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The map label for this gene is umuC [H]

Identifier: 66045997

GI number: 66045997

Start: 3348722

End: 3350002

Strand: Reverse

Name: umuC [H]

Synonym: Psyr_2761

Alternate gene names: 66045997

Gene position: 3350002-3348722 (Counterclockwise)

Preceding gene: 66045998

Following gene: 66045990

Centisome position: 54.97

GC content: 56.05

Gene sequence:

>1281_bases
ATGGCCGGTCATGAGAATGTCTTCGCGCTGATCGACTGCAACTGTTTTTATGCGAGCTGCGAGCGAGCTTTCCGTCCCGA
CCTGGCAAAGACTCCCATCGTAGTGCTCAGTAACAACGACGGATGTGTTATCGCCCGGAGCTATGACGCAAAACCATTTG
TGAAAATGGGTGCACCGTACTTTCAGATCAAGGACGTTTTGCGTCAGAACGGCGTGATTGCCTTCAGCAGCAATTACGCC
CTGTATGGCGACATGAGTGAGCGGGTTATGACGATCATCGAGTCGATGGTGCCCGCCTCGGAGGTTTATAGCATCGATGA
AGCGTTTGCCGATCTGACGGGCATACCGGGCGACATGACAGAATTTGGCCGGCGCATCCGGTCGAAAATCCTCAAATGCA
CCGGTATACCAGTTGGCGTTGGCATTGGGCCTACCAAGACGCTTGCCAAGCTGGCGAACCACACCGCTAAGAGACTGCTG
GCCCAAACAGGTGGAGTCGTTGACATCTGCGACCTGCACAAGCGCAACTGGGTGCTGCGCAATACGTGTGTGTCAGAGGT
GTGGGGAGTGGGAAAGAAGATGAAAGCGCATCTAGAGGCCATGAACATCCGAAGCGCAATGGATTTGGCCAATGCTGACG
CGCGCACCCTACGCACCAAGTTCAGTGTCGTCATTGAAAAGACTGCGCGAGAGCTGGCCGGCACGTCGTGTTTGGAAATG
AGCGAAGCTGATCCGCCCAAACAGGAAATCTGCAGCAGTCGAATGTTTGGGCAGCGCCTGACCACTATCGAGCCGATCAA
GGAAGCGGTGGCCACCTACACGCAGCGCGCCGCTGAAAAACTGCGTGCCCAGAATTCACTGTGCAAGAAGATGCGCGTCA
GTATCCGCACAGGTATGTTCAACCCGGATGAACCTAAATATGCGAATGGTGCGCTGGTCGAGCTGCCGTATCCCACCAAT
GACGTGCGCTTGCTGACGAAGGGTGCAACTGAGGCGGTCAACCGACTTTTCCGCCCAGGGTACAAGTACAGCAAGGCCGA
AGTGCTGCTGCTGGATCTTCGCCAACCTGGCGAGTTTACGGATGACCTGTTTGCGGAGTCGCAGCCAGCGGCGGTAGAAA
AGGTGATGGGCGTGCTCGACGAAATCAATGCACTCTGGGGGAGGGGGACATTGAGGGCCGGGAGCGTACCGTCCGATCCA
GACTGGGCAATGCGCAGGGACATGATGAGCCAGAGCTACACGACTCGATTGGATCAACTGTGGGTAGTCAGGGCGTACTG
A

Upstream 100 bases:

>100_bases
GTTATCCTTCAGTCAGAAAATCCGCATTTCGCACCTCGACACATCATGGAAGGCGATGAACTGTCCATCTTGGGAGTCGT
TCGTTACAGCGTGCGCGATC

Downstream 100 bases:

>100_bases
CCGTGCGCCCTTTGCGGTGAAGGATGCAGCGCGTGCTCAAGTGCCGCTACGCCTGGGAACCTGAATCCGACCGTCCCCCC
CACATTACCGGATCGACATT

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MAGHENVFALIDCNCFYASCERAFRPDLAKTPIVVLSNNDGCVIARSYDAKPFVKMGAPYFQIKDVLRQNGVIAFSSNYA
LYGDMSERVMTIIESMVPASEVYSIDEAFADLTGIPGDMTEFGRRIRSKILKCTGIPVGVGIGPTKTLAKLANHTAKRLL
AQTGGVVDICDLHKRNWVLRNTCVSEVWGVGKKMKAHLEAMNIRSAMDLANADARTLRTKFSVVIEKTARELAGTSCLEM
SEADPPKQEICSSRMFGQRLTTIEPIKEAVATYTQRAAEKLRAQNSLCKKMRVSIRTGMFNPDEPKYANGALVELPYPTN
DVRLLTKGATEAVNRLFRPGYKYSKAEVLLLDLRQPGEFTDDLFAESQPAAVEKVMGVLDEINALWGRGTLRAGSVPSDP
DWAMRRDMMSQSYTTRLDQLWVVRAY

