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The map label for this gene is cysH [H]

Identifier: 66045318

GI number: 66045318

Start: 2423281

End: 2424015

Strand: Reverse

Name: cysH [H]

Synonym: Psyr_2078

Alternate gene names: 66045318

Gene position: 2424015-2423281 (Counterclockwise)

Preceding gene: 66045320

Following gene: 66045313

Centisome position: 39.78

GC content: 59.32

Gene sequence:

>735_bases
ATGAGCCAACCTTTCGACGTCGCTGAACTGGCGACGACCTATGCGACCAAATCTGCACAAGACATTCTGAAACTGGCCTT
CGAGCACTTCGGCGACGACCTGTGGATCTCTTTCAGCGGTGCCGAGGACGTGGTTCTGGTCGACATGGCCTGGAAGCTGA
ACAAGAACGTCAAGGTCTTCAGCCTGGATACAGGGCGCCTGCATGCGCAAACCTATCGCTTCATCGAGCAGGTCCGCGAG
CACTACAAGATCGAGATCGAGATCGTTTCGCCCGATCACAGCAAGCTTGAACCTTTCGTCAAGGAAAAGGGCCTGTTCAG
CTTTTACCGGGACGGCCATGGCGAATGCTGCGGCATCCGCAAGATCGAGCCGCTGCGTCGCAAACTGTCTGGCGTCAGCG
CCTGGGCAACCGGCCAGCGCCGTGATCAGAGCCCCGGCACCCGCAGCGCCGTTGCTGCAGTGGAAATCGACAGCGCTTTT
TCGACAGCCGAGCGCACGCTGTACAAATTCAACCCGTTGGCACAAATGAGCAGCGAGGAAATCTGGGGCTACATCCGCAT
GCTGGAGCTGCCCTACAACAGCCTGCACGAGCGCGGCTTCATCAGCATCGGCTGCGAACCCTGCACCCGCCCGGTATTGC
CGAACCAGCACGAGCGCGAAGGTCGCTGGTGGTGGGAAGAAGCCACGCAGAAGGAATGCGGGCTGCATGCGGGCAATCTG
ATAGTGCGCGACTAA

Upstream 100 bases:

>100_bases
ACTCTAGCCGCTGGCAACGGCCACTGAACAGCGGATTTTGTTACCATTGCCGCCATCACGAGCGCTTAAGCGCCACTCTT
GCATTTTAGGAAGCCGCCTG

Downstream 100 bases:

>100_bases
TGTCGCGAGCGGCAAGCTTCAAGCTTCAAGCTTCAAGCTTCAAGTCAAAGCGCGTAGGGCTCTGGCTTGTAGCTTGTAGC
TTGTAGCTTGTAGCTTGTAG

Product: phosphoadenosine phosphosulfate reductase

Products: NA

Alternate protein names: 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAPS sulfotransferase; PAdoPS reductase [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MSQPFDVAELATTYATKSAQDILKLAFEHFGDDLWISFSGAEDVVLVDMAWKLNKNVKVFSLDTGRLHAQTYRFIEQVRE
HYKIEIEIVSPDHSKLEPFVKEKGLFSFYRDGHGECCGIRKIEPLRRKLSGVSAWATGQRRDQSPGTRSAVAAVEIDSAF
STAERTLYKFNPLAQMSSEEIWGYIRMLELPYNSLHERGFISIGCEPCTRPVLPNQHEREGRWWWEEATQKECGLHAGNL
IVRD

Sequences:

>Translated_244_residues
MSQPFDVAELATTYATKSAQDILKLAFEHFGDDLWISFSGAEDVVLVDMAWKLNKNVKVFSLDTGRLHAQTYRFIEQVRE
HYKIEIEIVSPDHSKLEPFVKEKGLFSFYRDGHGECCGIRKIEPLRRKLSGVSAWATGQRRDQSPGTRSAVAAVEIDSAF
STAERTLYKFNPLAQMSSEEIWGYIRMLELPYNSLHERGFISIGCEPCTRPVLPNQHEREGRWWWEEATQKECGLHAGNL
IVRD
>Mature_243_residues
SQPFDVAELATTYATKSAQDILKLAFEHFGDDLWISFSGAEDVVLVDMAWKLNKNVKVFSLDTGRLHAQTYRFIEQVREH
YKIEIEIVSPDHSKLEPFVKEKGLFSFYRDGHGECCGIRKIEPLRRKLSGVSAWATGQRRDQSPGTRSAVAAVEIDSAFS
TAERTLYKFNPLAQMSSEEIWGYIRMLELPYNSLHERGFISIGCEPCTRPVLPNQHEREGRWWWEEATQKECGLHAGNLI
VRD

Specific function: Reduction of activated sulfate into sulfite [H]

COG id: COG0175

COG function: function code EH; 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAPS reductase family. CysH subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789121, Length=201, Percent_Identity=27.363184079602, Blast_Score=81, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6325425, Length=230, Percent_Identity=28.695652173913, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011798
- InterPro:   IPR004511
- InterPro:   IPR002500
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01507 PAPS_reduct [H]

EC number: =1.8.4.8 [H]

Molecular weight: Translated: 27956; Mature: 27825

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPFDVAELATTYATKSAQDILKLAFEHFGDDLWISFSGAEDVVLVDMAWKLNKNVKVF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEECCCCEEEE
SLDTGRLHAQTYRFIEQVREHYKIEIEIVSPDHSKLEPFVKEKGLFSFYRDGHGECCGIR
EECCCCHHHHHHHHHHHHHHCEEEEEEEECCCCHHHHHHHHHCCCHHHHHCCCCCEECCC
KIEPLRRKLSGVSAWATGQRRDQSPGTRSAVAAVEIDSAFSTAERTLYKFNPLAQMSSEE
CHHHHHHHHCCCCHHCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHCCCHHHCCHHH
IWGYIRMLELPYNSLHERGFISIGCEPCTRPVLPNQHEREGRWWWEEATQKECGLHAGNL
HHHHHHHEECCHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCE
IVRD
EEEC
>Mature Secondary Structure 
SQPFDVAELATTYATKSAQDILKLAFEHFGDDLWISFSGAEDVVLVDMAWKLNKNVKVF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEECCCCEEEE
SLDTGRLHAQTYRFIEQVREHYKIEIEIVSPDHSKLEPFVKEKGLFSFYRDGHGECCGIR
EECCCCHHHHHHHHHHHHHHCEEEEEEEECCCCHHHHHHHHHCCCHHHHHCCCCCEECCC
KIEPLRRKLSGVSAWATGQRRDQSPGTRSAVAAVEIDSAFSTAERTLYKFNPLAQMSSEE
CHHHHHHHHCCCCHHCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHCCCHHHCCHHH
IWGYIRMLELPYNSLHERGFISIGCEPCTRPVLPNQHEREGRWWWEEATQKECGLHAGNL
HHHHHHHEECCHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCE
IVRD
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA