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The map label for this gene is mro [H]

Identifier: 66045605

GI number: 66045605

Start: 2746798

End: 2747946

Strand: Reverse

Name: mro [H]

Synonym: Psyr_2369

Alternate gene names: 66045605

Gene position: 2747946-2746798 (Counterclockwise)

Preceding gene: 66045610

Following gene: 66045601

Centisome position: 45.09

GC content: 59.01

Gene sequence:

>1149_bases
ATGAAAAAACATGCGCTTCTCAGCACCCTTGGACTGTCCTTGATGATCAGCACCCTGACCGCACAGGCCGCCGCACTCTC
CAGCGAACACAGCGCGTTCGGCCAACTGCCCGACGGCTCTGCCGTCGAAAAATACACCCTGCGCAACAGTCACGGCGTGC
AGGCCAGCATCATCACCTACGGCGCGACGCTGCAATCGCTGCTGGTACCTGACAAGGCCGGCAAGGTCGAAGACATCGTC
CTGGGTTTCGACGATGTGCAGGGCTACCAGAACAACGGTACGGTCTATTTCGGCGCGACCATCGGCCGCTTCGGCAACCG
GCTGGCAGGCGGCAAATTCAGTCTGGATGGCAAAACCTATCAGGTCCCGCTCAATGACAAGACCAACGCGCTGCACGGCG
GCACGCAGGGTTTTGACAAGCGTCTGTGGAAGGCAGAAGAAACCAAGAGCGGTGATTCGGTCGGCGTGAAGCTGACCTAC
CTGTCGCCGGACGGCGAGATGGGCTTTCCGGGTGCCCTGCTGACTGAAGTGACCTATAGCCTGAATGAAAAAAACGAGCT
GAAGATCGACTACCGCGCCACCACCGACAAACCGACGGTGCTGAACCTGACCAACCACAGCTATTTCAACCTGGCCGGCG
CTGGCAGTGGTGATGTGCTCAAACAGGTCGCCACCCTTCACGCCTCGCACTACACCCCGGTCAACGACAAGCTGATCCCG
ACCGGTGAACTGCCTGCTGTGGCTGGCACGCCCATGGACTTTCTCAAGCCCACCGCGTTCGGCAAACACATCAAGGCTGA
TCACCAGCAGTTGAAATACGCCGAACCCAAGCAAGGCGGGTTTGATTTCAACTGGGTGCTCGACACCAAGGGTGATGTGA
AGAAACTGGCCGCCGAGGTCAGCGATCCGCAATCAGGCCGCAGACTGCAACTGTTCACCACAGAGCCCGGCGTGCAGCTG
TACACCGGTAACTTCCTGGATGGCAGCATTCACGGCAAGGCAGGCAAGGTCTACCCGCACTGGGGCGCCTTTACCCTGGA
AACGCAGCACTACCCCGATGCACCCAACCAGCCGAAATTCCCCAGCACCCGACTGGATCCTGGCAAGGCCTACACCCAGA
CGACTGTGTTCAAATTCCTCAACGACTAA

Upstream 100 bases:

>100_bases
AATTTATTTTTCAAGCACCATTTTATAGGCTATACATCCATGCATCGGCTTGAATCCGATCAAATAGTCTTACCAATAAC
AATAAAAGCAGGCAGATCAG

Downstream 100 bases:

>100_bases
AGCGTTGAGCTGCCCGGCGCCTGTGATCAGAGCGCCGGGCAGCTTCAGGCTTACTGATTGCGCTTCATTGCCGCAGTCAG
GGTATCGACGTTGTAACGGA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKKHALLSTLGLSLMISTLTAQAAALSSEHSAFGQLPDGSAVEKYTLRNSHGVQASIITYGATLQSLLVPDKAGKVEDIV
LGFDDVQGYQNNGTVYFGATIGRFGNRLAGGKFSLDGKTYQVPLNDKTNALHGGTQGFDKRLWKAEETKSGDSVGVKLTY
LSPDGEMGFPGALLTEVTYSLNEKNELKIDYRATTDKPTVLNLTNHSYFNLAGAGSGDVLKQVATLHASHYTPVNDKLIP
TGELPAVAGTPMDFLKPTAFGKHIKADHQQLKYAEPKQGGFDFNWVLDTKGDVKKLAAEVSDPQSGRRLQLFTTEPGVQL
YTGNFLDGSIHGKAGKVYPHWGAFTLETQHYPDAPNQPKFPSTRLDPGKAYTQTTVFKFLND

Sequences:

