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The map label for this gene is hisM [H]

Identifier: 66047103

GI number: 66047103

Start: 4616996

End: 4617706

Strand: Direct

Name: hisM [H]

Synonym: Psyr_3876

Alternate gene names: 66047103

Gene position: 4616996-4617706 (Clockwise)

Preceding gene: 66047102

Following gene: 66047104

Centisome position: 75.77

GC content: 60.06

Gene sequence:

>711_bases
ATGATCGAATTGCTGCAGGAATACTGGAAACCCTTCCTTTATACAGATGGCGTCAACGTCACCGGCCTGGCGATGACCAT
GTGGCTGCTCAGCGCCTCCATCGCTATCGGCTTCTGCGTGTCGATCCCGCTGTCGATTGCGCGGGTGTCGAGAAACCGCT
GGGTGCGCTGGCCGGTGCAGTTCTACACCTACCTGTTTCGCGGCACGCCCCTCTATATACAGCTGCTGATCTGCTACACC
GGCATTTACAGCCTTGCCGCGGTGCGTGAACAGCCGATGCTCGATGCGTTCTTTCGCGATGCGATGAACTGCACGATCCT
GGCCTTCACCCTGAACACCTGCGCCTACACCACGGAGATCTTTGCCGGGGCGATCCGCAGCATGGCCCACGGCGAAGTCG
AAGCGGCCAAGGCCTACGGCCTGACCGGCTGGAAGCTTTACGCCTACGTGATCATGCCGTCGGTGCTGCGCCGCTCTCTG
CCGTATTACAGCAACGAAGTAATACTGATGCTGCACTCGACCACCGTGGCTTTTACCGCCACGGTGCCGGACATCCTGAA
AGTGGCGCGGGATGCCAACTCCGCCACCTTCATGACCTTCCAGTCCTTCGGTATCGCCGCCGTGATGTACCTGACCGTGA
CGTTCATTCTGGTCGGGCTGTTCCGCCTTGCCGAACGCCGCTGGCTGGCTTTTCTCGGCCCGGCCCATTAA

Upstream 100 bases:

>100_bases
TGCTGGCAGCATTGATCTACCTGCTGATCACCAGCGCCTCGAACTTCGCCCTGCGTTGGGCTGAGCGGTATTACGCCGCA
GGCAGCCGGGAGGCACAGCG

Downstream 100 bases:

>100_bases
TCAGGACTGAACATGCGCCATCATACCCATGACTTGCTGTCGCCAGTGCCGGGCACTGGCCGGCAAATCCACAGCTTCCA
TTACGGGCCGCAAAACGGCG

Product: amino acid ABC transporter permease

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MIELLQEYWKPFLYTDGVNVTGLAMTMWLLSASIAIGFCVSIPLSIARVSRNRWVRWPVQFYTYLFRGTPLYIQLLICYT
GIYSLAAVREQPMLDAFFRDAMNCTILAFTLNTCAYTTEIFAGAIRSMAHGEVEAAKAYGLTGWKLYAYVIMPSVLRRSL
PYYSNEVILMLHSTTVAFTATVPDILKVARDANSATFMTFQSFGIAAVMYLTVTFILVGLFRLAERRWLAFLGPAH

Sequences:

>Translated_236_residues
MIELLQEYWKPFLYTDGVNVTGLAMTMWLLSASIAIGFCVSIPLSIARVSRNRWVRWPVQFYTYLFRGTPLYIQLLICYT
GIYSLAAVREQPMLDAFFRDAMNCTILAFTLNTCAYTTEIFAGAIRSMAHGEVEAAKAYGLTGWKLYAYVIMPSVLRRSL
PYYSNEVILMLHSTTVAFTATVPDILKVARDANSATFMTFQSFGIAAVMYLTVTFILVGLFRLAERRWLAFLGPAH
>Mature_236_residues
MIELLQEYWKPFLYTDGVNVTGLAMTMWLLSASIAIGFCVSIPLSIARVSRNRWVRWPVQFYTYLFRGTPLYIQLLICYT
GIYSLAAVREQPMLDAFFRDAMNCTILAFTLNTCAYTTEIFAGAIRSMAHGEVEAAKAYGLTGWKLYAYVIMPSVLRRSL
PYYSNEVILMLHSTTVAFTATVPDILKVARDANSATFMTFQSFGIAAVMYLTVTFILVGLFRLAERRWLAFLGPAH

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=235, Percent_Identity=59.5744680851064, Blast_Score=308, Evalue=2e-85,
Organism=Escherichia coli, GI1787086, Length=210, Percent_Identity=32.3809523809524, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788226, Length=200, Percent_Identity=30.5, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787030, Length=209, Percent_Identity=27.7511961722488, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1788646, Length=214, Percent_Identity=28.9719626168224, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1786873, Length=189, Percent_Identity=25.9259259259259, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787087, Length=207, Percent_Identity=21.7391304347826, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786874, Length=214, Percent_Identity=26.6355140186916, Blast_Score=60, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26693; Mature: 26693

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELLQEYWKPFLYTDGVNVTGLAMTMWLLSASIAIGFCVSIPLSIARVSRNRWVRWPVQ
CHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHH
FYTYLFRGTPLYIQLLICYTGIYSLAAVREQPMLDAFFRDAMNCTILAFTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHH
FAGAIRSMAHGEVEAAKAYGLTGWKLYAYVIMPSVLRRSLPYYSNEVILMLHSTTVAFTA
HHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCEEEEEE
TVPDILKVARDANSATFMTFQSFGIAAVMYLTVTFILVGLFRLAERRWLAFLGPAH
HHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIELLQEYWKPFLYTDGVNVTGLAMTMWLLSASIAIGFCVSIPLSIARVSRNRWVRWPVQ
CHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHH
FYTYLFRGTPLYIQLLICYTGIYSLAAVREQPMLDAFFRDAMNCTILAFTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHH
FAGAIRSMAHGEVEAAKAYGLTGWKLYAYVIMPSVLRRSLPYYSNEVILMLHSTTVAFTA
HHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCEEEEEE
TVPDILKVARDANSATFMTFQSFGIAAVMYLTVTFILVGLFRLAERRWLAFLGPAH
HHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]