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The map label for this gene is lon2 [H]

Identifier: 66047171

GI number: 66047171

Start: 4691427

End: 4693844

Strand: Direct

Name: lon2 [H]

Synonym: Psyr_3944

Alternate gene names: 66047171

Gene position: 4691427-4693844 (Clockwise)

Preceding gene: 66047166

Following gene: 66047172

Centisome position: 76.99

GC content: 60.59

Gene sequence:

>2418_bases
ATGAGCGACCAGCAGACAGACTCGCCAGACTTGCCCAATGACGCAGACGAGCACGACGTGTCTCTGAGTTCCGACAGCAC
CTCGCTGGCCTTGCCCGGCCAGAACCTGCCCGACAAGGTTTACATCATTCCGATCCACAACCGTCCGTTCTTTCCGGCGC
AGGTCCTGCCTGTCATCGTCAATGAAGAGCCGTGGGCCGAAACGCTGGAGCTGGTCAGCAAGTCCGAGCACCATTCGCTG
GCGCTGTTCTTCATGGACACTCCGCAGGAAGATCCACGCCACTTCAAGACTGACGCACTCCCCGAGTACGGCACTCTGGT
CAAGGTTCACCACGCCAGTCGTGAAAATGGTCGTTTACAGTTCGTCGCGCAGGGCCTCAGCCGGGTGCGCATCCGTACCT
GGCTCAAGCATCATCGCCCGCCGTATCTGGTAGAAGTCGAATACCCGCAGCAGCCCAATGAGCCGACCGATGAAGTGAAG
GCCTACGGCATGGCCCTGATCAACGCGATCAAGGAACTGCTGCCGCTCAACCCGCTGTACAGCGAAGAGCTGAAGAATTA
TCTCAACCGTTTCAGCCCCAATGACCCCTCGCCGCTCACCGACTTTGCCGCTGCCCTGACCTCGGCCACCGGTGTCGAAT
TACAGGAAGTACTCGACTGTGTGCCGATGCTCAGGCGCATGGAGAAAGTCCTGCCGATGCTGCGCAAGGAAGTCGAGGTT
GCACGCCTGCAGAAGGAAATCTCTGCCGAGGTGAACCGCAAGATCGGCGAGCATCAGCGGCAGTTCTTCCTCAAGGAACA
GCTCAAGGTCATTCAGCAGGAGCTGGGCCTGAGCAAGGACGATCGCAGCGCCGACATCGAACAGTTCGAGCAGCGCCTGG
AAGGCAAGACCCTGCCGCCACAGGCGCGCAAGAAGTTCGACGAAGAAATCGGCAAGCTCAAGGTGCTGGAAACCGGCTCG
CCCGAATACGCCGTGACACGCAATTACCTGGACTGGACCAGCTCGTTGCCATGGGGCGTCTACGGCGCCGACAAGCTGGA
TCTCAAGCACGCACGCAAGGTGCTCGATCAGCACCATGCCGGGCTTGACGATATCAAGGCGCGGATTCTCGAATTCCTTG
CGGTGGGTGCCTACAAGGGCGAAATCAGCGGCTCGATCGTGCTGCTGGTCGGCCCGCCGGGGGTGGGCAAGACCAGTGTC
GGGCGCTCGATTGCCGAGTCGCTGGGGCGACCGTTCTATCGCCTGAGCGTGGGCGGCATGCGCGACGAGGCGGAAATCAA
GGGCCACCGCCGTACCTATATCGGTGCGCAACCGGGCAAGCTGGTGCAGGCGTTGAAAGACGTTGAAGTCATGAACCCGG
TCATCATGCTCGATGAAATCGACAAGATGGGCCAGAGCTATCAGGGCGACCCGGCGTCTGCCCTGCTGGAAACCCTGGAC
CCGGAACAGAACGTCGAGTTTCTCGATCACTACCTGGACCTGCGCCTGGACCTCTCCAAGGTCCTGTTCGTGTGCACGGC
CAACACGCTGGACTCGATCCCCGGCCCGCTGCTTGACCGGATGGAAGTGATTCGCCTGTCCGGCTATATCACCGAAGAGA
AGCTGGCAATCGCCAAACGCCACTTGTGGCCCAAGCAGTTGGCGAAAGCCGGCGTTGCGAAAAACAAGCTGAGCATCAGC
GACAGCGCACTGCGCGCCGTCATCGAGGGTTACGCTCGCGAAGCCGGTGTGCGGCATCTGGAGAAACAGCTTGGCAAGCT
GGTGCGCAAAGCTGTCGTGAAACTGCTGGACGAGCCCGATTCAGTGATCAAGATCGGGCCGAAAGACCTCGAAGCGTCGC
TGGGCATGCCGGTGTTCCGCAGCGAACAGGTGCTGTCCGGCACCGGCGTGATCACCGGTCTGGCATGGACCAGTATGGGC
GGCGCTACCCTGCCGATCGAGGCGACGCGCATTCATACGCTCAACCGCGGCTTCAAGCTGACCGGGCAATTGGGCGATGT
GATGAAGGAGTCGGCCGAAATTGCCTACAGCTACGTCAGCGCCAATCTGTCGAAGTTTGGTGGTGATGCGAAGTTCTTCG
ATGAGGCGTTCGTGCACGTACACGTCCCCGAAGGTGCCACCCCGAAAGACGGCCCGAGTGCGGGTGTGACCATGGCCAGC
GCCTTGCTGTCCCTGGCCCGCAACCAGCCGCCGAAAAAAGGCGTCGCCATGACCGGCGAACTGACCCTGACCGGGCATGT
ACTGCCCATCGGCGGCGTCCGCGAAAAAGTCATTGCCGCGCGGCGCCAGAAGATCCACGAACTGATCCTGCCGGAGCCTA
ACCGTGGCAACTTCGAAGAACTGCCGGACTATCTCAAGGAAGGCATTACCGTGCACTTCGCCAAACGCTTCGCCGACGTG
GTGAAGGTGTTGTTCTAA

