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The map label for this gene is nodT [H]

Identifier: 66046200

GI number: 66046200

Start: 3560826

End: 3562223

Strand: Direct

Name: nodT [H]

Synonym: Psyr_2969

Alternate gene names: 66046200

Gene position: 3560826-3562223 (Clockwise)

Preceding gene: 66046199

Following gene: 66046201

Centisome position: 58.43

GC content: 65.16

Gene sequence:

>1398_bases
ATGAGTGCGTACAAAGTCTTCATCCCGAGCCTGCTGGTCATGGCACTGGCGGCCTGCGCCGTAGGCCCGGACTACCAGGC
ACCGGTCACGGCGCCAGCGAAACTGGCGTCCGCCGCCCAAGGCAACTATGACCGCAGCAAAGTGGACAGGGTGTGGTGGC
AGCAGTTCGAGGACCCGACCCTCAATAAACTGGTGGCCAGGTCACTGGACGGCAACCGCGATCTGCGCGTCGCCTTCGCC
CGGCTCAAGTCGGCGCGCGCCATTCGCGATGACGTCGCCAACGATGTGATGCCAGTGGTGACCAGCCGCGCCAGCAGTGA
CATCGGCAAGGGTCAGCAACCCGGCATCACCGAGCGCCGGGTCAACAGCGAGCGCTATGACCTGGGCCTGGACATGGCCT
GGGAAGTGGACCTGTTCGGGCGTATACAGCGTCAGCTGGAAGCCAGCGATGCCGATCAGGACGCTGCAGAGGCCAACCTC
TATCAGTTGCAGGTCACGCTGATTGCCGAGGTGGTCGACGCCTACGGTCAACTGCGCGGCGCACAACTGCGTGAAGCCAT
TGCCCGCGACAACCTGAAAAATCAGCAAAGTTCTCAGGACGTGACCACGCAATTGCGCGATGCGGGCGTGGGCAACGAGC
TGGATGTGGTGCGTGCCGAGGCACGACTGGCCGCCGTCGAGGCGAGCGTTCCGCAGTTGCAGGCCGAGCAGGCTCGCCAA
CGCAATCGCATCGCCACGTTACTGGGCGAGCGTCCGGAAAACCTCAGCGTCGACTTGAGCCCGAGCAAGCTGCCGGCCAT
CGCCAAGGCCTTGCCGATTGGCGACCCGACGCAAGTGTTGCGCAATCGGCCCGACATCCGCGCAGCCGAGCGACAACTCG
CTGCCTCGACCGCCCGTATCGGCGTCGCGACTGCCGATCTGTTCCCAAGGGTCAGCCTGAGCGGGTTTCTGGGCTTTACC
GCCGGACGCGGCTCGCAGATCGGTTCGTCAGCGGCCAGAGCCTGGTCGCTGGGCCCCAGCATCACCTGGGCGGCCTTCGA
TCTGGGCAGTGTCCGGGCGCAGATTCGCAGTGCCGACGCCGACGCAGAAGGCGCACTGGCCAACTATGAGCAGCAGGTGC
TGCTCGCGCTGGAAGAGTCGGAGAACGCGTTCAGCGACTACGACAAACGCCAGCAGCGGCTGGTCTCACTGATGCGCCAG
AGCGATGCGAGTCGCTCGGCGGCCAGACTGGCCTCGGTGCAGTATCGCGAAGGCACGGCGGACTTTCTGGTCCTGCTGGA
TGCCGAGCGCGAGCGTCTGGCGGCCGAGGACGCTCAGGCGCAGGCAGAAATCGAGCTGTACCGTGGCATTGTGGCCATCT
ACAAGGCACTGGGTGGCGGCTGGCAACCTCAGGCCTGA

Upstream 100 bases:

>100_bases
CGGTGTTCTACGTGCTTATCCGTAATTACGTCGAACGCCAGGAGGCCCGCAAGGCCGCCAGGGTAAACAGCCAGCAAAAC
CTGCCTGCGGAGATGCATTG

Downstream 100 bases:

>100_bases
ACCTGAAAAGCCGGTAAACCCGCCCCGCGTCCGATCAGGCCGCGGGGCTTTTTTTGCCTGAAATCCGGCTGCATCATGAT
TGCCGTTTGACAGCTGCCAG

Product: RND efflux system, outer membrane lipoprotein, NodT

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSAYKVFIPSLLVMALAACAVGPDYQAPVTAPAKLASAAQGNYDRSKVDRVWWQQFEDPTLNKLVARSLDGNRDLRVAFA
RLKSARAIRDDVANDVMPVVTSRASSDIGKGQQPGITERRVNSERYDLGLDMAWEVDLFGRIQRQLEASDADQDAAEANL
YQLQVTLIAEVVDAYGQLRGAQLREAIARDNLKNQQSSQDVTTQLRDAGVGNELDVVRAEARLAAVEASVPQLQAEQARQ
RNRIATLLGERPENLSVDLSPSKLPAIAKALPIGDPTQVLRNRPDIRAAERQLAASTARIGVATADLFPRVSLSGFLGFT
AGRGSQIGSSAARAWSLGPSITWAAFDLGSVRAQIRSADADAEGALANYEQQVLLALEESENAFSDYDKRQQRLVSLMRQ
SDASRSAARLASVQYREGTADFLVLLDAERERLAAEDAQAQAEIELYRGIVAIYKALGGGWQPQA