>Translated_382_residues
MKKHALLSTLGLSLMISTLTAQAAALSSEHSAFGQLPDGSAVEKYTLRNSHGVQASIITYGATLQSLLVPDKAGKVEDIV
LGFDDVQGYQNNGTVYFGATIGRFGNRLAGGKFSLDGKTYQVPLNDKTNALHGGTQGFDKRLWKAEETKSGDSVGVKLTY
LSPDGEMGFPGALLTEVTYSLNEKNELKIDYRATTDKPTVLNLTNHSYFNLAGAGSGDVLKQVATLHASHYTPVNDKLIP
TGELPAVAGTPMDFLKPTAFGKHIKADHQQLKYAEPKQGGFDFNWVLDTKGDVKKLAAEVSDPQSGRRLQLFTTEPGVQL
YTGNFLDGSIHGKAGKVYPHWGAFTLETQHYPDAPNQPKFPSTRLDPGKAYTQTTVFKFLND
>Mature_382_residues
MKKHALLSTLGLSLMISTLTAQAAALSSEHSAFGQLPDGSAVEKYTLRNSHGVQASIITYGATLQSLLVPDKAGKVEDIV
LGFDDVQGYQNNGTVYFGATIGRFGNRLAGGKFSLDGKTYQVPLNDKTNALHGGTQGFDKRLWKAEETKSGDSVGVKLTY
LSPDGEMGFPGALLTEVTYSLNEKNELKIDYRATTDKPTVLNLTNHSYFNLAGAGSGDVLKQVATLHASHYTPVNDKLIP
TGELPAVAGTPMDFLKPTAFGKHIKADHQQLKYAEPKQGGFDFNWVLDTKGDVKKLAAEVSDPQSGRRLQLFTTEPGVQL
YTGNFLDGSIHGKAGKVYPHWGAFTLETQHYPDAPNQPKFPSTRLDPGKAYTQTTVFKFLND

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=354, Percent_Identity=46.6101694915254, Blast_Score=303, Evalue=1e-82,
Organism=Escherichia coli, GI1786971, Length=346, Percent_Identity=37.5722543352601, Blast_Score=228, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI17557428, Length=343, Percent_Identity=32.6530612244898, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI115533334, Length=343, Percent_Identity=32.6530612244898, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6319493, Length=341, Percent_Identity=29.3255131964809, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322004, Length=367, Percent_Identity=30.5177111716621, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6324399, Length=355, Percent_Identity=29.2957746478873, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24668282, Length=347, Percent_Identity=42.0749279538905, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24659048, Length=349, Percent_Identity=40.4011461318052, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24583720, Length=345, Percent_Identity=38.2608695652174, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24668278, Length=345, Percent_Identity=37.6811594202899, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24641876, Length=358, Percent_Identity=31.5642458100559, Blast_Score=190, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 41374; Mature: 41374

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHALLSTLGLSLMISTLTAQAAALSSEHSAFGQLPDGSAVEKYTLRNSHGVQASIITY
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCEEEEEECCCCCCEEEEEEE
GATLQSLLVPDKAGKVEDIVLGFDDVQGYQNNGTVYFGATIGRFGNRLAGGKFSLDGKTY
CHHHHHHHCCCCCCCCEEEEEECHHHCCCCCCCEEEECCCHHHHCCCCCCCEEEECCEEE
QVPLNDKTNALHGGTQGFDKRLWKAEETKSGDSVGVKLTYLSPDGEMGFPGALLTEVTYS
EEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHC
LNEKNELKIDYRATTDKPTVLNLTNHSYFNLAGAGSGDVLKQVATLHASHYTPVNDKLIP
CCCCCEEEEEEEECCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCC
TGELPAVAGTPMDFLKPTAFGKHIKADHQQLKYAEPKQGGFDFNWVLDTKGDVKKLAAEV
CCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHC
SDPQSGRRLQLFTTEPGVQLYTGNFLDGSIHGKAGKVYPHWGAFTLETQHYPDAPNQPKF
CCCCCCCEEEEEECCCCCEEEECCEECCEECCCCCCCCCCCCEEEEECCCCCCCCCCCCC
PSTRLDPGKAYTQTTVFKFLND
CCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKKHALLSTLGLSLMISTLTAQAAALSSEHSAFGQLPDGSAVEKYTLRNSHGVQASIITY
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCEEEEEECCCCCCEEEEEEE
GATLQSLLVPDKAGKVEDIVLGFDDVQGYQNNGTVYFGATIGRFGNRLAGGKFSLDGKTY
CHHHHHHHCCCCCCCCEEEEEECHHHCCCCCCCEEEECCCHHHHCCCCCCCEEEECCEEE
QVPLNDKTNALHGGTQGFDKRLWKAEETKSGDSVGVKLTYLSPDGEMGFPGALLTEVTYS
EEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHC
LNEKNELKIDYRATTDKPTVLNLTNHSYFNLAGAGSGDVLKQVATLHASHYTPVNDKLIP
CCCCCEEEEEEEECCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCC
TGELPAVAGTPMDFLKPTAFGKHIKADHQQLKYAEPKQGGFDFNWVLDTKGDVKKLAAEV
CCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHC
SDPQSGRRLQLFTTEPGVQLYTGNFLDGSIHGKAGKVYPHWGAFTLETQHYPDAPNQPKF
CCCCCCCEEEEEECCCCCEEEECCEECCEECCCCCCCCCCCCEEEEECCCCCCCCCCCCC
PSTRLDPGKAYTQTTVFKFLND
CCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]