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The map label for this gene is mrdA [H]

Identifier: 66047592

GI number: 66047592

Start: 5218555

End: 5220450

Strand: Reverse

Name: mrdA [H]

Synonym: Psyr_4365

Alternate gene names: 66047592

Gene position: 5220450-5218555 (Counterclockwise)

Preceding gene: 66047593

Following gene: 66047591

Centisome position: 85.67

GC content: 62.34

Gene sequence:

>1896_bases
ATGTCTCAACCGATCCGCCTCAAAGACCACGAAAAGGACGCACGCCTGGTGCGCGGCAGGGTCGTGTTCGGTGCTGTGGC
GGTGGTGTTGCTGGTGTGCGTGCTGATTGCCCGGTTGTATTACCTGCAGGTCATCCAGTACGAGTATCACTCCACGCTTT
CGGAAAATAACCGCGTTCACGTTCAGCCGATTCCGCCCAGCCGCGGGTTGATCTACGACCGTAACGGCGTTGTGGTCGCC
GATAACCGGCCCAGTTTCAGTCTCAGCATGACCCGTGAGCGCGCCGGCGAGTGGTCCAGCGTGCTCGACACCATTGTCGA
GATCCTGCAGCTCACCCCCGACGACCGCATCATCTTCGAAAAGCGCATGAAGCAGGGGCGTCGGCCATTCGAGCCGGTGC
CCATCCTGTTCGAGCTGAGCGAGGAGCAGATCGCCCTGATCGCCGTCAACCAGTTCCGCCTGCCGGGCGTCGAAGTGGTT
GCGCAACTGGTCAGGCATTACCCGCAAGGGCCGCACTTTGCCCACTCGGTCGGCTACATGGGGCGCATCAACGAGAAAGA
GCTCAAGAGCCTCGACCCGATCAATTACAGCGGCACGCACCATATCGGCAAGACCGGCATCGAGCGCTTTTACGAGCCCG
AGCTGCATGGTCAGGTCGGCTACGAAGAGGTCGAGACCAACGCCCGTGGTCGCGTATTGCGTGTGCTCAAGCGCACCGAC
CCGATCCCCGGCAAGGACATCGTCCTGAGCCTGGACATCAAGCTTCAGGAAGCCGCCGAAGCGGCACTGGGCGGGCGTCG
TGGTGCGGTCGTCGCACTGGACCCGGCCACCGGGGAAGTGCTGGCGATGGTCAGTGCGCCGAGCTTCGATCCGAATCTGT
TTGTCACCGGCATCAGCTTCAAGGCCTATGCCGAGCTGCGCGATTCCATCGACCGGCCGCTGTTCAACCGCATCCTGCGA
GGGCTGTACCCGCCGGGCTCGACCATCAAGCCCGCAGTGGCGATTGCCGGGCTGGATACCGGTGCGGTGACGCCTGGCTC
GCGGGTATTCGATCCGGGCTATTACCAACTGCCCAATTACGATCACAAGTACCGCAACTGGAACCGCACCGGCGATGGCT
GGGTCGATCTGGATACGGCGATCATGCGTTCAAATGACACGTACTTCTACGATCTGGCACACAAGGTGGGCATTGATCGA
CTCGCTACCTACATGAACAAGTTCGGTATCGGGCAGAAGGTCTCGCTGGACATGTTCGAAGAATCTCCCGGCCTGATGCC
GTCCCGTGAGTGGAAGCGCGCCACGCGCCGGCAAGCCTGGTTCCCCGGCGAAACCCTGATCCTCGGCATCGGTCAGGGCT
ACATGCAGGCGACGCCTTTGCAACTGGCCCAGGCGACCGCGCTGGTGGCCAACAAGGGTGTATGGAATCGGCCGCATCTG
GCCAGAACCATCGAAGGCAAGGCGCCCGTGGATGAAAATCCGATGCCGGACATCGTGCTGCGCGACCCGGCCAACTGGGG
ACGCGTCAACCATGGCATGCAGGAAGTGATGCACGGCGCGCGCGGTACGGCGCGCAAGGCCGCCATTGGTGCGCAGTACC
GGATTGCCGGCAAGAGCGGTACTGCCCAGGTGGTGGCCATCAAGCAGGGCGAGAAATACGACCGCACCAAGGTGCAGGAA
CGCCACCGCGACCACGCCTTGTTCGTCGGCTTCGCCCCGGCTGATAACCCGAAAATCGTTGTTGCAGTGATGGTCGAGAA
CGGCGAGTCCGGTTCCGGCGTTGCTGCACCCGTCGTGCGTCAGGTCCTGGACGCCTGGCTGCTCGACGAAAACGGCCATC
TCAAACCCGAGTACGCCGGTTCCCTGAATCTGGAGGCTGCGGCCCGTGAAGAGTAA

Upstream 100 bases:

>100_bases
GTGCGCATCCTGATCGGCGAGCAGATGTATCGCGCCTGGACGGTCCTGTCCGGGCACCCTTATCACAAGTAGCATCGTCT
TTACTGTGAATACGGCCTAA

Downstream 100 bases:

>100_bases
TTTCGACCGCATCCTGTCCAGTGAAGACGTGATGCGTCGCCGCGCCACGTTTCTGCAGCGCATTCATATCGATGGCCCAT
TGCTGATCCTGCTGCTGACG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 631; Mature: 630

Protein sequence:

>631_residues
MSQPIRLKDHEKDARLVRGRVVFGAVAVVLLVCVLIARLYYLQVIQYEYHSTLSENNRVHVQPIPPSRGLIYDRNGVVVA
DNRPSFSLSMTRERAGEWSSVLDTIVEILQLTPDDRIIFEKRMKQGRRPFEPVPILFELSEEQIALIAVNQFRLPGVEVV
AQLVRHYPQGPHFAHSVGYMGRINEKELKSLDPINYSGTHHIGKTGIERFYEPELHGQVGYEEVETNARGRVLRVLKRTD
PIPGKDIVLSLDIKLQEAAEAALGGRRGAVVALDPATGEVLAMVSAPSFDPNLFVTGISFKAYAELRDSIDRPLFNRILR
GLYPPGSTIKPAVAIAGLDTGAVTPGSRVFDPGYYQLPNYDHKYRNWNRTGDGWVDLDTAIMRSNDTYFYDLAHKVGIDR
LATYMNKFGIGQKVSLDMFEESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQATPLQLAQATALVANKGVWNRPHL
ARTIEGKAPVDENPMPDIVLRDPANWGRVNHGMQEVMHGARGTARKAAIGAQYRIAGKSGTAQVVAIKQGEKYDRTKVQE
RHRDHALFVGFAPADNPKIVVAVMVENGESGSGVAAPVVRQVLDAWLLDENGHLKPEYAGSLNLEAAAREE

Sequences:

>Translated_631_residues
MSQPIRLKDHEKDARLVRGRVVFGAVAVVLLVCVLIARLYYLQVIQYEYHSTLSENNRVHVQPIPPSRGLIYDRNGVVVA
DNRPSFSLSMTRERAGEWSSVLDTIVEILQLTPDDRIIFEKRMKQGRRPFEPVPILFELSEEQIALIAVNQFRLPGVEVV
AQLVRHYPQGPHFAHSVGYMGRINEKELKSLDPINYSGTHHIGKTGIERFYEPELHGQVGYEEVETNARGRVLRVLKRTD
PIPGKDIVLSLDIKLQEAAEAALGGRRGAVVALDPATGEVLAMVSAPSFDPNLFVTGISFKAYAELRDSIDRPLFNRILR
GLYPPGSTIKPAVAIAGLDTGAVTPGSRVFDPGYYQLPNYDHKYRNWNRTGDGWVDLDTAIMRSNDTYFYDLAHKVGIDR
LATYMNKFGIGQKVSLDMFEESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQATPLQLAQATALVANKGVWNRPHL
ARTIEGKAPVDENPMPDIVLRDPANWGRVNHGMQEVMHGARGTARKAAIGAQYRIAGKSGTAQVVAIKQGEKYDRTKVQE
RHRDHALFVGFAPADNPKIVVAVMVENGESGSGVAAPVVRQVLDAWLLDENGHLKPEYAGSLNLEAAAREE
>Mature_630_residues
SQPIRLKDHEKDARLVRGRVVFGAVAVVLLVCVLIARLYYLQVIQYEYHSTLSENNRVHVQPIPPSRGLIYDRNGVVVAD
NRPSFSLSMTRERAGEWSSVLDTIVEILQLTPDDRIIFEKRMKQGRRPFEPVPILFELSEEQIALIAVNQFRLPGVEVVA
QLVRHYPQGPHFAHSVGYMGRINEKELKSLDPINYSGTHHIGKTGIERFYEPELHGQVGYEEVETNARGRVLRVLKRTDP
IPGKDIVLSLDIKLQEAAEAALGGRRGAVVALDPATGEVLAMVSAPSFDPNLFVTGISFKAYAELRDSIDRPLFNRILRG
LYPPGSTIKPAVAIAGLDTGAVTPGSRVFDPGYYQLPNYDHKYRNWNRTGDGWVDLDTAIMRSNDTYFYDLAHKVGIDRL
ATYMNKFGIGQKVSLDMFEESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQATPLQLAQATALVANKGVWNRPHLA
RTIEGKAPVDENPMPDIVLRDPANWGRVNHGMQEVMHGARGTARKAAIGAQYRIAGKSGTAQVVAIKQGEKYDRTKVQER
HRDHALFVGFAPADNPKIVVAVMVENGESGSGVAAPVVRQVLDAWLLDENGHLKPEYAGSLNLEAAAREE

