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The map label for this gene is mrdA [H]

Identifier: 66045553

GI number: 66045553

Start: 2686551

End: 2688440

Strand: Direct

Name: mrdA [H]

Synonym: Psyr_2313

Alternate gene names: 66045553

Gene position: 2686551-2688440 (Clockwise)

Preceding gene: 66045552

Following gene: 66045554

Centisome position: 44.09

GC content: 60.42

Gene sequence:

>1890_bases
ATGCCCAATCCCATTCCCCTGAAAGACCACGAAAAAGAGACGCGGCTGGTCAATCAGCGTCTGATTGCCTGCGCAGTGCT
GGTCGGCCTGCTGGCTGCCTGTCTGGTCGCACGCATGTATTTCCTGCAGGTTACCGAGTTCGACTATCACTCGACCATTT
CCGAAAACAACCGTGTTCACGTACTGCCGATCCCGCCCGAGCGCGGTTTGATCTTTGACCGCAATGGCGAAGTGCTTGCC
GACAATCGTCCCAGTTTCAACCTGACCCTGACCCGCGAACGCGCTGGCGACTGGCACAAGGTGATCGATGAGCTGATGAC
CCTGCTGGAATTGCCCGATGAAGACCGGATTCTGTTCGACAAGGAGCTTAAGCAGGTTCGTCACCCGTTCGAGCCGGCAA
CATTGCTCTATGAACTCACCGAAGAGCAGATCGCCATTCTGGCGGTCAATCAGTACCTGCTGCCGGGCGTGGACGTGGCG
GCGCAGTTCGTTCGCCATTATCCGTTGGGCGCCCATTTCGCTCATTCGATCGGCTACGTCGGGCGTATCAACGAAAAGGA
AGCGGCGCACCTCGACAACGAGTATCGCGGCACGCAGTCCATCGGCAAGACCGGTGTCGAGCGCTTCTACGAATCCGAGC
TGCACGGCCACGTAGGCTATGAAGAGGTCGAAACCAACGCCCAGGGCCGCGTGCTGCGCGTGCTGAAACACACTGACCCG
GTGCCCGGCAAGAACATCACTCTCACCCTGGACGCGCACTTGCAGGCTGCGGCGGAAAACGCGCTGGGTGATCGACGTGG
TTCGGTGGTCGCACTGGACCCGGAAACCGGCGACGTGCTGGCGATGGTCAGCAAACCCAGCTTTGACCCCAACCTGTTCG
TCACCGGCATCAGCTTCAAACAATACGCGGCGCTGCGTGATTCCATTGATCGGCCACTGTTCAACCGTGTGCTGCGTGGC
CTGTATGCGCCGGGCTCGACGGTCAAGCCGGAAGTGGCGATTGCCGGTCTCGACAGCGGCGTGGTGACGGCCTCGACAAA
GGTCTTCGACCCCGGCTATTTCCAGTTGCCGGACTTCGACCACAAATACCGTAACTGGAACCACAGTGGCGACGGCTGGG
TGGACATGGACACGGCGATCATGCGTTCCAATGACACTTATTTCTACACCGTGGCGCACAAGCTCGGCATCGACCGCCTG
CACGACTACATGACCATGTTCGGCATCGGCCAGAAGGTGTCGCTGGACATGTTCGAGGAGTCTGCAGGGCTGATGCCGTC
CCGCGAATGGAAGCGGGCCACGCGTCGACAGGCATGGTTCCCTGGCGAAACGGTGATTCTCGGCATCGGTCAGGGTTACA
TGCAGGTCACGCCGTTGCAACTGGCCCAGGCCACGTCACTGATTGCCAGCAAGGGTGTCTGGCATCGACCGCACCTGGCG
ATGGAAGTCGGTGATACGGCGCCCGTTGACGAGCATCCGATGCCAAATATCGTGCTGCACGATCCCAACGAATGGAATCA
GGTCAATACCGGCATGCAGATGGTTATGCACGACCCGCGCGGCATTGCGCGGGATGCCGCCAAGGGCGCTCAGTACCGCA
TCGCCGGCAAAAGCGGTACGGCGCAGGTAGTGGCGATCAAGCAGGGCGAGCGCTACAACCGTTTGAAGACTCTGGAGCGT
AACCGTGACAACGCCTTGTTCGTGGGCTTTGCGCCAGCTGACCATCCCAAGATCGTCGTGTCGGTAACCATCGAAAACGG
CGAAGCAGGTGGCCGGGTAGCGGGCCCGGTGGTCCGGGAGATTCTCGATGCCTGGCTGCTGGACAGCGAAGGCAAGCTCA
AACCGGAGTACGCCACACCCGCCAAGGCACCGGGCAACCCGCACGCCTGA

Upstream 100 bases:

>100_bases
TTGATCGCCTGCAATCCGCCGCTTCTTGGTATGGTGCGCGCCGAAATCTTTATATACACCTTCAGTTGCGCCGTTTGCCC
TTCACCGAGAAGCTGTAGAA

Downstream 100 bases:

>100_bases
TCAGCGTTTTAAAGCGCTGGCCGAATGACCGAGCCCTGAACAGGGCTCAGGTTTTCTGAACTGTCGAGAATGCATTGGGT
CGACCACAGCAGGCGTGGCA

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 629; Mature: 628

Protein sequence:

>629_residues
MPNPIPLKDHEKETRLVNQRLIACAVLVGLLAACLVARMYFLQVTEFDYHSTISENNRVHVLPIPPERGLIFDRNGEVLA
DNRPSFNLTLTRERAGDWHKVIDELMTLLELPDEDRILFDKELKQVRHPFEPATLLYELTEEQIAILAVNQYLLPGVDVA
AQFVRHYPLGAHFAHSIGYVGRINEKEAAHLDNEYRGTQSIGKTGVERFYESELHGHVGYEEVETNAQGRVLRVLKHTDP
VPGKNITLTLDAHLQAAAENALGDRRGSVVALDPETGDVLAMVSKPSFDPNLFVTGISFKQYAALRDSIDRPLFNRVLRG
LYAPGSTVKPEVAIAGLDSGVVTASTKVFDPGYFQLPDFDHKYRNWNHSGDGWVDMDTAIMRSNDTYFYTVAHKLGIDRL
HDYMTMFGIGQKVSLDMFEESAGLMPSREWKRATRRQAWFPGETVILGIGQGYMQVTPLQLAQATSLIASKGVWHRPHLA
MEVGDTAPVDEHPMPNIVLHDPNEWNQVNTGMQMVMHDPRGIARDAAKGAQYRIAGKSGTAQVVAIKQGERYNRLKTLER
NRDNALFVGFAPADHPKIVVSVTIENGEAGGRVAGPVVREILDAWLLDSEGKLKPEYATPAKAPGNPHA

Sequences:

>Translated_629_residues
MPNPIPLKDHEKETRLVNQRLIACAVLVGLLAACLVARMYFLQVTEFDYHSTISENNRVHVLPIPPERGLIFDRNGEVLA
DNRPSFNLTLTRERAGDWHKVIDELMTLLELPDEDRILFDKELKQVRHPFEPATLLYELTEEQIAILAVNQYLLPGVDVA
AQFVRHYPLGAHFAHSIGYVGRINEKEAAHLDNEYRGTQSIGKTGVERFYESELHGHVGYEEVETNAQGRVLRVLKHTDP
VPGKNITLTLDAHLQAAAENALGDRRGSVVALDPETGDVLAMVSKPSFDPNLFVTGISFKQYAALRDSIDRPLFNRVLRG
LYAPGSTVKPEVAIAGLDSGVVTASTKVFDPGYFQLPDFDHKYRNWNHSGDGWVDMDTAIMRSNDTYFYTVAHKLGIDRL
HDYMTMFGIGQKVSLDMFEESAGLMPSREWKRATRRQAWFPGETVILGIGQGYMQVTPLQLAQATSLIASKGVWHRPHLA
MEVGDTAPVDEHPMPNIVLHDPNEWNQVNTGMQMVMHDPRGIARDAAKGAQYRIAGKSGTAQVVAIKQGERYNRLKTLER
NRDNALFVGFAPADHPKIVVSVTIENGEAGGRVAGPVVREILDAWLLDSEGKLKPEYATPAKAPGNPHA
>Mature_628_residues
PNPIPLKDHEKETRLVNQRLIACAVLVGLLAACLVARMYFLQVTEFDYHSTISENNRVHVLPIPPERGLIFDRNGEVLAD
NRPSFNLTLTRERAGDWHKVIDELMTLLELPDEDRILFDKELKQVRHPFEPATLLYELTEEQIAILAVNQYLLPGVDVAA
QFVRHYPLGAHFAHSIGYVGRINEKEAAHLDNEYRGTQSIGKTGVERFYESELHGHVGYEEVETNAQGRVLRVLKHTDPV
PGKNITLTLDAHLQAAAENALGDRRGSVVALDPETGDVLAMVSKPSFDPNLFVTGISFKQYAALRDSIDRPLFNRVLRGL
YAPGSTVKPEVAIAGLDSGVVTASTKVFDPGYFQLPDFDHKYRNWNHSGDGWVDMDTAIMRSNDTYFYTVAHKLGIDRLH
DYMTMFGIGQKVSLDMFEESAGLMPSREWKRATRRQAWFPGETVILGIGQGYMQVTPLQLAQATSLIASKGVWHRPHLAM
EVGDTAPVDEHPMPNIVLHDPNEWNQVNTGMQMVMHDPRGIARDAAKGAQYRIAGKSGTAQVVAIKQGERYNRLKTLERN
RDNALFVGFAPADHPKIVVSVTIENGEAGGRVAGPVVREILDAWLLDSEGKLKPEYATPAKAPGNPHA

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=635, Percent_Identity=41.5748031496063, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1786272, Length=617, Percent_Identity=26.418152350081, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70059; Mature: 69927