Sequences:

>Translated_465_residues
MSAYKVFIPSLLVMALAACAVGPDYQAPVTAPAKLASAAQGNYDRSKVDRVWWQQFEDPTLNKLVARSLDGNRDLRVAFA
RLKSARAIRDDVANDVMPVVTSRASSDIGKGQQPGITERRVNSERYDLGLDMAWEVDLFGRIQRQLEASDADQDAAEANL
YQLQVTLIAEVVDAYGQLRGAQLREAIARDNLKNQQSSQDVTTQLRDAGVGNELDVVRAEARLAAVEASVPQLQAEQARQ
RNRIATLLGERPENLSVDLSPSKLPAIAKALPIGDPTQVLRNRPDIRAAERQLAASTARIGVATADLFPRVSLSGFLGFT
AGRGSQIGSSAARAWSLGPSITWAAFDLGSVRAQIRSADADAEGALANYEQQVLLALEESENAFSDYDKRQQRLVSLMRQ
SDASRSAARLASVQYREGTADFLVLLDAERERLAAEDAQAQAEIELYRGIVAIYKALGGGWQPQA
>Mature_464_residues
SAYKVFIPSLLVMALAACAVGPDYQAPVTAPAKLASAAQGNYDRSKVDRVWWQQFEDPTLNKLVARSLDGNRDLRVAFAR
LKSARAIRDDVANDVMPVVTSRASSDIGKGQQPGITERRVNSERYDLGLDMAWEVDLFGRIQRQLEASDADQDAAEANLY
QLQVTLIAEVVDAYGQLRGAQLREAIARDNLKNQQSSQDVTTQLRDAGVGNELDVVRAEARLAAVEASVPQLQAEQARQR
NRIATLLGERPENLSVDLSPSKLPAIAKALPIGDPTQVLRNRPDIRAAERQLAASTARIGVATADLFPRVSLSGFLGFTA
GRGSQIGSSAARAWSLGPSITWAAFDLGSVRAQIRSADADAEGALANYEQQVLLALEESENAFSDYDKRQQRLVSLMRQS
DASRSAARLASVQYREGTADFLVLLDAERERLAAEDAQAQAEIELYRGIVAIYKALGGGWQPQA

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=477, Percent_Identity=27.6729559748428, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI2367348, Length=442, Percent_Identity=21.9457013574661, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 50519; Mature: 50388

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAYKVFIPSLLVMALAACAVGPDYQAPVTAPAKLASAAQGNYDRSKVDRVWWQQFEDPT
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCH
LNKLVARSLDGNRDLRVAFARLKSARAIRDDVANDVMPVVTSRASSDIGKGQQPGITERR
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
VNSERYDLGLDMAWEVDLFGRIQRQLEASDADQDAAEANLYQLQVTLIAEVVDAYGQLRG
CCCHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHCH
AQLREAIARDNLKNQQSSQDVTTQLRDAGVGNELDVVRAEARLAAVEASVPQLQAEQARQ
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHH
RNRIATLLGERPENLSVDLSPSKLPAIAKALPIGDPTQVLRNRPDIRAAERQLAASTARI
HHHHHHHHCCCCCCCEEECCCHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHH
GVATADLFPRVSLSGFLGFTAGRGSQIGSSAARAWSLGPSITWAAFDLGSVRAQIRSADA
CEEHHHHCCCCCHHHHHEECCCCCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCC
DAEGALANYEQQVLLALEESENAFSDYDKRQQRLVSLMRQSDASRSAARLASVQYREGTA
CCCCCHHCCHHHHHEEEHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DFLVLLDAERERLAAEDAQAQAEIELYRGIVAIYKALGGGWQPQA
EEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SAYKVFIPSLLVMALAACAVGPDYQAPVTAPAKLASAAQGNYDRSKVDRVWWQQFEDPT
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCH
LNKLVARSLDGNRDLRVAFARLKSARAIRDDVANDVMPVVTSRASSDIGKGQQPGITERR
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
VNSERYDLGLDMAWEVDLFGRIQRQLEASDADQDAAEANLYQLQVTLIAEVVDAYGQLRG
CCCHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHCH
AQLREAIARDNLKNQQSSQDVTTQLRDAGVGNELDVVRAEARLAAVEASVPQLQAEQARQ
HHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHH
RNRIATLLGERPENLSVDLSPSKLPAIAKALPIGDPTQVLRNRPDIRAAERQLAASTARI
HHHHHHHHCCCCCCCEEECCCHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHH
GVATADLFPRVSLSGFLGFTAGRGSQIGSSAARAWSLGPSITWAAFDLGSVRAQIRSADA
CEEHHHHCCCCCHHHHHEECCCCCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHCCCC
DAEGALANYEQQVLLALEESENAFSDYDKRQQRLVSLMRQSDASRSAARLASVQYREGTA
CCCCCHHCCHHHHHEEEHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DFLVLLDAERERLAAEDAQAQAEIELYRGIVAIYKALGGGWQPQA
EEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]