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The map label for this gene is hlyB [H]

Identifier: 66047445

GI number: 66047445

Start: 5023714

End: 5025339

Strand: Direct

Name: hlyB [H]

Synonym: Psyr_4218

Alternate gene names: 66047445

Gene position: 5023714-5025339 (Clockwise)

Preceding gene: 66047444

Following gene: 66047446

Centisome position: 82.44

GC content: 58.67

Gene sequence:

>1626_bases
ATGAACCTCAGATCGTTAAGCATTTCACGCAGGGCCTCCCTGTGTTTTGGCGTCATTACCTTGCTGTTGATCGGTCTGGG
AGCCTTCTCCTACGTACAGATCGGCCACCTGCGCGTAGCCGAACAGAACATAGAAGAAAACTCACTGCCCAGCGTTCAGG
TCGTCGACGACATTCAGATCGCCCTGCTTCACGCCCGTCTGGAAAGCATCCGCATGCTTGCCAGCAACGATCCGAGCGTA
CACGCCAGCGCAGAAGCCAAGGTACGGGAAGCGATCGAGGCGCTACGTGCCAACAGCGACTTCTATCAAAAACACCTGCT
GTCGGGAGAAGCCGACCGGGCGCAATTCGAAGAAGCCAATAACAAGATGGGCGTCTACATTGACGGCTTGAAACAGGTCG
TCGCACTGGACAGCGCTGATCACGAAAGAGCGGTCTCCCTTGCCAACGGAGAACAGGCCCTAAAGGCCGCTGCCTATCAG
GAAAAACTCACTGCGCTACGCGGGCACAATGCTGAAGAAGCGGTCGTCTCCGGGAAAGATGCCACTGCAGTCTACGACCA
CAGCGTCAACGTGTTGATGATTGTGCTGATCGCAGCGTTCCTGCTTACCGTGGTACTCGCGATTGCCCTGACACGCAGCA
TTGTCGACCCGATCAGCGCCTCGCTGAAACTGGCGGAAGACATCGCCGCCGGTGACCTGACCCGGCAATTGAGCGTTAGC
GGCAGTGATGAAGCATCACGCTTGATGACGGCCCTGAACACCATGTCGGGGAACCTGCGCACCACCATTCACGAAATTTC
CGGCGCGTCCGCGCAGTTGAGCACTGCCGCCGTCGAGATGACATCGATCACCGAAAGCGCCGACCGCACTCTGCAGCAAC
AGAACAGCGAAATCGAGCAGGCAGCGACTGCGGTAAACGAAATGAGTGCTGCCGTAGAAGAGGTCGCTCGTAATGCTACG
TCGACCTCGCAGGCCGCCCAACAGTCGAGCCTTTCCGCCGATCTGGGTAACCAGCGCGTTAACGAAACCCTGACCGCCAT
GCAAAACCTGACAGGCCTGGTCGAGGGTTCTTCCGCGCAAGTTACTGCGCTGGCCGGCCAGGCTCAGGACATCAGCAAAG
TGCTGGGCGTGATTCGCGGCATTGCCGAACAGACCAACCTGCTGGCACTCAATGCTGCCATCGAAGCTGCGCGTGCCGGC
GAACAGGGTCGCGGCTTTGCTGTGGTCGCCGATGAGGTGCGGGCTCTGGCGCATCGTACACAGACGTCCACGCAGGAAGT
CGAACAGATGATTTCAGCGATTCAGGCCGGCTCTTCCGCCACCGTCGAGTCGATGCACAAGAGCACTCAGGAAGTTCACG
TCACTCGCAAGACCGCAGAAGATGCCGGCGAATCGCTGCGCCAGATCACCGACTCGGTACTCGAGATCAATAACCGTAAC
CTGCAGATCGCGGCGGCCTCCGAGCAGCAGGCGCATGTAGCGCGTGATGTCGACAGAAGCCTGGTCAGCATTCGCGACCT
GGCCGTGCAGAGCAGCGAAGGCACCCGGCAGACCCTGATCGCCAGTACCGAACTTTCGCAGTTGGCGGTCAACCTGAATG
ATCTGGTTCTGCGCTTCAAGACATAA

Upstream 100 bases:

>100_bases
ACTTTCATCGCCATTCATTAAAGCTCTCTCGTTTCCAGCAGAAAACCAGTTACTGGAAGGAAAGTATTCGCCTTCGTCTG
TTTTGCCGCTGGAGGCAACC

Downstream 100 bases:

>100_bases
TCCAGGCCTCCACGCCAAGCGGCCATGACAGAAGGGCAGCAGATTCGTCTGCTGCCCTTCTTTTATGGAGTCAGTACAGT
TTCGGCAAAAAACCGGCAAT

Product: histidine kinase, HAMP region: chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MNLRSLSISRRASLCFGVITLLLIGLGAFSYVQIGHLRVAEQNIEENSLPSVQVVDDIQIALLHARLESIRMLASNDPSV
HASAEAKVREAIEALRANSDFYQKHLLSGEADRAQFEEANNKMGVYIDGLKQVVALDSADHERAVSLANGEQALKAAAYQ
EKLTALRGHNAEEAVVSGKDATAVYDHSVNVLMIVLIAAFLLTVVLAIALTRSIVDPISASLKLAEDIAAGDLTRQLSVS
GSDEASRLMTALNTMSGNLRTTIHEISGASAQLSTAAVEMTSITESADRTLQQQNSEIEQAATAVNEMSAAVEEVARNAT
STSQAAQQSSLSADLGNQRVNETLTAMQNLTGLVEGSSAQVTALAGQAQDISKVLGVIRGIAEQTNLLALNAAIEAARAG
EQGRGFAVVADEVRALAHRTQTSTQEVEQMISAIQAGSSATVESMHKSTQEVHVTRKTAEDAGESLRQITDSVLEINNRN
LQIAAASEQQAHVARDVDRSLVSIRDLAVQSSEGTRQTLIASTELSQLAVNLNDLVLRFKT

Sequences:

>Translated_541_residues
MNLRSLSISRRASLCFGVITLLLIGLGAFSYVQIGHLRVAEQNIEENSLPSVQVVDDIQIALLHARLESIRMLASNDPSV
HASAEAKVREAIEALRANSDFYQKHLLSGEADRAQFEEANNKMGVYIDGLKQVVALDSADHERAVSLANGEQALKAAAYQ
EKLTALRGHNAEEAVVSGKDATAVYDHSVNVLMIVLIAAFLLTVVLAIALTRSIVDPISASLKLAEDIAAGDLTRQLSVS
GSDEASRLMTALNTMSGNLRTTIHEISGASAQLSTAAVEMTSITESADRTLQQQNSEIEQAATAVNEMSAAVEEVARNAT
STSQAAQQSSLSADLGNQRVNETLTAMQNLTGLVEGSSAQVTALAGQAQDISKVLGVIRGIAEQTNLLALNAAIEAARAG
EQGRGFAVVADEVRALAHRTQTSTQEVEQMISAIQAGSSATVESMHKSTQEVHVTRKTAEDAGESLRQITDSVLEINNRN
LQIAAASEQQAHVARDVDRSLVSIRDLAVQSSEGTRQTLIASTELSQLAVNLNDLVLRFKT
>Mature_541_residues
MNLRSLSISRRASLCFGVITLLLIGLGAFSYVQIGHLRVAEQNIEENSLPSVQVVDDIQIALLHARLESIRMLASNDPSV
HASAEAKVREAIEALRANSDFYQKHLLSGEADRAQFEEANNKMGVYIDGLKQVVALDSADHERAVSLANGEQALKAAAYQ
EKLTALRGHNAEEAVVSGKDATAVYDHSVNVLMIVLIAAFLLTVVLAIALTRSIVDPISASLKLAEDIAAGDLTRQLSVS
GSDEASRLMTALNTMSGNLRTTIHEISGASAQLSTAAVEMTSITESADRTLQQQNSEIEQAATAVNEMSAAVEEVARNAT
STSQAAQQSSLSADLGNQRVNETLTAMQNLTGLVEGSSAQVTALAGQAQDISKVLGVIRGIAEQTNLLALNAAIEAARAG
EQGRGFAVVADEVRALAHRTQTSTQEVEQMISAIQAGSSATVESMHKSTQEVHVTRKTAEDAGESLRQITDSVLEINNRN
LQIAAASEQQAHVARDVDRSLVSIRDLAVQSSEGTRQTLIASTELSQLAVNLNDLVLRFKT