Upstream 100 bases:

>100_bases
TAACGGTTTTCCAACCGCTTTACAGACTATCGACCAAGACTATTGAAACCTGAGAGCCGCTGCCCCATCTAAGAGCCATG
TTCAACTTCTCAGGTGCCCC

Downstream 100 bases:

>100_bases
AGATTGATACTGCGCAGGTCCCACGCTGAACTGGCACAAGAGGTGTTCTATCGGGCGCCTCTCGTTCCGCACGCTCCAGC
GTGAGTGAGAATGCAGTTCT

Product: peptidase S16, ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 805; Mature: 804

Protein sequence:

>805_residues
MSDQQTDSPDLPNDADEHDVSLSSDSTSLALPGQNLPDKVYIIPIHNRPFFPAQVLPVIVNEEPWAETLELVSKSEHHSL
ALFFMDTPQEDPRHFKTDALPEYGTLVKVHHASRENGRLQFVAQGLSRVRIRTWLKHHRPPYLVEVEYPQQPNEPTDEVK
AYGMALINAIKELLPLNPLYSEELKNYLNRFSPNDPSPLTDFAAALTSATGVELQEVLDCVPMLRRMEKVLPMLRKEVEV
ARLQKEISAEVNRKIGEHQRQFFLKEQLKVIQQELGLSKDDRSADIEQFEQRLEGKTLPPQARKKFDEEIGKLKVLETGS
PEYAVTRNYLDWTSSLPWGVYGADKLDLKHARKVLDQHHAGLDDIKARILEFLAVGAYKGEISGSIVLLVGPPGVGKTSV
GRSIAESLGRPFYRLSVGGMRDEAEIKGHRRTYIGAQPGKLVQALKDVEVMNPVIMLDEIDKMGQSYQGDPASALLETLD
PEQNVEFLDHYLDLRLDLSKVLFVCTANTLDSIPGPLLDRMEVIRLSGYITEEKLAIAKRHLWPKQLAKAGVAKNKLSIS
DSALRAVIEGYAREAGVRHLEKQLGKLVRKAVVKLLDEPDSVIKIGPKDLEASLGMPVFRSEQVLSGTGVITGLAWTSMG
GATLPIEATRIHTLNRGFKLTGQLGDVMKESAEIAYSYVSANLSKFGGDAKFFDEAFVHVHVPEGATPKDGPSAGVTMAS
ALLSLARNQPPKKGVAMTGELTLTGHVLPIGGVREKVIAARRQKIHELILPEPNRGNFEELPDYLKEGITVHFAKRFADV
VKVLF

Sequences:

