Click here to switch to the map view.

The map label for this gene is fabB [H]

Identifier: 66045259

GI number: 66045259

Start: 2343838

End: 2345061

Strand: Reverse

Name: fabB [H]

Synonym: Psyr_2019

Alternate gene names: 66045259

Gene position: 2345061-2343838 (Counterclockwise)

Preceding gene: 66045260

Following gene: 66045256

Centisome position: 38.48

GC content: 60.87

Gene sequence:

>1224_bases
ATGCGCCGCGTCGTTATCACTGGTCTGGGTATTGTTTCCTGCTTGGGCAATGACAAAGACACCGTCACCGCTAACCTGCG
TGCTAACCGCCCTGGCATCCGCTTCAACCCGGAATATGCCGAAATGGGTCTGCGTAGCCAGGTTTCCGGCTCCATCGACC
TGAATCTGGAAGAACTGATCGATCGCAAGATCTTCCGCTTCGTCGGCCATGCGGCAGCCTATGCCTATCTGGCGATGAAA
GACGCCATTACCGATTCGGGCCTGACCGACGAGCAGGTTTCCAACGTGCGTACCGGTCTGATCGCCGGCAGCGGCGGCGC
CTCGACCCTGAACCAGATGGAAGCGCTGGATACCCTGCGTGAAAAAGGCGTCAAGCGTGTCGGCCCTTACCGCGTCACGC
GGACCATGGGCAGCACCGTTTCGGCCTGCCTGGCCACGCCGTTCAAGATCAAGGGTGTGAACTACTCCATCTCGTCCGCC
TGCGCCACCAGCGCACACTGCATCGGCAACGCTGTCGAGCAGATCCAGCTGGGCAAGCAGGACATCGTCTTTGCCGGTGG
CGGCGAAGAAGAGCACTGGAGCCAGTCGTTCCTGTTCGACGCGATGGGCGCGCTGTCCACCCAGTACAACGAGACGCCGG
AAAAAGCCTCGCGTGCCTACGATGCCAAGCGTGACGGTTTCGTCATTGCCGGTGGTGGCGGCATGGTGGTTGTCGAAGAA
CTCGAACACGCTCTGGCGCGTGGCGCGAAGATCTACGCAGAAATCGTCGGTTACGGCGCGACCTCCGATGGCTACGACAT
GGTCGCACCCAGCGGTGAAGGTGCCATTCGTTGCATGAAGATGGCGCTGGGCGATATCGACTCCGGTGCCATTGACTACA
TCAACACCCATGGCACCTCGACCCCGGTCGGCGACGCCAAGGAAATGGAGGGCGTGCGCGAAGTATTCGGCGCCAACGCT
CCGGCGATCAGCTCCACCAAGAGCCTGTCGGGCCACTCGCTGGGCGCCGCAGGTGTCCACGAAGCGATCTACTGCCTGCT
GATGATGGAGAACAACTTCATCGCAGGTTCGGCCAACATCGACGAGCTGGACCCGGTGGTTGCCGACATGCCTATCCTGC
TCAAGACCCAGGAAGATGCGAAGCTCGATCTGGTCATGAGCAACAGCTTCGGCTTCGGCGGCACCAACGCCACGCTGGTG
TTGAAACGCTGGGCGGGCAAGTAA

Upstream 100 bases:

>100_bases
GCCGACGGTTCGGTGAGTGTCGACGGTCGCGAAATCTATACCGCCGAAGGCCTCCGGGTCGGCGTGTTCACTTCCACTGA
AAATTTCTAAGGGTACTCGC

Downstream 100 bases:

>100_bases
TACTGCTTCTGCAACAAACAGAAAAGGCGCCTTTCAAGGCGCCTTTTTTGTGAGTCGGGCAAAGTGGCTAGTGTTCTTCG
GTATATCTACGGGGACAATG

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MRRVVITGLGIVSCLGNDKDTVTANLRANRPGIRFNPEYAEMGLRSQVSGSIDLNLEELIDRKIFRFVGHAAAYAYLAMK
DAITDSGLTDEQVSNVRTGLIAGSGGASTLNQMEALDTLREKGVKRVGPYRVTRTMGSTVSACLATPFKIKGVNYSISSA
CATSAHCIGNAVEQIQLGKQDIVFAGGGEEEHWSQSFLFDAMGALSTQYNETPEKASRAYDAKRDGFVIAGGGGMVVVEE
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMKMALGDIDSGAIDYINTHGTSTPVGDAKEMEGVREVFGANA
PAISSTKSLSGHSLGAAGVHEAIYCLLMMENNFIAGSANIDELDPVVADMPILLKTQEDAKLDLVMSNSFGFGGTNATLV
LKRWAGK

Sequences:

