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The map label for this gene is clpA [H]

Identifier: 66046412

GI number: 66046412

Start: 3810762

End: 3813035

Strand: Reverse

Name: clpA [H]

Synonym: Psyr_3183

Alternate gene names: 66046412

Gene position: 3813035-3810762 (Counterclockwise)

Preceding gene: 66046413

Following gene: 66046408

Centisome position: 62.57

GC content: 58.66

Gene sequence:

>2274_bases
ATGTTAAACCGTGAGCTCGAAGTCACCCTCAATCTTGCCTTCAAGGAGGCACGTTCGAAGCGTCATGAGTTCATGACGGT
CGAGCATCTCCTGCTGGCTCTATTGGATAATGAGGCTGCAGCCACTGTCCTGCGTGCCTGCGGCGCAAACCTCGATAAAC
TCAAGCATGATCTGCAGGAGTTCATCGACTCCACCACCCCGCTGATCCCCGTTCATGACGAGGATCGCGAGACACAACCG
ACGCTCGGGTTCCAGCGCGTGCTGCAACGGGCAGTCTTCCATGTGCAGAGCTCCGGCAAGCGCGAAGTGACCGGCGCCAA
CGTACTGGTTGCGATTTTCAGTGAGCAGGAAAGCCAGGCCGTATTTCTGCTTAAACAGCAGAGCGTGGCCCGGATCGATG
TCGTCAACTATATCGCCCACGGTATCTCCAAGGTGCCAGGGCATGGCGAACACTCTTCTGAAGGTGAGCAGGATATGCAG
GACGACGAGGGCGGTGAAGCATCTTCCTCAGGCAATCCTCTGGATGCCTATGCCAGCAATCTGAACGAGTTGGCGCGTCA
GGGACGCATCGACCCACTGGTCGGCCGCGAAAGCGAAGTCGAGCGGGTGGCACAGATTCTGGCTCGTCGTCGCAAGAACA
ATCCTTTGCTGGTCGGTGAAGCGGGTGTCGGTAAAACGGCCATCGCCGAAGGTCTGGCCAAGCGCATCGTCGACAATCAG
GTGCCTGACCTGCTTGCCAACAGCGTCGTCTACTCGCTCGACCTGGGCGCGTTGCTGGCCGGGACGAAATACCGCGGCGA
TTTCGAGAAGCGCTTCAAGGCGTTGCTCAACGAGCTGCGCAAGCGTCCCCAGGCGATCCTGTTCATTGACGAGATCCACA
CGATCATCGGTGCCGGCGCAGCTTCTGGCGGGGTAATGGATGCTTCCAACCTGCTCAAGCCGCTGCTGTCTTCCGGCGAG
ATTCGTTGCATCGGTTCGACCACCTTCCAGGAGTTTCGCGGGATTTTCGAGAAGGATCGTGCCTTGGCGCGTCGTTTCCA
GAAAGTCGATGTGTCCGAGCCTTCGGTCGAGGACACCATCGGTATCCTGCGTGGCCTGAAAAGCCGTTTCGAGCAGCATC
ACAGTATCGAATACAGCGACGAAGCCCTGCGCGCTGCCGCCGAGCTTGCATCGCGCTACATCAACGACCGTCATATGCCT
GACAAGGCCATTGACGTGATTGATGAAGCGGGTGCGTACCAGCGTCTGCAGCCGGTCGAAAAGCGCGCCAAACGTATCGA
TGTGCCCGAGGTTGAAGACATCGTTGCCAAGATCGCGCGTATTCCGCCAAAACACGTCAACAGCTCCGACAAGGAGCTGC
TGCGTAACCTGGAGCGCGATCTCAAGCTCACTGTATTCGGACAGGATGCGGCGATCGACTCGTTGTCGACGGCGATCAAG
CTGTCTCGCGCAGGTCTCAAGTCGCCTGACAAGCCGGTCGGTTCGTTCCTGTTCGCCGGTCCTACGGGCGTCGGCAAGAC
CGAGGCGGCTCGTCAGCTGGCCAAGGCACTGGGCGTCGAGTTGATCCGTTTCGACATGTCCGAGTATATGGAACGGCACA
CCGTTTCCCGTCTGATCGGCGCGCCTCCGGGCTATGTCGGTTTCGACCAGGGCGGTCTGCTGACCGAGGCCATTACCCGT
CAGCCACATTGCGTGCTGTTGCTCGATGAAATCGAAAAGGCTCACCCGGAAGTCTTCAACCTGCTTCTGCAGGTGATGGA
CCACGGTACGCTGACCGACAACAACGGGCGCAAGGCGGACTTCCGCAATGTGATCGTGATCATGACCACCAACGCCGGGG
CCGAGTCTGCTGCGCGGGCTTCGATCGGTTTCACGCATCAGGACCATTCGTCCGACGCGATGGAAGTGATCAAGAAGAGC
TTCACGCCAGAGTTCCGCAACCGCCTGGATACCATCATTCAGTTCGGTCGCCTCAGCCACGAAGTCATCAAGAGTGTGGT
CGACAAGTTCCTCACCGAGCTTCAGGCCCAGCTGGAAGACAAGCGCGTACTGCTCGAAGTGTCCGAGGCGGCGAGAAGCT
GGCTGGCGCAGGGTGGTTACGATGCAGCAATGGGTGCCAGACCGATGGCTCGCCTGATTCAGGACAAGATCAAACGGCCA
CTCGCCGAAGAGATCCTGTTCGGCGAACTGTCAGAGCATGGCGGCGTGGTTCACATCGATATCAAGGATGGCGAGATCAC
CTTCGATTTCGAAACCACGGCGGAAATGGCCTGA

Upstream 100 bases:

>100_bases
AATGCAGGTCAATCAATACGCCAGGGAGAGCCAGCATCCGCTACTCTGTGAGATCGAGAAGGACGGTTAAACGCCGACCA
CTTGGGTATGAGGTGAAGCT

Downstream 100 bases:

>100_bases
TGGCCGACGCCTCGCCCCGCATCATTGATCGATGCGGGGCAGGTCGAGGGCATCGGACGTAAAAAACAGGCATACAAAAA
CGCCCGGCTTATGCCGGGCG

Product: putative AAA ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 757; Mature: 757

Protein sequence:

>757_residues
MLNRELEVTLNLAFKEARSKRHEFMTVEHLLLALLDNEAAATVLRACGANLDKLKHDLQEFIDSTTPLIPVHDEDRETQP
TLGFQRVLQRAVFHVQSSGKREVTGANVLVAIFSEQESQAVFLLKQQSVARIDVVNYIAHGISKVPGHGEHSSEGEQDMQ
DDEGGEASSSGNPLDAYASNLNELARQGRIDPLVGRESEVERVAQILARRRKNNPLLVGEAGVGKTAIAEGLAKRIVDNQ
VPDLLANSVVYSLDLGALLAGTKYRGDFEKRFKALLNELRKRPQAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGE
IRCIGSTTFQEFRGIFEKDRALARRFQKVDVSEPSVEDTIGILRGLKSRFEQHHSIEYSDEALRAAAELASRYINDRHMP
DKAIDVIDEAGAYQRLQPVEKRAKRIDVPEVEDIVAKIARIPPKHVNSSDKELLRNLERDLKLTVFGQDAAIDSLSTAIK
LSRAGLKSPDKPVGSFLFAGPTGVGKTEAARQLAKALGVELIRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTEAITR
QPHCVLLLDEIEKAHPEVFNLLLQVMDHGTLTDNNGRKADFRNVIVIMTTNAGAESAARASIGFTHQDHSSDAMEVIKKS
FTPEFRNRLDTIIQFGRLSHEVIKSVVDKFLTELQAQLEDKRVLLEVSEAARSWLAQGGYDAAMGARPMARLIQDKIKRP
LAEEILFGELSEHGGVVHIDIKDGEITFDFETTAEMA

Sequences:

>Translated_757_residues
MLNRELEVTLNLAFKEARSKRHEFMTVEHLLLALLDNEAAATVLRACGANLDKLKHDLQEFIDSTTPLIPVHDEDRETQP
TLGFQRVLQRAVFHVQSSGKREVTGANVLVAIFSEQESQAVFLLKQQSVARIDVVNYIAHGISKVPGHGEHSSEGEQDMQ
DDEGGEASSSGNPLDAYASNLNELARQGRIDPLVGRESEVERVAQILARRRKNNPLLVGEAGVGKTAIAEGLAKRIVDNQ
VPDLLANSVVYSLDLGALLAGTKYRGDFEKRFKALLNELRKRPQAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGE
IRCIGSTTFQEFRGIFEKDRALARRFQKVDVSEPSVEDTIGILRGLKSRFEQHHSIEYSDEALRAAAELASRYINDRHMP
DKAIDVIDEAGAYQRLQPVEKRAKRIDVPEVEDIVAKIARIPPKHVNSSDKELLRNLERDLKLTVFGQDAAIDSLSTAIK
LSRAGLKSPDKPVGSFLFAGPTGVGKTEAARQLAKALGVELIRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTEAITR
QPHCVLLLDEIEKAHPEVFNLLLQVMDHGTLTDNNGRKADFRNVIVIMTTNAGAESAARASIGFTHQDHSSDAMEVIKKS
FTPEFRNRLDTIIQFGRLSHEVIKSVVDKFLTELQAQLEDKRVLLEVSEAARSWLAQGGYDAAMGARPMARLIQDKIKRP
LAEEILFGELSEHGGVVHIDIKDGEITFDFETTAEMA
>Mature_757_residues
MLNRELEVTLNLAFKEARSKRHEFMTVEHLLLALLDNEAAATVLRACGANLDKLKHDLQEFIDSTTPLIPVHDEDRETQP
TLGFQRVLQRAVFHVQSSGKREVTGANVLVAIFSEQESQAVFLLKQQSVARIDVVNYIAHGISKVPGHGEHSSEGEQDMQ
DDEGGEASSSGNPLDAYASNLNELARQGRIDPLVGRESEVERVAQILARRRKNNPLLVGEAGVGKTAIAEGLAKRIVDNQ
VPDLLANSVVYSLDLGALLAGTKYRGDFEKRFKALLNELRKRPQAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGE
IRCIGSTTFQEFRGIFEKDRALARRFQKVDVSEPSVEDTIGILRGLKSRFEQHHSIEYSDEALRAAAELASRYINDRHMP
DKAIDVIDEAGAYQRLQPVEKRAKRIDVPEVEDIVAKIARIPPKHVNSSDKELLRNLERDLKLTVFGQDAAIDSLSTAIK
LSRAGLKSPDKPVGSFLFAGPTGVGKTEAARQLAKALGVELIRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTEAITR
QPHCVLLLDEIEKAHPEVFNLLLQVMDHGTLTDNNGRKADFRNVIVIMTTNAGAESAARASIGFTHQDHSSDAMEVIKKS
FTPEFRNRLDTIIQFGRLSHEVIKSVVDKFLTELQAQLEDKRVLLEVSEAARSWLAQGGYDAAMGARPMARLIQDKIKRP
LAEEILFGELSEHGGVVHIDIKDGEITFDFETTAEMA

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=299, Percent_Identity=31.1036789297659, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI1787109, Length=753, Percent_Identity=65.7370517928287, Blast_Score=1026, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=415, Percent_Identity=42.6506024096386, Blast_Score=305, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6320464, Length=324, Percent_Identity=45.0617283950617, Blast_Score=283, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6323002, Length=408, Percent_Identity=37.5, Blast_Score=262, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83533; Mature: 83533

