Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 66046688

GI number: 66046688

Start: 4122450

End: 4123865

Strand: Reverse

Name: atoC [H]

Synonym: Psyr_3459

Alternate gene names: 66046688

Gene position: 4123865-4122450 (Counterclockwise)

Preceding gene: 66046689

Following gene: 66046687

Centisome position: 67.67

GC content: 61.23

Gene sequence:

>1416_bases
ATGCCGATCAATGTGCTGCTGGTCGAGGATGACCGTTCGCTCCGGGAAGCGCTTGGGGAAACCCTCGAGCTGGCCGGTTA
TGACTATAAGGCGGTCGGTTCCGCCGAAGAAGCACTGGTGGCTGCCGAGGCAACGCCCTTCAGCCTGGTGATCAGTGACG
TCAACATGCCGGGCATGGACGGCCACCAGTTGTTGAGTCTGTTGCGCAGCCGGCATCCGCAACTGCCGGTGCTGCTGATG
ACGGCGCATGGCGCAGTCGAGCGCGCTGTCGATGCCATGCGTCAGGGGGCTGCGGATTACCTGGTCAAACCCTTCGAGCC
CAAGGCGCTGATCGCGCTGGTTGCGCGGCATGCACTGGGTCGTCTGGAACCTGCCGAGCGCGACGGGCCGATTGCCGTCG
AGCCCGCCAGTATCCAGTTGCTGAACCTGGCCAGTCGCGTGGCGAAAAGCGACTCCACCGTGTTGATCTCCGGCGAGTCC
GGGACCGGCAAAGAGGTTTTGGCGCGTTTCATTCATCAAAACTCGCCCCGTGCCGATAAGCCTTTTATTGCGATCAACTG
TGCGGCGATTCCGGACAACATGCTGGAAGCCACGTTATTCGGTCATGAGAAGGGTTCGTTTACCGGCGCCATTGCGGCGC
AGGCTGGCAAGTTCGAGCAGGCTGACGGCGGGACGATCCTGCTGGACGAGATTTCCGAAATGCCGCTGGGGCTGCAAGCC
AAATTGCTGCGTGTGTTGCAGGAGCGCGAAGTCGAACGCGTAGGGGCGCGCAAGCCGATCGTTCTGGATATCCGCGTCGT
GGCGACCACCAACCGCGATCTGGCGGGTGAAGTGGCGGCGGGGCGCTTTCGTGAAGATCTGTTTTATCGCCTGTCGGTAT
TTCCACTGGCATGGCAGGCGTTGCGTCAAAGGACTGCCGATATTCTGCCGTTGGCCGAGCGGCTTCTGGCCAAACACGTC
AATAAAATGAAGCATGCGCCGGTTCGTCTTTCCGCCGAAGCGCAGCAGTGTCTGGTGAGCTATCCATGGCCCGGGAATGT
GCGGGAGCTGGATAACGCTGTGCAGCGGGCCTTGATTCTGCAGCAGGGCGGGGTGATTCAGGCGCAGGATTTCTGTCTGT
CCGGGCCGGTTACCAGCCTGCCTGTTGCTGCCTCTGTCGAGGCTGCAGTGGCAGTGACTGGCACTACCGTGGCGGAGAAT
GCAGGTGCCGGCGTCAGTCCGGAATCTGTCGGCGCGCTGGGCGATGACCTCAGGCGTCACGAGTTTCAAATGATCATCGA
CACCCTGCGTTCTGAACGGGGACGTCGCAAGGAGGCTGCGGAACGCCTGGGTATCAGCCCGCGTACATTGCGCTACAAGC
TGGCGCAGATGCGTGACGCCGGAATGGATGTGGAAGCCTATCTGTTTGCCACATGA

Upstream 100 bases:

>100_bases
ATCAGGGGCGCGTGGATTATTTGTCGCGGGTCGGCCGTGGTACCTGCGCCATTGTCAGTCTGCCGTTGATCCCGGCTTCC
AGTCCGACAGGTAATAACTG

Downstream 100 bases:

>100_bases
ACCAGGCACACGGATCGCCGCTCCCGATCGGCGGTCACTGAATATTTTTGCTGTGATACAAGCCTGAAATAATCCCGGCG
CCCCGTAGATACGGGCGGCC

Product: helix-turn-helix, Fis-type

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MPINVLLVEDDRSLREALGETLELAGYDYKAVGSAEEALVAAEATPFSLVISDVNMPGMDGHQLLSLLRSRHPQLPVLLM
TAHGAVERAVDAMRQGAADYLVKPFEPKALIALVARHALGRLEPAERDGPIAVEPASIQLLNLASRVAKSDSTVLISGES
GTGKEVLARFIHQNSPRADKPFIAINCAAIPDNMLEATLFGHEKGSFTGAIAAQAGKFEQADGGTILLDEISEMPLGLQA
KLLRVLQEREVERVGARKPIVLDIRVVATTNRDLAGEVAAGRFREDLFYRLSVFPLAWQALRQRTADILPLAERLLAKHV
NKMKHAPVRLSAEAQQCLVSYPWPGNVRELDNAVQRALILQQGGVIQAQDFCLSGPVTSLPVAASVEAAVAVTGTTVAEN
AGAGVSPESVGALGDDLRRHEFQMIIDTLRSERGRRKEAAERLGISPRTLRYKLAQMRDAGMDVEAYLFAT

Sequences:

>Translated_471_residues
MPINVLLVEDDRSLREALGETLELAGYDYKAVGSAEEALVAAEATPFSLVISDVNMPGMDGHQLLSLLRSRHPQLPVLLM
TAHGAVERAVDAMRQGAADYLVKPFEPKALIALVARHALGRLEPAERDGPIAVEPASIQLLNLASRVAKSDSTVLISGES
GTGKEVLARFIHQNSPRADKPFIAINCAAIPDNMLEATLFGHEKGSFTGAIAAQAGKFEQADGGTILLDEISEMPLGLQA
KLLRVLQEREVERVGARKPIVLDIRVVATTNRDLAGEVAAGRFREDLFYRLSVFPLAWQALRQRTADILPLAERLLAKHV
NKMKHAPVRLSAEAQQCLVSYPWPGNVRELDNAVQRALILQQGGVIQAQDFCLSGPVTSLPVAASVEAAVAVTGTTVAEN
AGAGVSPESVGALGDDLRRHEFQMIIDTLRSERGRRKEAAERLGISPRTLRYKLAQMRDAGMDVEAYLFAT
>Mature_470_residues
PINVLLVEDDRSLREALGETLELAGYDYKAVGSAEEALVAAEATPFSLVISDVNMPGMDGHQLLSLLRSRHPQLPVLLMT
AHGAVERAVDAMRQGAADYLVKPFEPKALIALVARHALGRLEPAERDGPIAVEPASIQLLNLASRVAKSDSTVLISGESG
TGKEVLARFIHQNSPRADKPFIAINCAAIPDNMLEATLFGHEKGSFTGAIAAQAGKFEQADGGTILLDEISEMPLGLQAK
LLRVLQEREVERVGARKPIVLDIRVVATTNRDLAGEVAAGRFREDLFYRLSVFPLAWQALRQRTADILPLAERLLAKHVN
KMKHAPVRLSAEAQQCLVSYPWPGNVRELDNAVQRALILQQGGVIQAQDFCLSGPVTSLPVAASVEAAVAVTGTTVAENA
GAGVSPESVGALGDDLRRHEFQMIIDTLRSERGRRKEAAERLGISPRTLRYKLAQMRDAGMDVEAYLFAT

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=466, Percent_Identity=41.2017167381974, Blast_Score=334, Evalue=8e-93,
Organism=Escherichia coli, GI1790437, Length=462, Percent_Identity=40.04329004329, Blast_Score=318, Evalue=6e-88,
Organism=Escherichia coli, GI1790299, Length=463, Percent_Identity=39.3088552915767, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI1788905, Length=387, Percent_Identity=42.8940568475452, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI87082117, Length=228, Percent_Identity=56.578947368421, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1789087, Length=338, Percent_Identity=42.603550295858, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87082152, Length=322, Percent_Identity=43.7888198757764, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1789233, Length=324, Percent_Identity=42.9012345679012, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1786524, Length=227, Percent_Identity=48.0176211453744, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI87081872, Length=333, Percent_Identity=37.5375375375375, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1787583, Length=324, Percent_Identity=37.037037037037, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI1789828, Length=250, Percent_Identity=33.2, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081858, Length=329, Percent_Identity=31.0030395136778, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI87082012, Length=112, Percent_Identity=39.2857142857143, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1789402, Length=154, Percent_Identity=30.5194805194805, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786784, Length=181, Percent_Identity=28.1767955801105, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789809, Length=171, Percent_Identity=30.4093567251462, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790552, Length=119, Percent_Identity=37.8151260504202, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50899; Mature: 50768

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPINVLLVEDDRSLREALGETLELAGYDYKAVGSAEEALVAAEATPFSLVISDVNMPGMD
CCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHEEEECCCCEEEEEECCCCCCCC
GHQLLSLLRSRHPQLPVLLMTAHGAVERAVDAMRQGAADYLVKPFEPKALIALVARHALG
HHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHC
RLEPAERDGPIAVEPASIQLLNLASRVAKSDSTVLISGESGTGKEVLARFIHQNSPRADK
CCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCC
PFIAINCAAIPDNMLEATLFGHEKGSFTGAIAAQAGKFEQADGGTILLDEISEMPLGLQA
CEEEEEEEECCCHHHHHHHCCCCCCCCCEEHHHCCCCCCCCCCCEEEEECHHCCCCCHHH
KLLRVLQEREVERVGARKPIVLDIRVVATTNRDLAGEVAAGRFREDLFYRLSVFPLAWQA
HHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LRQRTADILPLAERLLAKHVNKMKHAPVRLSAEAQQCLVSYPWPGNVRELDNAVQRALIL
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHEEECCCCCCHHHHHHHHHHHHHH
QQGGVIQAQDFCLSGPVTSLPVAASVEAAVAVTGTTVAENAGAGVSPESVGALGDDLRRH
HCCCEEEECCEEECCCCCCCCCHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
EFQMIIDTLRSERGRRKEAAERLGISPRTLRYKLAQMRDAGMDVEAYLFAT
HHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEC
>Mature Secondary Structure 
PINVLLVEDDRSLREALGETLELAGYDYKAVGSAEEALVAAEATPFSLVISDVNMPGMD
CEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHEEEECCCCEEEEEECCCCCCCC
GHQLLSLLRSRHPQLPVLLMTAHGAVERAVDAMRQGAADYLVKPFEPKALIALVARHALG
HHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHC
RLEPAERDGPIAVEPASIQLLNLASRVAKSDSTVLISGESGTGKEVLARFIHQNSPRADK
CCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCC
PFIAINCAAIPDNMLEATLFGHEKGSFTGAIAAQAGKFEQADGGTILLDEISEMPLGLQA
CEEEEEEEECCCHHHHHHHCCCCCCCCCEEHHHCCCCCCCCCCCEEEEECHHCCCCCHHH
KLLRVLQEREVERVGARKPIVLDIRVVATTNRDLAGEVAAGRFREDLFYRLSVFPLAWQA
HHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LRQRTADILPLAERLLAKHVNKMKHAPVRLSAEAQQCLVSYPWPGNVRELDNAVQRALIL
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHEEECCCCCCHHHHHHHHHHHHHH
QQGGVIQAQDFCLSGPVTSLPVAASVEAAVAVTGTTVAENAGAGVSPESVGALGDDLRRH
HCCCEEEECCEEECCCCCCCCCHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
EFQMIIDTLRSERGRRKEAAERLGISPRTLRYKLAQMRDAGMDVEAYLFAT
HHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]