Click here to switch to the map view.

The map label for this gene is panE [H]

Identifier: 66047315

GI number: 66047315

Start: 4873624

End: 4874544

Strand: Direct

Name: panE [H]

Synonym: Psyr_4088

Alternate gene names: 66047315

Gene position: 4873624-4874544 (Clockwise)

Preceding gene: 66047312

Following gene: 66047316

Centisome position: 79.98

GC content: 64.39

Gene sequence:

>921_bases
ATGGCGGCGACATGGCATGTTCTCGGTGCGGGCAGCCTGGGCAGTCTCTGGGCGACGCGACTGGCTCGCGCGAATCTGCC
GGTGCGGTTGATCCTTCGCAACACGGATCGGCTGGCCGCCTATCAAGCCAATGGCAGTTGCGTGACGCTGGTCGAAAACG
ATATCGCCCATGCGTACCCGGTCGAAGCACAGACCGCCGACCATCGACAGCCCATCGAACGACTGCTGGTGGCCTGCAAG
GCTTACGAGGCCGAGCAGGCTGTCGCACAGCTGGCTCCGCGATTGACGGCGCAGGCCGACGTCATCCTGTTGCAGAACGG
TCTGGGCAGCCAGGACGCAGTGGCCGCACAAATACCCCACGCGCGCTGCCTGTTCGCGTCCAGCACCGAAGGCGCGTTTC
TGGAGTCGGACTGGCGCGTCAGGTTCGCTGGCCATGGTTTCAACTGGCTGGGTGATGTATCCGACCCGACAGCCCCCGCG
CTTGTGCAGGATTTGCACGACAGTGGCATTCCCCACGAATGGACGCCGGACATCCTGACCCGACTGTGGCGCAAGCTGGC
ACTCAACTGTGCGATCAACCCGCTGACGGTCCTGCACGACTGCCGTAATGGTGGCCTGCTCGAGCACGCCTGCGAGGTCG
CCACGCTGTGCGCCGAGCTGAGCGATCTGCTGGGCCGCTGCGGCCAGCCAGCGGCTGCGCAGGAACTGCATGCGGAAGTG
CTACGGGTCATCCAGGCGACCGCCGCCAACTACTCTTCCATGTATCAGGATGTGCTTCACGGGCGACGCACCGAAATCAG
CTACCTGCTGGGTTACGCGTGCGCAGCCGCAGTGCGTCATGGCTGCCCGGCACCGCACCTGCAGCATTTGCAGACGCGTC
TGACCGCTCATCTGGCAAGCAAGGGTTTGCGTACCGACTAG

Upstream 100 bases:

>100_bases
CATTATAACGAGACTTTTCCGGCGTTCACTGTGAGCCTTCCATGCACATCCTTGTTTTCACCTTCTGCAGACCGCTTCAG
CGCCATAACGTGCCGCTGTG

Downstream 100 bases:

>100_bases
CCCGCGCTACCCTGCTCGCATTACCCGTCACTGCGACTTGCCCAATGCCCTTGCGCCAACGCCTGGAAAACCTGCCCGTC
GGCCAGAAACTGCTGGCCGC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MAATWHVLGAGSLGSLWATRLARANLPVRLILRNTDRLAAYQANGSCVTLVENDIAHAYPVEAQTADHRQPIERLLVACK
AYEAEQAVAQLAPRLTAQADVILLQNGLGSQDAVAAQIPHARCLFASSTEGAFLESDWRVRFAGHGFNWLGDVSDPTAPA
LVQDLHDSGIPHEWTPDILTRLWRKLALNCAINPLTVLHDCRNGGLLEHACEVATLCAELSDLLGRCGQPAAAQELHAEV
LRVIQATAANYSSMYQDVLHGRRTEISYLLGYACAAAVRHGCPAPHLQHLQTRLTAHLASKGLRTD

Sequences:

>Translated_306_residues
MAATWHVLGAGSLGSLWATRLARANLPVRLILRNTDRLAAYQANGSCVTLVENDIAHAYPVEAQTADHRQPIERLLVACK
AYEAEQAVAQLAPRLTAQADVILLQNGLGSQDAVAAQIPHARCLFASSTEGAFLESDWRVRFAGHGFNWLGDVSDPTAPA
LVQDLHDSGIPHEWTPDILTRLWRKLALNCAINPLTVLHDCRNGGLLEHACEVATLCAELSDLLGRCGQPAAAQELHAEV
LRVIQATAANYSSMYQDVLHGRRTEISYLLGYACAAAVRHGCPAPHLQHLQTRLTAHLASKGLRTD
>Mature_305_residues
AATWHVLGAGSLGSLWATRLARANLPVRLILRNTDRLAAYQANGSCVTLVENDIAHAYPVEAQTADHRQPIERLLVACKA
YEAEQAVAQLAPRLTAQADVILLQNGLGSQDAVAAQIPHARCLFASSTEGAFLESDWRVRFAGHGFNWLGDVSDPTAPAL
VQDLHDSGIPHEWTPDILTRLWRKLALNCAINPLTVLHDCRNGGLLEHACEVATLCAELSDLLGRCGQPAAAQELHAEVL
RVIQATAANYSSMYQDVLHGRRTEISYLLGYACAAAVRHGCPAPHLQHLQTRLTAHLASKGLRTD

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=298, Percent_Identity=32.2147651006711, Blast_Score=125, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6321854, Length=339, Percent_Identity=26.5486725663717, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33156; Mature: 33025

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATWHVLGAGSLGSLWATRLARANLPVRLILRNTDRLAAYQANGSCVTLVENDIAHAYP
CCCEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCHHEEEECCCCEEEEEECCCCCCCC
VEAQTADHRQPIERLLVACKAYEAEQAVAQLAPRLTAQADVILLQNGLGSQDAVAAQIPH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCC
ARCLFASSTEGAFLESDWRVRFAGHGFNWLGDVSDPTAPALVQDLHDSGIPHEWTPDILT
CEEEEECCCCCCEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHH
RLWRKLALNCAINPLTVLHDCRNGGLLEHACEVATLCAELSDLLGRCGQPAAAQELHAEV
HHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LRVIQATAANYSSMYQDVLHGRRTEISYLLGYACAAAVRHGCPAPHLQHLQTRLTAHLAS
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
KGLRTD
CCCCCC
>Mature Secondary Structure 
AATWHVLGAGSLGSLWATRLARANLPVRLILRNTDRLAAYQANGSCVTLVENDIAHAYP
CCEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCHHEEEECCCCEEEEEECCCCCCCC
VEAQTADHRQPIERLLVACKAYEAEQAVAQLAPRLTAQADVILLQNGLGSQDAVAAQIPH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCC
ARCLFASSTEGAFLESDWRVRFAGHGFNWLGDVSDPTAPALVQDLHDSGIPHEWTPDILT
CEEEEECCCCCCEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHH
RLWRKLALNCAINPLTVLHDCRNGGLLEHACEVATLCAELSDLLGRCGQPAAAQELHAEV
HHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LRVIQATAANYSSMYQDVLHGRRTEISYLLGYACAAAVRHGCPAPHLQHLQTRLTAHLAS
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
KGLRTD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]