Sequences:

>Translated_426_residues
MAGHENVFALIDCNCFYASCERAFRPDLAKTPIVVLSNNDGCVIARSYDAKPFVKMGAPYFQIKDVLRQNGVIAFSSNYA
LYGDMSERVMTIIESMVPASEVYSIDEAFADLTGIPGDMTEFGRRIRSKILKCTGIPVGVGIGPTKTLAKLANHTAKRLL
AQTGGVVDICDLHKRNWVLRNTCVSEVWGVGKKMKAHLEAMNIRSAMDLANADARTLRTKFSVVIEKTARELAGTSCLEM
SEADPPKQEICSSRMFGQRLTTIEPIKEAVATYTQRAAEKLRAQNSLCKKMRVSIRTGMFNPDEPKYANGALVELPYPTN
DVRLLTKGATEAVNRLFRPGYKYSKAEVLLLDLRQPGEFTDDLFAESQPAAVEKVMGVLDEINALWGRGTLRAGSVPSDP
DWAMRRDMMSQSYTTRLDQLWVVRAY
>Mature_425_residues
AGHENVFALIDCNCFYASCERAFRPDLAKTPIVVLSNNDGCVIARSYDAKPFVKMGAPYFQIKDVLRQNGVIAFSSNYAL
YGDMSERVMTIIESMVPASEVYSIDEAFADLTGIPGDMTEFGRRIRSKILKCTGIPVGVGIGPTKTLAKLANHTAKRLLA
QTGGVVDICDLHKRNWVLRNTCVSEVWGVGKKMKAHLEAMNIRSAMDLANADARTLRTKFSVVIEKTARELAGTSCLEMS
EADPPKQEICSSRMFGQRLTTIEPIKEAVATYTQRAAEKLRAQNSLCKKMRVSIRTGMFNPDEPKYANGALVELPYPTND
VRLLTKGATEAVNRLFRPGYKYSKAEVLLLDLRQPGEFTDDLFAESQPAAVEKVMGVLDEINALWGRGTLRAGSVPSDPD
WAMRRDMMSQSYTTRLDQLWVVRAY

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=422, Percent_Identity=47.6303317535545, Blast_Score=395, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 47294; Mature: 47163

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGHENVFALIDCNCFYASCERAFRPDLAKTPIVVLSNNDGCVIARSYDAKPFVKMGAPY
CCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHCCCH
FQIKDVLRQNGVIAFSSNYALYGDMSERVMTIIESMVPASEVYSIDEAFADLTGIPGDMT
HHHHHHHHHCCEEEEECCEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHH
EFGRRIRSKILKCTGIPVGVGIGPTKTLAKLANHTAKRLLAQTGGVVDICDLHKRNWVLR
HHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHCCCHHH
NTCVSEVWGVGKKMKAHLEAMNIRSAMDLANADARTLRTKFSVVIEKTARELAGTSCLEM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHC
SEADPPKQEICSSRMFGQRLTTIEPIKEAVATYTQRAAEKLRAQNSLCKKMRVSIRTGMF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NPDEPKYANGALVELPYPTNDVRLLTKGATEAVNRLFRPGYKYSKAEVLLLDLRQPGEFT
CCCCCCCCCCCEEECCCCCCCCEEEECCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC
DDLFAESQPAAVEKVMGVLDEINALWGRGTLRAGSVPSDPDWAMRRDMMSQSYTTRLDQL
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHE
WVVRAY
EEEECC
>Mature Secondary Structure 
AGHENVFALIDCNCFYASCERAFRPDLAKTPIVVLSNNDGCVIARSYDAKPFVKMGAPY
CCCCCEEEEEECCHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHCCCH
FQIKDVLRQNGVIAFSSNYALYGDMSERVMTIIESMVPASEVYSIDEAFADLTGIPGDMT
HHHHHHHHHCCEEEEECCEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHH
EFGRRIRSKILKCTGIPVGVGIGPTKTLAKLANHTAKRLLAQTGGVVDICDLHKRNWVLR
HHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHCCCHHH
NTCVSEVWGVGKKMKAHLEAMNIRSAMDLANADARTLRTKFSVVIEKTARELAGTSCLEM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHC
SEADPPKQEICSSRMFGQRLTTIEPIKEAVATYTQRAAEKLRAQNSLCKKMRVSIRTGMF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NPDEPKYANGALVELPYPTNDVRLLTKGATEAVNRLFRPGYKYSKAEVLLLDLRQPGEFT
CCCCCCCCCCCEEECCCCCCCCEEEECCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC
DDLFAESQPAAVEKVMGVLDEINALWGRGTLRAGSVPSDPDWAMRRDMMSQSYTTRLDQL
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHE
WVVRAY
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]