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The map label for this gene is fumC-1 [H]

Identifier: 66046890

GI number: 66046890

Start: 4347509

End: 4348903

Strand: Direct

Name: fumC-1 [H]

Synonym: Psyr_3661

Alternate gene names: 66046890

Gene position: 4347509-4348903 (Clockwise)

Preceding gene: 66046882

Following gene: 66046891

Centisome position: 71.34

GC content: 62.87

Gene sequence:

>1395_bases
GTGAGCCGCACCGAAACCGATAGCATTGGCCCGATCGAAGTCCCCGAAGATGCCTACTGGGGCGCGCAGACCCAACGCTC
ACTGATCAATTTTGCGATTGGCGACCAGCGAATGCCGCTGCCCGTCCTGCACGCACTGACCCTGATCAAGAAAGCTGCCG
CACGGGTCAACGATCGAAATGGCGACTTGCCTGCCGACATCGCCCGCCTGATCGAACAGGCCGCCGACGAAGTGCTCGAC
GGTCAGCATGACGCGCAATTTCCGCTGGTGGTCTGGCAGACCGGCAGTGGCACGCAGAGCAACATGAACGTCAACGAGGT
GATCGCAGGCCGCGCCAACGAACTGGCTGGCCAGGGGCGTGGCGGCAAGTCACCGGTTCACCCCAACGATCATGTCAACC
GCTCGCAAAGCTCCAACGACTGCTTCCCGACGGCCATGCACATTGCCACTGCCCAGGCGGTCAAGGCGCAGCTGCTGCCG
GCCATCGCCGAACTGTCCAGCGGGCTGGCTGAACAGGCCGCGCGGCACATGAAGCTGGTCAAGACCGGGCGCACACACAT
GATGGACGCGACGCCGATCACCTTCGGCCAGGAGCTGTCCGGGTTTGTCGCGCAACTCGATTATGCGGAAAAAGCCATTC
GCGCCGCCCTGCCCGCCGTCTACGAGCTGGCTCAGGGCGGAACAGCAGTCGGCACCGGGCTCAATGCGCCCAAGGGCTTT
GCCGAAGCCATTGCCGCAGAACTGGCCGCTCTCTCAGGCCTGCCATTCGTTACCGCACCCAACAAGTTCGCCGCGCTGGC
CGGTCACGAGCCACTTGCAGCGCTGTCCGGCGCACTGAAGACGCTGGCCGGCACACTGATGAAGATTGCCAACGACCTGC
GTCTGCTGGGCTCAGGCCCGCGTGCCGGTCTGGCAGAAGTCAGACTGCCTGCCAACGAGCCCGGCAGTTCGATCATGCCC
GGCAAGGTCAACCCGACCCAGTGCGAGGCCTTGTCGATGCTCGCCTGCCAGGTCATGGGCAACGACGTGACCATCGGTTT
CGCCGCCAGTCAGGGCCACCTGCAACTGAACGTGTACAAGCCGGTGATCATCCATAACGTTCTGCAGTCGATTCGCCTGC
TGGCCGACGGCTGCAGCAATTTCAACGAGCACTGCATCGCGGGCATGGAGCCGGATGGCGAAAAAATGGCCGAACACCTG
GAGCGCGGCCTGATGCTGGTCACCGCACTCAATCCGCATATCGGCTATGACAAGTCGGCGCAGATTGCCAAGAAAGCCTA
CACCGAAGGTCTGACCCTGCGCGAAGCGGCATTGGCGCTGGGTTACCTGACCGATGAAGAGTTCGATGCCTGGGTGCGGC
CGGACAAAATGCTCGAGGCAGGCAGTAATGGCTGA

Upstream 100 bases:

>100_bases
GCTCAACCCCCGGTTCACCCAGCGGTTAAAAAGCACTGCGCGGGAACCCTGTGGGCATATGGACACCTAACCCTGCAACG
CACTTAAAGGAGTAAGACCA

Downstream 100 bases:

>100_bases
TGCCAGAAGCGGCGCAACGCCACTGGAAGGCAATGGCAAACGAATCCTGATGGTCTACGGCACGCCGAAGGCCATCAGTT
TCTGCCACGCCCTGGGTGAC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSRTETDSIGPIEVPEDAYWGAQTQRSLINFAIGDQRMPLPVLHALTLIKKAAARVNDRNGDLPADIARLIEQAADEVLD
GQHDAQFPLVVWQTGSGTQSNMNVNEVIAGRANELAGQGRGGKSPVHPNDHVNRSQSSNDCFPTAMHIATAQAVKAQLLP
AIAELSSGLAEQAARHMKLVKTGRTHMMDATPITFGQELSGFVAQLDYAEKAIRAALPAVYELAQGGTAVGTGLNAPKGF
AEAIAAELAALSGLPFVTAPNKFAALAGHEPLAALSGALKTLAGTLMKIANDLRLLGSGPRAGLAEVRLPANEPGSSIMP
GKVNPTQCEALSMLACQVMGNDVTIGFAASQGHLQLNVYKPVIIHNVLQSIRLLADGCSNFNEHCIAGMEPDGEKMAEHL
ERGLMLVTALNPHIGYDKSAQIAKKAYTEGLTLREAALALGYLTDEEFDAWVRPDKMLEAGSNG

Sequences:

>Translated_464_residues
MSRTETDSIGPIEVPEDAYWGAQTQRSLINFAIGDQRMPLPVLHALTLIKKAAARVNDRNGDLPADIARLIEQAADEVLD
GQHDAQFPLVVWQTGSGTQSNMNVNEVIAGRANELAGQGRGGKSPVHPNDHVNRSQSSNDCFPTAMHIATAQAVKAQLLP
AIAELSSGLAEQAARHMKLVKTGRTHMMDATPITFGQELSGFVAQLDYAEKAIRAALPAVYELAQGGTAVGTGLNAPKGF
AEAIAAELAALSGLPFVTAPNKFAALAGHEPLAALSGALKTLAGTLMKIANDLRLLGSGPRAGLAEVRLPANEPGSSIMP
GKVNPTQCEALSMLACQVMGNDVTIGFAASQGHLQLNVYKPVIIHNVLQSIRLLADGCSNFNEHCIAGMEPDGEKMAEHL
ERGLMLVTALNPHIGYDKSAQIAKKAYTEGLTLREAALALGYLTDEEFDAWVRPDKMLEAGSNG
>Mature_463_residues
SRTETDSIGPIEVPEDAYWGAQTQRSLINFAIGDQRMPLPVLHALTLIKKAAARVNDRNGDLPADIARLIEQAADEVLDG
QHDAQFPLVVWQTGSGTQSNMNVNEVIAGRANELAGQGRGGKSPVHPNDHVNRSQSSNDCFPTAMHIATAQAVKAQLLPA
IAELSSGLAEQAARHMKLVKTGRTHMMDATPITFGQELSGFVAQLDYAEKAIRAALPAVYELAQGGTAVGTGLNAPKGFA
EAIAAELAALSGLPFVTAPNKFAALAGHEPLAALSGALKTLAGTLMKIANDLRLLGSGPRAGLAEVRLPANEPGSSIMPG
KVNPTQCEALSMLACQVMGNDVTIGFAASQGHLQLNVYKPVIIHNVLQSIRLLADGCSNFNEHCIAGMEPDGEKMAEHLE
RGLMLVTALNPHIGYDKSAQIAKKAYTEGLTLREAALALGYLTDEEFDAWVRPDKMLEAGSNG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=458, Percent_Identity=59.1703056768559, Blast_Score=542, Evalue=1e-154,
Organism=Homo sapiens, GI266458395, Length=84, Percent_Identity=41.6666666666667, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=60.3070175438597, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI87082375, Length=450, Percent_Identity=40.2222222222222, Blast_Score=315, Evalue=5e-87,
Organism=Caenorhabditis elegans, GI17553882, Length=458, Percent_Identity=58.296943231441, Blast_Score=557, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=57.0987654320988, Blast_Score=395, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324993, Length=458, Percent_Identity=55.2401746724891, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24640179, Length=459, Percent_Identity=58.3877995642701, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24640177, Length=459, Percent_Identity=58.3877995642701, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=55.7483731019523, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI78710009, Length=460, Percent_Identity=53.9130434782609, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=46.8546637744035, Blast_Score=432, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49036; Mature: 48905

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTETDSIGPIEVPEDAYWGAQTQRSLINFAIGDQRMPLPVLHALTLIKKAAARVNDRN
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
GDLPADIARLIEQAADEVLDGQHDAQFPLVVWQTGSGTQSNMNVNEVIAGRANELAGQGR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCHHHHCCCCC
GGKSPVHPNDHVNRSQSSNDCFPTAMHIATAQAVKAQLLPAIAELSSGLAEQAARHMKLV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTGRTHMMDATPITFGQELSGFVAQLDYAEKAIRAALPAVYELAQGGTAVGTGLNAPKGF
HCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHH
AEAIAAELAALSGLPFVTAPNKFAALAGHEPLAALSGALKTLAGTLMKIANDLRLLGSGP
HHHHHHHHHHHCCCCEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RAGLAEVRLPANEPGSSIMPGKVNPTQCEALSMLACQVMGNDVTIGFAASQGHLQLNVYK
CCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECC
PVIIHNVLQSIRLLADGCSNFNEHCIAGMEPDGEKMAEHLERGLMLVTALNPHIGYDKSA
HHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCHH
QIAKKAYTEGLTLREAALALGYLTDEEFDAWVRPDKMLEAGSNG
HHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHCCCHHHHHCCCCC
>Mature Secondary Structure 
SRTETDSIGPIEVPEDAYWGAQTQRSLINFAIGDQRMPLPVLHALTLIKKAAARVNDRN
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
GDLPADIARLIEQAADEVLDGQHDAQFPLVVWQTGSGTQSNMNVNEVIAGRANELAGQGR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCHHHHCCCCC
GGKSPVHPNDHVNRSQSSNDCFPTAMHIATAQAVKAQLLPAIAELSSGLAEQAARHMKLV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KTGRTHMMDATPITFGQELSGFVAQLDYAEKAIRAALPAVYELAQGGTAVGTGLNAPKGF
HCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHH
AEAIAAELAALSGLPFVTAPNKFAALAGHEPLAALSGALKTLAGTLMKIANDLRLLGSGP
HHHHHHHHHHHCCCCEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RAGLAEVRLPANEPGSSIMPGKVNPTQCEALSMLACQVMGNDVTIGFAASQGHLQLNVYK
CCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECC
PVIIHNVLQSIRLLADGCSNFNEHCIAGMEPDGEKMAEHLERGLMLVTALNPHIGYDKSA
HHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCHH
QIAKKAYTEGLTLREAALALGYLTDEEFDAWVRPDKMLEAGSNG
HHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]