Click here to switch to the map view.

The map label for this gene is ppiA [H]

Identifier: 66047053

GI number: 66047053

Start: 4554341

End: 4554904

Strand: Direct

Name: ppiA [H]

Synonym: Psyr_3826

Alternate gene names: 66047053

Gene position: 4554341-4554904 (Clockwise)

Preceding gene: 66047052

Following gene: 66047054

Centisome position: 74.74

GC content: 57.09

Gene sequence:

>564_bases
ATGCTGAAAAAAATCGCTCTCGCCGCCTGCTCCGTGCTGTTCGCCGCCAACCTGATGGCTGCCCCGGATAAAGCCACGCA
CGTGGTGCTCGACACCAGTTTCGGCCAGATTGAAATCGAACTCGCAGACACCAAGGCGCCGGTCAGCACCCAGAACTTTC
TGGGTTATGTCGACAGCGGCTTCTACACCAACACCATCTTTCACCGGGTGATTCCGGGCTTCATGGTGCAAGGCGGTGGC
TTCACCCCGCAGATGGTTCAGAAGCAGACCAAGGATCCGATCAAGAACGAAGCCCAGAACGGTTTGCATAACGTCCGCGG
CACCATTGCCATGGCGCGTACCTCGGACGTGAACTCGGCCACCAGTCAATTCTTCATCAACACCAACGACAATGCCATGC
TCGACAACGGCGCACGCGACTTCGGTTACGCAGTGTTCGGCAAAGTCGTCAAGGGCATGGACGTCGTCGACAACATCGTC
AACGCCCGCACCACTACTCAGAAAGGCATGCAAAACGTGCCAGTCGACCCGATCCTGATCAAGTCCGCCAAACGCGTCAA
CTGA

Upstream 100 bases:

>100_bases
TGAAGTGCTGCAAACCCGCCAATACGCTGGGCAAAAAAAGCCAAACGTGGTTACCTTGCCGGTCACAGTCGATATCTCTT
AATGAAGGACGTGTTGCCAC

Downstream 100 bases:

>100_bases
TCGGGAAACCTGCACCGCATGAAGCCTTGGGCTTCGTGCGGTCCGGACGGGAGAGCCTCCACTTATCAAGGAGAACCCAC
GTCGCGTGGGTGTGATAGCC

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MLKKIALAACSVLFAANLMAAPDKATHVVLDTSFGQIEIELADTKAPVSTQNFLGYVDSGFYTNTIFHRVIPGFMVQGGG
FTPQMVQKQTKDPIKNEAQNGLHNVRGTIAMARTSDVNSATSQFFINTNDNAMLDNGARDFGYAVFGKVVKGMDVVDNIV
NARTTTQKGMQNVPVDPILIKSAKRVN

Sequences:

>Translated_187_residues
MLKKIALAACSVLFAANLMAAPDKATHVVLDTSFGQIEIELADTKAPVSTQNFLGYVDSGFYTNTIFHRVIPGFMVQGGG
FTPQMVQKQTKDPIKNEAQNGLHNVRGTIAMARTSDVNSATSQFFINTNDNAMLDNGARDFGYAVFGKVVKGMDVVDNIV
NARTTTQKGMQNVPVDPILIKSAKRVN
>Mature_187_residues
MLKKIALAACSVLFAANLMAAPDKATHVVLDTSFGQIEIELADTKAPVSTQNFLGYVDSGFYTNTIFHRVIPGFMVQGGG
FTPQMVQKQTKDPIKNEAQNGLHNVRGTIAMARTSDVNSATSQFFINTNDNAMLDNGARDFGYAVFGKVVKGMDVVDNIV
NARTTTQKGMQNVPVDPILIKSAKRVN

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=147, Percent_Identity=36.0544217687075, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI24308049, Length=175, Percent_Identity=30.8571428571429, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI64276486, Length=126, Percent_Identity=38.0952380952381, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI22547212, Length=157, Percent_Identity=34.3949044585987, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI7657473, Length=157, Percent_Identity=34.3949044585987, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI22547215, Length=157, Percent_Identity=34.3949044585987, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI7706339, Length=176, Percent_Identity=32.3863636363636, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789763, Length=185, Percent_Identity=62.7027027027027, Blast_Score=223, Evalue=7e-60,
Organism=Escherichia coli, GI1786736, Length=158, Percent_Identity=54.4303797468354, Blast_Score=164, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17532641, Length=163, Percent_Identity=32.5153374233129, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=157, Percent_Identity=35.6687898089172, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=146, Percent_Identity=36.3013698630137, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=135, Percent_Identity=37.7777777777778, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539498, Length=159, Percent_Identity=35.2201257861635, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=192, Percent_Identity=33.8541666666667, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323562, Length=161, Percent_Identity=34.1614906832298, Blast_Score=66, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321848, Length=151, Percent_Identity=36.4238410596026, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17986117, Length=176, Percent_Identity=34.6590909090909, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19922376, Length=167, Percent_Identity=31.1377245508982, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19922912, Length=158, Percent_Identity=36.0759493670886, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45549139, Length=148, Percent_Identity=35.8108108108108, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24664125, Length=132, Percent_Identity=37.1212121212121, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357783, Length=132, Percent_Identity=37.1212121212121, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20229; Mature: 20229

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKIALAACSVLFAANLMAAPDKATHVVLDTSFGQIEIELADTKAPVSTQNFLGYVDSG
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHCCC
FYTNTIFHRVIPGFMVQGGGFTPQMVQKQTKDPIKNEAQNGLHNVRGTIAMARTSDVNSA
CHHHHHHHHHCCCCEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHEEEEEECCCCCCC
TSQFFINTNDNAMLDNGARDFGYAVFGKVVKGMDVVDNIVNARTTTQKGMQNVPVDPILI
CCEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
KSAKRVN
CCCCCCC
>Mature Secondary Structure
MLKKIALAACSVLFAANLMAAPDKATHVVLDTSFGQIEIELADTKAPVSTQNFLGYVDSG
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHCCC
FYTNTIFHRVIPGFMVQGGGFTPQMVQKQTKDPIKNEAQNGLHNVRGTIAMARTSDVNSA
CHHHHHHHHHCCCCEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHEEEEEECCCCCCC
TSQFFINTNDNAMLDNGARDFGYAVFGKVVKGMDVVDNIVNARTTTQKGMQNVPVDPILI
CCEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
KSAKRVN
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 8581173 [H]