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The map label for this gene is ycdW [C]

Identifier: 66045450

GI number: 66045450

Start: 2568228

End: 2569187

Strand: Reverse

Name: ycdW [C]

Synonym: Psyr_2210

Alternate gene names: 66045450

Gene position: 2569187-2568228 (Counterclockwise)

Preceding gene: 66045451

Following gene: 66045449

Centisome position: 42.16

GC content: 61.15

Gene sequence:

>960_bases
ATGACCCGACTCGTGATAGCCAGCCAACTGGATAATGACTTCAATCAGGTCATCCGCGAGCGGCTTGCAGTGACCCATCC
AGAAGCCAGGGTCATCGGCGTACCGGCCGGCGTGCCGAGCGACCTGCCTGCCGAGGTCAGCATTCTGCTGGCGCGCCCTA
TCAATGTGCATGGTTATGAAGCCCCTGCCTCGCCGCCTCCGGGCTGGCCTTATGGCCTGAAATGGATTCAGGTGGTGTCT
TCGGGCATCGACTTCTATCCTGGCTGGCTGTTCGACGGCCCGCCGGTCAGCACCTCGCGGGGCAGCGCGGCAGAAAACAT
TGCCGAGTTCTCGTTGGCCGCCATTTTCGCTGCTGCCAAACACCTGCCGGACATCTGGGTGCATGACTCGCAATGGAATT
TCACTGCACTGACGCCACTCAAGGGCACTACGCTCGGAATTCTCGGCTTCGGCGCCATCGGTAGCAGCCTGGCCGGTAAA
GCGCTGGCACTGGGCATCAACGTTGTGGCATTGCGGCAGAGCCAGACACCGTTCGAGGTTGATGGCGTCGAAAGTACACG
CGACATTCACGAGCTTTTCTCCCGCGCCGACCATCTGGTGCTGGCCGCACCGTTGACACCTGCCACACGGCACATCGTCA
ACGCTGACGTACTGAACAGCGCCAAACCCGGCCTGCACCTGATCAACATCGCCCGTGGTGGGCTGCTTGATCATGAGGCG
CTGCTCAATGCACTGGACCAGGGAAACATTGGCCTCGCGTCGCTGGACGTCACCGAACCCGAGCCCCTGCCGGACGGTCA
TCCCCTGTATGCACACCCCAGAGTACGCCTGTCACCCCACACCTCGGCGATCTCCAGCAATAGCCGCCACGAAATAGCCG
ACAGCTTTCTGGCCAACCTTGACCGTTTCCTCAGCGGGCAGGCCTTGCAGAATCAGGCTGATCACCAGCGTGGCTACTGA

Upstream 100 bases:

>100_bases
CCGAATACACTGGCAATACGCTGCGTGACAATCTCGGTCTTGAAGTGCCGGCCAATCGTTATGCAAAGGCTGTCGCCCAT
CAATCGGACGAGGCTGTGGC

Downstream 100 bases:

>100_bases
CGAAAATCATCTCCATTGCGCTGCGTGGGGATACCACTCCTGACACTCAGTGCCACCTTCAAATACCGAGCGTGCCATGC
CCAAACCGATAAAACACACA

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MTRLVIASQLDNDFNQVIRERLAVTHPEARVIGVPAGVPSDLPAEVSILLARPINVHGYEAPASPPPGWPYGLKWIQVVS
SGIDFYPGWLFDGPPVSTSRGSAAENIAEFSLAAIFAAAKHLPDIWVHDSQWNFTALTPLKGTTLGILGFGAIGSSLAGK
ALALGINVVALRQSQTPFEVDGVESTRDIHELFSRADHLVLAAPLTPATRHIVNADVLNSAKPGLHLINIARGGLLDHEA
LLNALDQGNIGLASLDVTEPEPLPDGHPLYAHPRVRLSPHTSAISSNSRHEIADSFLANLDRFLSGQALQNQADHQRGY

Sequences:

>Translated_319_residues
MTRLVIASQLDNDFNQVIRERLAVTHPEARVIGVPAGVPSDLPAEVSILLARPINVHGYEAPASPPPGWPYGLKWIQVVS
SGIDFYPGWLFDGPPVSTSRGSAAENIAEFSLAAIFAAAKHLPDIWVHDSQWNFTALTPLKGTTLGILGFGAIGSSLAGK
ALALGINVVALRQSQTPFEVDGVESTRDIHELFSRADHLVLAAPLTPATRHIVNADVLNSAKPGLHLINIARGGLLDHEA
LLNALDQGNIGLASLDVTEPEPLPDGHPLYAHPRVRLSPHTSAISSNSRHEIADSFLANLDRFLSGQALQNQADHQRGY
>Mature_318_residues
TRLVIASQLDNDFNQVIRERLAVTHPEARVIGVPAGVPSDLPAEVSILLARPINVHGYEAPASPPPGWPYGLKWIQVVSS
GIDFYPGWLFDGPPVSTSRGSAAENIAEFSLAAIFAAAKHLPDIWVHDSQWNFTALTPLKGTTLGILGFGAIGSSLAGKA
LALGINVVALRQSQTPFEVDGVESTRDIHELFSRADHLVLAAPLTPATRHIVNADVLNSAKPGLHLINIARGGLLDHEAL
LNALDQGNIGLASLDVTEPEPLPDGHPLYAHPRVRLSPHTSAISSNSRHEIADSFLANLDRFLSGQALQNQADHQRGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=247, Percent_Identity=29.1497975708502, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI23308577, Length=215, Percent_Identity=28.3720930232558, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI145580578, Length=175, Percent_Identity=30.8571428571429, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI4557499, Length=175, Percent_Identity=30.8571428571429, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI145580575, Length=187, Percent_Identity=29.9465240641711, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI61743967, Length=175, Percent_Identity=32, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4557497, Length=175, Percent_Identity=32, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI87081824, Length=221, Percent_Identity=32.1266968325792, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082289, Length=217, Percent_Identity=30.4147465437788, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789279, Length=219, Percent_Identity=26.4840182648402, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787645, Length=227, Percent_Identity=25.9911894273128, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=227, Percent_Identity=27.3127753303965, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25147481, Length=192, Percent_Identity=27.0833333333333, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320925, Length=233, Percent_Identity=28.755364806867, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322116, Length=229, Percent_Identity=27.9475982532751, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=171, Percent_Identity=30.4093567251462, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=187, Percent_Identity=28.3422459893048, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24585516, Length=231, Percent_Identity=30.3030303030303, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI28571528, Length=172, Percent_Identity=35.4651162790698, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19921140, Length=182, Percent_Identity=31.8681318681319, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574286, Length=251, Percent_Identity=27.8884462151394, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45551003, Length=249, Percent_Identity=27.3092369477912, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24585514, Length=249, Percent_Identity=27.3092369477912, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574282, Length=249, Percent_Identity=27.3092369477912, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45552429, Length=249, Percent_Identity=27.3092369477912, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574284, Length=249, Percent_Identity=27.3092369477912, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646446, Length=175, Percent_Identity=33.7142857142857, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646448, Length=175, Percent_Identity=33.7142857142857, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646452, Length=175, Percent_Identity=33.7142857142857, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646450, Length=175, Percent_Identity=33.7142857142857, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI62472511, Length=175, Percent_Identity=33.7142857142857, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 34137; Mature: 34006

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLVIASQLDNDFNQVIRERLAVTHPEARVIGVPAGVPSDLPAEVSILLARPINVHGYE
CCEEEEHHHHCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCC
APASPPPGWPYGLKWIQVVSSGIDFYPGWLFDGPPVSTSRGSAAENIAEFSLAAIFAAAK
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HLPDIWVHDSQWNFTALTPLKGTTLGILGFGAIGSSLAGKALALGINVVALRQSQTPFEV
HCCCEEEECCCCCEEEECCCCCCEEEEEEHHHHHHHHCCCEEEECEEEEEEECCCCCCEE
DGVESTRDIHELFSRADHLVLAAPLTPATRHIVNADVLNSAKPGLHLINIARGGLLDHEA
CCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHH
LLNALDQGNIGLASLDVTEPEPLPDGHPLYAHPRVRLSPHTSAISSNSRHEIADSFLANL
HHHHHCCCCCCEEEEECCCCCCCCCCCCEEECCEEEECCCCHHHCCCCHHHHHHHHHHHH
DRFLSGQALQNQADHQRGY
HHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TRLVIASQLDNDFNQVIRERLAVTHPEARVIGVPAGVPSDLPAEVSILLARPINVHGYE
CEEEEHHHHCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCC
APASPPPGWPYGLKWIQVVSSGIDFYPGWLFDGPPVSTSRGSAAENIAEFSLAAIFAAAK
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
HLPDIWVHDSQWNFTALTPLKGTTLGILGFGAIGSSLAGKALALGINVVALRQSQTPFEV
HCCCEEEECCCCCEEEECCCCCCEEEEEEHHHHHHHHCCCEEEECEEEEEEECCCCCCEE
DGVESTRDIHELFSRADHLVLAAPLTPATRHIVNADVLNSAKPGLHLINIARGGLLDHEA
CCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHH
LLNALDQGNIGLASLDVTEPEPLPDGHPLYAHPRVRLSPHTSAISSNSRHEIADSFLANL
HHHHHCCCCCCEEEEECCCCCCCCCCCCEEECCEEEECCCCHHHCCCCHHHHHHHHHHHH
DRFLSGQALQNQADHQRGY
HHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]