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The map label for this gene is hbpA [H]

Identifier: 66045778

GI number: 66045778

Start: 2957409

End: 2958974

Strand: Direct

Name: hbpA [H]

Synonym: Psyr_2542

Alternate gene names: 66045778

Gene position: 2957409-2958974 (Clockwise)

Preceding gene: 66045777

Following gene: 66045779

Centisome position: 48.53

GC content: 60.73

Gene sequence:

>1566_bases
ATGAAACCACTCGTTCGTTCATTGCTGGCGTCGGCCCTCTTGCTGGCCGCCGGCGGTGTCACGGCACAGGACTTGCGCAT
CGGTTACGCCGACCCGGTCTCGTCCCTCGACCCACAGCTGAACAATTATGCAGGCGACCGCTCGGTAGCGCTGCATGCCT
TCGAATCGCTGGTCAGCCGCCGTGACGACAAGACCCTGCCAGGTCTGGCCAAGAGCTGGAAGGTGGTGGATGACACCACC
TGGGAGTTCGCCCTGCGTGATGACGTCAAATGGCAGGATGGCACGCCGCTGACCGCTGATGACCTGGTCTTCTCCTTCGA
GCGCGCGCGAAACGTGCCCGGCAGCGTGGCCTCGTATGCAGGTGCCATGCGTACCGTTGAATCGATCAAGGCCAGGGATG
ATCACACGCTGATCATCAAGACCCGTTCGCCCAATGCCAATCTGCTGCCGGACATCGATTCGATCTATATCGTCAGTCGC
CATGCCGGTGCGGCAGCCAGCAGCGCCGATTACAACTCGGGCAAGGCGATGATCGGCACCGGGCCTTACCGGTTTGTCTC
GTTCGTGCCGGGCGATCGCACGATATTCGCTCGCAACGACAATTACTGGGGTGGAAAACCGACCTGGGACAAGGTTGATT
TCCGTTTCATCGCCAACGCCGCCAACCGTACCGCGGCCTTGCTGGCAGGCGATGTCGACGTGATCGACAAGGTATCGCCT
ACCGATGTGGCGCGCCTGCGCAAAACGCCGAACGTCAATGTCTTCGCCTATCAAGGGCTGCGTGCGCTGATCATTCAGCC
GAGTTTCCGTGCCGGTCCGAACGAATTCATTCGCGACAACGCGGGCAAGCCGCTGGCCGAAAACCCGCTGCTGGATGTAC
GCGTGCGCAAGGCGCTGTCCCTGGCGATCAATCGTCCGGCCATCAACGAGCGCATCATGCAAGGCACCGTCACCGAAGCC
AATCAATGGATGCCGGCCAACACGTTCGGTTACAACCCGCAGATCAAGAACATCCCTTATGACCTCAAGCAGGCCAAGGA
CCTGCTGGCGCAGGCAGGTTTCCCCGAAGGCTTCCAATTGACTGTGCATGTGCCGGGCGACCGTTATCCGCAGGCACCGG
AGGTCATGCAGGCGGTGGCGCAGTTCTGGACGCGGATTGGCGTCAAGGTTCAGCTTGAGGTATTGCCGTGGGCGGTGTAT
GCGGGCAAGGCGAACAAGAATGAACTGGCGATCAGCGTGATTGCCTGGGGCAATGGCACCGGCGAAGCGGCCTATGCCCT
GACCAATATTCTGACCACGGTCGACAGCAGCAAAGGGCAGGGCGCTTCGAACTGGGGCCATTACAGCAATCCGCTGGTGG
ACAAGGCCCTGGCTGATTCGACCGCTGAATTCGACGAGGCCAGGCGGCGCAAGATTCTCCAGGACTCGGTGCAGATTGTC
AGCGATGACGTCGGCATCATCCCGCTGTTCCATTACCAGAACATCTGGGCAGCGCGCAAAGGCCTCAAGGTCGAGCCACT
GGTCAGCGACCGCACTGCAGCGACCATGGTCACCGAGCAGCCTTGA

Upstream 100 bases:

