percent_Identity=31.7535545023697, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR007698
- InterPro:   IPR011032
- InterPro:   IPR014184
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF01262 AlaDh_PNT_C [H]

EC number: =1.2.1.46 [H]

Molecular weight: Translated: 41822; Mature: 41691

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGNRGVVYLGAGKVEVQSIPFPKMEDPRGKRIEHGVILRVVSTNICGSDQHMVRGRTTA
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEECCCCCH
QTGLVLGHEITGEVLEAGRDVEHLKVGDLVSVPFNVACGRCRSCKEQNTGVCLTVNPARP
HCCEEECCHHHHHHHHCCCCCCEEECCCEEECCHHHHCCHHHCHHCCCCCEEEEECCCCC
GGAYGYVDMGDWVGGQAEYVLVPYADFNLLKLPDRDAAMEKIRDLTCLSDILPTGYHGAV
CCCEEEEECCCCCCCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEE
TAGVGPGSTVYVAGAGPVGLAAAASARLLGAAVVIVGDVNPTRLVHAKAQGFEIADLSQD
EECCCCCCEEEEECCCCHHHHHHHHHHEEEEEEEEEECCCCCEEEEECCCCCEEECCCCC
TPLHEQIAALLGEPEVDCAIDAVGFEARGHGHAGAQAEAPATVLNSLMGVVRVAGKIGIP
CCHHHHHHHHHCCCCCCEEEEEECEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
GLYVTEDPGAVDAAAKMGSLSIRFGLGWAKSHSFHTGQTPVMKYNRQLMQAIMWDRIKIA
EEEEECCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEE
DIVGVEVISLDDAPRGYGEFDSGVPKKFVIDPHGLFGAA
EEECEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure 
SGNRGVVYLGAGKVEVQSIPFPKMEDPRGKRIEHGVILRVVSTNICGSDQHMVRGRTTA
CCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEECCCCCH
QTGLVLGHEITGEVLEAGRDVEHLKVGDLVSVPFNVACGRCRSCKEQNTGVCLTVNPARP
HCCEEECCHHHHHHHHCCCCCCEEECCCEEECCHHHHCCHHHCHHCCCCCEEEEECCCCC
GGAYGYVDMGDWVGGQAEYVLVPYADFNLLKLPDRDAAMEKIRDLTCLSDILPTGYHGAV
CCCEEEEECCCCCCCCCCEEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEE
TAGVGPGSTVYVAGAGPVGLAAAASARLLGAAVVIVGDVNPTRLVHAKAQGFEIADLSQD
EECCCCCCEEEEECCCCHHHHHHHHHHEEEEEEEEEECCCCCEEEEECCCCCEEECCCCC
TPLHEQIAALLGEPEVDCAIDAVGFEARGHGHAGAQAEAPATVLNSLMGVVRVAGKIGIP
CCHHHHHHHHHCCCCCCEEEEEECEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
GLYVTEDPGAVDAAAKMGSLSIRFGLGWAKSHSFHTGQTPVMKYNRQLMQAIMWDRIKIA
EEEEECCCCCHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEE
DIVGVEVISLDDAPRGYGEFDSGVPKKFVIDPHGLFGAA
EEECEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8169197 [H]