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The map label for this gene is frmA [H]

Identifier: 66046187

GI number: 66046187

Start: 3543485

End: 3544594

Strand: Direct

Name: frmA [H]

Synonym: Psyr_2956

Alternate gene names: 66046187

Gene position: 3543485-3544594 (Clockwise)

Preceding gene: 66046186

Following gene: 66046188

Centisome position: 58.15

GC content: 58.74

Gene sequence:

>1110_bases
ATGAAGTCTCGTGCTGCAGTTGCATTTGAACCTGGCAAGCCGCTCCAGATCGTCGAGATCGACGTCGAGCCGCCACGCAA
GGGCGAAGTGCTGATCAAGATCACCGATACCGGTGTATGCCATACGGATGCTTTCACACTTTCGGGCGATGATCCGGAAG
GCCTGTTCCCGGTAGTACTGGGCCATGAAGGCGCCGGCATCGTCATGGAAGTAGGCGAAGGCGTGACCAGCGTGAAAGTC
GGTGACCACGTCATTCCGCTGTACACCGCCGAATGCGGCGAGTGCCTGTTCTGTAAATCGGGCAAAACCAACCTGTGCAC
CGCTGTGCGCGCCACTCAGGGCAAAGGCGTGATGCCGGACGGCACTTCACGCTTCTCCTACAACGGCCAACCCCTGTACC
ACTACATGGGTTGCTCGACCTTCAGCGAGTACACTGTTGTCGCTGAAGTTTCTGTCGCGAAGATCAATCCAGACGCCAAC
CCCGAGCACGTCTGCCTGCTCGGCTGCGGCGTGACTACCGGCATTGGCGCGGTGCACAACACGGCCAAAGTCCAGCCTGG
CGACACAGTCGCGGTATTTGGCCTGGGCGGCATCGGTCTGGCGGCGATTCAGGGTGCGCGTCAGGCCAAGGCAGGACGCA
TCATCGCTATCGACACCAACCCTGCCAAGTTCGAACTGGCCCGTTCGTTTGGCGCTACCGACTGTGTGAATCCAAAAGAT
CACGAACAGCCGATCCAGCAGGTGATCATTGAGATGACTGGCTGGGGTGTCGACCACTCCTTCGAATGTATCGGTAACGT
GCATGTGATGCGCGCTGCGCTCGAATGTGCCCACCGCGGCTGGGGCCAATCGATCGTCATTGGTGTTGCCGGTGCCGGTC
AGGAAATCTCGACCCGTCCCTTCCAGCTGGTCACCGGCCGTACCTGGAAAGGCTCGGCGTTTGGCGGCGTAAAAGGCCGT
AGCCAACTGCCGAAGATGGTTGAAGACGCGATGAAAGGCGAGATCGAGCTGGCACCTTTTGTCACTCACACCATGGGCCT
GGATCGCATCAATGAAGCGTTTGACTTGATGCACGAAGGCAAGTCGATCCGCACCGTCATCAAATACTGA

Upstream 100 bases:

>100_bases
TTGCTGTGAAATCTTCCAGAACGCAGTGACAGGCACCTATCGATGCTCGGCCCAAAGACAACGATCAAAGGCTCGAGCAT
CATCAATTGGAGAAAATCAC

Downstream 100 bases:

>100_bases
TGTCGTCCACTGTTCCGGGGCAGTTGCCATGGAACCTGTTCCAAGTCACCCCTATAGCTGGAGGTACACTGTGAGCGATG
TAAAACTTCACCCTGCGCTG

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MKSRAAVAFEPGKPLQIVEIDVEPPRKGEVLIKITDTGVCHTDAFTLSGDDPEGLFPVVLGHEGAGIVMEVGEGVTSVKV
GDHVIPLYTAECGECLFCKSGKTNLCTAVRATQGKGVMPDGTSRFSYNGQPLYHYMGCSTFSEYTVVAEVSVAKINPDAN
PEHVCLLGCGVTTGIGAVHNTAKVQPGDTVAVFGLGGIGLAAIQGARQAKAGRIIAIDTNPAKFELARSFGATDCVNPKD
HEQPIQQVIIEMTGWGVDHSFECIGNVHVMRAALECAHRGWGQSIVIGVAGAGQEISTRPFQLVTGRTWKGSAFGGVKGR
SQLPKMVEDAMKGEIELAPFVTHTMGLDRINEAFDLMHEGKSIRTVIKY

Sequences:

>Translated_369_residues
MKSRAAVAFEPGKPLQIVEIDVEPPRKGEVLIKITDTGVCHTDAFTLSGDDPEGLFPVVLGHEGAGIVMEVGEGVTSVKV
GDHVIPLYTAECGECLFCKSGKTNLCTAVRATQGKGVMPDGTSRFSYNGQPLYHYMGCSTFSEYTVVAEVSVAKINPDAN
PEHVCLLGCGVTTGIGAVHNTAKVQPGDTVAVFGLGGIGLAAIQGARQAKAGRIIAIDTNPAKFELARSFGATDCVNPKD
HEQPIQQVIIEMTGWGVDHSFECIGNVHVMRAALECAHRGWGQSIVIGVAGAGQEISTRPFQLVTGRTWKGSAFGGVKGR
SQLPKMVEDAMKGEIELAPFVTHTMGLDRINEAFDLMHEGKSIRTVIKY
>Mature_369_residues
MKSRAAVAFEPGKPLQIVEIDVEPPRKGEVLIKITDTGVCHTDAFTLSGDDPEGLFPVVLGHEGAGIVMEVGEGVTSVKV
GDHVIPLYTAECGECLFCKSGKTNLCTAVRATQGKGVMPDGTSRFSYNGQPLYHYMGCSTFSEYTVVAEVSVAKINPDAN
PEHVCLLGCGVTTGIGAVHNTAKVQPGDTVAVFGLGGIGLAAIQGARQAKAGRIIAIDTNPAKFELARSFGATDCVNPKD
HEQPIQQVIIEMTGWGVDHSFECIGNVHVMRAALECAHRGWGQSIVIGVAGAGQEISTRPFQLVTGRTWKGSAFGGVKGR
SQLPKMVEDAMKGEIELAPFVTHTMGLDRINEAFDLMHEGKSIRTVIKY

