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The map label for this gene is hisQ [H]

Identifier: 66047102

GI number: 66047102

Start: 4616271

End: 4616999

Strand: Direct

Name: hisQ [H]

Synonym: Psyr_3875

Alternate gene names: 66047102

Gene position: 4616271-4616999 (Clockwise)

Preceding gene: 66047101

Following gene: 66047103

Centisome position: 75.75

GC content: 59.81

Gene sequence:

>729_bases
ATGCTCGATGCACTCATGCAAAACCTGGGACTCTCGGCATTCAGCCTGAAGGGCTTTGGCCCGCTGTTGCTGGAAGGCAC
CTGGATGACCGTCAAACTGGCTGTGCTGTCGCTTGCGCTGAGCATTTTGCTCGGACTGATCGGGGCCAGCGCCAAACTGT
CGAGCTCTGCGCTGCTGCGCGTGCCGGCGCAAATCTACACGACACTGATCCGCGGTGTTCCGGACCTGGTGTTGATGCTG
CTGATTTTCTACAGCCTGCAAACCTGGCTCACCATGCTGACCGACGCGATGGAATGGGAATACATCGAGATCAACCCGTT
CGGCGCAGGCGTCATCACCCTGGGCTTCATCTATGGCGCGTACTTCACCGAGACCTTTCGCGGCGCGATTCTGTCCGTGC
CTCGCGGTCAGGTGGAAGCAGCGACGGCCTATGGATTGAAACGCGGCCAGCGATTTCGTTACGTCGTGTTCCCGCAGATG
ATGCGTTACGCGCTGCCGGGGATCGGCAACAACTGGCAGGTGCTGCTCAAGGCGACTGCGCTGGTATCGATCATCGGCCT
GGCCGATCTGGTCAAGGCGTCACAGGATGCGGGCAAGAGCACCTATCAGCTGTTCTACTTTCTGGTGCTGGCAGCATTGA
TCTACCTGCTGATCACCAGCGCCTCGAACTTCGCCCTGCGTTGGGCTGAGCGGTATTACGCCGCAGGCAGCCGGGAGGCA
CAGCGATGA

Upstream 100 bases:

>100_bases
TGAACCTCTACAGCGGTAAATAACACCCCGACGCCCATCGATTTCGGCGATCATTCGTTGCCCGATCGGTGGGCGTTTTT
GTTGGTAACAAGGCCTATCC

Downstream 100 bases:

>100_bases
TCGAATTGCTGCAGGAATACTGGAAACCCTTCCTTTATACAGATGGCGTCAACGTCACCGGCCTGGCGATGACCATGTGG
CTGCTCAGCGCCTCCATCGC

Product: amino acid ABC transporter permease

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MLDALMQNLGLSAFSLKGFGPLLLEGTWMTVKLAVLSLALSILLGLIGASAKLSSSALLRVPAQIYTTLIRGVPDLVLML
LIFYSLQTWLTMLTDAMEWEYIEINPFGAGVITLGFIYGAYFTETFRGAILSVPRGQVEAATAYGLKRGQRFRYVVFPQM
MRYALPGIGNNWQVLLKATALVSIIGLADLVKASQDAGKSTYQLFYFLVLAALIYLLITSASNFALRWAERYYAAGSREA
QR

Sequences:

>Translated_242_residues
MLDALMQNLGLSAFSLKGFGPLLLEGTWMTVKLAVLSLALSILLGLIGASAKLSSSALLRVPAQIYTTLIRGVPDLVLML
LIFYSLQTWLTMLTDAMEWEYIEINPFGAGVITLGFIYGAYFTETFRGAILSVPRGQVEAATAYGLKRGQRFRYVVFPQM
MRYALPGIGNNWQVLLKATALVSIIGLADLVKASQDAGKSTYQLFYFLVLAALIYLLITSASNFALRWAERYYAAGSREA
QR
>Mature_242_residues
MLDALMQNLGLSAFSLKGFGPLLLEGTWMTVKLAVLSLALSILLGLIGASAKLSSSALLRVPAQIYTTLIRGVPDLVLML
LIFYSLQTWLTMLTDAMEWEYIEINPFGAGVITLGFIYGAYFTETFRGAILSVPRGQVEAATAYGLKRGQRFRYVVFPQM
MRYALPGIGNNWQVLLKATALVSIIGLADLVKASQDAGKSTYQLFYFLVLAALIYLLITSASNFALRWAERYYAAGSREA
QR

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=226, Percent_Identity=58.4070796460177, Blast_Score=267, Evalue=6e-73,
Organism=Escherichia coli, GI1787087, Length=212, Percent_Identity=36.3207547169811, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1787030, Length=211, Percent_Identity=34.5971563981043, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1788645, Length=206, Percent_Identity=33.495145631068, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1788226, Length=200, Percent_Identity=31.5, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786873, Length=216, Percent_Identity=26.3888888888889, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786874, Length=184, Percent_Identity=28.804347826087, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787086, Length=219, Percent_Identity=27.3972602739726, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI87082239, Length=215, Percent_Identity=28.8372093023256, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26647; Mature: 26647

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDALMQNLGLSAFSLKGFGPLLLEGTWMTVKLAVLSLALSILLGLIGASAKLSSSALLR
CHHHHHHHCCCCEEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
VPAQIYTTLIRGVPDLVLMLLIFYSLQTWLTMLTDAMEWEYIEINPFGAGVITLGFIYGA
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHH
YFTETFRGAILSVPRGQVEAATAYGLKRGQRFRYVVFPQMMRYALPGIGNNWQVLLKATA
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCCCHHHHHHHHH
LVSIIGLADLVKASQDAGKSTYQLFYFLVLAALIYLLITSASNFALRWAERYYAAGSREA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
QR
CC
>Mature Secondary Structure
MLDALMQNLGLSAFSLKGFGPLLLEGTWMTVKLAVLSLALSILLGLIGASAKLSSSALLR
CHHHHHHHCCCCEEECCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
VPAQIYTTLIRGVPDLVLMLLIFYSLQTWLTMLTDAMEWEYIEINPFGAGVITLGFIYGA
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHH
YFTETFRGAILSVPRGQVEAATAYGLKRGQRFRYVVFPQMMRYALPGIGNNWQVLLKATA
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCCCHHHHHHHHH
LVSIIGLADLVKASQDAGKSTYQLFYFLVLAALIYLLITSASNFALRWAERYYAAGSREA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
QR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]