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=321, Percent_Identity=32.398753894081, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1787690, Length=471, Percent_Identity=28.6624203821656, Blast_Score=140, Evalue=3e-34,
Organism=Escherichia coli, GI1788194, Length=352, Percent_Identity=30.1136363636364, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788195, Length=300, Percent_Identity=30.6666666666667, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1789453, Length=309, Percent_Identity=27.831715210356, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 57561; Mature: 57561

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRSLSISRRASLCFGVITLLLIGLGAFSYVQIGHLRVAEQNIEENSLPSVQVVDDIQI
CCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHEEEHHHCCCCCCCCCEEEHHHHHH
ALLHARLESIRMLASNDPSVHASAEAKVREAIEALRANSDFYQKHLLSGEADRAQFEEAN
HHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHCC
NKMGVYIDGLKQVVALDSADHERAVSLANGEQALKAAAYQEKLTALRGHNAEEAVVSGKD
CCCEEEEHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCC
ATAVYDHSVNVLMIVLIAAFLLTVVLAIALTRSIVDPISASLKLAEDIAAGDLTRQLSVS
CCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
GSDEASRLMTALNTMSGNLRTTIHEISGASAQLSTAAVEMTSITESADRTLQQQNSEIEQ
CCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AATAVNEMSAAVEEVARNATSTSQAAQQSSLSADLGNQRVNETLTAMQNLTGLVEGSSAQ
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCE
VTALAGQAQDISKVLGVIRGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALAHRT
EEEECCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHH
QTSTQEVEQMISAIQAGSSATVESMHKSTQEVHVTRKTAEDAGESLRQITDSVLEINNRN
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
LQIAAASEQQAHVARDVDRSLVSIRDLAVQSSEGTRQTLIASTELSQLAVNLNDLVLRFK
EEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEHHHHHHHHHCHHHEEEEEC
T
C
>Mature Secondary Structure
MNLRSLSISRRASLCFGVITLLLIGLGAFSYVQIGHLRVAEQNIEENSLPSVQVVDDIQI
CCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHEEEHHHCCCCCCCCCEEEHHHHHH
ALLHARLESIRMLASNDPSVHASAEAKVREAIEALRANSDFYQKHLLSGEADRAQFEEAN
HHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHCC
NKMGVYIDGLKQVVALDSADHERAVSLANGEQALKAAAYQEKLTALRGHNAEEAVVSGKD
CCCEEEEHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCC
ATAVYDHSVNVLMIVLIAAFLLTVVLAIALTRSIVDPISASLKLAEDIAAGDLTRQLSVS
CCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
GSDEASRLMTALNTMSGNLRTTIHEISGASAQLSTAAVEMTSITESADRTLQQQNSEIEQ
CCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AATAVNEMSAAVEEVARNATSTSQAAQQSSLSADLGNQRVNETLTAMQNLTGLVEGSSAQ
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCE
VTALAGQAQDISKVLGVIRGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRALAHRT
EEEECCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHH
QTSTQEVEQMISAIQAGSSATVESMHKSTQEVHVTRKTAEDAGESLRQITDSVLEINNRN
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
LQIAAASEQQAHVARDVDRSLVSIRDLAVQSSEGTRQTLIASTELSQLAVNLNDLVLRFK
EEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEHHHHHHHHHCHHHEEEEEC
T
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]