>Translated_805_residues
MSDQQTDSPDLPNDADEHDVSLSSDSTSLALPGQNLPDKVYIIPIHNRPFFPAQVLPVIVNEEPWAETLELVSKSEHHSL
ALFFMDTPQEDPRHFKTDALPEYGTLVKVHHASRENGRLQFVAQGLSRVRIRTWLKHHRPPYLVEVEYPQQPNEPTDEVK
AYGMALINAIKELLPLNPLYSEELKNYLNRFSPNDPSPLTDFAAALTSATGVELQEVLDCVPMLRRMEKVLPMLRKEVEV
ARLQKEISAEVNRKIGEHQRQFFLKEQLKVIQQELGLSKDDRSADIEQFEQRLEGKTLPPQARKKFDEEIGKLKVLETGS
PEYAVTRNYLDWTSSLPWGVYGADKLDLKHARKVLDQHHAGLDDIKARILEFLAVGAYKGEISGSIVLLVGPPGVGKTSV
GRSIAESLGRPFYRLSVGGMRDEAEIKGHRRTYIGAQPGKLVQALKDVEVMNPVIMLDEIDKMGQSYQGDPASALLETLD
PEQNVEFLDHYLDLRLDLSKVLFVCTANTLDSIPGPLLDRMEVIRLSGYITEEKLAIAKRHLWPKQLAKAGVAKNKLSIS
DSALRAVIEGYAREAGVRHLEKQLGKLVRKAVVKLLDEPDSVIKIGPKDLEASLGMPVFRSEQVLSGTGVITGLAWTSMG
GATLPIEATRIHTLNRGFKLTGQLGDVMKESAEIAYSYVSANLSKFGGDAKFFDEAFVHVHVPEGATPKDGPSAGVTMAS
ALLSLARNQPPKKGVAMTGELTLTGHVLPIGGVREKVIAARRQKIHELILPEPNRGNFEELPDYLKEGITVHFAKRFADV
VKVLF
>Mature_804_residues
SDQQTDSPDLPNDADEHDVSLSSDSTSLALPGQNLPDKVYIIPIHNRPFFPAQVLPVIVNEEPWAETLELVSKSEHHSLA
LFFMDTPQEDPRHFKTDALPEYGTLVKVHHASRENGRLQFVAQGLSRVRIRTWLKHHRPPYLVEVEYPQQPNEPTDEVKA
YGMALINAIKELLPLNPLYSEELKNYLNRFSPNDPSPLTDFAAALTSATGVELQEVLDCVPMLRRMEKVLPMLRKEVEVA
RLQKEISAEVNRKIGEHQRQFFLKEQLKVIQQELGLSKDDRSADIEQFEQRLEGKTLPPQARKKFDEEIGKLKVLETGSP
EYAVTRNYLDWTSSLPWGVYGADKLDLKHARKVLDQHHAGLDDIKARILEFLAVGAYKGEISGSIVLLVGPPGVGKTSVG
RSIAESLGRPFYRLSVGGMRDEAEIKGHRRTYIGAQPGKLVQALKDVEVMNPVIMLDEIDKMGQSYQGDPASALLETLDP
EQNVEFLDHYLDLRLDLSKVLFVCTANTLDSIPGPLLDRMEVIRLSGYITEEKLAIAKRHLWPKQLAKAGVAKNKLSISD
SALRAVIEGYAREAGVRHLEKQLGKLVRKAVVKLLDEPDSVIKIGPKDLEASLGMPVFRSEQVLSGTGVITGLAWTSMGG
ATLPIEATRIHTLNRGFKLTGQLGDVMKESAEIAYSYVSANLSKFGGDAKFFDEAFVHVHVPEGATPKDGPSAGVTMASA
LLSLARNQPPKKGVAMTGELTLTGHVLPIGGVREKVIAARRQKIHELILPEPNRGNFEELPDYLKEGITVHFAKRFADVV
KVLF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=837, Percent_Identity=41.0991636798088, Blast_Score=641, Evalue=0.0,
Organism=Homo sapiens, GI31377667, Length=748, Percent_Identity=37.1657754010695, Blast_Score=468, Evalue=1e-131,
Organism=Escherichia coli, GI1786643, Length=765, Percent_Identity=40.9150326797386, Blast_Score=556, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17505831, Length=703, Percent_Identity=42.9587482219061, Blast_Score=573, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17556486, Length=537, Percent_Identity=39.1061452513966, Blast_Score=419, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=724, Percent_Identity=44.475138121547, Blast_Score=601, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24666867, Length=682, Percent_Identity=47.2140762463343, Blast_Score=650, Evalue=0.0,
Organism=Drosophila melanogaster, GI221513036, Length=682, Percent_Identity=47.2140762463343, Blast_Score=650, Evalue=0.0,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89399; Mature: 89268

