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The map label for this gene is mucA [H]

Identifier: 66047184

GI number: 66047184

Start: 4705394

End: 4705984

Strand: Reverse

Name: mucA [H]

Synonym: Psyr_3957

Alternate gene names: 66047184

Gene position: 4705984-4705394 (Counterclockwise)

Preceding gene: 66047185

Following gene: 66047183

Centisome position: 77.23

GC content: 59.9

Gene sequence:

>591_bases
ATGAGTCGTGAAGCCCTGCAGGAATCGCTGTCCGCGGTACTGGATAACGAAGCGGACGAACTGGAATTACGTCGGGTATT
GAATGCCATTGACGATGCCGATACTCGCGCCACCTGGTCGCGTTACCAAGTTGCTCGTGCAGCGATGCACAAAGAGCTGC
TGGTGCCTCATCTGGATATCTCGGCTGCTGTGTCTGCCGCGATCGCCGATGAAGTCAGCCCGCTCAAGGCAGCTCGCGGT
CCTTGGCGTACGCTGGGTCGTCTGGCCGTTGCAGCGTCGGTTACCGTAGCCGTTCTGGCTGGTGTCCGCCTGTACAACCA
GGATGACATTGCCGGTGCACAACTGGCACAGCAGACCCAACAGCCTGCCAACCTGACTGTTCCGCAAGTCAAAGGCCCGG
CCGTACTGGCTGGTTACACTGAAAGCGCCGAGCAAGCGCCTGGTCCTATGGCCAATGGTGTGTTGCAGGGCGGTGGTCAA
GGTGACCAGCGTCTGCCGGGCTATCTGCGCCAGCACGCCCAGGAAGCAGCGTTGAAAGGTACTGAAAGCGCGCTGCCATA
CGCACGTGCTGCGAGCCTGGAAAACCGTTAA

Upstream 100 bases:

>100_bases
CTCTCGGATCTTCCGCGCTCGGGAAGCCATCGATAAAGCCCTGCAGCCGTTGTTGCAGGAATCCTGAGACAGCGGCGATA
GCCCAAGAGAGGAACCCGCC

Downstream 100 bases:

>100_bases
GGAGGATCATGCGAGCCGTCCCTCTACTGCCGTTACTGCTTGGTGGATGGCTTGCCCTCCCGGTACAGGCTGATGATGCG
CAAGACGCAATCAATCGTCT

Product: anti sigma-E protein RseA, N-terminal:anti sigma-E protein RseA, C-terminal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MSREALQESLSAVLDNEADELELRRVLNAIDDADTRATWSRYQVARAAMHKELLVPHLDISAAVSAAIADEVSPLKAARG
PWRTLGRLAVAASVTVAVLAGVRLYNQDDIAGAQLAQQTQQPANLTVPQVKGPAVLAGYTESAEQAPGPMANGVLQGGGQ
GDQRLPGYLRQHAQEAALKGTESALPYARAASLENR

Sequences:

>Translated_196_residues
MSREALQESLSAVLDNEADELELRRVLNAIDDADTRATWSRYQVARAAMHKELLVPHLDISAAVSAAIADEVSPLKAARG
PWRTLGRLAVAASVTVAVLAGVRLYNQDDIAGAQLAQQTQQPANLTVPQVKGPAVLAGYTESAEQAPGPMANGVLQGGGQ
GDQRLPGYLRQHAQEAALKGTESALPYARAASLENR
>Mature_195_residues
SREALQESLSAVLDNEADELELRRVLNAIDDADTRATWSRYQVARAAMHKELLVPHLDISAAVSAAIADEVSPLKAARGP
WRTLGRLAVAASVTVAVLAGVRLYNQDDIAGAQLAQQTQQPANLTVPQVKGPAVLAGYTESAEQAPGPMANGVLQGGGQG
DQRLPGYLRQHAQEAALKGTESALPYARAASLENR

Specific function: Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate- producing form. Inactivation of mucA causes a switch from the non- mucoid to mucoid state resulting in constitutive expression of alginate

COG id: COG3073

COG function: function code T; Negative regulator of sigma E activity

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rseA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005573
- InterPro:   IPR005572 [H]

Pfam domain/function: PF03873 RseA_C; PF03872 RseA_N [H]

EC number: NA

Molecular weight: Translated: 20727; Mature: 20595

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSREALQESLSAVLDNEADELELRRVLNAIDDADTRATWSRYQVARAAMHKELLVPHLDI
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
SAAVSAAIADEVSPLKAARGPWRTLGRLAVAASVTVAVLAGVRLYNQDDIAGAQLAQQTQ
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
QPANLTVPQVKGPAVLAGYTESAEQAPGPMANGVLQGGGQGDQRLPGYLRQHAQEAALKG
CCCCCCCCCCCCCEEEECCCHHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCC
TESALPYARAASLENR
CHHHCCHHHHHCCCCC
>Mature Secondary Structure 
SREALQESLSAVLDNEADELELRRVLNAIDDADTRATWSRYQVARAAMHKELLVPHLDI
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
SAAVSAAIADEVSPLKAARGPWRTLGRLAVAASVTVAVLAGVRLYNQDDIAGAQLAQQTQ
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
QPANLTVPQVKGPAVLAGYTESAEQAPGPMANGVLQGGGQGDQRLPGYLRQHAQEAALKG
CCCCCCCCCCCCCEEEECCCHHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCC
TESALPYARAASLENR
CHHHCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8412698; 8378309; 10984043 [H]