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNRELEVTLNLAFKEARSKRHEFMTVEHLLLALLDNEAAATVLRACGANLDKLKHDLQE
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHH
FIDSTTPLIPVHDEDRETQPTLGFQRVLQRAVFHVQSSGKREVTGANVLVAIFSEQESQA
HHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECCCEEEEEEECCCCCCE
VFLLKQQSVARIDVVNYIAHGISKVPGHGEHSSEGEQDMQDDEGGEASSSGNPLDAYASN
EEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHH
LNELARQGRIDPLVGRESEVERVAQILARRRKNNPLLVGEAGVGKTAIAEGLAKRIVDNQ
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCC
VPDLLANSVVYSLDLGALLAGTKYRGDFEKRFKALLNELRKRPQAILFIDEIHTIIGAGA
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCC
ASGGVMDASNLLKPLLSSGEIRCIGSTTFQEFRGIFEKDRALARRFQKVDVSEPSVEDTI
CCCCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
GILRGLKSRFEQHHSIEYSDEALRAAAELASRYINDRHMPDKAIDVIDEAGAYQRLQPVE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHH
KRAKRIDVPEVEDIVAKIARIPPKHVNSSDKELLRNLERDLKLTVFGQDAAIDSLSTAIK
HHHHHCCCCCHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
LSRAGLKSPDKPVGSFLFAGPTGVGKTEAARQLAKALGVELIRFDMSEYMERHTVSRLIG
HHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APPGYVGFDQGGLLTEAITRQPHCVLLLDEIEKAHPEVFNLLLQVMDHGTLTDNNGRKAD
CCCCCCCCCCCCHHHHHHCCCCCEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCC
FRNVIVIMTTNAGAESAARASIGFTHQDHSSDAMEVIKKSFTPEFRNRLDTIIQFGRLSH
CCCEEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
EVIKSVVDKFLTELQAQLEDKRVLLEVSEAARSWLAQGGYDAAMGARPMARLIQDKIKRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHCH
LAEEILFGELSEHGGVVHIDIKDGEITFDFETTAEMA
HHHHHHHHHHHHCCCEEEEEEECCEEEEEECCCCCCC
>Mature Secondary Structure
MLNRELEVTLNLAFKEARSKRHEFMTVEHLLLALLDNEAAATVLRACGANLDKLKHDLQE
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHH
FIDSTTPLIPVHDEDRETQPTLGFQRVLQRAVFHVQSSGKREVTGANVLVAIFSEQESQA
HHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECCCEEEEEEECCCCCCE
VFLLKQQSVARIDVVNYIAHGISKVPGHGEHSSEGEQDMQDDEGGEASSSGNPLDAYASN
EEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHH
LNELARQGRIDPLVGRESEVERVAQILARRRKNNPLLVGEAGVGKTAIAEGLAKRIVDNQ
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHCC
VPDLLANSVVYSLDLGALLAGTKYRGDFEKRFKALLNELRKRPQAILFIDEIHTIIGAGA
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCC
ASGGVMDASNLLKPLLSSGEIRCIGSTTFQEFRGIFEKDRALARRFQKVDVSEPSVEDTI
CCCCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
GILRGLKSRFEQHHSIEYSDEALRAAAELASRYINDRHMPDKAIDVIDEAGAYQRLQPVE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHH
KRAKRIDVPEVEDIVAKIARIPPKHVNSSDKELLRNLERDLKLTVFGQDAAIDSLSTAIK
HHHHHCCCCCHHHHHHHHHHCCCHHCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
LSRAGLKSPDKPVGSFLFAGPTGVGKTEAARQLAKALGVELIRFDMSEYMERHTVSRLIG
HHHHCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APPGYVGFDQGGLLTEAITRQPHCVLLLDEIEKAHPEVFNLLLQVMDHGTLTDNNGRKAD
CCCCCCCCCCCCHHHHHHCCCCCEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCC
FRNVIVIMTTNAGAESAARASIGFTHQDHSSDAMEVIKKSFTPEFRNRLDTIIQFGRLSH
CCCEEEEEECCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
EVIKSVVDKFLTELQAQLEDKRVLLEVSEAARSWLAQGGYDAAMGARPMARLIQDKIKRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHCH
LAEEILFGELSEHGGVVHIDIKDGEITFDFETTAEMA
HHHHHHHHHHHHCCCEEEEEEECCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]