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The map label for this gene is aroP [H]

Identifier: 66046809

GI number: 66046809

Start: 4262944

End: 4264353

Strand: Reverse

Name: aroP [H]

Synonym: Psyr_3580

Alternate gene names: 66046809

Gene position: 4264353-4262944 (Counterclockwise)

Preceding gene: 66046810

Following gene: 66046808

Centisome position: 69.98

GC content: 59.79

Gene sequence:

>1410_bases
ATGAGTGAAACAACCTCACCCTCGGGCGAACTGAAACGTGGCCTGAAGAATCGACACATCCAGTTGATCGCCCTGGGCGG
TGCTATCGGAACGGGCCTGTTTCTCGGCTCGGCGGGCGTGCTGAAATCAGCCGGGCCGTCGATGATTCTCGGTTATGCCA
TCTGTGGCTTCATCGCCTTCATGATCATGCGCCAGCTGGGCGAGATGATCGTCGAAGAGCCGGTCGCCGGCTCGTTCAGC
CACTTCGCCCACAACTACTGGGGCGGTTTCGCCGGCTTTCTGTCGGGCTGGAATTGCTGGCTGCTGTACATCCTGGTCGG
CATGTCCGAGCTGACTGCTGTCGGCAAATACATCCATTACTGGTTGCCGGACATCCCGGGCTGGGTATCCGCGGCAGCCT
TCTTCGTGCTGATCAATGCCATCAACCTGACCAACGTCAAGGTCTTCGGCGAGACCGAATTCTGGTTCGCGATCATCAAG
GTGGTGGCGATCATCGGCATGATTGCGTTGGGCAGTTACATGCTGGTCAGTGGCAGCGGTGGCCCGCAGGCCTCGGTCAG
CAACCTCTGGGAGCATGGCGGATTCTTTCCCAATGGTGTCAGCGGTTTGGTGATGGCGCTGGCAATCATCATGTTCTCCT
TCGGCGGCCTGGAAATGCTCGGTTTCACTGCTGCCGAAGCCGAACAGCCGAAGACCGTAATTCCCAAGGCGATCAACCAG
GTCATCTACCGCATCCTGATTTTCTACATCGGCGCGCTGGTGGTCCTGTTGTCACTGACGCCGTGGGACAGCCTGCTGGC
CAGCCTCAATGCGTCTGGCGATTCCTACAGCGGCAGCCCGTTCGTGCAGGTGTTCTCGATGCTGGGTAGCGACACGGCGG
CGCACATCCTCAACTTTGTGGTGCTGACGGCAGCGCTGTCGGTCTACAACAGCGGCACCTATTGCAACAGCCGCATGCTG
GTGGGCATGGCCGAGCAGGGTGATGCGCCCAGGGCGCTGGCCCAGGTCGACAAACGCGGGGTGCCGGTCAAGGCTATCTT
CGCCTCTGCCGCCGTGACACTGGTCGCGGTGCTGCTCAATTATTTCGTGCCGCAGCAGGCGCTGGAACTGTTGATGTCGC
TGGTGGTGGCCACGCTGGTGATCAACTGGGCGATGATCAGCTACTCGCACCTGAAATTCCGCCAGCACATGAACCGCACC
GCACAAGTGCCGCTGTTCAAGGCGCTGTGGTATCCCTATGGCAACTACGTGTGCCTGGCCTTCGTGGTGTTCATCCTCGG
CATCATGCTGATGATCCCCGGCATCCAGATCTCGGTGTATGCGATCCCGGTGTGGCTGGCGGTGATGTGGGTCTGTTACC
GGGCCAAAAACAGGCGTAGCGTTGTCGTGCCTGCCGAGTCTGGCAAATAG

Upstream 100 bases:

>100_bases
ACGCTCCGGGCCATCCGCCTCGAACGCTGCAATTCTGTTGCGCCACGAGCGCAACAGGTTCTATTCCGTCACAGAACACG
ATCGATCAGGTGGCTATTGA

Downstream 100 bases:

>100_bases
CCTTGTCTGTTTCCGAGAAGAAGAGACCCCGATGCTGGTGATTTCCAACAACGTTCATCTGCCCGACGCCGAGATCGAGT
TGACCGCTATCCGTGCCCAG

Product: amino acid permease-associated region

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSETTSPSGELKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAICGFIAFMIMRQLGEMIVEEPVAGSFS
HFAHNYWGGFAGFLSGWNCWLLYILVGMSELTAVGKYIHYWLPDIPGWVSAAAFFVLINAINLTNVKVFGETEFWFAIIK
VVAIIGMIALGSYMLVSGSGGPQASVSNLWEHGGFFPNGVSGLVMALAIIMFSFGGLEMLGFTAAEAEQPKTVIPKAINQ
VIYRILIFYIGALVVLLSLTPWDSLLASLNASGDSYSGSPFVQVFSMLGSDTAAHILNFVVLTAALSVYNSGTYCNSRML
VGMAEQGDAPRALAQVDKRGVPVKAIFASAAVTLVAVLLNYFVPQQALELLMSLVVATLVINWAMISYSHLKFRQHMNRT
AQVPLFKALWYPYGNYVCLAFVVFILGIMLMIPGIQISVYAIPVWLAVMWVCYRAKNRRSVVVPAESGK

Sequences:

>Translated_469_residues
MSETTSPSGELKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAICGFIAFMIMRQLGEMIVEEPVAGSFS
HFAHNYWGGFAGFLSGWNCWLLYILVGMSELTAVGKYIHYWLPDIPGWVSAAAFFVLINAINLTNVKVFGETEFWFAIIK
VVAIIGMIALGSYMLVSGSGGPQASVSNLWEHGGFFPNGVSGLVMALAIIMFSFGGLEMLGFTAAEAEQPKTVIPKAINQ
VIYRILIFYIGALVVLLSLTPWDSLLASLNASGDSYSGSPFVQVFSMLGSDTAAHILNFVVLTAALSVYNSGTYCNSRML
VGMAEQGDAPRALAQVDKRGVPVKAIFASAAVTLVAVLLNYFVPQQALELLMSLVVATLVINWAMISYSHLKFRQHMNRT
AQVPLFKALWYPYGNYVCLAFVVFILGIMLMIPGIQISVYAIPVWLAVMWVCYRAKNRRSVVVPAESGK
>Mature_468_residues
SETTSPSGELKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAICGFIAFMIMRQLGEMIVEEPVAGSFSH
FAHNYWGGFAGFLSGWNCWLLYILVGMSELTAVGKYIHYWLPDIPGWVSAAAFFVLINAINLTNVKVFGETEFWFAIIKV
VAIIGMIALGSYMLVSGSGGPQASVSNLWEHGGFFPNGVSGLVMALAIIMFSFGGLEMLGFTAAEAEQPKTVIPKAINQV
IYRILIFYIGALVVLLSLTPWDSLLASLNASGDSYSGSPFVQVFSMLGSDTAAHILNFVVLTAALSVYNSGTYCNSRMLV
GMAEQGDAPRALAQVDKRGVPVKAIFASAAVTLVAVLLNYFVPQQALELLMSLVVATLVINWAMISYSHLKFRQHMNRTA
QVPLFKALWYPYGNYVCLAFVVFILGIMLMIPGIQISVYAIPVWLAVMWVCYRAKNRRSVVVPAESGK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=370, Percent_Identity=25.4054054054054, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI258645169, Length=401, Percent_Identity=21.4463840399002, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI258614003, Length=402, Percent_Identity=21.6417910447761, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI258614005, Length=402, Percent_Identity=21.6417910447761, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786302, Length=466, Percent_Identity=65.6652360515021, Blast_Score=609, Evalue=1e-176,
Organism=Escherichia coli, GI1786789, Length=461, Percent_Identity=56.6160520607375, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI48994972, Length=422, Percent_Identity=44.0758293838863, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1790653, Length=455, Percent_Identity=38.6813186813187, Blast_Score=338, Evalue=5e-94,
Organism=Escherichia coli, GI1786602, Length=462, Percent_Identity=41.7748917748918, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI87081915, Length=392, Percent_Identity=39.2857142857143, Blast_Score=294, Evalue=1e-80,
Organism=Escherichia coli, GI1789017, Length=443, Percent_Identity=34.5372460496614, Blast_Score=264, Evalue=8e-72,
Organism=Escherichia coli, GI1788480, Length=398, Percent_Identity=36.9346733668342, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI87081708, Length=418, Percent_Identity=34.688995215311, Blast_Score=242, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17532491, Length=381, Percent_Identity=24.6719160104987, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17531343, Length=378, Percent_Identity=24.0740740740741, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=405, Percent_Identity=24.1975308641975, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=442, Percent_Identity=34.3891402714932, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6324061, Length=452, Percent_Identity=33.4070796460177, Blast_Score=212, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6321053, Length=427, Percent_Identity=30.6791569086651, Blast_Score=200, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6319824, Length=406, Percent_Identity=31.5270935960591, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6324924, Length=456, Percent_Identity=31.140350877193, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6322892, Length=395, Percent_Identity=32.1518987341772, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320717, Length=406, Percent_Identity=30.7881773399015, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324059, Length=448, Percent_Identity=32.8125, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6324553, Length=400, Percent_Identity=33.25, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6319608, Length=424, Percent_Identity=29.9528301886792, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6320251, Length=406, Percent_Identity=29.3103448275862, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6324990, Length=365, Percent_Identity=33.1506849315069, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321629, Length=396, Percent_Identity=31.0606060606061, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6319542, Length=404, Percent_Identity=28.7128712871287, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319543, Length=400, Percent_Identity=28.5, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322967, Length=445, Percent_Identity=28.7640449438202, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324981, Length=445, Percent_Identity=28.7640449438202, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320364, Length=501, Percent_Identity=26.1477045908184, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI161077963, Length=414, Percent_Identity=25.1207729468599, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221512776, Length=419, Percent_Identity=20.5250596658711, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24666159, Length=419, Percent_Identity=20.5250596658711, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24667468, Length=256, Percent_Identity=26.171875, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50753; Mature: 50621

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETTSPSGELKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAICGFIAF
CCCCCCCCHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHH
MIMRQLGEMIVEEPVAGSFSHFAHNYWGGFAGFLSGWNCWLLYILVGMSELTAVGKYIHY
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
WLPDIPGWVSAAAFFVLINAINLTNVKVFGETEFWFAIIKVVAIIGMIALGSYMLVSGSG
HCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEEECCC
GPQASVSNLWEHGGFFPNGVSGLVMALAIIMFSFGGLEMLGFTAAEAEQPKTVIPKAINQ
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHCCCCCCHHHHHHHHH
VIYRILIFYIGALVVLLSLTPWDSLLASLNASGDSYSGSPFVQVFSMLGSDTAAHILNFV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
VLTAALSVYNSGTYCNSRMLVGMAEQGDAPRALAQVDKRGVPVKAIFASAAVTLVAVLLN
HHHHHHHHHCCCCEECCEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
YFVPQQALELLMSLVVATLVINWAMISYSHLKFRQHMNRTAQVPLFKALWYPYGNYVCLA
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHH
FVVFILGIMLMIPGIQISVYAIPVWLAVMWVCYRAKNRRSVVVPAESGK
HHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
>Mature Secondary Structure 
SETTSPSGELKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAICGFIAF
CCCCCCCHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHH
MIMRQLGEMIVEEPVAGSFSHFAHNYWGGFAGFLSGWNCWLLYILVGMSELTAVGKYIHY
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
WLPDIPGWVSAAAFFVLINAINLTNVKVFGETEFWFAIIKVVAIIGMIALGSYMLVSGSG
HCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCEEEEECCC
GPQASVSNLWEHGGFFPNGVSGLVMALAIIMFSFGGLEMLGFTAAEAEQPKTVIPKAINQ
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHCCCCCCHHHHHHHHH
VIYRILIFYIGALVVLLSLTPWDSLLASLNASGDSYSGSPFVQVFSMLGSDTAAHILNFV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHH
VLTAALSVYNSGTYCNSRMLVGMAEQGDAPRALAQVDKRGVPVKAIFASAAVTLVAVLLN
HHHHHHHHHCCCCEECCEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
YFVPQQALELLMSLVVATLVINWAMISYSHLKFRQHMNRTAQVPLFKALWYPYGNYVCLA
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHH
FVVFILGIMLMIPGIQISVYAIPVWLAVMWVCYRAKNRRSVVVPAESGK
HHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]