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The map label for this gene is accA1 [H]

Identifier: 66045703

GI number: 66045703

Start: 2858815

End: 2860764

Strand: Reverse

Name: accA1 [H]

Synonym: Psyr_2467

Alternate gene names: 66045703

Gene position: 2860764-2858815 (Counterclockwise)

Preceding gene: 66045704

Following gene: 66045700

Centisome position: 46.95

GC content: 63.9

Gene sequence:

>1950_bases
ATGAGCATGCCCGAGCTGACCACGCTGTTGATTGCCAACCGCGGCGAGATCGCCTGCCGCATCATGCGCACGGCGAAAAA
CATGGGCCTTACCACGGTCGCCGTGCACAGCGCCATTGACCGTGACGCACGGCATAGCCGCGAGGCCGATCTCTGCGTGG
ACCTTGGCGGCAGCAAAGCCGCAGACAGTTATCTGGCGATCGACAGGCTTATCGAAGCCGCCCGGGCGAGTGGCGCGCAC
GCGATCCATCCCGGCTACGGTTTTCTGTCTGAAAACGCCGATTTTGCGCGTGCCGTCGAAGACGCCGGGCTGATTTTCCT
CGGCCCACCCGCCTCGGCCATCGATGCCATGGGCAGCAAATCCGCTGCCAAGGCCTTGATGGAGCAGGCAGGCGTGCCGT
TGGTGCCGGGCTATCACGGTGAAGCACAGGACGTCGAGACGTTCCGCGCCGCTGCCGAGCGTATCGGCTACCCGGTGCTG
TTGAAAGCCACCGCTGGCGGCGGCGGCAAAGGCATGAAAGTGGTCGAGCATACGGGTGAACTGGCCGAAGCGCTGGCTTC
CGCGCAACGCGAGGCGCTGTCCTCGTTCGGTGACGCGAGGATGCTGGTGGAGAAGTACGTGCTCACCCCGCGCCACGTCG
AAATCCAGGTGTTTGCCGACCGGCATGGCAACTGCCTGTACCTCAATGAGCGCGATTGCTCCATTCAGCGCCGACACCAG
AAGGTTGTCGAGGAAGCACCGGCGCCCGGCCTGACGGCCTCATTGCGCAAGGCCATGGGCGAAGCCGCGGTGAAAGCCGC
ACAAGCCATCGGCTACGTCGGTGCGGGTACGGTGGAGTTCCTGCTGGACGCACGCGGCGAGTTTTTCTTCATGGAAATGA
ATACCCGCCTGCAGGTAGAGCATCCGGTCACCGAGTACATCACGGGGCTGGACCTGGTGGAATGGCAGATCCGTGTCGCC
AGAGGCGAATCGCTACCCATCACCCAGGAGCAGGTGCCCCTGACCGGCCACGCCATCGAGGTCCGTCTGTACGCCGAAGA
CCCGGTCAACGACTTTCTTCCGGCCACCGGCACGCTGGAGCTCTACAGAGAGCCTGCGCCCGGCCCCGGCAGGCGGGTGG
ACAGCGGCGTTGCCGAGGGCGACAGCATTTCGCCCTTCTACGACCCGATGCTCGGCAAGCTGATTGCCTGGGGCGAAGAC
CGCGAGCAAGCCCGCCTGCGCCTGCTGGCCATGCTCGATGAATTTGCAGTGGGCGGAGTCAGGACCAACCTGGCGTTTCT
GCGCAGAATCATCGCGCATCCAGCGTTCGCCGCCGCGCAGCTTGATACCGGCTTCATTCCCCACCATCAGGCGCAACTGC
TGCCGCACACCAATGAGCCGGACGAGACATTCTGGCAGGCCGCTGCCGAGGCCTTCAGCCAGAGCGAACCGGCACGCATC
GATCAAGCCGATCCGTATTCGCCCTGGGCAGTCAGCAGCGGCTTTCGCGCCGGCCTGCCTGCGCAGACGGATCTGCGACT
GAGCTGCAACGGTCTAACCCGCAACACCTGCCTGCGCAACAGCAGCCCCTCGTTATTCACTCTGAGTGGCGAGCATTTGC
AGGTCGAGCACAACGGTGTGCGCCAACGACACCTGGCGATACGACGCGGCAATACGCTGTATCTCGAATGGCAAGGCGAG
GTGCAAACCGTCACCCGCCTGGACGCCATCGCCCAGGCAGACGTCGGTGAGGGTCAGCATGCAGGCCTGACAGCACCGAT
GAATGGCAGCATCGTACGGGTATTGGTTGAAGTGGGTCAGGCTGTCGAGCCTGGCGCGCAACTGGTGGTGCTGGAAGCCA
TGAAGATGGAACACAGCATCCGCGCCGCCAGCGCCGGAGTGATTACCGCGCTCTACTGCCACGAGGGAGAGATGGTCAAC
GAAGGCGCGGTGCTGGTGGAGCTGGACTGA

