Click here to switch to the map view.

The map label for this gene is cynR [H]

Identifier: 66046340

GI number: 66046340

Start: 3728244

End: 3729146

Strand: Reverse

Name: cynR [H]

Synonym: Psyr_3111

Alternate gene names: 66046340

Gene position: 3729146-3728244 (Counterclockwise)

Preceding gene: 66046342

Following gene: 66046338

Centisome position: 61.2

GC content: 60.8

Gene sequence:

>903_bases
ATGGACCTGCGTGATCTCACCTATTTCGAAACTATTGCCGAACTGGGGCATCTCGGACGGGCTGCGGAGAAGCTCAATCG
CAGCCAGCCAGCGCTGACCAAAAGCATTCAGCGCCTTGAGGAATCATTCGGCACGCGACTGTTTCAGCGTGACGGCCGAC
GCATCAAGTTGACGCCCGTGGGCGAGCTGCTCCAGGCGCGTGGCAAGGAATTGCAGCAAAGCATCGCCCAGACCCAGCGC
GAGATTCGGGATTTCGCCAGTGGCATGGTGGGCAACATACGGGTCGGCTGCGCTGCGACGATGGCGGAATACCTGATGCC
GAAACTGACTTCGGCCTTGTTGCAGCGTACCCCGGACGTCACCTTGAAGCTGGTGATAGGTCAGGATGACCTGCTGCGCG
AATCGTTGCGCTCCGGTCAGCTGGACATGATCATTTGCGCGCTGGCGCCCGACAGCGAAGACGTCACCAGCTTCGCCATA
CTGCAGGACGAAGCTGTGGTGGTCGCCAGCAAGAATCATCCGATTTTCAAGCCGTCGTTGAAGATGAGTGACCTGTGCGC
GTATCGCTGGGTACTGCCGCCGGTGAGTGTTTCATCGCGCAAATGGCTCGACGCGACCTTCGCCGCTCACGGCCTGCCGC
TGCCGACGGTGCAGATCGAAGCGAATTCGATCTCGCTGCTGCCGGGGCTGATTGCCCGCAGCAACCTGTTGAGCTTCATT
GCCCGCGAGTCGCTGGAGTTCGGCAAGACCATGCAGCACCTGCGCGAGGTGCCGCTCGAGCAGACCACCCTCAAACGCAC
CATTGGTGTGACGTTGCGCAAGGGCGGTTATCTGTCTCCTGCGGCAGAAGGCATGTTGCAGATGCTGCGCGACAACGGCG
GGGACTTTCGGGGTTGGGGCTGA

Upstream 100 bases:

>100_bases
TCTCCTTGATTGGGGTAAATCACATACGCACAGTATCGACTTCGCAACTCATCAAGTCTATTTTCTAATAATCATGAATT
GATAACTTTGGTTGATAGAT

Downstream 100 bases:

>100_bases
CAGCCTGCGTTCAGCCGCTCCCCGGCAGGGCCTGAAAGCCACTCAGGTACCTTGCCAGCGCCTCTGCGCCCAGTTCCACG
GTCGAGCTGGTACCCGCCCA

Product: regulatory protein, LysR:LysR, substrate-binding

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MDLRDLTYFETIAELGHLGRAAEKLNRSQPALTKSIQRLEESFGTRLFQRDGRRIKLTPVGELLQARGKELQQSIAQTQR
EIRDFASGMVGNIRVGCAATMAEYLMPKLTSALLQRTPDVTLKLVIGQDDLLRESLRSGQLDMIICALAPDSEDVTSFAI
LQDEAVVVASKNHPIFKPSLKMSDLCAYRWVLPPVSVSSRKWLDATFAAHGLPLPTVQIEANSISLLPGLIARSNLLSFI
ARESLEFGKTMQHLREVPLEQTTLKRTIGVTLRKGGYLSPAAEGMLQMLRDNGGDFRGWG

Sequences:

>Translated_300_residues
MDLRDLTYFETIAELGHLGRAAEKLNRSQPALTKSIQRLEESFGTRLFQRDGRRIKLTPVGELLQARGKELQQSIAQTQR
EIRDFASGMVGNIRVGCAATMAEYLMPKLTSALLQRTPDVTLKLVIGQDDLLRESLRSGQLDMIICALAPDSEDVTSFAI
LQDEAVVVASKNHPIFKPSLKMSDLCAYRWVLPPVSVSSRKWLDATFAAHGLPLPTVQIEANSISLLPGLIARSNLLSFI
ARESLEFGKTMQHLREVPLEQTTLKRTIGVTLRKGGYLSPAAEGMLQMLRDNGGDFRGWG
>Mature_300_residues
MDLRDLTYFETIAELGHLGRAAEKLNRSQPALTKSIQRLEESFGTRLFQRDGRRIKLTPVGELLQARGKELQQSIAQTQR
EIRDFASGMVGNIRVGCAATMAEYLMPKLTSALLQRTPDVTLKLVIGQDDLLRESLRSGQLDMIICALAPDSEDVTSFAI
LQDEAVVVASKNHPIFKPSLKMSDLCAYRWVLPPVSVSSRKWLDATFAAHGLPLPTVQIEANSISLLPGLIARSNLLSFI
ARESLEFGKTMQHLREVPLEQTTLKRTIGVTLRKGGYLSPAAEGMLQMLRDNGGDFRGWG

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=293, Percent_Identity=32.0819112627986, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI87081904, Length=293, Percent_Identity=26.6211604095563, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1787601, Length=245, Percent_Identity=27.7551020408163, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI145693105, Length=302, Percent_Identity=25.1655629139073, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790399, Length=292, Percent_Identity=24.3150684931507, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788748, Length=295, Percent_Identity=26.1016949152542, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790208, Length=174, Percent_Identity=31.0344827586207, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789506, Length=291, Percent_Identity=22.3367697594502, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788297, Length=233, Percent_Identity=26.1802575107296, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788887, Length=185, Percent_Identity=30.2702702702703, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788481, Length=281, Percent_Identity=23.1316725978648, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789639, Length=206, Percent_Identity=24.2718446601942, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI87082132, Length=302, Percent_Identity=25.4966887417219, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787879, Length=194, Percent_Identity=27.8350515463918, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI2367136, Length=143, Percent_Identity=32.8671328671329, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787806, Length=293, Percent_Identity=23.2081911262799, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787530, Length=216, Percent_Identity=23.6111111111111, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1789204, Length=217, Percent_Identity=26.2672811059908, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081684, Length=290, Percent_Identity=24.4827586206897, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082024, Length=172, Percent_Identity=25, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1786401, Length=122, Percent_Identity=31.9672131147541, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33231; Mature: 33231

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRDLTYFETIAELGHLGRAAEKLNRSQPALTKSIQRLEESFGTRLFQRDGRRIKLTPV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCH
GELLQARGKELQQSIAQTQREIRDFASGMVGNIRVGCAATMAEYLMPKLTSALLQRTPDV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
TLKLVIGQDDLLRESLRSGQLDMIICALAPDSEDVTSFAILQDEAVVVASKNHPIFKPSL
EEEEEECCHHHHHHHHHCCCEEEEEEEECCCCCCHHHEEEEECCEEEEEECCCCCCCCCC
KMSDLCAYRWVLPPVSVSSRKWLDATFAAHGLPLPTVQIEANSISLLPGLIARSNLLSFI
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
ARESLEFGKTMQHLREVPLEQTTLKRTIGVTLRKGGYLSPAAEGMLQMLRDNGGDFRGWG
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDLRDLTYFETIAELGHLGRAAEKLNRSQPALTKSIQRLEESFGTRLFQRDGRRIKLTPV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCH
GELLQARGKELQQSIAQTQREIRDFASGMVGNIRVGCAATMAEYLMPKLTSALLQRTPDV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
TLKLVIGQDDLLRESLRSGQLDMIICALAPDSEDVTSFAILQDEAVVVASKNHPIFKPSL
EEEEEECCHHHHHHHHHCCCEEEEEEEECCCCCCHHHEEEEECCEEEEEECCCCCCCCCC
KMSDLCAYRWVLPPVSVSSRKWLDATFAAHGLPLPTVQIEANSISLLPGLIARSNLLSFI
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
ARESLEFGKTMQHLREVPLEQTTLKRTIGVTLRKGGYLSPAAEGMLQMLRDNGGDFRGWG
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]