>100_bases
GGTTTCGCCGAATCACCAGAGCGCCTGTCACCTGAATGACCAACGCTGAACGGGCACCTCAAGCCCGTCACCCTCTGCCA
TTGCGTACAAGGAACCACCC

Downstream 100 bases:

>100_bases
TTTTCTTCCATGACCGCGCCGCTTTTGCCAGCGCTGCGCGAATGCAACTACAGCCTCGCAGGACCTTTCATGACATCGAC
CACTGAACATTCAACGACAC

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MKPLVRSLLASALLLAAGGVTAQDLRIGYADPVSSLDPQLNNYAGDRSVALHAFESLVSRRDDKTLPGLAKSWKVVDDTT
WEFALRDDVKWQDGTPLTADDLVFSFERARNVPGSVASYAGAMRTVESIKARDDHTLIIKTRSPNANLLPDIDSIYIVSR
HAGAAASSADYNSGKAMIGTGPYRFVSFVPGDRTIFARNDNYWGGKPTWDKVDFRFIANAANRTAALLAGDVDVIDKVSP
TDVARLRKTPNVNVFAYQGLRALIIQPSFRAGPNEFIRDNAGKPLAENPLLDVRVRKALSLAINRPAINERIMQGTVTEA
NQWMPANTFGYNPQIKNIPYDLKQAKDLLAQAGFPEGFQLTVHVPGDRYPQAPEVMQAVAQFWTRIGVKVQLEVLPWAVY
AGKANKNELAISVIAWGNGTGEAAYALTNILTTVDSSKGQGASNWGHYSNPLVDKALADSTAEFDEARRRKILQDSVQIV
SDDVGIIPLFHYQNIWAARKGLKVEPLVSDRTAATMVTEQP

Sequences:

>Translated_521_residues
MKPLVRSLLASALLLAAGGVTAQDLRIGYADPVSSLDPQLNNYAGDRSVALHAFESLVSRRDDKTLPGLAKSWKVVDDTT
WEFALRDDVKWQDGTPLTADDLVFSFERARNVPGSVASYAGAMRTVESIKARDDHTLIIKTRSPNANLLPDIDSIYIVSR
HAGAAASSADYNSGKAMIGTGPYRFVSFVPGDRTIFARNDNYWGGKPTWDKVDFRFIANAANRTAALLAGDVDVIDKVSP
TDVARLRKTPNVNVFAYQGLRALIIQPSFRAGPNEFIRDNAGKPLAENPLLDVRVRKALSLAINRPAINERIMQGTVTEA
NQWMPANTFGYNPQIKNIPYDLKQAKDLLAQAGFPEGFQLTVHVPGDRYPQAPEVMQAVAQFWTRIGVKVQLEVLPWAVY
AGKANKNELAISVIAWGNGTGEAAYALTNILTTVDSSKGQGASNWGHYSNPLVDKALADSTAEFDEARRRKILQDSVQIV
SDDVGIIPLFHYQNIWAARKGLKVEPLVSDRTAATMVTEQP
>Mature_521_residues
MKPLVRSLLASALLLAAGGVTAQDLRIGYADPVSSLDPQLNNYAGDRSVALHAFESLVSRRDDKTLPGLAKSWKVVDDTT
WEFALRDDVKWQDGTPLTADDLVFSFERARNVPGSVASYAGAMRTVESIKARDDHTLIIKTRSPNANLLPDIDSIYIVSR
HAGAAASSADYNSGKAMIGTGPYRFVSFVPGDRTIFARNDNYWGGKPTWDKVDFRFIANAANRTAALLAGDVDVIDKVSP
TDVARLRKTPNVNVFAYQGLRALIIQPSFRAGPNEFIRDNAGKPLAENPLLDVRVRKALSLAINRPAINERIMQGTVTEA
NQWMPANTFGYNPQIKNIPYDLKQAKDLLAQAGFPEGFQLTVHVPGDRYPQAPEVMQAVAQFWTRIGVKVQLEVLPWAVY
AGKANKNELAISVIAWGNGTGEAAYALTNILTTVDSSKGQGASNWGHYSNPLVDKALADSTAEFDEARRRKILQDSVQIV
SDDVGIIPLFHYQNIWAARKGLKVEPLVSDRTAATMVTEQP