Upstream 100 bases:

>100_bases
AACGCACACCTGGCTGGCAGCCCGTCAAGGATCAGCCGCCTGGCAATCCCGTTCCAGCAGCCTCGACAGCCCGGCACGAA
CCTCAGAAGGACTCGCAATC

Downstream 100 bases:

>100_bases
CGCTCGTCAACCGCCACACATGAAAACGCCCTGAACAGTCAGGGCGTTTTCGTGCAGCAACTTTCGTGCAGCAACTTCCT
TGCAAAAAAGAGACGCCTAG

Product: carbamoyl-phosphate synthase subunit L

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MSMPELTTLLIANRGEIACRIMRTAKNMGLTTVAVHSAIDRDARHSREADLCVDLGGSKAADSYLAIDRLIEAARASGAH
AIHPGYGFLSENADFARAVEDAGLIFLGPPASAIDAMGSKSAAKALMEQAGVPLVPGYHGEAQDVETFRAAAERIGYPVL
LKATAGGGGKGMKVVEHTGELAEALASAQREALSSFGDARMLVEKYVLTPRHVEIQVFADRHGNCLYLNERDCSIQRRHQ
KVVEEAPAPGLTASLRKAMGEAAVKAAQAIGYVGAGTVEFLLDARGEFFFMEMNTRLQVEHPVTEYITGLDLVEWQIRVA
RGESLPITQEQVPLTGHAIEVRLYAEDPVNDFLPATGTLELYREPAPGPGRRVDSGVAEGDSISPFYDPMLGKLIAWGED
REQARLRLLAMLDEFAVGGVRTNLAFLRRIIAHPAFAAAQLDTGFIPHHQAQLLPHTNEPDETFWQAAAEAFSQSEPARI
DQADPYSPWAVSSGFRAGLPAQTDLRLSCNGLTRNTCLRNSSPSLFTLSGEHLQVEHNGVRQRHLAIRRGNTLYLEWQGE
VQTVTRLDAIAQADVGEGQHAGLTAPMNGSIVRVLVEVGQAVEPGAQLVVLEAMKMEHSIRAASAGVITALYCHEGEMVN
EGAVLVELD

Sequences:

>Translated_649_residues
MSMPELTTLLIANRGEIACRIMRTAKNMGLTTVAVHSAIDRDARHSREADLCVDLGGSKAADSYLAIDRLIEAARASGAH
AIHPGYGFLSENADFARAVEDAGLIFLGPPASAIDAMGSKSAAKALMEQAGVPLVPGYHGEAQDVETFRAAAERIGYPVL
LKATAGGGGKGMKVVEHTGELAEALASAQREALSSFGDARMLVEKYVLTPRHVEIQVFADRHGNCLYLNERDCSIQRRHQ
KVVEEAPAPGLTASLRKAMGEAAVKAAQAIGYVGAGTVEFLLDARGEFFFMEMNTRLQVEHPVTEYITGLDLVEWQIRVA
RGESLPITQEQVPLTGHAIEVRLYAEDPVNDFLPATGTLELYREPAPGPGRRVDSGVAEGDSISPFYDPMLGKLIAWGED
REQARLRLLAMLDEFAVGGVRTNLAFLRRIIAHPAFAAAQLDTGFIPHHQAQLLPHTNEPDETFWQAAAEAFSQSEPARI
DQADPYSPWAVSSGFRAGLPAQTDLRLSCNGLTRNTCLRNSSPSLFTLSGEHLQVEHNGVRQRHLAIRRGNTLYLEWQGE
VQTVTRLDAIAQADVGEGQHAGLTAPMNGSIVRVLVEVGQAVEPGAQLVVLEAMKMEHSIRAASAGVITALYCHEGEMVN
EGAVLVELD
>Mature_648_residues
SMPELTTLLIANRGEIACRIMRTAKNMGLTTVAVHSAIDRDARHSREADLCVDLGGSKAADSYLAIDRLIEAARASGAHA
IHPGYGFLSENADFARAVEDAGLIFLGPPASAIDAMGSKSAAKALMEQAGVPLVPGYHGEAQDVETFRAAAERIGYPVLL
KATAGGGGKGMKVVEHTGELAEALASAQREALSSFGDARMLVEKYVLTPRHVEIQVFADRHGNCLYLNERDCSIQRRHQK
VVEEAPAPGLTASLRKAMGEAAVKAAQAIGYVGAGTVEFLLDARGEFFFMEMNTRLQVEHPVTEYITGLDLVEWQIRVAR
GESLPITQEQVPLTGHAIEVRLYAEDPVNDFLPATGTLELYREPAPGPGRRVDSGVAEGDSISPFYDPMLGKLIAWGEDR
EQARLRLLAMLDEFAVGGVRTNLAFLRRIIAHPAFAAAQLDTGFIPHHQAQLLPHTNEPDETFWQAAAEAFSQSEPARID
QADPYSPWAVSSGFRAGLPAQTDLRLSCNGLTRNTCLRNSSPSLFTLSGEHLQVEHNGVRQRHLAIRRGNTLYLEWQGEV
QTVTRLDAIAQADVGEGQHAGLTAPMNGSIVRVLVEVGQAVEPGAQLVVLEAMKMEHSIRAASAGVITALYCHEGEMVNE
GAVLVELD

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=667, Percent_Identity=45.2773613193403, Blast_Score=589, Evalue=1e-168,
Organism=Homo sapiens, GI189095269, Length=675, Percent_Identity=41.6296296296296, Blast_Score=491, Evalue=1e-139,
Organism=Homo sapiens, GI65506442, Length=668, Percent_Identity=42.0658682634731, Blast_Score=491, Evalue=1e-138,
Organism=Homo sapiens, GI295821183, Length=661, Percent_Identity=40.695915279879, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI106049528, Length=460, Percent_Identity=44.7826086956522, Blast_Score=368, Evalue=1e-101,
Organism=Homo sapiens, GI106049295, Length=460, Percent_Identity=44.7826086956522, Blast_Score=368, Evalue=1e-101,
Organism=Homo sapiens, GI106049292, Length=460, Percent_Identity=44.7826086956522, Blast_Score=368, Evalue=1e-101,
Organism=Homo sapiens, GI38679960, Length=714, Percent_Identity=27.8711484593838, Blast_Score=251, Evalue=2e-66,
Organism=Homo sapiens, GI38679977, Length=714, Percent_Identity=27.8711484593838, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI38679967, Length=714, Percent_Identity=27.8711484593838, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI38679974, Length=714, Percent_Identity=27.8711484593838, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI38679971, Length=714, Percent_Identity=27.8711484593838, Blast_Score=250, Evalue=3e-66,
Organism=Homo sapiens, GI134142062, Length=724, Percent_Identity=27.2099447513812, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI18105007, Length=267, Percent_Identity=26.9662921348315, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1789654, Length=432, Percent_Identity=52.5462962962963, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71987519, Length=658, Percent_Identity=45.2887537993921, Blast_Score=541, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17567343, Length=682, Percent_Identity=40.9090909090909, Blast_Score=493, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17562816, Length=461, Percent_Identity=43.3839479392625, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133931226, Length=487, Percent_Identity=28.5420944558522, Blast_Score=197, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71997163, Length=655, Percent_Identity=25.4961832061069, Blast_Score=197, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71997168, Length=437, Percent_Identity=29.0617848970252, Blast_Score=193, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319685, Length=448, Percent_Identity=43.75, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319695, Length=449, Percent_Identity=43.652561247216, Blast_Score=348, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=449, Percent_Identity=44.7661469933185, Blast_Score=346, Evalue=7e-96,
Organism=Saccharomyces cerevisiae, GI6324343, Length=716, Percent_Identity=27.9329608938547, Blast_Score=236, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6323863, Length=682, Percent_Identity=27.1260997067449, Blast_Score=231, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24651757, Length=671, Percent_Identity=42.4739195230999, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24651759, Length=632, Percent_Identity=41.9303797468354, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=46.1024498886414, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=46.1024498886414, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=46.1024498886414, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=46.1024498886414, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=46.1024498886414, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=46.1024498886414, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=46.1024498886414, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=46.1024498886414, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=46.1024498886414, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=46.1024498886414, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI161076409, Length=721, Percent_Identity=28.8488210818308, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI161076407, Length=721, Percent_Identity=28.8488210818308, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24586460, Length=721, Percent_Identity=28.8488210818308, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24586458, Length=721, Percent_Identity=28.8488210818308, Blast_Score=246, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 70049; Mature: 69918

