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The map label for this gene is lysA [H]

Identifier: 66045821

GI number: 66045821

Start: 3029650

End: 3030858

Strand: Direct

Name: lysA [H]

Synonym: Psyr_2585

Alternate gene names: 66045821

Gene position: 3029650-3030858 (Clockwise)

Preceding gene: 66045820

Following gene: 66045822

Centisome position: 49.72

GC content: 61.12

Gene sequence:

>1209_bases
ATGCATAAGGTGCCGGAGACCGTACTGGCGGCCATCAAGGAGGCTCGGGCGCTGGAAACCGACCCGCTGGCGGCCTTCTT
CTACGATCTGGACGCGTTGCAGCAGCATGTCAGTGAAGTCATGGCGGCGCTGCCCGCAGGTGTCGAGCTGTATTACGCGA
TCAAGGCCAACAGCGAAGCGCTGATGCTGGAAACCCTGGCCCCTCTGGTCAGTGGCTTTGAAATTTCCTCTGGGGGCGAG
ATCGAGCGGGTGATGGCCTGTCCGACACGCAAGCCCTACGTGTTCTCGGGCCCAGGCAAACTCGATTCCGATCTGCGCTC
GGCGTTGCTCAACAAGGTTGAAGCCATTCACCTGGAGAGCCTCAACGAAATCGCGCGTCTGCAACAGCTGGCAGAACAGG
CGGGGCGCGTGCAGCCGGTGTTCCTGCGCATCAATCCGCAACTGCCCGCTGCACAGTCGAGCCGGCTGGCGATGGCCGGG
ACCGCGACACCGTTCGGCATTGACGAAGCCGACCTGGCCGAGGCGGTCAGACGCGTGGACAACGCCAGCCACCTGACGCT
CAAGGGCTTTCACGTACATGCCATGTCGCATCAGATGTCGGTTGAACGTCATGAGCAGTTGCTCGATTTCTACCTGCAGC
GCTGGCAGGAATGGAAGGCTTTGGCCCGCGACCCGAGCCAGCTCACCCATTTCAACGTCGGCGGCGGTATTGGCGTCGAT
TACCTCAACAGCCAGCAGTTCGACTGGCAGCGGCTGTGCCGTTATCTGGAAAAACGCCTGGGCGAGCAGCACGACGCGCC
GATCCTGCGCTTTGAGCCGGGACGCTTCATCAGCGCCTATTGCGGCTATTACGCCATCGAGGTGCTGGACAGCAAAACCA
GCCACGGCGAGCATTTTCTGGTCTGCCGAGGCGGAACTCACCAGTTTCGCCTGCCGGTTGCGCAAAGCCATGACCATCCG
GTTATCCATCTGCCGAGTACGCCGCAGCCAGCTGCCTCGTCAGAACAGGCTTATACCATTGTCGGCCAGCTATGCACGCC
CAAGGACGTGCTGAGCCGTCGCCAGCCACTCAAGGGTGTGAACATTGGTGACCTGCTGGTTCTGCCGCTGGCGGGAGCGT
ATGGCTACAACATTTCCCATGCCGACTTTCTCTGTCATCCACGACCGTCACAGCACTTCGTGCGCAACGGCGAACGGGTT
CGCCAATGA

Upstream 100 bases:

>100_bases
ATTGCCTGCAAGACCAACCTCAAGGTCCGGCTCGCCGCCAAGGCCGATCGCGAAGCCAACTATGTGCGTCTTGCGTCGCC
GTGGGCCACGGAGGCACGTT

Downstream 100 bases:

>100_bases
GTTTCAACGTCCCACGTAGCTGGGTAGTGGTCAACGTGCTGCTCGGTACGCTGACGGTCAGTCTGAGCAACAGTTCGCTC
AACCCGGCGCTGCCTGCCTT

Product: Orn/DAP/Arg decarboxylase 2:Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MHKVPETVLAAIKEARALETDPLAAFFYDLDALQQHVSEVMAALPAGVELYYAIKANSEALMLETLAPLVSGFEISSGGE
IERVMACPTRKPYVFSGPGKLDSDLRSALLNKVEAIHLESLNEIARLQQLAEQAGRVQPVFLRINPQLPAAQSSRLAMAG
TATPFGIDEADLAEAVRRVDNASHLTLKGFHVHAMSHQMSVERHEQLLDFYLQRWQEWKALARDPSQLTHFNVGGGIGVD
YLNSQQFDWQRLCRYLEKRLGEQHDAPILRFEPGRFISAYCGYYAIEVLDSKTSHGEHFLVCRGGTHQFRLPVAQSHDHP
VIHLPSTPQPAASSEQAYTIVGQLCTPKDVLSRRQPLKGVNIGDLLVLPLAGAYGYNISHADFLCHPRPSQHFVRNGERV
RQ

Sequences:

>Translated_402_residues
MHKVPETVLAAIKEARALETDPLAAFFYDLDALQQHVSEVMAALPAGVELYYAIKANSEALMLETLAPLVSGFEISSGGE
IERVMACPTRKPYVFSGPGKLDSDLRSALLNKVEAIHLESLNEIARLQQLAEQAGRVQPVFLRINPQLPAAQSSRLAMAG
TATPFGIDEADLAEAVRRVDNASHLTLKGFHVHAMSHQMSVERHEQLLDFYLQRWQEWKALARDPSQLTHFNVGGGIGVD
YLNSQQFDWQRLCRYLEKRLGEQHDAPILRFEPGRFISAYCGYYAIEVLDSKTSHGEHFLVCRGGTHQFRLPVAQSHDHP
VIHLPSTPQPAASSEQAYTIVGQLCTPKDVLSRRQPLKGVNIGDLLVLPLAGAYGYNISHADFLCHPRPSQHFVRNGERV
RQ
>Mature_402_residues
MHKVPETVLAAIKEARALETDPLAAFFYDLDALQQHVSEVMAALPAGVELYYAIKANSEALMLETLAPLVSGFEISSGGE
IERVMACPTRKPYVFSGPGKLDSDLRSALLNKVEAIHLESLNEIARLQQLAEQAGRVQPVFLRINPQLPAAQSSRLAMAG
TATPFGIDEADLAEAVRRVDNASHLTLKGFHVHAMSHQMSVERHEQLLDFYLQRWQEWKALARDPSQLTHFNVGGGIGVD
YLNSQQFDWQRLCRYLEKRLGEQHDAPILRFEPGRFISAYCGYYAIEVLDSKTSHGEHFLVCRGGTHQFRLPVAQSHDHP
VIHLPSTPQPAASSEQAYTIVGQLCTPKDVLSRRQPLKGVNIGDLLVLPLAGAYGYNISHADFLCHPRPSQHFVRNGERV
RQ

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=404, Percent_Identity=24.2574257425743, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44752; Mature: 44752

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKVPETVLAAIKEARALETDPLAAFFYDLDALQQHVSEVMAALPAGVELYYAIKANSEA
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
LMLETLAPLVSGFEISSGGEIERVMACPTRKPYVFSGPGKLDSDLRSALLNKVEAIHLES
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
LNEIARLQQLAEQAGRVQPVFLRINPQLPAAQSSRLAMAGTATPFGIDEADLAEAVRRVD
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHC
NASHLTLKGFHVHAMSHQMSVERHEQLLDFYLQRWQEWKALARDPSQLTHFNVGGGIGVD
CCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEECCCCCCCC
YLNSQQFDWQRLCRYLEKRLGEQHDAPILRFEPGRFISAYCGYYAIEVLDSKTSHGEHFL
CCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHEEEEECCCCCCCCEEE
VCRGGTHQFRLPVAQSHDHPVIHLPSTPQPAASSEQAYTIVGQLCTPKDVLSRRQPLKGV
EEECCCCEEEECCCCCCCCCEEECCCCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCCCC
NIGDLLVLPLAGAYGYNISHADFLCHPRPSQHFVRNGERVRQ
CCCCCCEEECCCCCCCCCCCCCEEECCCCHHHHHHCCHHHCC
>Mature Secondary Structure
MHKVPETVLAAIKEARALETDPLAAFFYDLDALQQHVSEVMAALPAGVELYYAIKANSEA
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCC
LMLETLAPLVSGFEISSGGEIERVMACPTRKPYVFSGPGKLDSDLRSALLNKVEAIHLES
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
LNEIARLQQLAEQAGRVQPVFLRINPQLPAAQSSRLAMAGTATPFGIDEADLAEAVRRVD
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHC
NASHLTLKGFHVHAMSHQMSVERHEQLLDFYLQRWQEWKALARDPSQLTHFNVGGGIGVD
CCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEECCCCCCCC
YLNSQQFDWQRLCRYLEKRLGEQHDAPILRFEPGRFISAYCGYYAIEVLDSKTSHGEHFL
CCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHEEEEECCCCCCCCEEE
VCRGGTHQFRLPVAQSHDHPVIHLPSTPQPAASSEQAYTIVGQLCTPKDVLSRRQPLKGV
EEECCCCEEEECCCCCCCCCEEECCCCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCCCC
NIGDLLVLPLAGAYGYNISHADFLCHPRPSQHFVRNGERVRQ
CCCCCCEEECCCCCCCCCCCCCEEECCCCHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]