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQQTDSPDLPNDADEHDVSLSSDSTSLALPGQNLPDKVYIIPIHNRPFFPAQVLPVIV
CCCCCCCCCCCCCCCCCCCCEECCCCCEEEECCCCCCCEEEEEEECCCCCCCHHHEEEEE
NEEPWAETLELVSKSEHHSLALFFMDTPQEDPRHFKTDALPEYGTLVKVHHASRENGRLQ
CCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHH
FVAQGLSRVRIRTWLKHHRPPYLVEVEYPQQPNEPTDEVKAYGMALINAIKELLPLNPLY
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHH
SEELKNYLNRFSPNDPSPLTDFAAALTSATGVELQEVLDCVPMLRRMEKVLPMLRKEVEV
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLQKEISAEVNRKIGEHQRQFFLKEQLKVIQQELGLSKDDRSADIEQFEQRLEGKTLPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCH
QARKKFDEEIGKLKVLETGSPEYAVTRNYLDWTSSLPWGVYGADKLDLKHARKVLDQHHA
HHHHHHHHHHCCEEEEECCCCCEEEECCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GLDDIKARILEFLAVGAYKGEISGSIVLLVGPPGVGKTSVGRSIAESLGRPFYRLSVGGM
CHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCC
RDEAEIKGHRRTYIGAQPGKLVQALKDVEVMNPVIMLDEIDKMGQSYQGDPASALLETLD
CCHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHCC
PEQNVEFLDHYLDLRLDLSKVLFVCTANTLDSIPGPLLDRMEVIRLSGYITEEKLAIAKR
CCCCHHHHHHHHHHHHCHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
HLWPKQLAKAGVAKNKLSISDSALRAVIEGYAREAGVRHLEKQLGKLVRKAVVKLLDEPD
CCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SVIKIGPKDLEASLGMPVFRSEQVLSGTGVITGLAWTSMGGATLPIEATRIHTLNRGFKL
CEEEECCHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHCCCCCCCCEEHHHHHHHCCCEEE
TGQLGDVMKESAEIAYSYVSANLSKFGGDAKFFDEAFVHVHVPEGATPKDGPSAGVTMAS
ECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEECCCCCCCCCCCCHHHHHHH
ALLSLARNQPPKKGVAMTGELTLTGHVLPIGGVREKVIAARRQKIHELILPEPNRGNFEE
HHHHHHHCCCCCCCCEEECEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LPDYLKEGITVHFAKRFADVVKVLF
HHHHHHCCCCHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SDQQTDSPDLPNDADEHDVSLSSDSTSLALPGQNLPDKVYIIPIHNRPFFPAQVLPVIV
CCCCCCCCCCCCCCCCCCCEECCCCCEEEECCCCCCCEEEEEEECCCCCCCHHHEEEEE
NEEPWAETLELVSKSEHHSLALFFMDTPQEDPRHFKTDALPEYGTLVKVHHASRENGRLQ
CCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHH
FVAQGLSRVRIRTWLKHHRPPYLVEVEYPQQPNEPTDEVKAYGMALINAIKELLPLNPLY
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHH
SEELKNYLNRFSPNDPSPLTDFAAALTSATGVELQEVLDCVPMLRRMEKVLPMLRKEVEV
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLQKEISAEVNRKIGEHQRQFFLKEQLKVIQQELGLSKDDRSADIEQFEQRLEGKTLPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCH
QARKKFDEEIGKLKVLETGSPEYAVTRNYLDWTSSLPWGVYGADKLDLKHARKVLDQHHA
HHHHHHHHHHCCEEEEECCCCCEEEECCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GLDDIKARILEFLAVGAYKGEISGSIVLLVGPPGVGKTSVGRSIAESLGRPFYRLSVGGM
CHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCC
RDEAEIKGHRRTYIGAQPGKLVQALKDVEVMNPVIMLDEIDKMGQSYQGDPASALLETLD
CCHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHCC
PEQNVEFLDHYLDLRLDLSKVLFVCTANTLDSIPGPLLDRMEVIRLSGYITEEKLAIAKR
CCCCHHHHHHHHHHHHCHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
HLWPKQLAKAGVAKNKLSISDSALRAVIEGYAREAGVRHLEKQLGKLVRKAVVKLLDEPD
CCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SVIKIGPKDLEASLGMPVFRSEQVLSGTGVITGLAWTSMGGATLPIEATRIHTLNRGFKL
CEEEECCHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHCCCCCCCCEEHHHHHHHCCCEEE
TGQLGDVMKESAEIAYSYVSANLSKFGGDAKFFDEAFVHVHVPEGATPKDGPSAGVTMAS
ECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEECCCCCCCCCCCCHHHHHHH
ALLSLARNQPPKKGVAMTGELTLTGHVLPIGGVREKVIAARRQKIHELILPEPNRGNFEE
HHHHHHHCCCCCCCCEEECEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LPDYLKEGITVHFAKRFADVVKVLF
HHHHHHCCCCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA