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The map label for this gene is Hgd [H]

Identifier: 66046754

GI number: 66046754

Start: 4201804

End: 4202694

Strand: Reverse

Name: Hgd [H]

Synonym: Psyr_3525

Alternate gene names: 66046754

Gene position: 4202694-4201804 (Counterclockwise)

Preceding gene: 66046758

Following gene: 66046753

Centisome position: 68.97

GC content: 64.31

Gene sequence:

>891_bases
ATGACTTTGAAAGCAGGTGTGATCGGACTGGGCAACATGGGCGGCGGCATGGCGGCCACGCTGGCCGGCAAGGGCTTTGA
TGTCAGCGGCTTCGACCTGTCGCAGGCCGCGCTGGCCCAGGCCGAAAGCAAGGGCGTCAAGCCGGTTGCCGATCGCACGC
AACTGATTCAAGGCGTGGACATTCTGATCCTCTCGCTGCCCAAGGCCGAGCACGTGGAGTCGGTGTGCCTCGGCGCGGGT
GGCATCAACGAGGTGGGGCGCAAGGGCCTTATCGTCGTCGATACCACGACGTCGACGCCGGAAATGAGCCGCAAGGTCGC
CGCCGAACTGGCGAAGAACGGCATCGCCTTCATCGACGCGCCGGTGTCTGGCGGCCCGAAAGGCGCTGCCACCGGCAGCA
TGTCGATGGTGATCGGTGCCGAGGATGCTGACCTGGCGCGCGCCATGCCGGTCCTGGAAGGCATGAGCGGGACACGCGTG
CACGTCGGGCAATGTGGCGCAGGGAACGTGGCCAAGATCGCCAACAACATGCTCGCCGCCTGTCACCTGATCAGCACTGC
CGAAGCCGTGGCGATGGCCGCGCGTGCAGGGGTCGATCCGGAAAAACTTCTGCAGGGTCTGAATGCCGGTTCCGGACGCA
GCGGTGCCACGCAAGTGATGTTCCCGACCTGGGTACTCAACAAGGCCTATGACTCCGGCTTCACCATGGGCCTGATGCGC
AAGGACGTCGGCCTGGCCAGCGATCTGGCGGACAGCCTGGACATGGACCTGCCGCTGTCGCGCGTCGTCGCGCAGTTGTG
GCAGGCCAGCAGTGAAACCCTGGCGGACAACGAAGACTTCTGCGCCATCGTGCAACGCACCGATGGCAAACTTTACGGTC
ATGGAGAATAA

Upstream 100 bases:

>100_bases
GAGAGCGCTGTCCATACTCGAATCACCAGCACATTGCCGGCCGCAGGGGCCCGCAGCGTCATCCTCTAATTCGTACAAAA
TCTTTGATCGGGATGCAGAC

Downstream 100 bases:

>100_bases
GCGATGAGCACTGCAAGAATCCTCGAACTGATGCGTCCTTACTGGGGCGATCGCAGTGTCATCGCCAGCTACGTCGGCGG
CCAGTTCATCGAAGGTCACG

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTLKAGVIGLGNMGGGMAATLAGKGFDVSGFDLSQAALAQAESKGVKPVADRTQLIQGVDILILSLPKAEHVESVCLGAG
GINEVGRKGLIVVDTTTSTPEMSRKVAAELAKNGIAFIDAPVSGGPKGAATGSMSMVIGAEDADLARAMPVLEGMSGTRV
HVGQCGAGNVAKIANNMLAACHLISTAEAVAMAARAGVDPEKLLQGLNAGSGRSGATQVMFPTWVLNKAYDSGFTMGLMR
KDVGLASDLADSLDMDLPLSRVVAQLWQASSETLADNEDFCAIVQRTDGKLYGHGE

Sequences:

>Translated_296_residues
MTLKAGVIGLGNMGGGMAATLAGKGFDVSGFDLSQAALAQAESKGVKPVADRTQLIQGVDILILSLPKAEHVESVCLGAG
GINEVGRKGLIVVDTTTSTPEMSRKVAAELAKNGIAFIDAPVSGGPKGAATGSMSMVIGAEDADLARAMPVLEGMSGTRV
HVGQCGAGNVAKIANNMLAACHLISTAEAVAMAARAGVDPEKLLQGLNAGSGRSGATQVMFPTWVLNKAYDSGFTMGLMR
KDVGLASDLADSLDMDLPLSRVVAQLWQASSETLADNEDFCAIVQRTDGKLYGHGE
>Mature_295_residues
TLKAGVIGLGNMGGGMAATLAGKGFDVSGFDLSQAALAQAESKGVKPVADRTQLIQGVDILILSLPKAEHVESVCLGAGG
INEVGRKGLIVVDTTTSTPEMSRKVAAELAKNGIAFIDAPVSGGPKGAATGSMSMVIGAEDADLARAMPVLEGMSGTRVH
VGQCGAGNVAKIANNMLAACHLISTAEAVAMAARAGVDPEKLLQGLNAGSGRSGATQVMFPTWVLNKAYDSGFTMGLMRK
DVGLASDLADSLDMDLPLSRVVAQLWQASSETLADNEDFCAIVQRTDGKLYGHGE

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=286, Percent_Identity=33.5664335664336, Blast_Score=148, Evalue=5e-36,
Organism=Escherichia coli, GI145693186, Length=267, Percent_Identity=32.2097378277154, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1786719, Length=283, Percent_Identity=30.0353356890459, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790315, Length=283, Percent_Identity=26.8551236749117, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1789092, Length=292, Percent_Identity=29.4520547945205, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17557316, Length=288, Percent_Identity=30.9027777777778, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24655230, Length=286, Percent_Identity=31.4685314685315, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI19922568, Length=286, Percent_Identity=31.4685314685315, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30216; Mature: 30085

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKAGVIGLGNMGGGMAATLAGKGFDVSGFDLSQAALAQAESKGVKPVADRTQLIQGVD
CCCCCCEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCE
ILILSLPKAEHVESVCLGAGGINEVGRKGLIVVDTTTSTPEMSRKVAAELAKNGIAFIDA
EEEEECCCHHHHHHHHHCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEC
PVSGGPKGAATGSMSMVIGAEDADLARAMPVLEGMSGTRVHVGQCGAGNVAKIANNMLAA
CCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHH
CHLISTAEAVAMAARAGVDPEKLLQGLNAGSGRSGATQVMFPTWVLNKAYDSGFTMGLMR
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHCCCCCHHHHH
KDVGLASDLADSLDMDLPLSRVVAQLWQASSETLADNEDFCAIVQRTDGKLYGHGE
HHCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEECCC
>Mature Secondary Structure 
TLKAGVIGLGNMGGGMAATLAGKGFDVSGFDLSQAALAQAESKGVKPVADRTQLIQGVD
CCCCCEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCE
ILILSLPKAEHVESVCLGAGGINEVGRKGLIVVDTTTSTPEMSRKVAAELAKNGIAFIDA
EEEEECCCHHHHHHHHHCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEC
PVSGGPKGAATGSMSMVIGAEDADLARAMPVLEGMSGTRVHVGQCGAGNVAKIANNMLAA
CCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHH
CHLISTAEAVAMAARAGVDPEKLLQGLNAGSGRSGATQVMFPTWVLNKAYDSGFTMGLMR
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHCCCCCHHHHH
KDVGLASDLADSLDMDLPLSRVVAQLWQASSETLADNEDFCAIVQRTDGKLYGHGE
HHCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA