Click here to switch to the map view.

The map label for this gene is speA [H]

Identifier: 66047608

GI number: 66047608

Start: 5236745

End: 5238658

Strand: Direct

Name: speA [H]

Synonym: Psyr_4381

Alternate gene names: 66047608

Gene position: 5236745-5238658 (Clockwise)

Preceding gene: 66047607

Following gene: 66047609

Centisome position: 85.94

GC content: 61.08

Gene sequence:

>1914_bases
ATGTCCGTAAGACGCACACGTAAAGACGATGGCAGCCAATGGACCGTTGCGGACAGCCGCAGCGTTTACGGCATTCGCCA
TTGGGGCGCGGGTTATTTTGCTATCAACGAAGCGGGACGCGTTGAAGTCCGTCCCAACGGGCCGGACAGCTCGCCCATCG
ATCTTTACGAACAGGTCGACAATTTGCGCAAGAGCGGCCTGTCGCTGCCCTTGCTGGTGCGCTTCCCCGACATTCTGCAG
GACCGTGTGCGTCAGCTGACCGGCGCGTTCGACAGCAACATCGCGCGCCTGGAATACCAGAGCAAGTACACCGCGCTGTA
CCCGATCAAGGTCAACCAGCAGGAAGCGGTGGTGGAAAACATCATCGCCACGCAGAACGTCTCCATCGGCCTGGAAGCGG
GCTCCAAGCCTGAGCTGATGGCGGTGCTGGCACTGGCGCCCAAAGGCGGCACCATCGTCTGCAACGGTTACAAGGACCGT
GAGTTCATCCGTCTGGCGCTGATGGGCCAGAAGCTGGGCCACAACGTGTTCATCGTCATCGAGAAAGAGTCCGAAGTCGA
ACTGGTGATCGAAGAAGCCGCCGAACTGAAGGTCGCTCCCCAGGTTGGCCTGCGCGTACGCCTCTCCTCCCTGGCGTCGA
GCAAATGGGCGGATACCGGTGGCGAGAAATCCAAGTTCGGTCTGTCGGCTGCGCAGTTGCTGTCGGTGGTCGAGCGTTTC
CGCAAGGCCGGCCTGGATCAGGGCATTCGCCTGCTGCACTTCCACATGGGCTCGCAGATCGCCAACCTGGCCGACTATCA
GCACGGTTTCAAGGAGGCGATCCGTTACTACGGCGAACTGCGCAAGCTCGGCCTGCCGGTGGATTACATCGATGTCGGGG
GTGGTCTGGGGGTCGATTACGACGGTACGCACTCGCGCAACGCCAGCTCGATCAACTACGACATGGACGACTATGCAGGC
GTCGTGGTCGGCATGCTCAAGGAATTCTGCGACGCGCAAAGCCTGCCGCACCCGCATATCTTCTCGGAAAGCGGCCGCTC
GCTGACCGCCCACCACGCCATGCTGGTGGTGCAGGTGACCGACGTCGAAAAACACAACGACGAAGTCCCGGAAATCGCCG
ACAAGGCCAGCCTGCCGGAAACCGTGCAATGGCTGGTCGACCTGCTGGGCCCGACTGACATCGAGATGGTCACCGAAACC
TACTGGCGCGCCACGCACTACATGAGCGACATCGCGGCCCAGTACGCCGATGGCAAGATCAGCCTGTCGGAAAAAGCGCT
GGGCGAGCAATGCTACTTCGCCGTCTGCCGTCGCCTGTACAACTCGCTGAAAGCCCGTCAACGCTCGCATCGTCAGGTGC
TGGACGAGCTCAACGACAAGCTGGCCGACAAGTACATCTGCAACTTCTCGGTGTTCCAGAGCCTGCCGGACACCTGGGCC
ATTGGCCAGGTGCTGCCGATTCTGCCCCTGCACCGCCTGAATGAAGAGCCGGTGCGCCGCGCCGTGCTGCAGGACCTGAC
CTGCGATTCGGACGGCAAGATCAAGCAGTACGTCGACGAGCAGAGCATCGAGACCAGCATGCCGGTGCATTCGCTGAACG
AAGGCGAAGACTATCTGCTGGGGATCTTCCTGGTGGGCGCCTACCAGGAAATTCTCGGCGACATGCACAACCTGTTCGGT
GATACCGATTCGGTGAACATCTACCAGAACCCGGACGGCAGCGTTTACCACGCAGGCATCGAAACCCACGACACCATCGA
AGACATGCTGCGCTACGTGCACCTGTCGCCGGAAGAACTGATGACCCATTACCGGGACAAGGTCGCCAGCGCCAAGATCA
CCCCACGCGAGCGCACCTACTTCCTCGATGCCTTGCGCCTGGGGCTGACCCGCTCGTCGTACCTGTCGTCCTGA