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMPELTTLLIANRGEIACRIMRTAKNMGLTTVAVHSAIDRDARHSREADLCVDLGGSKA
CCCCCEEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCC
ADSYLAIDRLIEAARASGAHAIHPGYGFLSENADFARAVEDAGLIFLGPPASAIDAMGSK
CHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHCCCH
SAAKALMEQAGVPLVPGYHGEAQDVETFRAAAERIGYPVLLKATAGGGGKGMKVVEHTGE
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHH
LAEALASAQREALSSFGDARMLVEKYVLTPRHVEIQVFADRHGNCLYLNERDCSIQRRHQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHH
KVVEEAPAPGLTASLRKAMGEAAVKAAQAIGYVGAGTVEFLLDARGEFFFMEMNTRLQVE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEECCEEEEC
HPVTEYITGLDLVEWQIRVARGESLPITQEQVPLTGHAIEVRLYAEDPVNDFLPATGTLE
CCHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHCCCCCCEE
LYREPAPGPGRRVDSGVAEGDSISPFYDPMLGKLIAWGEDREQARLRLLAMLDEFAVGGV
EEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCH
RTNLAFLRRIIAHPAFAAAQLDTGFIPHHQAQLLPHTNEPDETFWQAAAEAFSQSEPARI
HHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCC
DQADPYSPWAVSSGFRAGLPAQTDLRLSCNGLTRNTCLRNSSPSLFTLSGEHLQVEHNGV
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCCEEEECCCEEEEECCCC
RQRHLAIRRGNTLYLEWQGEVQTVTRLDAIAQADVGEGQHAGLTAPMNGSIVRVLVEVGQ
HHHHHEEECCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCC
AVEPGAQLVVLEAMKMEHSIRAASAGVITALYCHEGEMVNEGAVLVELD
CCCCCCCEEEEHHHHHHHHHHHHCCCEEEEEEECCCCEECCCEEEEEEC
>Mature Secondary Structure 
SMPELTTLLIANRGEIACRIMRTAKNMGLTTVAVHSAIDRDARHSREADLCVDLGGSKA
CCCCEEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCC
ADSYLAIDRLIEAARASGAHAIHPGYGFLSENADFARAVEDAGLIFLGPPASAIDAMGSK
CHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHCCCH
SAAKALMEQAGVPLVPGYHGEAQDVETFRAAAERIGYPVLLKATAGGGGKGMKVVEHTGE
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHH
LAEALASAQREALSSFGDARMLVEKYVLTPRHVEIQVFADRHGNCLYLNERDCSIQRRHQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCCHHHHHHH
KVVEEAPAPGLTASLRKAMGEAAVKAAQAIGYVGAGTVEFLLDARGEFFFMEMNTRLQVE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEECCEEEEC
HPVTEYITGLDLVEWQIRVARGESLPITQEQVPLTGHAIEVRLYAEDPVNDFLPATGTLE
CCHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHCCCCCCEE
LYREPAPGPGRRVDSGVAEGDSISPFYDPMLGKLIAWGEDREQARLRLLAMLDEFAVGGV
EEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCH
RTNLAFLRRIIAHPAFAAAQLDTGFIPHHQAQLLPHTNEPDETFWQAAAEAFSQSEPARI
HHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCC
DQADPYSPWAVSSGFRAGLPAQTDLRLSCNGLTRNTCLRNSSPSLFTLSGEHLQVEHNGV
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCCEEEECCCEEEEECCCC
RQRHLAIRRGNTLYLEWQGEVQTVTRLDAIAQADVGEGQHAGLTAPMNGSIVRVLVEVGQ
HHHHHEEECCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCC
AVEPGAQLVVLEAMKMEHSIRAASAGVITALYCHEGEMVNEGAVLVELD
CCCCCCCEEEEHHHHHHHHHHHHCCCEEEEEEECCCCEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]