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The map label for this gene is nrdB [H]

Identifier: 66046950

GI number: 66046950

Start: 4409880

End: 4411127

Strand: Direct

Name: nrdB [H]

Synonym: Psyr_3721

Alternate gene names: 66046950

Gene position: 4409880-4411127 (Clockwise)

Preceding gene: 66046949

Following gene: 66046954

Centisome position: 72.37

GC content: 58.57

Gene sequence:

>1248_bases
ATGCTGAGCTGGGACGAATTCGATAAGGAAGACGGCGAAGTAGTCGCCAAAGCGACCAACGCCGGTCATGCCAACGAAGC
CAACATGGACCGCCTCGACAGCGCCGGTGGCCTGGCTGCACAGGAAGCCCGCGCCGTGACCGCCGCCGACTCCGCTGCCC
TGATCCGCGCCAAGAAAGCGCTGGACGCACTGGACGTCGCTGAAGGCCTGGCCGAGCTCGAAGGCGCCAGCGCCCGCGTC
GCCGTTGACGAAAAAATGATGATCAACTGCCGCGCCGACCTCAACCAGCTCGTGCCTTTCAAGTACGACTGGGCCTGGCA
GAAGTACCTGGACGGTTGCGCAAACCACTGGATGCCGCAAGAAGTCAACATGACCGCCGACATCGCCCTCTGGAAAAACC
CGGAAGGCCTGACCGACGACGAGCGCCGCATCGTCATGCGTAACCTGGGCTTCTTCTCCACTGCCGACTCGCTGGTTGCC
AACAACCTGGTATTGGCCGTGTATCGCCTGATCACCAACCCGGAGTGCCGCCAGTACATCCTGCGCCAGGCCTTCGAAGA
GGCGATCCACACCCACGCCTACCAGTACTGCATCGAATCGCTGGCCATGGATGAAGGCGAGATCTTCAACATGTACCACG
AGATCCCGTCGGTCGCTAAAAAAGCAGCCTGGGGCCTGAAGTACACCCGTTCGATCTCCGATCCGAAGTTCGAAACCGGC
ACCGTCGACACCGACAAAGAGCTGCTGCGCAACCTGATCGCCTACTACTGCGTTCTGGAAGGCATTTTCTTCTATTGCGG
CTTCACCCAGATTCTCTCGATGGGCCGCCGCAACAAGATGACCGGCGTTGCCGAGCAGTTCCAGTACATCCTGCGCGACG
AGTCCATGCACCTGAACTTCGGCATCGACGTGATCAACCAGATCAAAATCGAAAACCCGCACCTGTGGGATGCCGAGATG
AAAGAAGAAGCCACGCAGATGATCCTGCAAGGCACCCAGCTGGAAATCGAATACGCCCGCGACACCATGCCCCGCGGCGT
ACTCGGCATGAACGCTGCGATGATGGAAGACTACCTGAAATTCATCGCTAACCGCCGCTTGAGCCAGATTGGCTTGAAGG
AAGAGTATCCAGGGACGACCAACCCGTTCCCCTGGATGAGCGAGATCATGGACTTGAAGAAAGAGAAGAACTTCTTTGAG
ACTCGGGTTATTGAGTATCAGACGGGCGGGGCGTTGAGCTGGGATTGA

Upstream 100 bases:

>100_bases
CATACTCCAGTGCCTTCGTCTTCCACGTGACGTCGGCGCACCACATCTTGAAATCTAATCACGGGCGCCAAGGCGACCCC
TAAGCAGGAGCCTCATCACC

Downstream 100 bases:

>100_bases
TTTGCATCCCGCGGAGTTGCAATAAAAGCTGAACCCATCTCATCAAAAATGAAACGGGTTCTGAGAAAAGGGCTGCCAAC
TGGCAGCCTTTTTTATTTTT

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MLSWDEFDKEDGEVVAKATNAGHANEANMDRLDSAGGLAAQEARAVTAADSAALIRAKKALDALDVAEGLAELEGASARV
AVDEKMMINCRADLNQLVPFKYDWAWQKYLDGCANHWMPQEVNMTADIALWKNPEGLTDDERRIVMRNLGFFSTADSLVA
NNLVLAVYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLAMDEGEIFNMYHEIPSVAKKAAWGLKYTRSISDPKFETG
TVDTDKELLRNLIAYYCVLEGIFFYCGFTQILSMGRRNKMTGVAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDAEM
KEEATQMILQGTQLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLSQIGLKEEYPGTTNPFPWMSEIMDLKKEKNFFE
TRVIEYQTGGALSWD

Sequences:

>Translated_415_residues
MLSWDEFDKEDGEVVAKATNAGHANEANMDRLDSAGGLAAQEARAVTAADSAALIRAKKALDALDVAEGLAELEGASARV
AVDEKMMINCRADLNQLVPFKYDWAWQKYLDGCANHWMPQEVNMTADIALWKNPEGLTDDERRIVMRNLGFFSTADSLVA
NNLVLAVYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLAMDEGEIFNMYHEIPSVAKKAAWGLKYTRSISDPKFETG
TVDTDKELLRNLIAYYCVLEGIFFYCGFTQILSMGRRNKMTGVAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDAEM
KEEATQMILQGTQLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLSQIGLKEEYPGTTNPFPWMSEIMDLKKEKNFFE
TRVIEYQTGGALSWD
>Mature_415_residues
MLSWDEFDKEDGEVVAKATNAGHANEANMDRLDSAGGLAAQEARAVTAADSAALIRAKKALDALDVAEGLAELEGASARV
AVDEKMMINCRADLNQLVPFKYDWAWQKYLDGCANHWMPQEVNMTADIALWKNPEGLTDDERRIVMRNLGFFSTADSLVA
NNLVLAVYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLAMDEGEIFNMYHEIPSVAKKAAWGLKYTRSISDPKFETG
TVDTDKELLRNLIAYYCVLEGIFFYCGFTQILSMGRRNKMTGVAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDAEM
KEEATQMILQGTQLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLSQIGLKEEYPGTTNPFPWMSEIMDLKKEKNFFE
TRVIEYQTGGALSWD

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI4557845, Length=386, Percent_Identity=27.4611398963731, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI260064013, Length=386, Percent_Identity=27.4611398963731, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI42544136, Length=320, Percent_Identity=28.4375, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI289177074, Length=355, Percent_Identity=26.7605633802817, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI289177076, Length=296, Percent_Identity=28.7162162162162, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI1788567, Length=298, Percent_Identity=25.8389261744966, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17551968, Length=321, Percent_Identity=29.9065420560748, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI193206379, Length=297, Percent_Identity=25.2525252525253, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17567153, Length=224, Percent_Identity=26.7857142857143, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322434, Length=334, Percent_Identity=30.2395209580838, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6321619, Length=320, Percent_Identity=23.125, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18079279, Length=320, Percent_Identity=30.3125, Blast_Score=151, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 47214; Mature: 47214

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSWDEFDKEDGEVVAKATNAGHANEANMDRLDSAGGLAAQEARAVTAADSAALIRAKKA
CCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHH
LDALDVAEGLAELEGASARVAVDEKMMINCRADLNQLVPFKYDWAWQKYLDGCANHWMPQ
HHHHHHHHHHHHHCCCCEEEEECCHHEEEEHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
EVNMTADIALWKNPEGLTDDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNPECRQYI
CCCCEEEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LRQAFEEAIHTHAYQYCIESLAMDEGEIFNMYHEIPSVAKKAAWGLKYTRSISDPKFETG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCC
TVDTDKELLRNLIAYYCVLEGIFFYCGFTQILSMGRRNKMTGVAEQFQYILRDESMHLNF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEE
GIDVINQIKIENPHLWDAEMKEEATQMILQGTQLEIEYARDTMPRGVLGMNAAMMEDYLK
CHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEHHCCCCCCHHHCHHHHHHHHHH
FIANRRLSQIGLKEEYPGTTNPFPWMSEIMDLKKEKNFFETRVIEYQTGGALSWD
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHEEEEECCCCCCCC
>Mature Secondary Structure
MLSWDEFDKEDGEVVAKATNAGHANEANMDRLDSAGGLAAQEARAVTAADSAALIRAKKA
CCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHH
LDALDVAEGLAELEGASARVAVDEKMMINCRADLNQLVPFKYDWAWQKYLDGCANHWMPQ
HHHHHHHHHHHHHCCCCEEEEECCHHEEEEHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
EVNMTADIALWKNPEGLTDDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNPECRQYI
CCCCEEEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LRQAFEEAIHTHAYQYCIESLAMDEGEIFNMYHEIPSVAKKAAWGLKYTRSISDPKFETG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCC
TVDTDKELLRNLIAYYCVLEGIFFYCGFTQILSMGRRNKMTGVAEQFQYILRDESMHLNF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEE
GIDVINQIKIENPHLWDAEMKEEATQMILQGTQLEIEYARDTMPRGVLGMNAAMMEDYLK
CHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEHHCCCCCCHHHCHHHHHHHHHH
FIANRRLSQIGLKEEYPGTTNPFPWMSEIMDLKKEKNFFETRVIEYQTGGALSWD
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]