>Translated_407_residues
MRRVVITGLGIVSCLGNDKDTVTANLRANRPGIRFNPEYAEMGLRSQVSGSIDLNLEELIDRKIFRFVGHAAAYAYLAMK
DAITDSGLTDEQVSNVRTGLIAGSGGASTLNQMEALDTLREKGVKRVGPYRVTRTMGSTVSACLATPFKIKGVNYSISSA
CATSAHCIGNAVEQIQLGKQDIVFAGGGEEEHWSQSFLFDAMGALSTQYNETPEKASRAYDAKRDGFVIAGGGGMVVVEE
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMKMALGDIDSGAIDYINTHGTSTPVGDAKEMEGVREVFGANA
PAISSTKSLSGHSLGAAGVHEAIYCLLMMENNFIAGSANIDELDPVVADMPILLKTQEDAKLDLVMSNSFGFGGTNATLV
LKRWAGK
>Mature_407_residues
MRRVVITGLGIVSCLGNDKDTVTANLRANRPGIRFNPEYAEMGLRSQVSGSIDLNLEELIDRKIFRFVGHAAAYAYLAMK
DAITDSGLTDEQVSNVRTGLIAGSGGASTLNQMEALDTLREKGVKRVGPYRVTRTMGSTVSACLATPFKIKGVNYSISSA
CATSAHCIGNAVEQIQLGKQDIVFAGGGEEEHWSQSFLFDAMGALSTQYNETPEKASRAYDAKRDGFVIAGGGGMVVVEE
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMKMALGDIDSGAIDYINTHGTSTPVGDAKEMEGVREVFGANA
PAISSTKSLSGHSLGAAGVHEAIYCLLMMENNFIAGSANIDELDPVVADMPILLKTQEDAKLDLVMSNSFGFGGTNATLV
LKRWAGK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=35.9712230215827, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI223972627, Length=138, Percent_Identity=44.9275362318841, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI41872631, Length=345, Percent_Identity=28.4057971014493, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1788663, Length=405, Percent_Identity=67.1604938271605, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=37.3170731707317, Blast_Score=235, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=419, Percent_Identity=34.8448687350835, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=40.7547169811321, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17550940, Length=359, Percent_Identity=26.1838440111421, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI212642053, Length=387, Percent_Identity=24.5478036175711, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=450, Percent_Identity=31.1111111111111, Blast_Score=180, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=37.6190476190476, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI19920632, Length=342, Percent_Identity=27.7777777777778, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221330659, Length=342, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24581345, Length=414, Percent_Identity=24.3961352657005, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43047; Mature: 43047

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGLGIVSCLGNDKDTVTANLRANRPGIRFNPEYAEMGLRSQVSGSIDLNLEELI
CCEEEEECCHHHHHCCCCCCEEEEEEECCCCCCEECCHHHHCCCHHHCCCCCCCCHHHHH
DRKIFRFVGHAAAYAYLAMKDAITDSGLTDEQVSNVRTGLIAGSGGASTLNQMEALDTLR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEECCCCHHHHHHHHHHHHHH
EKGVKRVGPYRVTRTMGSTVSACLATPFKIKGVNYSISSACATSAHCIGNAVEQIQLGKQ
HCCCHHCCCCHHHHHHHHHHHHHHCCCEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCCC
DIVFAGGGEEEHWSQSFLFDAMGALSTQYNETPEKASRAYDAKRDGFVIAGGGGMVVVEE
EEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEECCCCEEEHHH
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMKMALGDIDSGAIDYINTHGTS
HHHHHHCCHHEEEHHHCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCCC
TPVGDAKEMEGVREVFGANAPAISSTKSLSGHSLGAAGVHEAIYCLLMMENNFIAGSANI
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEEECCEEECCCCC
DELDPVVADMPILLKTQEDAKLDLVMSNSFGFGGTNATLVLKRWAGK
HHHCHHHHCCCEEEECCCCCEEEEEEECCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure
MRRVVITGLGIVSCLGNDKDTVTANLRANRPGIRFNPEYAEMGLRSQVSGSIDLNLEELI
CCEEEEECCHHHHHCCCCCCEEEEEEECCCCCCEECCHHHHCCCHHHCCCCCCCCHHHHH
DRKIFRFVGHAAAYAYLAMKDAITDSGLTDEQVSNVRTGLIAGSGGASTLNQMEALDTLR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEEEECCCCHHHHHHHHHHHHHH
EKGVKRVGPYRVTRTMGSTVSACLATPFKIKGVNYSISSACATSAHCIGNAVEQIQLGKQ
HCCCHHCCCCHHHHHHHHHHHHHHCCCEEEECCCEEHHHHHHHHHHHHHHHHHHHHCCCC
DIVFAGGGEEEHWSQSFLFDAMGALSTQYNETPEKASRAYDAKRDGFVIAGGGGMVVVEE
EEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEECCCCEEEHHH
LEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAIRCMKMALGDIDSGAIDYINTHGTS
HHHHHHCCHHEEEHHHCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCCC
TPVGDAKEMEGVREVFGANAPAISSTKSLSGHSLGAAGVHEAIYCLLMMENNFIAGSANI
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEEECCEEECCCCC
DELDPVVADMPILLKTQEDAKLDLVMSNSFGFGGTNATLVLKRWAGK
HHHCHHHHCCCEEEECCCCCEEEEEEECCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]