Specific function: Important role in heme acquisition or metabolism [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=475, Percent_Identity=27.5789473684211, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1787495, Length=540, Percent_Identity=24.8148148148148, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI87081878, Length=540, Percent_Identity=26.6666666666667, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1787052, Length=509, Percent_Identity=26.3261296660118, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1787762, Length=515, Percent_Identity=26.0194174757282, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1787551, Length=546, Percent_Identity=23.4432234432234, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789397, Length=498, Percent_Identity=23.0923694779116, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1789887, Length=481, Percent_Identity=25.1559251559252, Blast_Score=102, Evalue=7e-23,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 57019; Mature: 57019

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLVRSLLASALLLAAGGVTAQDLRIGYADPVSSLDPQLNNYAGDRSVALHAFESLVSR
CCHHHHHHHHHHHHHHCCCCCHHHEEECCCCCHHHCCCCHHHCCCCCHHHHHHHHHHHHC
RDDKTLPGLAKSWKVVDDTTWEFALRDDVKWQDGTPLTADDLVFSFERARNVPGSVASYA
CCCCCCCCHHHCCEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
GAMRTVESIKARDDHTLIIKTRSPNANLLPDIDSIYIVSRHAGAAASSADYNSGKAMIGT
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEC
GPYRFVSFVPGDRTIFARNDNYWGGKPTWDKVDFRFIANAANRTAALLAGDVDVIDKVSP
CCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCHHHHCCCCC
TDVARLRKTPNVNVFAYQGLRALIIQPSFRAGPNEFIRDNAGKPLAENPLLDVRVRKALS
HHHHHHHCCCCCEEEEECCCEEEEECCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHH
LAINRPAINERIMQGTVTEANQWMPANTFGYNPQIKNIPYDLKQAKDLLAQAGFPEGFQL
HHHCCCHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEE
TVHVPGDRYPQAPEVMQAVAQFWTRIGVKVQLEVLPWAVYAGKANKNELAISVIAWGNGT
EEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCEEEEEEEECCCC
GEAAYALTNILTTVDSSKGQGASNWGHYSNPLVDKALADSTAEFDEARRRKILQDSVQIV
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SDDVGIIPLFHYQNIWAARKGLKVEPLVSDRTAATMVTEQP
CCCCCEEEEEHHHHHHHHHCCCEECCCCCCCCEEEEEECCC
>Mature Secondary Structure
MKPLVRSLLASALLLAAGGVTAQDLRIGYADPVSSLDPQLNNYAGDRSVALHAFESLVSR
CCHHHHHHHHHHHHHHCCCCCHHHEEECCCCCHHHCCCCHHHCCCCCHHHHHHHHHHHHC
RDDKTLPGLAKSWKVVDDTTWEFALRDDVKWQDGTPLTADDLVFSFERARNVPGSVASYA
CCCCCCCCHHHCCEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
GAMRTVESIKARDDHTLIIKTRSPNANLLPDIDSIYIVSRHAGAAASSADYNSGKAMIGT
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEC
GPYRFVSFVPGDRTIFARNDNYWGGKPTWDKVDFRFIANAANRTAALLAGDVDVIDKVSP
CCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCHHHHCCCCC
TDVARLRKTPNVNVFAYQGLRALIIQPSFRAGPNEFIRDNAGKPLAENPLLDVRVRKALS
HHHHHHHCCCCCEEEEECCCEEEEECCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHH
LAINRPAINERIMQGTVTEANQWMPANTFGYNPQIKNIPYDLKQAKDLLAQAGFPEGFQL
HHHCCCHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEE
TVHVPGDRYPQAPEVMQAVAQFWTRIGVKVQLEVLPWAVYAGKANKNELAISVIAWGNGT
EEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCCCEEEEEEEECCCC
GEAAYALTNILTTVDSSKGQGASNWGHYSNPLVDKALADSTAEFDEARRRKILQDSVQIV
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SDDVGIIPLFHYQNIWAARKGLKVEPLVSDRTAATMVTEQP
CCCCCEEEEEHHHHHHHHHCCCEECCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]