Upstream 100 bases:

>100_bases
TCCGGCGGCTGAACCCGCGAATCAAATCGTCATTTCCACCCATTACAATGCGCGCAGTCAGCTTCAGGCTGGCGCAACGA
CTTATTTATAGGGGACTTCG

Downstream 100 bases:

>100_bases
TCGTTGCGCGGAGCCAGATCTAACTGCTTATCGTGCCAATGCTGCGCATTGGCATGCAGTTCGTGACGCGGAGCGTGAGG
AACGAGAGGTGCCCGTAACC

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 637; Mature: 636

Protein sequence:

>637_residues
MSVRRTRKDDGSQWTVADSRSVYGIRHWGAGYFAINEAGRVEVRPNGPDSSPIDLYEQVDNLRKSGLSLPLLVRFPDILQ
DRVRQLTGAFDSNIARLEYQSKYTALYPIKVNQQEAVVENIIATQNVSIGLEAGSKPELMAVLALAPKGGTIVCNGYKDR
EFIRLALMGQKLGHNVFIVIEKESEVELVIEEAAELKVAPQVGLRVRLSSLASSKWADTGGEKSKFGLSAAQLLSVVERF
RKAGLDQGIRLLHFHMGSQIANLADYQHGFKEAIRYYGELRKLGLPVDYIDVGGGLGVDYDGTHSRNASSINYDMDDYAG
VVVGMLKEFCDAQSLPHPHIFSESGRSLTAHHAMLVVQVTDVEKHNDEVPEIADKASLPETVQWLVDLLGPTDIEMVTET
YWRATHYMSDIAAQYADGKISLSEKALGEQCYFAVCRRLYNSLKARQRSHRQVLDELNDKLADKYICNFSVFQSLPDTWA
IGQVLPILPLHRLNEEPVRRAVLQDLTCDSDGKIKQYVDEQSIETSMPVHSLNEGEDYLLGIFLVGAYQEILGDMHNLFG
DTDSVNIYQNPDGSVYHAGIETHDTIEDMLRYVHLSPEELMTHYRDKVASAKITPRERTYFLDALRLGLTRSSYLSS

Sequences:

>Translated_637_residues
MSVRRTRKDDGSQWTVADSRSVYGIRHWGAGYFAINEAGRVEVRPNGPDSSPIDLYEQVDNLRKSGLSLPLLVRFPDILQ
DRVRQLTGAFDSNIARLEYQSKYTALYPIKVNQQEAVVENIIATQNVSIGLEAGSKPELMAVLALAPKGGTIVCNGYKDR
EFIRLALMGQKLGHNVFIVIEKESEVELVIEEAAELKVAPQVGLRVRLSSLASSKWADTGGEKSKFGLSAAQLLSVVERF
RKAGLDQGIRLLHFHMGSQIANLADYQHGFKEAIRYYGELRKLGLPVDYIDVGGGLGVDYDGTHSRNASSINYDMDDYAG
VVVGMLKEFCDAQSLPHPHIFSESGRSLTAHHAMLVVQVTDVEKHNDEVPEIADKASLPETVQWLVDLLGPTDIEMVTET
YWRATHYMSDIAAQYADGKISLSEKALGEQCYFAVCRRLYNSLKARQRSHRQVLDELNDKLADKYICNFSVFQSLPDTWA
IGQVLPILPLHRLNEEPVRRAVLQDLTCDSDGKIKQYVDEQSIETSMPVHSLNEGEDYLLGIFLVGAYQEILGDMHNLFG
DTDSVNIYQNPDGSVYHAGIETHDTIEDMLRYVHLSPEELMTHYRDKVASAKITPRERTYFLDALRLGLTRSSYLSS
>Mature_636_residues
SVRRTRKDDGSQWTVADSRSVYGIRHWGAGYFAINEAGRVEVRPNGPDSSPIDLYEQVDNLRKSGLSLPLLVRFPDILQD
RVRQLTGAFDSNIARLEYQSKYTALYPIKVNQQEAVVENIIATQNVSIGLEAGSKPELMAVLALAPKGGTIVCNGYKDRE
FIRLALMGQKLGHNVFIVIEKESEVELVIEEAAELKVAPQVGLRVRLSSLASSKWADTGGEKSKFGLSAAQLLSVVERFR
KAGLDQGIRLLHFHMGSQIANLADYQHGFKEAIRYYGELRKLGLPVDYIDVGGGLGVDYDGTHSRNASSINYDMDDYAGV
VVGMLKEFCDAQSLPHPHIFSESGRSLTAHHAMLVVQVTDVEKHNDEVPEIADKASLPETVQWLVDLLGPTDIEMVTETY
WRATHYMSDIAAQYADGKISLSEKALGEQCYFAVCRRLYNSLKARQRSHRQVLDELNDKLADKYICNFSVFQSLPDTWAI
GQVLPILPLHRLNEEPVRRAVLQDLTCDSDGKIKQYVDEQSIETSMPVHSLNEGEDYLLGIFLVGAYQEILGDMHNLFGD
TDSVNIYQNPDGSVYHAGIETHDTIEDMLRYVHLSPEELMTHYRDKVASAKITPRERTYFLDALRLGLTRSSYLSS

