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The map label for this gene is ywrD [H]

Identifier: 66045917

GI number: 66045917

Start: 3252821

End: 3254470

Strand: Direct

Name: ywrD [H]

Synonym: Psyr_2681

Alternate gene names: 66045917

Gene position: 3252821-3254470 (Clockwise)

Preceding gene: 66045916

Following gene: 66045919

Centisome position: 53.38

GC content: 62.97

Gene sequence:

>1650_bases
ATGCGCTGGACCCCAAGGGCTAAACCTTTCGTCTTCTGCCAAAGAGAAACGCTTATGTTCGATGATCTGGATTACAACCA
ACCGTACGCGTCGGCCCGCTCGCCGGTGATGGGCAACAACATGGTCGCCTGCTCTCAGCCATTGGCCGCTCAGGCCGGGC
TGGACATGCTGCGCCGTGGCGGTAACGCGGTCGACGCCGCCATCGCCGCGGCCATGGTGCTGACTGTGGTCGAGCCCACC
GGCTGCGGAATCGGCAGCGATGCCTTCGCCATCGTCTGGGACGGCAGCAAGCTGCAAGGCTTGAACGCGTCCGGCCGCGC
GCCACAAGCCTGGACACCGGAATACTTCGAAGGCCAGAGCCAGATGGCGCAACGCGGCTGGCCTGCGGTCAGCGTGCCAG
GTGCGGTATCGGCCTGGGTGGAACTGTCAGCGCGCTACGGCAAACTGCCCTTCGCGACCCTGGCCGAACCGGCGATTGGC
TACGCCCGCGACGGCTATCAGGTCACGCCGATCATCGCCGAGTTGTGGAAACGCGGCGCGCATCTGCTCAAAGACCAACC
GGGCTTTGCCGAGTGCTTCATGCCGGGTGGCAAGGCCCCTATGGCCGGAGAAAAAATCCGGCTCAAGGATCACGCCCGCA
CGCTGGAACTGATCGCGCAGACCAAAGGCGAAGCGTTCTATCGCGGCGAACTGGCGCAAACCATCATCGCCCATGCCAAC
GCCAATGGCAGCGTAATGAGCCTCGACGACCTGGCGACGCATACCGTGGACTGGATCGACACCCTGTCGGTGCCCTACGC
AGGCGCTGTGGTGCATGAACTCCCGCCGAATGGCCAGGGCATTGCCACCTTGGCCGGCCTGACCATGCTCGAAGCACTGG
GCGTCGGCGAACACCCGGTGGACAGCCTTGAAACGGTTCACCCGGTGCTGGAAGCAATGAAACTGGCCTTGGCCGACCTC
GACGAACATGTCGCCGACAGCGAGCACATGCGCGTGCCCTCAGCCGATTTGCTGGGCAAGGCGTACCTGACAGAACGCGC
GGGCCTGATCACCGATCAGGCCGCCAATCCCGGGCACGGCTCGCCAAAACCGGGCGGCACGGTGTACCTCTCGGCAGCGG
ACGAAAGCGGCATGATGATCTCGTTCATCCAGTCCAACTACATGGGCTTCGGTTCGGGTGTGGTGGTACCCGGTACGGGC
ATCAGCATGCAGAACCGTGGCGCGGGCTTCTCGCTGGATCCGCAACACGTCAATTACGTTGCGCCGCGCAAACGCCCGTT
CCATACCATCATCCCCGGTTTTGTCATGAATGCCGACGGCACGCCGCTGATGTCCTTCGGTTTGATGGGCGGCCCGATGC
AGGCGCAGGGTCATTTGCAGATGATGATGCGCATCCTGCGCTACAAACAGAACCCGCAAGCCGCTGCCGACGCACCGCGC
TGGAGAATCGAAGCCGGTCTGAAAGTCGCCGTGGAGCGTGCGTTTGACCCCGAAGTGGTGAAAGCACTGCGCGCCAAAGG
TCACGACATCGATGTCGAAGAACCGAGCGGCGTGTTTGCCTTCGGCGGTGCGCAGATTATTCAGCGCACCGCGCATGGAT
ACGTGGGCGGGACCGATCCGAGAAAGGACGGAACGGTCGCAGCTTATTAA

Upstream 100 bases:

>100_bases
AAGAATTTCATGGAGCAGGCTCCGTGGATGTCGATTGCGCCTGGCGTGGCGATCTACATCACGGTCCTGTGTTTCAACCT
GCTGGGTGACGGCCTGCGCG

Downstream 100 bases:

