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The map label for this gene is hemN [H]

Identifier: 66046652

GI number: 66046652

Start: 4087450

End: 4088835

Strand: Direct

Name: hemN [H]

Synonym: Psyr_3423

Alternate gene names: 66046652

Gene position: 4087450-4088835 (Clockwise)

Preceding gene: 66046651

Following gene: 66046654

Centisome position: 67.08

GC content: 60.53

Gene sequence:

>1386_bases
ATGCTTGACGCCATTCGTTGGGATTCAGACCTGATCCATCGCTACGATGTGGCAGGACCGCGCTATACGTCCTATCCGAC
AGCGGTGCAGTTTCATACCCAAGTGGGTGCCTTCGAGCTGCTGCACGCGCTACGCGAAAGCCGCAAGGCGTCACGTCCGT
TGTCGCTCTACGTGCATCTGCCCTTCTGCGCGAACATTTGCTACTACTGCGCCTGCAACAAAGTCATCACCAAGGATCGC
GGACGCGCCCAGGCCTACCTGCAACGGCTCGAGCACGAGATACAAATGCTCGCCTGTCACCTGGCGCCCGGTCAGGTGGT
GGAGCAACTGCACCTGGGCGGCGGTACGCCGACCTTTCTCAGCCATGCTGAACTGCGCCGCTTGATGGCGCAGTTGCGCT
TGCATTTCAATCTGCTGGAAGACGACTCCGGCGACTATGGCATCGAGATCGATCCTCGCGAAGCGGACTGGGCGACGATG
GGACTGCTGCGCGAGCTGGGTTTCAACCGGGTCAGCCTGGGCGTTCAGGACCTCGACCCGACGGTGCAGCGGGCGATCAA
CCGCATGCAGAGCCTGGAAGAGACCCGCGCGATTGTTGAAGCAGCGCGCACGCTGCAATTTCGTTCGGTGAATATTGATC
TGATCTACGGTCTGCCCGCGCAAAACCCGCAGACCTTCAGCCACACCGTGGACAAGGTCATCGATCTGCAGCCTGATCGG
CTGTCGGTGTTCAACTATGCGCATCTGCCCGAGCGCTTCATGCCGCAGCGGCGCATCGACGCGGCGGATCTGCCGGATGC
AGCGAGCAAACTGCTGATGCTGCAGCGCACCGTCGAACAATTGGGCAACGCCGGCTATCGCTACATCGGCATGGACCATT
TCGCCCTGCCCGACGACGAGCTGGCCACCGCCCAGGAAGACCTGACCCTGCAGCGCAACTTTCAGGGCTATACCACGCAT
GGCCACTGCGATCTGATCGGGCTGGGGGTTTCGGCCATCAGCCAGGTCGGCGAGCTGTACAGCCAGAACAGCAGCGACCT
GAGCGAATATTCAAGGCTGCTGGACAGCGATCAGCCCGCAACCAAACGCGGCCTGCTCTGCAACGATGACGACCGCATCA
GGCGCGCGATCATTCAGCAGTTGATCTGCCACTTCACACTGGAGTTCGGCGAGATCGAAAAGACTTTCCGCATCGATTTC
AGGGACTATTTCCGCGATGCGTGGCCGCAACTGCTTGGCATGGCCAGCGACGGGCTGATTACGCTGAGCGAGACGGGCAT
TGAAGTCAGACCGGCGGGCCGACTGCTGGTGCGCGCTGTGTGCATGGTCTTCGATGCCTACCTGACCCGGCAGAAAAACA
GACAGCAGTTCTCTCGGGTGATATGA

Upstream 100 bases:

>100_bases
ATTGAGGCCGGTAACTCTTGCCATTTGATCCACATCAACGCCGCCCCTCGGCCTCCTGCGTATGCTCGCGACATCGCCAG
CCGGACCGGGAAACGCGCGC

Downstream 100 bases:

>100_bases
GCCGTTGCCAAGTGCTACATTTTGGCCAGAACCAGCATGCCCGCCTTGGTCTTGTCGCCGTCACTGGAGCCCAGGCTGTT
CATGAGCGACGACAGATCGG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MLDAIRWDSDLIHRYDVAGPRYTSYPTAVQFHTQVGAFELLHALRESRKASRPLSLYVHLPFCANICYYCACNKVITKDR
GRAQAYLQRLEHEIQMLACHLAPGQVVEQLHLGGGTPTFLSHAELRRLMAQLRLHFNLLEDDSGDYGIEIDPREADWATM
GLLRELGFNRVSLGVQDLDPTVQRAINRMQSLEETRAIVEAARTLQFRSVNIDLIYGLPAQNPQTFSHTVDKVIDLQPDR
LSVFNYAHLPERFMPQRRIDAADLPDAASKLLMLQRTVEQLGNAGYRYIGMDHFALPDDELATAQEDLTLQRNFQGYTTH
GHCDLIGLGVSAISQVGELYSQNSSDLSEYSRLLDSDQPATKRGLLCNDDDRIRRAIIQQLICHFTLEFGEIEKTFRIDF
RDYFRDAWPQLLGMASDGLITLSETGIEVRPAGRLLVRAVCMVFDAYLTRQKNRQQFSRVI

Sequences:

>Translated_461_residues
MLDAIRWDSDLIHRYDVAGPRYTSYPTAVQFHTQVGAFELLHALRESRKASRPLSLYVHLPFCANICYYCACNKVITKDR
GRAQAYLQRLEHEIQMLACHLAPGQVVEQLHLGGGTPTFLSHAELRRLMAQLRLHFNLLEDDSGDYGIEIDPREADWATM
GLLRELGFNRVSLGVQDLDPTVQRAINRMQSLEETRAIVEAARTLQFRSVNIDLIYGLPAQNPQTFSHTVDKVIDLQPDR
LSVFNYAHLPERFMPQRRIDAADLPDAASKLLMLQRTVEQLGNAGYRYIGMDHFALPDDELATAQEDLTLQRNFQGYTTH
GHCDLIGLGVSAISQVGELYSQNSSDLSEYSRLLDSDQPATKRGLLCNDDDRIRRAIIQQLICHFTLEFGEIEKTFRIDF
RDYFRDAWPQLLGMASDGLITLSETGIEVRPAGRLLVRAVCMVFDAYLTRQKNRQQFSRVI
>Mature_461_residues
MLDAIRWDSDLIHRYDVAGPRYTSYPTAVQFHTQVGAFELLHALRESRKASRPLSLYVHLPFCANICYYCACNKVITKDR
GRAQAYLQRLEHEIQMLACHLAPGQVVEQLHLGGGTPTFLSHAELRRLMAQLRLHFNLLEDDSGDYGIEIDPREADWATM
GLLRELGFNRVSLGVQDLDPTVQRAINRMQSLEETRAIVEAARTLQFRSVNIDLIYGLPAQNPQTFSHTVDKVIDLQPDR
LSVFNYAHLPERFMPQRRIDAADLPDAASKLLMLQRTVEQLGNAGYRYIGMDHFALPDDELATAQEDLTLQRNFQGYTTH
GHCDLIGLGVSAISQVGELYSQNSSDLSEYSRLLDSDQPATKRGLLCNDDDRIRRAIIQQLICHFTLEFGEIEKTFRIDF
RDYFRDAWPQLLGMASDGLITLSETGIEVRPAGRLLVRAVCMVFDAYLTRQKNRQQFSRVI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=248, Percent_Identity=30.241935483871, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI87082341, Length=460, Percent_Identity=50.2173913043478, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI1789325, Length=284, Percent_Identity=27.112676056338, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52518; Mature: 52518

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDAIRWDSDLIHRYDVAGPRYTSYPTAVQFHTQVGAFELLHALRESRKASRPLSLYVHL
CCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
PFCANICYYCACNKVITKDRGRAQAYLQRLEHEIQMLACHLAPGQVVEQLHLGGGTPTFL
CHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHH
SHAELRRLMAQLRLHFNLLEDDSGDYGIEIDPREADWATMGLLRELGFNRVSLGVQDLDP
HHHHHHHHHHHHHHHHHEECCCCCCCCEEECCCCCHHHHHHHHHHCCCCEEECCHHHCCH
TVQRAINRMQSLEETRAIVEAARTLQFRSVNIDLIYGLPAQNPQTFSHTVDKVIDLQPDR
HHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEECCCCCCCCHHHHHHHHHHCCCCCC
LSVFNYAHLPERFMPQRRIDAADLPDAASKLLMLQRTVEQLGNAGYRYIGMDHFALPDDE
CHHHHHHHCCHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHH
LATAQEDLTLQRNFQGYTTHGHCDLIGLGVSAISQVGELYSQNSSDLSEYSRLLDSDQPA
HHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
TKRGLLCNDDDRIRRAIIQQLICHFTLEFGEIEKTFRIDFRDYFRDAWPQLLGMASDGLI
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEECHHHHHHHHHHHHHCCCCCCEE
TLSETGIEVRPAGRLLVRAVCMVFDAYLTRQKNRQQFSRVI
EEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDAIRWDSDLIHRYDVAGPRYTSYPTAVQFHTQVGAFELLHALRESRKASRPLSLYVHL
CCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
PFCANICYYCACNKVITKDRGRAQAYLQRLEHEIQMLACHLAPGQVVEQLHLGGGTPTFL
CHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHH
SHAELRRLMAQLRLHFNLLEDDSGDYGIEIDPREADWATMGLLRELGFNRVSLGVQDLDP
HHHHHHHHHHHHHHHHHEECCCCCCCCEEECCCCCHHHHHHHHHHCCCCEEECCHHHCCH
TVQRAINRMQSLEETRAIVEAARTLQFRSVNIDLIYGLPAQNPQTFSHTVDKVIDLQPDR
HHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEECCCCCCCCHHHHHHHHHHCCCCCC
LSVFNYAHLPERFMPQRRIDAADLPDAASKLLMLQRTVEQLGNAGYRYIGMDHFALPDDE
CHHHHHHHCCHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHH
LATAQEDLTLQRNFQGYTTHGHCDLIGLGVSAISQVGELYSQNSSDLSEYSRLLDSDQPA
HHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
TKRGLLCNDDDRIRRAIIQQLICHFTLEFGEIEKTFRIDFRDYFRDAWPQLLGMASDGLI
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEECHHHHHHHHHHHHHCCCCCCEE
TLSETGIEVRPAGRLLVRAVCMVFDAYLTRQKNRQQFSRVI
EEECCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9767567; 10984043 [H]