Specific function: Catalyzes the biosynthesis of agmatine from arginine [H]

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789307, Length=623, Percent_Identity=45.2648475120385, Blast_Score=541, Evalue=1e-155,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 71308; Mature: 71176

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRRTRKDDGSQWTVADSRSVYGIRHWGAGYFAINEAGRVEVRPNGPDSSPIDLYEQVD
CCCCCCCCCCCCEEEEECCCCEEEEEECCCEEEEECCCCEEEECCCCCCCCHHHHHHHHH
NLRKSGLSLPLLVRFPDILQDRVRQLTGAFDSNIARLEYQSKYTALYPIKVNQQEAVVEN
HHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEEEECHHHHHHHH
IIATQNVSIGLEAGSKPELMAVLALAPKGGTIVCNGYKDREFIRLALMGQKLGHNVFIVI
HHHHCCCEEEECCCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEE
EKESEVELVIEEAAELKVAPQVGLRVRLSSLASSKWADTGGEKSKFGLSAAQLLSVVERF
ECCCCHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RKAGLDQGIRLLHFHMGSQIANLADYQHGFKEAIRYYGELRKLGLPVDYIDVGGGLGVDY
HHCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
DGTHSRNASSINYDMDDYAGVVVGMLKEFCDAQSLPHPHIFSESGRSLTAHHAMLVVQVT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEEEEE
DVEKHNDEVPEIADKASLPETVQWLVDLLGPTDIEMVTETYWRATHYMSDIAAQYADGKI
CCHHCCCCCHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
SLSEKALGEQCYFAVCRRLYNSLKARQRSHRQVLDELNDKLADKYICNFSVFQSLPDTWA
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHH
IGQVLPILPLHRLNEEPVRRAVLQDLTCDSDGKIKQYVDEQSIETSMPVHSLNEGEDYLL
HHHHHHHCCHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHEE
GIFLVGAYQEILGDMHNLFGDTDSVNIYQNPDGSVYHAGIETHDTIEDMLRYVHLSPEEL
HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCHHHHHHHHHHHCCCHHHH
MTHYRDKVASAKITPRERTYFLDALRLGLTRSSYLSS
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHCCC
>Mature Secondary Structure 
SVRRTRKDDGSQWTVADSRSVYGIRHWGAGYFAINEAGRVEVRPNGPDSSPIDLYEQVD
CCCCCCCCCCCEEEEECCCCEEEEEECCCEEEEECCCCEEEECCCCCCCCHHHHHHHHH
NLRKSGLSLPLLVRFPDILQDRVRQLTGAFDSNIARLEYQSKYTALYPIKVNQQEAVVEN
HHHHCCCCCEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEEEECHHHHHHHH
IIATQNVSIGLEAGSKPELMAVLALAPKGGTIVCNGYKDREFIRLALMGQKLGHNVFIVI
HHHHCCCEEEECCCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEE
EKESEVELVIEEAAELKVAPQVGLRVRLSSLASSKWADTGGEKSKFGLSAAQLLSVVERF
ECCCCHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RKAGLDQGIRLLHFHMGSQIANLADYQHGFKEAIRYYGELRKLGLPVDYIDVGGGLGVDY
HHCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
DGTHSRNASSINYDMDDYAGVVVGMLKEFCDAQSLPHPHIFSESGRSLTAHHAMLVVQVT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEEEEE
DVEKHNDEVPEIADKASLPETVQWLVDLLGPTDIEMVTETYWRATHYMSDIAAQYADGKI
CCHHCCCCCHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
SLSEKALGEQCYFAVCRRLYNSLKARQRSHRQVLDELNDKLADKYICNFSVFQSLPDTWA
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCHHH
IGQVLPILPLHRLNEEPVRRAVLQDLTCDSDGKIKQYVDEQSIETSMPVHSLNEGEDYLL
HHHHHHHCCHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHEE
GIFLVGAYQEILGDMHNLFGDTDSVNIYQNPDGSVYHAGIETHDTIEDMLRYVHLSPEEL
HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCCHHHHHHHHHHHCCCHHHH
MTHYRDKVASAKITPRERTYFLDALRLGLTRSSYLSS
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]