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=368, Percent_Identity=64.6739130434783, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=50.1355013550135, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=51.0695187165775, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=49.5934959349593, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=48.780487804878, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=48.2384823848238, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=48.2384823848238, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=46.5940054495913, Blast_Score=357, Evalue=9e-99,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=46.814404432133, Blast_Score=351, Evalue=5e-97,
Organism=Homo sapiens, GI156627571, Length=361, Percent_Identity=24.6537396121884, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=85.0948509485095, Blast_Score=641, Evalue=0.0,
Organism=Escherichia coli, GI1790045, Length=379, Percent_Identity=28.2321899736148, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1787863, Length=361, Percent_Identity=26.8698060941828, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI87082125, Length=380, Percent_Identity=25.2631578947368, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI87081918, Length=339, Percent_Identity=30.9734513274336, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788073, Length=381, Percent_Identity=26.509186351706, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786825, Length=245, Percent_Identity=28.1632653061224, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1788075, Length=363, Percent_Identity=25.3443526170799, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI226510992, Length=349, Percent_Identity=26.0744985673352, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788407, Length=234, Percent_Identity=28.6324786324786, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786518, Length=368, Percent_Identity=26.9021739130435, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790718, Length=351, Percent_Identity=24.2165242165242, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=58.1769436997319, Blast_Score=456, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=57.8666666666667, Blast_Score=451, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=58.3090379008746, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17562584, Length=372, Percent_Identity=26.3440860215054, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=252, Percent_Identity=31.3492063492063, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=362, Percent_Identity=24.585635359116, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=192, Percent_Identity=30.2083333333333, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=372, Percent_Identity=61.8279569892473, Blast_Score=464, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319621, Length=375, Percent_Identity=30.6666666666667, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323961, Length=366, Percent_Identity=27.8688524590164, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6323729, Length=369, Percent_Identity=27.6422764227642, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=367, Percent_Identity=26.7029972752044, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323099, Length=387, Percent_Identity=28.9405684754522, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=362, Percent_Identity=27.0718232044199, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=362, Percent_Identity=27.0718232044199, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=64.945652173913, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI17137530, Length=253, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737897, Length=254, Percent_Identity=27.1653543307087, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39178; Mature: 39178

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRAAVAFEPGKPLQIVEIDVEPPRKGEVLIKITDTGVCHTDAFTLSGDDPEGLFPVVL
CCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCEEECCEEEECCCCCCCEEEEEE
GHEGAGIVMEVGEGVTSVKVGDHVIPLYTAECGECLFCKSGKTNLCTAVRATQGKGVMPD
CCCCCEEEEECCCCEEEEEECCEEEEEEECCCCCEEEECCCCCCEEEEEEECCCCCCCCC
GTSRFSYNGQPLYHYMGCSTFSEYTVVAEVSVAKINPDANPEHVCLLGCGVTTGIGAVHN
CCCEECCCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCEEEEEECCCHHCCCHHCC
TAKVQPGDTVAVFGLGGIGLAAIQGARQAKAGRIIAIDTNPAKFELARSFGATDCVNPKD
CCEECCCCEEEEEECCCCHHHHHCCCHHHCCCEEEEEECCCCHHHHHHHCCCCCCCCCCC
HEQPIQQVIIEMTGWGVDHSFECIGNVHVMRAALECAHRGWGQSIVIGVAGAGQEISTRP
HHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRTWKGSAFGGVKGRSQLPKMVEDAMKGEIELAPFVTHTMGLDRINEAFDLMHEG
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECHHHHHHCHHHHHHHHHHHHCC
KSIRTVIKY
CCEEHEECC
>Mature Secondary Structure
MKSRAAVAFEPGKPLQIVEIDVEPPRKGEVLIKITDTGVCHTDAFTLSGDDPEGLFPVVL
CCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCEEECCEEEECCCCCCCEEEEEE
GHEGAGIVMEVGEGVTSVKVGDHVIPLYTAECGECLFCKSGKTNLCTAVRATQGKGVMPD
CCCCCEEEEECCCCEEEEEECCEEEEEEECCCCCEEEECCCCCCEEEEEEECCCCCCCCC
GTSRFSYNGQPLYHYMGCSTFSEYTVVAEVSVAKINPDANPEHVCLLGCGVTTGIGAVHN
CCCEECCCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCEEEEEECCCHHCCCHHCC
TAKVQPGDTVAVFGLGGIGLAAIQGARQAKAGRIIAIDTNPAKFELARSFGATDCVNPKD
CCEECCCCEEEEEECCCCHHHHHCCCHHHCCCEEEEEECCCCHHHHHHHCCCCCCCCCCC
HEQPIQQVIIEMTGWGVDHSFECIGNVHVMRAALECAHRGWGQSIVIGVAGAGQEISTRP
HHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRTWKGSAFGGVKGRSQLPKMVEDAMKGEIELAPFVTHTMGLDRINEAFDLMHEG
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECHHHHHHCHHHHHHHHHHHHCC
KSIRTVIKY
CCEEHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]