>100_bases
CCGAGGCCTCTAGCGCTTGGCAGGCGGCGACCGGTCGTGCGCAGTGAGCGAATCCGTTCAAAGTAGCGGTGGTTTTTTTA
CTTTAAAGCGACTTAACTCA

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MRWTPRAKPFVFCQRETLMFDDLDYNQPYASARSPVMGNNMVACSQPLAAQAGLDMLRRGGNAVDAAIAAAMVLTVVEPT
GCGIGSDAFAIVWDGSKLQGLNASGRAPQAWTPEYFEGQSQMAQRGWPAVSVPGAVSAWVELSARYGKLPFATLAEPAIG
YARDGYQVTPIIAELWKRGAHLLKDQPGFAECFMPGGKAPMAGEKIRLKDHARTLELIAQTKGEAFYRGELAQTIIAHAN
ANGSVMSLDDLATHTVDWIDTLSVPYAGAVVHELPPNGQGIATLAGLTMLEALGVGEHPVDSLETVHPVLEAMKLALADL
DEHVADSEHMRVPSADLLGKAYLTERAGLITDQAANPGHGSPKPGGTVYLSAADESGMMISFIQSNYMGFGSGVVVPGTG
ISMQNRGAGFSLDPQHVNYVAPRKRPFHTIIPGFVMNADGTPLMSFGLMGGPMQAQGHLQMMMRILRYKQNPQAAADAPR
WRIEAGLKVAVERAFDPEVVKALRAKGHDIDVEEPSGVFAFGGAQIIQRTAHGYVGGTDPRKDGTVAAY

Sequences:

>Translated_549_residues
MRWTPRAKPFVFCQRETLMFDDLDYNQPYASARSPVMGNNMVACSQPLAAQAGLDMLRRGGNAVDAAIAAAMVLTVVEPT
GCGIGSDAFAIVWDGSKLQGLNASGRAPQAWTPEYFEGQSQMAQRGWPAVSVPGAVSAWVELSARYGKLPFATLAEPAIG
YARDGYQVTPIIAELWKRGAHLLKDQPGFAECFMPGGKAPMAGEKIRLKDHARTLELIAQTKGEAFYRGELAQTIIAHAN
ANGSVMSLDDLATHTVDWIDTLSVPYAGAVVHELPPNGQGIATLAGLTMLEALGVGEHPVDSLETVHPVLEAMKLALADL
DEHVADSEHMRVPSADLLGKAYLTERAGLITDQAANPGHGSPKPGGTVYLSAADESGMMISFIQSNYMGFGSGVVVPGTG
ISMQNRGAGFSLDPQHVNYVAPRKRPFHTIIPGFVMNADGTPLMSFGLMGGPMQAQGHLQMMMRILRYKQNPQAAADAPR
WRIEAGLKVAVERAFDPEVVKALRAKGHDIDVEEPSGVFAFGGAQIIQRTAHGYVGGTDPRKDGTVAAY
>Mature_549_residues
MRWTPRAKPFVFCQRETLMFDDLDYNQPYASARSPVMGNNMVACSQPLAAQAGLDMLRRGGNAVDAAIAAAMVLTVVEPT
GCGIGSDAFAIVWDGSKLQGLNASGRAPQAWTPEYFEGQSQMAQRGWPAVSVPGAVSAWVELSARYGKLPFATLAEPAIG
YARDGYQVTPIIAELWKRGAHLLKDQPGFAECFMPGGKAPMAGEKIRLKDHARTLELIAQTKGEAFYRGELAQTIIAHAN
ANGSVMSLDDLATHTVDWIDTLSVPYAGAVVHELPPNGQGIATLAGLTMLEALGVGEHPVDSLETVHPVLEAMKLALADL
DEHVADSEHMRVPSADLLGKAYLTERAGLITDQAANPGHGSPKPGGTVYLSAADESGMMISFIQSNYMGFGSGVVVPGTG
ISMQNRGAGFSLDPQHVNYVAPRKRPFHTIIPGFVMNADGTPLMSFGLMGGPMQAQGHLQMMMRILRYKQNPQAAADAPR
WRIEAGLKVAVERAFDPEVVKALRAKGHDIDVEEPSGVFAFGGAQIIQRTAHGYVGGTDPRKDGTVAAY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=535, Percent_Identity=27.4766355140187, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI73915090, Length=535, Percent_Identity=27.4766355140187, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI73915096, Length=535, Percent_Identity=27.4766355140187, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI73915094, Length=535, Percent_Identity=27.4766355140187, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI113429324, Length=524, Percent_Identity=26.7175572519084, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI113429326, Length=529, Percent_Identity=26.4650283553875, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI153266885, Length=551, Percent_Identity=24.6823956442831, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI153266901, Length=552, Percent_Identity=24.4565217391304, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI109148539, Length=523, Percent_Identity=26.3862332695985, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI153266907, Length=547, Percent_Identity=23.5831809872029, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI30581157, Length=198, Percent_Identity=28.7878787878788, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI30581155, Length=198, Percent_Identity=28.7878787878788, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789856, Length=538, Percent_Identity=28.4386617100372, Blast_Score=186, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17506189, Length=502, Percent_Identity=25.2988047808765, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI212646519, Length=480, Percent_Identity=24.375, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI72000294, Length=480, Percent_Identity=24.375, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI193208245, Length=478, Percent_Identity=25.9414225941423, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193208247, Length=478, Percent_Identity=25.9414225941423, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17542894, Length=543, Percent_Identity=23.3885819521179, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323330, Length=454, Percent_Identity=23.1277533039648, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI18859893, Length=509, Percent_Identity=25.5402750491159, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24642670, Length=555, Percent_Identity=24.1441441441441, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24642666, Length=555, Percent_Identity=24.1441441441441, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45551474, Length=555, Percent_Identity=24.1441441441441, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI161077878, Length=555, Percent_Identity=24.1441441441441, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI161077880, Length=555, Percent_Identity=24.1441441441441, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI161077496, Length=519, Percent_Identity=23.6994219653179, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18859741, Length=522, Percent_Identity=23.7547892720307, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 58589; Mature: 58589

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWTPRAKPFVFCQRETLMFDDLDYNQPYASARSPVMGNNMVACSQPLAAQAGLDMLRRG
CCCCCCCCCEEEEECCEEEECCCCCCCCCHHCCCCCCCCCEEECCCCHHHHHHHHHHHCC
GNAVDAAIAAAMVLTVVEPTGCGIGSDAFAIVWDGSKLQGLNASGRAPQAWTPEYFEGQS
CCHHHHHHHHHHHHHEECCCCCCCCCCCEEEEECCCEECCCCCCCCCCCCCCCHHHCCHH
QMAQRGWPAVSVPGAVSAWVELSARYGKLPFATLAEPAIGYARDGYQVTPIIAELWKRGA
HHHHCCCCCEECCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEEECHHHHHHHHCCH
HLLKDQPGFAECFMPGGKAPMAGEKIRLKDHARTLELIAQTKGEAFYRGELAQTIIAHAN
HHHCCCCCHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCC
ANGSVMSLDDLATHTVDWIDTLSVPYAGAVVHELPPNGQGIATLAGLTMLEALGVGEHPV
CCCCEEEHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCH
DSLETVHPVLEAMKLALADLDEHVADSEHMRVPSADLLGKAYLTERAGLITDQAANPGHG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCCCCCC
SPKPGGTVYLSAADESGMMISFIQSNYMGFGSGVVVPGTGISMQNRGAGFSLDPQHVNYV
CCCCCCEEEEEECCCCCCEEEEEHHCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHCCEE
APRKRPFHTIIPGFVMNADGTPLMSFGLMGGPMQAQGHLQMMMRILRYKQNPQAAADAPR
CCCCCCCCEECCCEEECCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHCCCCC
WRIEAGLKVAVERAFDPEVVKALRAKGHDIDVEEPSGVFAFGGAQIIQRTAHGYVGGTDP
EEECCCCEEEEHHCCCHHHHHHHHHCCCCCCCCCCCCEEEECHHHHHHHHHCCCCCCCCC
RKDGTVAAY
CCCCCEECC
>Mature Secondary Structure
MRWTPRAKPFVFCQRETLMFDDLDYNQPYASARSPVMGNNMVACSQPLAAQAGLDMLRRG
CCCCCCCCCEEEEECCEEEECCCCCCCCCHHCCCCCCCCCEEECCCCHHHHHHHHHHHCC
GNAVDAAIAAAMVLTVVEPTGCGIGSDAFAIVWDGSKLQGLNASGRAPQAWTPEYFEGQS
CCHHHHHHHHHHHHHEECCCCCCCCCCCEEEEECCCEECCCCCCCCCCCCCCCHHHCCHH
QMAQRGWPAVSVPGAVSAWVELSARYGKLPFATLAEPAIGYARDGYQVTPIIAELWKRGA
HHHHCCCCCEECCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEEECHHHHHHHHCCH
HLLKDQPGFAECFMPGGKAPMAGEKIRLKDHARTLELIAQTKGEAFYRGELAQTIIAHAN
HHHCCCCCHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCC
ANGSVMSLDDLATHTVDWIDTLSVPYAGAVVHELPPNGQGIATLAGLTMLEALGVGEHPV
CCCCEEEHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCH
DSLETVHPVLEAMKLALADLDEHVADSEHMRVPSADLLGKAYLTERAGLITDQAANPGHG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCCCCCC
SPKPGGTVYLSAADESGMMISFIQSNYMGFGSGVVVPGTGISMQNRGAGFSLDPQHVNYV
CCCCCCEEEEEECCCCCCEEEEEHHCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHCCEE
APRKRPFHTIIPGFVMNADGTPLMSFGLMGGPMQAQGHLQMMMRILRYKQNPQAAADAPR
CCCCCCCCEECCCEEECCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHCCCCC
WRIEAGLKVAVERAFDPEVVKALRAKGHDIDVEEPSGVFAFGGAQIIQRTAHGYVGGTDP
EEECCCCEEEEHHCCCHHHHHHHHHCCCCCCCCCCCCEEEECHHHHHHHHHCCCCCCCCC
RKDGTVAAY
CCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]