Click here to switch to the map view.

The map label for this gene is ribA [H]

Identifier: 66047683

GI number: 66047683

Start: 5320112

End: 5320777

Strand: Reverse

Name: ribA [H]

Synonym: Psyr_4456

Alternate gene names: 66047683

Gene position: 5320777-5320112 (Counterclockwise)

Preceding gene: 66047684

Following gene: 66047682

Centisome position: 87.32

GC content: 60.66

Gene sequence:

>666_bases
ATGCAAATCTTGCGAATTTCCAGTCTTCATACTGATCAGGAGCACACGGTGCCCGTCGTCTTTGTCGCCGCTTCCAAACT
GCCCACTCCCTTTGCAGAGTTTGCCATGCACGGCTTTATCGAGTCGGCAACCGGCCGTGAACATGTCGTCCTGAGTCTGG
GCGATGTGGCGGACGGTGAGCCGGTTCTGGGTCGCGTACATTCCGAATGCCTGACCGGCGACGCCCTGTTCAGTCAGCGT
TGCGATTGCGGCTCTCAACTGGAGGCTGCCCTGCGCGCCATCGCCACCGAAGGGCGGGGCGTACTGTTGTATTTGCGCCA
GGAAGGGCGCGGTATCGGTCTGATGAACAAGATCCGCGCCTACGAGCTGCAGGATGGCGGTGCCGATACGGTTGAAGCCA
ACGAGCGTCTGGGCTTTGCTGCCGATCAGCGTGACTACGCGATCTGCCTGCCGATGCTTCAGCATCTGGGCGTGCAGTCG
CTACGGCTTATGACCAACAACCCGCGCAAGGTCAAAGCCTTGACCGAGATGGGCATCAGGGTCGCTGAGCGCGTGCCGCT
GCACACCGGACAAAACCCGCACAACCGCCTTTATCTGGCAACCAAGGCGGGCAAGCTGGGGCACATGATGGGCAACGAAC
ATCAAAGCGAGGTCGGCCCCGCGTGA

Upstream 100 bases:

>100_bases
GGCGGTGAGCAGTGAGCGGATGAGCGCTTCTATCTATCGAACTTTATGATCTAAATGCCCGAGAATTCACCCTGAGCGTC
TGCAGGAACCTGCTGTTACA

Downstream 100 bases:

>100_bases
CACGCAGCGAGGTTCGTCAAAAGCTCGAGATGCAATGGTGGCGTCAACTGGGTCTGACCCTGGCGCCATTGCTGGTGGTC
TGTCTATTTTTCGGTGCCAG

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MQILRISSLHTDQEHTVPVVFVAASKLPTPFAEFAMHGFIESATGREHVVLSLGDVADGEPVLGRVHSECLTGDALFSQR
CDCGSQLEAALRAIATEGRGVLLYLRQEGRGIGLMNKIRAYELQDGGADTVEANERLGFAADQRDYAICLPMLQHLGVQS
LRLMTNNPRKVKALTEMGIRVAERVPLHTGQNPHNRLYLATKAGKLGHMMGNEHQSEVGPA

Sequences:

>Translated_221_residues
MQILRISSLHTDQEHTVPVVFVAASKLPTPFAEFAMHGFIESATGREHVVLSLGDVADGEPVLGRVHSECLTGDALFSQR
CDCGSQLEAALRAIATEGRGVLLYLRQEGRGIGLMNKIRAYELQDGGADTVEANERLGFAADQRDYAICLPMLQHLGVQS
LRLMTNNPRKVKALTEMGIRVAERVPLHTGQNPHNRLYLATKAGKLGHMMGNEHQSEVGPA
>Mature_221_residues
MQILRISSLHTDQEHTVPVVFVAASKLPTPFAEFAMHGFIESATGREHVVLSLGDVADGEPVLGRVHSECLTGDALFSQR
CDCGSQLEAALRAIATEGRGVLLYLRQEGRGIGLMNKIRAYELQDGGADTVEANERLGFAADQRDYAICLPMLQHLGVQS
LRLMTNNPRKVKALTEMGIRVAERVPLHTGQNPHNRLYLATKAGKLGHMMGNEHQSEVGPA

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=189, Percent_Identity=65.6084656084656, Blast_Score=258, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=42.3529411764706, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000926 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 24075; Mature: 24075

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQILRISSLHTDQEHTVPVVFVAASKLPTPFAEFAMHGFIESATGREHVVLSLGDVADGE
CCEEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
PVLGRVHSECLTGDALFSQRCDCGSQLEAALRAIATEGRGVLLYLRQEGRGIGLMNKIRA
HHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHEE
YELQDGGADTVEANERLGFAADQRDYAICLPMLQHLGVQSLRLMTNNPRKVKALTEMGIR
EEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHEEEHHCCCCHHHHHHHHHHHH
VAERVPLHTGQNPHNRLYLATKAGKLGHMMGNEHQSEVGPA
HHHHCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MQILRISSLHTDQEHTVPVVFVAASKLPTPFAEFAMHGFIESATGREHVVLSLGDVADGE
CCEEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
PVLGRVHSECLTGDALFSQRCDCGSQLEAALRAIATEGRGVLLYLRQEGRGIGLMNKIRA
HHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHEE
YELQDGGADTVEANERLGFAADQRDYAICLPMLQHLGVQSLRLMTNNPRKVKALTEMGIR
EEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHEEEHHCCCCHHHHHHHHHHHH
VAERVPLHTGQNPHNRLYLATKAGKLGHMMGNEHQSEVGPA
HHHHCCCCCCCCCCCEEEEEECCCCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]