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The map label for this gene is arpR [H]

Identifier: 66047233

GI number: 66047233

Start: 4770168

End: 4770827

Strand: Reverse

Name: arpR [H]

Synonym: Psyr_4006

Alternate gene names: 66047233

Gene position: 4770827-4770168 (Counterclockwise)

Preceding gene: 66047237

Following gene: 66047232

Centisome position: 78.29

GC content: 57.42

Gene sequence:

>660_bases
ATGGTTCGTCGCACCAAAGAGGAAGCTCAGATCACTCGCAGCCAGATTCTGGAGGCTGCCGAGCAGGCTTTTTATGAGCG
AGGCGTCGCCCGCACCACACTGGCCGACATTGCAACCCTTGCCGGTGTGACGCGAGGCGCCATCTATTGGCACTTTAACA
ATAAGGCCGATCTGGTGCAGGCCATGCTCGACAGTCTTCAGGAACCCCTCGACGAAATGGCGCAGGCCAGTCAGAGCGAG
GAAGAGGAAGACCCGCTGGGCTGCATGAGAAATCTGTTGATTCACCTGTTTCATGAGCTCGCACTGGACCCGAAAACCCG
TCGCATCAATGAAATCCTGTTTCACAAGTGCGAGTTTACCGACGAGATGTGTGATTTTCGTCGTCAGCGCCAGGACAACG
CCATACAGTGCCACGATCGGATCACCCTGGGGCTGAACAATGCCGTACGCCAGGGGCAGCTACCCAAAAGGCTGGACACT
GCGCGCGCTGCAGTGGCCCTGTTTGCCTACGTCAACGGCATCATCTATCAATGGCTGCTGGTTCCGGACAGCTTCTCGCT
GCCTGCAGAGGCCGAGCAACTGGTCGACGTGTGCCTGGACATGCTGCGTTTCAGCCCGACGTTGCTGATCGATAATAACC
GCTCGACAGTGGGTGCCTGA

Upstream 100 bases:

>100_bases
CAGCCAATTCGGGACAAGGCGAGACAAATGCCGCCCGGCCATATCTCGAGGCATGACGCAAGACGCGTGCCTGAGGTGAA
TTTTTTGAGGTCTTATTGCC

Downstream 100 bases:

>100_bases
CTGAACATGACCGGCGGGGCACCCGCCGGTTCCGCCTGCCAGCGACGCTGTGCAGAGCCTGACTCCGATTCGTGCCTCTT
ATAGAGTGTGTTTACCGATC

Product: regulatory protein, TetR

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MVRRTKEEAQITRSQILEAAEQAFYERGVARTTLADIATLAGVTRGAIYWHFNNKADLVQAMLDSLQEPLDEMAQASQSE
EEEDPLGCMRNLLIHLFHELALDPKTRRINEILFHKCEFTDEMCDFRRQRQDNAIQCHDRITLGLNNAVRQGQLPKRLDT
ARAAVALFAYVNGIIYQWLLVPDSFSLPAEAEQLVDVCLDMLRFSPTLLIDNNRSTVGA

Sequences:

>Translated_219_residues
MVRRTKEEAQITRSQILEAAEQAFYERGVARTTLADIATLAGVTRGAIYWHFNNKADLVQAMLDSLQEPLDEMAQASQSE
EEEDPLGCMRNLLIHLFHELALDPKTRRINEILFHKCEFTDEMCDFRRQRQDNAIQCHDRITLGLNNAVRQGQLPKRLDT
ARAAVALFAYVNGIIYQWLLVPDSFSLPAEAEQLVDVCLDMLRFSPTLLIDNNRSTVGA
>Mature_219_residues
MVRRTKEEAQITRSQILEAAEQAFYERGVARTTLADIATLAGVTRGAIYWHFNNKADLVQAMLDSLQEPLDEMAQASQSE
EEEDPLGCMRNLLIHLFHELALDPKTRRINEILFHKCEFTDEMCDFRRQRQDNAIQCHDRITLGLNNAVRQGQLPKRLDT
ARAAVALFAYVNGIIYQWLLVPDSFSLPAEAEQLVDVCLDMLRFSPTLLIDNNRSTVGA

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=208, Percent_Identity=38.9423076923077, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1789664, Length=210, Percent_Identity=37.1428571428571, Blast_Score=110, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24921; Mature: 24921

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRRTKEEAQITRSQILEAAEQAFYERGVARTTLADIATLAGVTRGAIYWHFNNKADLVQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHH
AMLDSLQEPLDEMAQASQSEEEEDPLGCMRNLLIHLFHELALDPKTRRINEILFHKCEFT
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
DEMCDFRRQRQDNAIQCHDRITLGLNNAVRQGQLPKRLDTARAAVALFAYVNGIIYQWLL
HHHHHHHHHHCCCCEEHHHHHEECHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VPDSFSLPAEAEQLVDVCLDMLRFSPTLLIDNNRSTVGA
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
>Mature Secondary Structure
MVRRTKEEAQITRSQILEAAEQAFYERGVARTTLADIATLAGVTRGAIYWHFNNKADLVQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHH
AMLDSLQEPLDEMAQASQSEEEEDPLGCMRNLLIHLFHELALDPKTRRINEILFHKCEFT
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
DEMCDFRRQRQDNAIQCHDRITLGLNNAVRQGQLPKRLDTARAAVALFAYVNGIIYQWLL
HHHHHHHHHHCCCCEEHHHHHEECHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VPDSFSLPAEAEQLVDVCLDMLRFSPTLLIDNNRSTVGA
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]