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNPIPLKDHEKETRLVNQRLIACAVLVGLLAACLVARMYFLQVTEFDYHSTISENNRVH
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHCCCCCCEE
VLPIPPERGLIFDRNGEVLADNRPSFNLTLTRERAGDWHKVIDELMTLLELPDEDRILFD
EEECCCCCCEEECCCCCEEECCCCCEEEEEEHHHCCCHHHHHHHHHHHHHCCCCCCEEEH
KELKQVRHPFEPATLLYELTEEQIAILAVNQYLLPGVDVAAQFVRHYPLGAHFAHSIGYV
HHHHHHHCCCCHHHHHHHHHHCCEEEEEECHHHCCCHHHHHHHHHHCCCCHHHHHHCCCC
GRINEKEAAHLDNEYRGTQSIGKTGVERFYESELHGHVGYEEVETNAQGRVLRVLKHTDP
CCCCCHHHHHCCCHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEEECCCCC
VPGKNITLTLDAHLQAAAENALGDRRGSVVALDPETGDVLAMVSKPSFDPNLFVTGISFK
CCCCEEEEEEECHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEECCCCCCCEEEEECCHH
QYAALRDSIDRPLFNRVLRGLYAPGSTVKPEVAIAGLDSGVVTASTKVFDPGYFQLPDFD
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEEEEECCCCEECCCCC
HKYRNWNHSGDGWVDMDTAIMRSNDTYFYTVAHKLGIDRLHDYMTMFGIGQKVSLDMFEE
HHHCCCCCCCCCEEECCHHEEECCCCEEEEEHHHHCHHHHHHHHHHHCCCCCEEHHHHHH
SAGLMPSREWKRATRRQAWFPGETVILGIGQGYMQVTPLQLAQATSLIASKGVWHRPHLA
CCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCEEECHHHHHHHHHHHHHCCCCCCCCEE
MEVGDTAPVDEHPMPNIVLHDPNEWNQVNTGMQMVMHDPRGIARDAAKGAQYRIAGKSGT
EECCCCCCCCCCCCCCEEEECCCCCCHHHCCHHEEEECCCCHHHHHCCCCEEEEECCCCC
AQVVAIKQGERYNRLKTLERNRDNALFVGFAPADHPKIVVSVTIENGEAGGRVAGPVVRE
EEEEEEECCCHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCCHHHHHHH
ILDAWLLDSEGKLKPEYATPAKAPGNPHA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PNPIPLKDHEKETRLVNQRLIACAVLVGLLAACLVARMYFLQVTEFDYHSTISENNRVH
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHCCCCCCEE
VLPIPPERGLIFDRNGEVLADNRPSFNLTLTRERAGDWHKVIDELMTLLELPDEDRILFD
EEECCCCCCEEECCCCCEEECCCCCEEEEEEHHHCCCHHHHHHHHHHHHHCCCCCCEEEH
KELKQVRHPFEPATLLYELTEEQIAILAVNQYLLPGVDVAAQFVRHYPLGAHFAHSIGYV
HHHHHHHCCCCHHHHHHHHHHCCEEEEEECHHHCCCHHHHHHHHHHCCCCHHHHHHCCCC
GRINEKEAAHLDNEYRGTQSIGKTGVERFYESELHGHVGYEEVETNAQGRVLRVLKHTDP
CCCCCHHHHHCCCHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEEECCCCC
VPGKNITLTLDAHLQAAAENALGDRRGSVVALDPETGDVLAMVSKPSFDPNLFVTGISFK
CCCCEEEEEEECHHHHHHHHHCCCCCCCEEEECCCCCCEEEEEECCCCCCCEEEEECCHH
QYAALRDSIDRPLFNRVLRGLYAPGSTVKPEVAIAGLDSGVVTASTKVFDPGYFQLPDFD
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEEEEECCCCEECCCCC
HKYRNWNHSGDGWVDMDTAIMRSNDTYFYTVAHKLGIDRLHDYMTMFGIGQKVSLDMFEE
HHHCCCCCCCCCEEECCHHEEECCCCEEEEEHHHHCHHHHHHHHHHHCCCCCEEHHHHHH
SAGLMPSREWKRATRRQAWFPGETVILGIGQGYMQVTPLQLAQATSLIASKGVWHRPHLA
CCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCEEECHHHHHHHHHHHHHCCCCCCCCEE
MEVGDTAPVDEHPMPNIVLHDPNEWNQVNTGMQMVMHDPRGIARDAAKGAQYRIAGKSGT
EECCCCCCCCCCCCCCEEEECCCCCCHHHCCHHEEEECCCCHHHHHCCCCEEEEECCCCC
AQVVAIKQGERYNRLKTLERNRDNALFVGFAPADHPKIVVSVTIENGEAGGRVAGPVVRE
EEEEEEECCCHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCCHHHHHHH
ILDAWLLDSEGKLKPEYATPAKAPGNPHA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]