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The map label for this gene is gutB [H]

Identifier: 66045803

GI number: 66045803

Start: 2980696

End: 2981811

Strand: Reverse

Name: gutB [H]

Synonym: Psyr_2567

Alternate gene names: 66045803

Gene position: 2981811-2980696 (Counterclockwise)

Preceding gene: 66045804

Following gene: 66045802

Centisome position: 48.93

GC content: 60.93

Gene sequence:

>1116_bases
ATGTCCACCGTCACCGAACGCACTGCCGAACAACTTTCACCGGTCATCCCGAAAACCATGCAGGCCGTGGTCTGCCACGG
TCCGGAAGACTACCGGCTGGAAACCGTGGATGTGCCGACTCCCGGCCCCGACGAAATCCTCACCAAGGTCGAGCTGTGTG
GCATCTGCATGGGCGACATCAAGACCTATCGCGGCGCGCCCTCGTTCTGGGGCGATGCCGAGCAGCCTCGCTACGTCAAA
CCACCGATGATTCCCGGCCATGAATTCGTCTGTCGCGTGGTGGCGCTCGGCCCTGGCGCCGAAAAGCGTGGCGTGCAGAT
CGGCGACCGGGTGATCTCCGAGCAGATCGTGCCGTGCTGGGGCTGCCGCTTCTGTAACCACGGACAGTACTGGATGTGCC
AGAAGCACGACCTTTACGGCTTTCAGAACAACGTGCAGGGCGCCATGGCCCAGTACATGATTTTTACCAGGGAAGGCATC
ATTCACAAGGTGCCCGACTCGATTGCCCCGGACGAAGCCATCCTCATCGAACCACTGGCCTGCTCGCTGCACGCAGCCGA
ACGGGCCGACGTCGATTTCGACGACATTGTGGTCGTCGCCGGTGCCGGCACACTGGGCCTTGGGATCATTGGCGCGGTGC
GCATGCGTAACCCGAAAAAACTCATCGTTCTCGACATGAAGCCCGAGCGCGCCGCCCTCGCCCTGCGCATGGGCGCCGAT
GAGGTGTGGAACCCGGCCGAGGTCGACGTGCTGGCGAAGATCCGCGAGATAACCGACGGCTACGGTTGCGACATCTATAT
AGAAGCCACCGGACACCACAAGGCGGTCAACCAAGGCCTGGCGATGCTGCGCAAACTCGGACGCTTTGTGGAGTTCAGCG
TATTCAACGATGAGGCCACGGTGGACTGGTCGATCATCGGTGACCGCAAGGAGCTGGACGTGCTCGGTTCTCACCTCGGC
CCTTACATGTACCCGCGCGCCATCGACTTTATCGGCAACCGCAAGATCGACATGCGCGACGTCGTCACGCACAAATTTCC
CCTGGCGCAGTTCAAGGAGGCGTTTGCCGTCATGGAACGCGGTGATAAATCATTGAAGGTGGTTCTGGAACCCTGA

Upstream 100 bases:

>100_bases
TGCTCAGCGACGCCGCCAGCATGATCACCGGCGAAAACGTAGTGATCGACGGCGGCTACAGCATCCAGTAATTCATTTTT
CTGTCGTGAGGTTCATCGTC

Downstream 100 bases:

>100_bases
TCCGCCCGATCCTTATAAAAAGAACACAGGAAATCGCGTTATGAACCGAGTGATAAACGATCCGGACCAGGTGGTCGAGG
ACATGCTGCGCGGCATTCTG

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: Glucitol dehydrogenase; L-iditol 2-dehydrogenase [H]

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSTVTERTAEQLSPVIPKTMQAVVCHGPEDYRLETVDVPTPGPDEILTKVELCGICMGDIKTYRGAPSFWGDAEQPRYVK
PPMIPGHEFVCRVVALGPGAEKRGVQIGDRVISEQIVPCWGCRFCNHGQYWMCQKHDLYGFQNNVQGAMAQYMIFTREGI
IHKVPDSIAPDEAILIEPLACSLHAAERADVDFDDIVVVAGAGTLGLGIIGAVRMRNPKKLIVLDMKPERAALALRMGAD
EVWNPAEVDVLAKIREITDGYGCDIYIEATGHHKAVNQGLAMLRKLGRFVEFSVFNDEATVDWSIIGDRKELDVLGSHLG
PYMYPRAIDFIGNRKIDMRDVVTHKFPLAQFKEAFAVMERGDKSLKVVLEP

Sequences:

>Translated_371_residues
MSTVTERTAEQLSPVIPKTMQAVVCHGPEDYRLETVDVPTPGPDEILTKVELCGICMGDIKTYRGAPSFWGDAEQPRYVK
PPMIPGHEFVCRVVALGPGAEKRGVQIGDRVISEQIVPCWGCRFCNHGQYWMCQKHDLYGFQNNVQGAMAQYMIFTREGI
IHKVPDSIAPDEAILIEPLACSLHAAERADVDFDDIVVVAGAGTLGLGIIGAVRMRNPKKLIVLDMKPERAALALRMGAD
EVWNPAEVDVLAKIREITDGYGCDIYIEATGHHKAVNQGLAMLRKLGRFVEFSVFNDEATVDWSIIGDRKELDVLGSHLG
PYMYPRAIDFIGNRKIDMRDVVTHKFPLAQFKEAFAVMERGDKSLKVVLEP
>Mature_370_residues
STVTERTAEQLSPVIPKTMQAVVCHGPEDYRLETVDVPTPGPDEILTKVELCGICMGDIKTYRGAPSFWGDAEQPRYVKP
PMIPGHEFVCRVVALGPGAEKRGVQIGDRVISEQIVPCWGCRFCNHGQYWMCQKHDLYGFQNNVQGAMAQYMIFTREGII
HKVPDSIAPDEAILIEPLACSLHAAERADVDFDDIVVVAGAGTLGLGIIGAVRMRNPKKLIVLDMKPERAALALRMGADE
VWNPAEVDVLAKIREITDGYGCDIYIEATGHHKAVNQGLAMLRKLGRFVEFSVFNDEATVDWSIIGDRKELDVLGSHLGP
YMYPRAIDFIGNRKIDMRDVVTHKFPLAQFKEAFAVMERGDKSLKVVLEP

Specific function: Reduces glucitol to fructose [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=352, Percent_Identity=27.8409090909091, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4501929, Length=383, Percent_Identity=23.7597911227154, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4501933, Length=384, Percent_Identity=23.1770833333333, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788073, Length=334, Percent_Identity=29.6407185628743, Blast_Score=155, Evalue=6e-39,
Organism=Escherichia coli, GI1790045, Length=339, Percent_Identity=27.4336283185841, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1787863, Length=353, Percent_Identity=27.1954674220963, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI226510992, Length=339, Percent_Identity=27.1386430678466, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87082125, Length=361, Percent_Identity=27.9778393351801, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788407, Length=338, Percent_Identity=23.9644970414201, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788075, Length=367, Percent_Identity=25.3405994550409, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786825, Length=409, Percent_Identity=25.9168704156479, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790718, Length=344, Percent_Identity=25.2906976744186, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562876, Length=345, Percent_Identity=28.9855072463768, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17562878, Length=351, Percent_Identity=28.2051282051282, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71988145, Length=368, Percent_Identity=25.8152173913043, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562584, Length=366, Percent_Identity=25.1366120218579, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=344, Percent_Identity=26.1627906976744, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6322619, Length=344, Percent_Identity=25, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319257, Length=275, Percent_Identity=29.0909090909091, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=344, Percent_Identity=25, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6319258, Length=286, Percent_Identity=26.2237762237762, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=363, Percent_Identity=24.7933884297521, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=379, Percent_Identity=27.1767810026385, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137530, Length=342, Percent_Identity=26.9005847953216, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI17737897, Length=341, Percent_Identity=26.9794721407625, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.14 [H]

Molecular weight: Translated: 41179; Mature: 41048

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVTERTAEQLSPVIPKTMQAVVCHGPEDYRLETVDVPTPGPDEILTKVELCGICMGDI
CCCHHHHHHHHHCCCCCHHHHHEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
KTYRGAPSFWGDAEQPRYVKPPMIPGHEFVCRVVALGPGAEKRGVQIGDRVISEQIVPCW
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCCCCCCCHHHHHHHHHHCCCHH
GCRFCNHGQYWMCQKHDLYGFQNNVQGAMAQYMIFTREGIIHKVPDSIAPDEAILIEPLA
CCEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEEEECHH
CSLHAAERADVDFDDIVVVAGAGTLGLGIIGAVRMRNPKKLIVLDMKPERAALALRMGAD
HHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHEECCCCEEEEEECCCCCEEEEEECCCC
EVWNPAEVDVLAKIREITDGYGCDIYIEATGHHKAVNQGLAMLRKLGRFVEFSVFNDEAT
CCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEEEEECCCCE
VDWSIIGDRKELDVLGSHLGPYMYPRAIDFIGNRKIDMRDVVTHKFPLAQFKEAFAVMER
EEEEEECCCHHHHHHHHHCCCHHCHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHC
GDKSLKVVLEP
CCCEEEEEECC
>Mature Secondary Structure 
STVTERTAEQLSPVIPKTMQAVVCHGPEDYRLETVDVPTPGPDEILTKVELCGICMGDI
CCHHHHHHHHHCCCCCHHHHHEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
KTYRGAPSFWGDAEQPRYVKPPMIPGHEFVCRVVALGPGAEKRGVQIGDRVISEQIVPCW
HHHCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCCCCCCCHHHHHHHHHHCCCHH
GCRFCNHGQYWMCQKHDLYGFQNNVQGAMAQYMIFTREGIIHKVPDSIAPDEAILIEPLA
CCEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEEEECHH
CSLHAAERADVDFDDIVVVAGAGTLGLGIIGAVRMRNPKKLIVLDMKPERAALALRMGAD
HHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHEECCCCEEEEEECCCCCEEEEEECCCC
EVWNPAEVDVLAKIREITDGYGCDIYIEATGHHKAVNQGLAMLRKLGRFVEFSVFNDEAT
CCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHEEEEEECCCCE
VDWSIIGDRKELDVLGSHLGPYMYPRAIDFIGNRKIDMRDVVTHKFPLAQFKEAFAVMER
EEEEEECCCHHHHHHHHHCCCHHCHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHC
GDKSLKVVLEP
CCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10086842; 11058132 [H]