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=615, Percent_Identity=43.5772357723577, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1786272, Length=631, Percent_Identity=24.8811410459588, Blast_Score=145, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70167; Mature: 70036

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPIRLKDHEKDARLVRGRVVFGAVAVVLLVCVLIARLYYLQVIQYEYHSTLSENNRVH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VQPIPPSRGLIYDRNGVVVADNRPSFSLSMTRERAGEWSSVLDTIVEILQLTPDDRIIFE
EEECCCCCCEEEECCCEEEECCCCCEEEEECHHHCCCHHHHHHHHHHHHHCCCCCHHHHH
KRMKQGRRPFEPVPILFELSEEQIALIAVNQFRLPGVEVVAQLVRHYPQGPHFAHSVGYM
HHHHHCCCCCCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHCCCC
GRINEKELKSLDPINYSGTHHIGKTGIERFYEPELHGQVGYEEVETNARGRVLRVLKRTD
CCCCHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHCC
PIPGKDIVLSLDIKLQEAAEAALGGRRGAVVALDPATGEVLAMVSAPSFDPNLFVTGISF
CCCCCCEEEEEEEEHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCCCCEEEEECCH
KAYAELRDSIDRPLFNRILRGLYPPGSTIKPAVAIAGLDTGAVTPGSRVFDPGYYQLPNY
HHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCC
DHKYRNWNRTGDGWVDLDTAIMRSNDTYFYDLAHKVGIDRLATYMNKFGIGQKVSLDMFE
CCHHCCCCCCCCCEEEECHHHHCCCCCEEEECHHHHCHHHHHHHHHHHCCCCEEEEEHHH
ESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQATPLQLAQATALVANKGVWNRPHL
CCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCHHCCHHHHHHHHHHHHCCCCCCCCCH
ARTIEGKAPVDENPMPDIVLRDPANWGRVNHGMQEVMHGARGTARKAAIGAQYRIAGKSG
HEEECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHCCCEEEEECCCC
TAQVVAIKQGEKYDRTKVQERHRDHALFVGFAPADNPKIVVAVMVENGESGSGVAAPVVR
CEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCHHHHHHH
QVLDAWLLDENGHLKPEYAGSLNLEAAAREE
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQPIRLKDHEKDARLVRGRVVFGAVAVVLLVCVLIARLYYLQVIQYEYHSTLSENNRVH
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VQPIPPSRGLIYDRNGVVVADNRPSFSLSMTRERAGEWSSVLDTIVEILQLTPDDRIIFE
EEECCCCCCEEEECCCEEEECCCCCEEEEECHHHCCCHHHHHHHHHHHHHCCCCCHHHHH
KRMKQGRRPFEPVPILFELSEEQIALIAVNQFRLPGVEVVAQLVRHYPQGPHFAHSVGYM
HHHHHCCCCCCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHCCCC
GRINEKELKSLDPINYSGTHHIGKTGIERFYEPELHGQVGYEEVETNARGRVLRVLKRTD
CCCCHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHCC
PIPGKDIVLSLDIKLQEAAEAALGGRRGAVVALDPATGEVLAMVSAPSFDPNLFVTGISF
CCCCCCEEEEEEEEHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCCCCCEEEEECCH
KAYAELRDSIDRPLFNRILRGLYPPGSTIKPAVAIAGLDTGAVTPGSRVFDPGYYQLPNY
HHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCC
DHKYRNWNRTGDGWVDLDTAIMRSNDTYFYDLAHKVGIDRLATYMNKFGIGQKVSLDMFE
CCHHCCCCCCCCCEEEECHHHHCCCCCEEEECHHHHCHHHHHHHHHHHCCCCEEEEEHHH
ESPGLMPSREWKRATRRQAWFPGETLILGIGQGYMQATPLQLAQATALVANKGVWNRPHL
CCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCHHCCHHHHHHHHHHHHCCCCCCCCCH
ARTIEGKAPVDENPMPDIVLRDPANWGRVNHGMQEVMHGARGTARKAAIGAQYRIAGKSG
HEEECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHCCCEEEEECCCC
TAQVVAIKQGEKYDRTKVQERHRDHALFVGFAPADNPKIVVAVMVENGESGSGVAAPVVR
CEEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCHHHHHHH
QVLDAWLLDENGHLKPEYAGSLNLEAAAREE
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]